检索结果-南通市图书馆

Journal of Geoscience and Environment Protection 2019年第4期7卷 99-121页

作者： siting xie College of Economics Jinan University Guangzhou China

With the continuous development of urban public transportation, the harmful GHG emissions and pollutants generated by itself and the consequent issues such as the losses of residents’ health, economic value and residents’ welfare have become the focus of social attention. In order to study the impacts of promoting new energy vehicles on public transportation pollution mitigation and residents’ health benefits, this paper adopts the LEAP model to build some scenarios that fulfill different development needs to quantitatively analyze the ownership of new energy buses, the reduction of pollutants and the losses of residents’ health welfare. It is concluded that promoting new energy buses comprehensively can significantly reduce the emissions of atmospheric pollutants and the economic losses of residents’ health, but cannot fully realize the targets of greenhouse gas reduction under Life Cycle Analysis.

关键词： New Energy Buses Emission Mitigation Economic Benefits Life-Cycle Analysis Scenario Analysis

基于京麟机器人的校园无人配送系统研究——以广州华夏职业学院为例

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算机应用文摘 2024年第6期40卷 88-90页

作者：谢晓嘉陈思婷沈木燕广州华夏职业学院广州510935

近年来,随着智能制造的转型升级和智慧物流的创新发展,物流机器人(包括AGV、AMR、无人叉车、拆零栋选机器人等)已成为人们日常生活和工作中的重要组成部分。然而,目前许多大型电子商务平台主要集中在无人配送车的研究上,对于校园和封闭... 详细信息

近年来,随着智能制造的转型升级和智慧物流的创新发展,物流机器人(包括AGV、AMR、无人叉车、拆零栋选机器人等)已成为人们日常生活和工作中的重要组成部分。然而,目前许多大型电子商务平台主要集中在无人配送车的研究上,对于校园和封闭式居民区等末端快递配送服务的细节关注较少。文章以京东智慧物流产教融合人才培养基地为背景,以京东京麟机器人为基础,对校园内如何实现无人配送进行研究。通过设计基于移动机器人的校园无人配送系统解决方案,在探索构建完整的电商-物流一体化校园生态链条。

关键词：物流配送机器人无人配送系统京麟机器人

基于哲学探究活动的5-6岁儿童批判性思维能力的情境判断测验编制

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北京教育学院学报 2024年第1期38卷 41-49页

作者：谢庆斌薛曼莉林思婷尤诗源何梅玲郑敏希福建师范大学教育学院福建福州350007 南京师范大学教育科学学院江苏南京210097 福州市儿童学园福建福州350001 福建师范大学实验幼儿园福建福州350007

批判性思维是一种从儿童期开始发展并影响人一生的重要能力。基于哲学探究活动的5~6岁儿童批判性思维能力的情境判断测验,选取符合儿童真实生活的故事情景,从综合调节、评价调节、说明、分析和推断五个能力维度,重点评价儿童思维的“过... 详细信息

批判性思维是一种从儿童期开始发展并影响人一生的重要能力。基于哲学探究活动的5~6岁儿童批判性思维能力的情境判断测验,选取符合儿童真实生活的故事情景,从综合调节、评价调节、说明、分析和推断五个能力维度,重点评价儿童思维的“过程”而非思维的“结果”。结果显示,批判性思维各个能力维度与儿童情感意识、同理心、解决冲突、工作记忆、抑制控制和社会性显著正相关;师幼冲突与综合调节、分析能力显著负相关;外化情绪问题与评价调节能力相关不显著,与其他能力维度显著负相关;内化问题和学习问题与各个能力维度显著负相关。

