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In situ TEM observation of nucleation and crystallization of nanoparticle in ceramic glasses

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In situ TEM observation of nucleation and crystallization of...

Plasmonic enhancement and polarization dependence of nonlinear upconversion emissions from single gold nanorod@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures

第二届全国光电材料与器件学术研讨会

作者： Ting Wang Xue yu Jianbei Qiu siu fung yu Xuhui Xu College of Materials and Chemistry & Chemical Engineering Chengdu University of Technology College of Materials Science and Engineering Kunming University of Science and Technology Department of Applied Physics The Hong Kong Polytechnic University

Direct nucleates to a new thermodynamic phase and multiple-step nucleation via metastable intermediates are the contradictory mechanisms to explain the nucleation process of *** observation of their coexistence further confuses our understanding on the growth kinetics of ***,we perform real-time in situ transmission electron microscopy imaging of ZnO,Ba LaF,and Ag nanocrystals growth in the amorphous *** to the slow nucleation rate in the amorphous glass,the amorphous-to-crystalline phase transition of all the nanocrystals can be captured in *** a result,we reveal the missing puzzle of the nucleation kinetics-the heterogeneous crystallization occurs initially at the interface of the amorphous *** discovery resolves the inconsistency between the classical and non-classical nucleation theory and the uncertainties of the nanocrystal formation observed recently.

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Light(Science & Applications) 2016年第1期5卷 224-234页

作者： Jijun He Wei Zheng Filip Ligmajer Chi-Fai Chan Zhiyong Bao Ka-Leung Wong Xueyuan Chen Jianhua Hao Jiyan Dai siu-fung yu Dang yuan Lei Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Central European Institute of Technology Brno University of TechnologyBrno 61669Czech Republic Department of Chemistry Hong Kong Baptist UniversityHong KongChina

Lanthanide-doped upconversion nanocrystals(UCNCs)have recently become an attractive nonlinear fluorescence material for use in bioimaging because of their tunable spectral characteristics and exceptional *** materials are often introduced into the vicinity of UCNCs to increase their emission intensity by means of enlarging the absorption cross-section and accelerating the radiative decay ***,plasmonic nanostructures(e.g.,gold nanorods,GNRs)can also influence the polarization state of the UC fluorescence—an effect that is of fundamental importance for fluorescence polarization-based imaging methods yet has not been discussed *** study this effect,we synthesized GNR@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures with precise control over the thickness of the SiO_(2) *** evaluated the shell thicknessdependent plasmonic enhancement of the emission intensity in ensemble and studied the plasmonic modulation of the emission polarization at the single-particle *** hybrid plasmonic UC nanostructures with an optimal shell thickness exhibit an improved bioimaging performance compared with bare UCNCs,and we observed a polarized nature of the light at both UC emission bands,which stems from the relationship between the excitation polarization and GNR *** used electrodynamic simulations combined with Förster resonance energy transfer theory to fully explain the observed *** results provide extensive insights into how the coherent interaction between the emission dipoles of UCNCs and the plasmonic dipoles of the GNR determines the emission polarization state in various situations and thus open the way to the accurate control of the UC emission anisotropy for a wide range of bioimaging and biosensing applications.

关键词： Förster resonance energy transfer gold nanorods lanthanide-doped upconversion nanocrystals plasmon-enhanced nonlinear fluorescence polarization modulation

Ischemic stroke with concomitant clear cell carcinoma of the ovary:A case report and review of literature

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World Journal of Clinical Cases 2024年第20期12卷 4397-4404页

作者： Wing yu Sharon siu Dah-Ching Ding Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalHualien 970Taiwan Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTzu Chi UniversityHualien 970Taiwan Institute of Medical Sciences Tzu Chi UniversityHualien 970Taiwan

