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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

2003年康复医学发展论坛暨庆祝中国康复医学会成立20周年学术大会

作者： siu pui lam, Ho pui So, I Tang, S Chong, E Tang, W Kwan, T Ma, D Woo, CC Leung, A Yeung. Department of Rehabilitation & Extended Care, TWGHs Wong Tai Sin Hospital

Aims and objectivesSANS had contributed to significant mortality and morbidity worldwide. We had developed acomprehensive SARS pulmonary rehabilitation program (PRP) for recovered SARS patients.

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex pui Kin lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi pui Yi Ho Feijun Hu Yujeong Kim Hill lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

An AI-empowered indoor digital contact tracing system for COVID-19 outbreaks in residential care homes

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Infectious Disease Modelling 2024年第2期9卷 474-482页

作者： Jiahui Meng Justina Yat Wa Liu Lin Yang Man Sing Wong Hilda Tsang Boyu Yu Jincheng Yu Freddy Man-Hin lam Daihai He Lei Yang Yan Li Gilman Kit-Hang siu Stefanos Tyrovolas Yao Jie Xie David Man David H.K.Shum School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Research Centre of Textiles for Future Fashion The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Computing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Nutrition and Food Studies George Mason UniversityUSA Tung Wah College Hong Kong Special Administrative RegionChina Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

An AI-empowered indoor digital contact-tracing system was developed using a centralized architecture and advanced low-energy Bluetooth technologies for indoor positioning,with careful preservation of privacy and data *** analyzed the contact pattern data from two RCHs and investigated a COVID-19 outbreak in one study *** evaluate the effectiveness of the system in containing outbreaks with minimal contacts under quarantine,a simulation study was conducted to compare the impact of different quarantine strategies on outbreak containment within *** significant difference in contact hours between weekdays and weekends was observed for some pairs of RCH residents and staff during the two-week data collection *** significant difference between secondary cases and uninfected contacts was observed in a COVID-19 outbreak in terms of their demographics and contact *** results based on the collected contact data indicated that a threshold of accumulative contact hours one or two days prior to diagnosis of the index case could dramatically increase the efficiency of outbreak containment within RCHs by targeted isolation of the close *** study demonstrated the feasibility and efficiency of employing an AI-empowered system in indoor digital contact tracing of outbreaks in RCHs in the post-pandemic era.

关键词： COVID-19 Indoor contact tracing Contact pattern Outbreak containment Artificial intelligence

Non-conventional modeling of extreme significant wave height through random sets

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Acta Oceanologica Sinica 2014年第7期33卷 125-130页

作者： ZHANG Yi lam Jasmine siu Lee Division of Infrastructure Systems and Maritime Studies School of Civil and Environmental EngineeringN1-B1a-25 Nanyang Technological UniversitySingapore Division of Infrastructure Systems and Maritime Studies School of Civil and Environmental EngineeringN1-01b-43 Nanyang Technological UniversitySingapore

The analysis and design of offshore structures necessitates the consideration of wave loads. Realistic modeling of wave loads is particularly important to ensure reliable performance of these structures. Among the available methods for the modeling of the extreme significant wave height on a statistical basis, the peak over threshold method has attracted most attention. This method employs Poisson process to character- ize time-varying properties in the parameters of an extreme value distribution. In this paper, the peak over threshold method is reviewed and extended to account for subjectivity in the modeling. The freedom in selecting the threshold and the time span to separate extremes from the original time series data is incorpo- rated as imprecision in the model. This leads to an extension from random variables to random sets in the probabilistic model for the extreme significant wave height. The extended model is also applied to different periods of the sampled data to evaluate the significance of the climatic conditions on the uncertainties of the parameters.