关键词：批判性思维儿童思维发展情境判断测验儿童哲学

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2022年第5期42卷 447-470页

作者： Ming Huang Wen Dong Ruihui xie Jilin Wu Qiao Su Wuguo Li Kai Yao Yuelong Chen Qianghua Zhou Qiang Zhang Wenwen Li Liang Cheng Shengmeng Peng siting Chen Jian Huang Xu Chen Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120P.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120P.R.China Guangdong Provincial Clinical Research Center for Urological Diseases GuangzhouGuangdong 510120P.R.China Animal Experiment Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Department of Urology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background:Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic options.Emerging evidence shows that heat shock factor 1(HSF1)drives diversified transcriptome to promote tumor growth and serves as a promising therapeutic target.However,the roles of HSF1 in lymphatic metastasis remain largely unknown.Herein,we aimed to illustrate the clinical roles and mechanisms of HSF1 in the lymphatic metastasis of bladder cancer and explore its therapeutic potential.Methods:We screened the most relevant gene to lymphatic metastasis among overexpressed heat shock factors(HSFs)and heat shock proteins(HSPs),and analyzed its clinical relevance in three cohorts.Functional in vitro and in vivo assays were performed in HSF1-silenced and-regained models.We also used Coimmunoprecipitation to identify the binding proteins of HSF1 and chromatin immunoprecipitation and dual-luciferase reporter assays to investigate the transcriptional program directed by HSF1.The pharmacological inhibitor of HSF1,KRIBB11,was evaluated in popliteal lymph node metastasis models and patientderived xenograft models of bladder cancer.Results:HSF1 expression was positively associated with lymphatic metastasis status,tumor stage,advanced grade,and poor prognosis of bladder cancer.Importantly,HSF1 enhanced the epithelial-mesenchymal transition(EMT)of cancer cells in primary tumor to initiate metastasis,proliferation of cancer cells in lymph nodes,and macrophages infiltration to facilitate multistep lymphatic metastasis.Mechanistically,HSF1 interacted with protein arginine methyltransferase 5(PRMT5)and jointly induced the monomethylation of histone H3 at arginine 2(H3R2me1)and symmetric dimethylation of histone H3 at arginine 2(H3R2me2s).This recruited the WD repeat domain 5(WDR5)/mixed-lineage leukemia(MLL)complex to increase the trimethylation of histone H3 at lysine 4(H3K4me3);resulting in upregulation of lymphoid enhancer-binding factor 1(LEF1),matrix metallopeptidase 9(MMP9),C-C motif chemokine ligan

关键词： HSF1 PRMT5 KRIBB11 transcriptional program bladder cancer lymphatic metastasis prognostic factor targeted therapy

Structure evolution of oxygen removal from porous carbon for optimizing supercapacitor performance

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2020年第12期29卷 396-404页

作者： siting Yuan Xianhong Huang Hao Wang Lijing xie Jiayao Cheng Qingqiang Kong Guohua Sun Cheng-Meng Chen CAS Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The presence of oxygen functional groups is detrimental to the capacitive performance of porous carbon electrode in organic electrolyte. In this regards, hydrogen thermal reduction has been demonstrated effective approach in removing the unstable surface oxygen while maintaining the high porosity of carbon matrix. However, the exact evolution mechanism of various oxygen species during this process, as well as the correlation with electrochemical properties, is still under development. Herein, biomass-based porous carbon is adopted as the model material to trace its structure evolution of oxygen removal under hydrogen thermal reduction process with the temperature range of 400–800 °C. The optimum microstructure with low oxygen content of 0.90% and proper pore size distribution was achieved at 700°C. XPS, TPRMS and Boehm titration results indicate that the oxygen elimination undergoes three distinctive stages(intermolecular dehydration, hydrogenation and decomposition reactions). The optimum microstructure with low oxygen content of 0.90% and proper pore size distribution was achieved at 700 °C. Benefiting from the stable electrochemical interface and the optimized porous structure, the as-obtained HAC-700 exhibit significantly suppressed self-discharge and leak current, with improved cycling stability, which is attributable to the stabilization of electrochemical interface between carbon surface and electrolyte. The result provides insights for rational design of surface chemistry for high-performance carbon electrode towards advanced energy storage.