BACKGROUND Ischemic stroke is a rare event associated with an elevated risk of blood clot formation owing to an underlying ***,we present a case of ovarian carcinoma that led to cerebral *** SUMMARY A 43-year-old woman experienced sudden onset right-sided paralysis and difficulty speaking two days after discovery of a large ovarian tumor measuring approximately 14 cm,which was suspected to be *** examination revealed left middle cerebral artery *** patient had a history of hypertension and *** stabilization with heparin treatment and vital signs management,the patient underwent debulking surgery,including total hysterectomy,bilateral salpingo-oophorectomy,omentectomy,and bilateral pelvic and para-aortic lymph node *** final diagnosis was clear cell carcinoma of the right ovary(stage IA).Subsequently,the patient completed six rounds of adjuvant chemotherapy while simultaneously undergoing ***,the patient is able to walk independently,although she still experiences *** Prompt medical intervention and interdisciplinary care are crucial in the setting of incidental findings such as a large ovarian tumor.

关键词： Ovarian cancer Ischemic stroke Coagulation Infarction Case report

NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： yue Yao Yi Xu Liang yu Ting-Mao Xue Zhi-Jie Xiao Pui-Chi Tin Hiu-Ling fung Hoi-Tang Ma Jing-Ping yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

Hepatic venous outflow obstruction after piggyback liver transplantation by an unusual mechanism:Report of a case

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World Journal of Gastroenterology 2006年第33期12卷 5416-5418页

作者： Simon siu-Man Ng Simon Chun-Ho yu Janet fung-Yee Lee Paul Bo-San Lai Wan-Yee Lau Departments of Surgery and Diagnostic Radiology & Organ Imaging Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China

Hepatic venous outflow obstruction after piggyback liver transplantation is a very rare complication. An unusual mechanism aggravating it is reported. A 33-year-old man with end-stage hepatitis B liver cirrhosis underwent a piggyback orthotopic liver transplantation using a full-size cadaveric graft. Two months after transplantation, he developed gross ascites refractory to maximal diuretic therapy. Doppler ultrasound showed patent portal and hepatic veins. Serial computed tomography scans revealed a hypoperfused right posterior segment of the liver which subsequently underwent atrophy. Hepatic venography demonstrated a high-grade stenosis with an element of torsion of venous drainage at the anastomosis. The stenosis was successfully treated with repeated percutaneous balloon angioplasty. The patient remained asymptomatic six months afterwards with complete resolution of ascites and peripheral edema. We postulate that liver allograft segmental hypoperfusion and atrophy may aggravate or result in a hepatic venous outflow problem by the mechanism of torsion effect. Percutaneous balloon angioplasty is a safe and effective treatment modality for anastomotic stenosis.

关键词： Hepatic venous outflow obstruction Piggyback Liver transplantation Percutaneous balloon angioplasty

Multi-limb necrotizing fasciitis in a patient with rectal cancer

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World Journal of Gastroenterology 2006年第32期12卷 5256-5258页

作者： Shirley yuk Wah Liu Simon siu Man Ng Janet fung Yee Lee Department of Surgery Prince of Wales Hospital 30-32 Ngan Shing StreetShatinN.T.Hong KongChina

Necrotizing fasciitis is a devastating soft tissue infection affecting fascias and subcutaneous soft tissues. Literature reviews have identified several related risk factors, including malignancy, alcoholism, malnutrition, diabetes, male gender and old age. There are only scanty case reports in the literature describing its rare association with colorectal malignancy. All published cases are attributed to bowel perforation resulting in necrotizing fasciitis over the perineal region. Isolated upper or lower limb diseases are rarely identified. Simultaneous upper and lower limb infection in colorectal cancer patients has never been described in the literature. We report an unusual case of multi-limb necrotizing fasciitis in a patient with underlying non-perforated rectal carcinoma.