关键词： offshore engineering extreme value distribution wave height peak over threshold randomset Pareto distribution

k-Dimensional hashing scheme for hard disk integrity verification in computer forensics

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第10期12卷 809-818页

作者： Zoe Lin JIANG Lucas Chi Kwong HUI siu Ming YIU Kam pui CHOW School of Computer Science and Technology Harbin Institute of Technology Shenzhen Graduate School Department of Computer Science The University of Hong Kong

Verifying the integrity of a hard disk is an important concern in computer forensics,as the law enforcement party needs to confirm that the data inside the hard disk have not been modified during the investigation.A typical approach is to compute a single chained hash value of all sectors in a specific ***,this technique loses the integrity of all other sectors even if only one of the sectors becomes a bad sector occasionally or is modified *** this paper we propose a k-dimensional hashing scheme,kD for short,to distribute sectors into a kD space,and to calculate multiple hash values for sectors in k dimensions as integrity *** the integrity of the sectors can be verified depending on any hash value calculated using the sectors,the probability to verify the integrity of unchanged sectors can be high even with bad/modified sectors in the hard *** show how to efficiently implement this kD hashing scheme such that the storage of hash values can be reduced while increasing the chance of an unaffected sector to be verified *** results of a 3D scheme show that both the time for computing the hash values and the storage for the hash values are reasonable.

关键词： Computer forensics Digital evidence Hard disk integrity k-Dimensional hashing

Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection

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World Journal of Gastroenterology 2009年第26期15卷 3288-3297页

作者： Elegance Ting pui lam Cindy Lo Kuen lam Ching Lung Lai Man Fung Yuen Daniel Yee Tak Fong Department of Medicine The University of Hong Kong Department of Nursing Studies The University of Hong Kong

AIM： To test the psychometric properties of a Chinese [（Hong Kong） HK] translation of the chronic liver disease questionnaire （CLDQ）. METHODS： A Chinese （HK） translation of the CLDQ was developed by iterative translation and cognitive debriefing. It was then administered to 72 uncomplicated and 78 complicated chronic hepatitis B （CriB） patients in Hong Kong together with a structured questionnaire on service utilization, and the Chinese （HK） SF-36 Health Survey Version 2 （SF-36v2）. RESULTS： Scaling success was ≥ 80% for all but three items. A new factor assessing sleep was found and items of two （Fatigue and Systemic Symptoms） subscales tended to load on the same factor. Internal consistency and test-retest reliabilities ranged from 0.58-0.90 for different subscales. Construct validity was confirmed by the expected correlations between the SF-36v2 Health Survey and CLDQ scores. Mean scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB, supporting sensitivity in detecting differences between groups.CONCLUSION： The Chinese （HK） CLDQ is valid, reliable and sensitive for patients with CHB. Some modifications to the scaling structure might further improve its psychometric properties,

关键词： Chronic liver disease Health-related quality of life Hepatitis B Southern Chinese Validity

Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome

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World Journal of Emergency Medicine 2021年第2期12卷 143-150页

作者： Rex pui Kin lam Eric Ho Yin Lau Wai lam Yip Joe Kai Shing Leung Matthew Sik Hon Tsui Emergency Medicine Unit Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina Accident and Emergency Department Pamela Youde Nethersole Eastern HospitalHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding *** reasons for consumption include regulating bodily functions,curing disease,and building up health.

关键词： has editor curing

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混凝土应力状态对碳化深度的影响

建筑结构学报 2018年第S1期39卷 397-404页

作者：王健 NG pui-lam 苏瀚杜进生北京交通大学土木建筑工程学院北京100044 维尔纽斯皇家理工大学土木工程学院维尔纽斯10223

为考虑混凝土应力状态对碳化深度的影响,在混凝土碳化深度模型中增加了应力影响系数。利用已有文献的试验数据,进一步研究了应力影响系数随混凝土应力比变化的规律,并分别建立了应力影响系数随混凝土拉、压应力比变化的计算式。将建立... 详细信息

为考虑混凝土应力状态对碳化深度的影响,在混凝土碳化深度模型中增加了应力影响系数。利用已有文献的试验数据,进一步研究了应力影响系数随混凝土应力比变化的规律,并分别建立了应力影响系数随混凝土拉、压应力比变化的计算式。将建立的应力影响系数计算式与既有的3组典型计算式进行了对比,结果表明,建立的应力影响系数计算式较合理,具有较高的预测精度。对规范中的应力影响系数计算式进行了评价,结果表明,在混凝土拉应力状态下,应力影响系数取值偏于不安全;相反,在混凝土压应力状态下,取值偏于保守,因此可将文中所提计算式作为规范中应力影响系数的修正式。

关键词：混凝土碳化深度模型应力状态应力影响系数