关键词： Necrotizing fasciitis Soft tissue infection Colorectal cancer Malignancy Group G streptococcus

Role and outcome of conventional surgery in the treatment of pyogenic liver abscess in the modern era of minimally invasive therapy

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World Journal of Gastroenterology 2008年第5期14卷 747-751页

作者： Simon siu-Man Ng Janet fung-Yee Lee Paul Bo-San Lai Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China

AIM:To evaluate the role and outcome of conventional surgery in the treatment of pyogenic liver abscess in the modern era of minimally invasive therapy. METHODS:The medical records of thirteen patients with pyogenic liver abscess who underwent surgical treatment between January 1995 and December 2002 were retrospectively reviewed to determine the clinical presentation, indication and nature of surgery, and out-come of surgery. RESULTS:The patients were predominantly women (10/13) with a mean age of 65 ± 17 years. Their main presenting symptoms were abdominal pain (100%) and fever (77%). The aetiologies included biliary (n = 6), cryptogenic (n = 3), portal (n = 2), and trauma (n = 2). Seven patients underwent percutaneous drainage as the initial treatment. Of these, three patients developed peritonitis secondary to peritoneal spillage. Another four patients failed to respond because of multilocula-tion. Salvage surgery was required in these patients. Six patients proceeded to straight laparotomy:two had marked sepsis and multiloculated abscess that precluded percutaneous drainage, and four presented with perito-nitis of uncertain pathology. Surgical procedures included deroofment and drainage (n = 9), liver resection (n = 3), peritoneal lavage (n = 2), cholecystectomy (n = 4), and exploration of common bile duct (n = 2). One patient required reoperation because of bleeding. Three patients required further percutaneous drainage after surgery. The overall mortality was 46%. Four patients died of multiorgan failure and two patients died of pulmonary embolism. CONCLUSION:Surgical treatment of pyogenic liver ab-scess is occasionally needed when percutaneous drainage has failed due to various reasons. Mortality rate in this group of patients has remained high.

关键词： Pyogenic liver abscess Surgical drainage Liver resection Percutaneous drainage Outcome

Liver Transplantation for Hepatitis B Virus-related Hepatocellular Carcinoma in Hong Kong

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 283-288页

作者： Ka Wing Ma Kenneth siu Ho Chok James Yan yue fung Chung Mau Lo Department of Surgery The University of Hong KongHong KongChina State Key Laboratory for Liver Research The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)is the fifth most common cancer and the third most common cause of cancer-related deaths *** resection is frequently limited in Hong Kong by hepatitis B virus-related cirrhosis,and liver transplantation is the treatment of *** transplanta-tion has been shown to produce superior oncological benefits,when compared to hepatectomy for *** developments in the context of patient selection criteria,modification of organ allocation,bridging therapy,salvage liver transplanta-tion and pharmaceutical breakthrough have improved the survival of HCC *** this article,we will share our experience in transplanting hepatitis B virus-related HCC patients in Hong Kong and discuss the recent progress in several areas of liver transplantation.

关键词： Liver transplantation Hepatitis B Hepatocel ular carcinoma Review

Performance improvement of solution-processed CdS/CdTe solar cells with a thin compact TiO_2 buffer layer

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Science Bulletin 2016年第1期61卷 86-91页

作者： Aashir Waleed Qianpeng Zhang Mohammad Mahdi Tavakoli siu-fung Leung Leilei Gu Jin He Xiaoliang Mo Zhiyong Fan Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology Peking University Shenzhen SOC Key Laboratory PKUHKUST Shenzhen-Hongkong Instituition Department of Materials Science Fudan University

The device performance of CdS/CdTe solar cells largely depends on not only the back ohmic contact, but also the conformality of Cd S window layer coating. In order to reduce the light absorption loss in Cd S, the Cd S thickness is usually less than 100 nm. However, pinholes in Cd S and non-conformal coverage of Cd S on transparent conducting oxide layer will cause shunting thus leading to device performance degradation and failure. In this paper, low-temperature and low-cost fabrication methods, i.e., chemical bath deposition and electrochemical deposition, were used to deposit Cd S and Cd Te, respectively. It was found that the yield of device was around 20 % due to shunting. In order to alleviate this problem, a compact layer of TiO2 was inserted between the fluorine-doped tin oxide and Cd S as a buffer layer. The thickness effect of TiO2 was studied and showed that devices with thin(20 nm thickness) TiO2 performed better than the counterparts with thick layers. It was discovered that device yield improved to 80 % and stability in air substantially improved with TiO2 layer.

关键词： Thin films Titanium dioxide Solarenergy Cadmium compounds