关键词： Starch-based activated carbon Oxygen functional groups Hydrogen thermal reduction Structural evolution Organic electrolytes Electrochemistry

Intratumoral Bacteria Dysbiosis Is Associated with Human Papillary Thyroid Cancer and Correlated with Oncogenic Signaling Pathways

在线全文

学校读者我要写书评

暂无评论

Engineering 2023年第9期28卷 179-192页

作者： Shuang Yu Yanqiang Ding Xuejie Wang Siu Kin Ng siting Cao Weixin Liu Zhuming Guo Yubin xie Shubin Hong Lixia Xu Xiaoxing Li Jie Li Weiming Lv Sui Peng Yanbing Li Joseph J.Y.Sung Jun Yu Haipeng Xiao Department of Endocrinology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseThe Chinese University of Hong KongHong Kong 999077China Department of Head and Neck Surgery Sun Yat-Sen University Cancer CenterGuangzhou 510060China Clinical Trials Unit The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Breast and Thyroid Surgery The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Lee Kong Chian School of Medicine Nanyang Technology UniversitySingapore 308232Singapore

Emerging evidence suggests that microbial dysbiosis plays vital roles in many human cancers.However,knowledge of whether the microbial community in thyroid tumor is related to tumorigenesis remains elusive.In this study,we aimed to explore the microbial community in thyroid tissues and its contribution to papillary thyroid cancer(PTC).In parallel,we performed microbial profiling and transcriptome sequencing in the tumor and adjacent normal tissues of a large cohort of 340 PTC and benign thyroid nodule(BTN)patients.Distinct microbial signatures were identified in PTC,BTN,and their adjacent nontumor tissues.Intra-thyroid tissue bacteria were verified by means of bacteria staining,fluorescence in situ hybridization,and immunoelectron microscopy.We found that 17 bacterial taxa were differentially abundant in PTC compared with BTN,which included enrichment in PTC of the pathobionts Rhodococcus,Neisseria,Streptococcus,Halomonas,and Devosia,and depletion of the beneficial bacteria Amycolatopsis.These differentially abundant bacteria could differentiate PTC tumor tissues(PTC-T)from BTN tissues(BTN-T)with an area under the curve(AUC)of 81.66%.Microbial network analysis showed increased correlation strengths among the bacterial taxa in PTC-T in comparison with BTN-T.Immunefunction-corresponding bacteria(i.e.,Erwinia,Bacillus,and Acinetobacter)were found to be enriched in PTC with Hashimoto’s thyroiditis.Moreover,our integrative analysis revealed that the PTC-enriched bacteria had a positive association with key PTC-oncogenic pathway-related genes,including BRAF,KRAS,IRAK4,CTNNB1,PIK3CA,MAP3K7,and EGFR.In conclusion,our results suggest that intratumor bacteria dysbiosis is associated with the thyroid tumorigenesis and oncogenic signaling pathways of PTC.

关键词： Papillary thyroid cancer Benign thyroid nodule Bacteria Transcriptome Hashimoto’s thyroiditis

基于激发态运动方程耦合簇的神经网络透热势能矩阵:苯硫酚^(1)πσ^(*)态-介导的光解

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2022年第3期35卷 461-470,I0002页

作者：侯思婷李超凡韩慧仙谢长建西北大学现代物理研究所陕西省理论物理前沿重点实验室西安710127 西北大学物理学院西安710127

本文用最近发展的神经网络拟合方法[Chin.J.Chem.Phys.34,825(2021)]构造了一个新的涉及苯硫酚^(1)πσ^(*)态-介导光解的^(1)ππ^(*)和^(1)πσ^(*)态耦合非绝热势能面.势能面包含了解离过程中的三个关键振动模式,即S-H伸缩、弯曲和... 详细信息

本文用最近发展的神经网络拟合方法[Chin.J.Chem.Phys.34,825(2021)]构造了一个新的涉及苯硫酚^(1)πσ^(*)态-介导光解的^(1)ππ^(*)和^(1)πσ^(*)态耦合非绝热势能面.势能面包含了解离过程中的三个关键振动模式,即S-H伸缩、弯曲和扭转振动.由于单双激发态运动方程耦合簇方法具有简单、效率高、精度高的优点,采用激发态运动方程耦合簇方法计算了苯硫酚激发态^(1)ππ^(*)和^(1)πσ^(*)的绝热能量.神经网络拟合绝热激发态S_(1)和S_(2)态的均方根误差分别为0.89和1.33 meV,表明神经网络方法具有很高的拟合精度.在构建非绝热势能面的过程中,仅利用了体系绝热势能,避免了非常耗时的非绝热耦合计算,极大地提高了效率.为了检测新的非绝热势能面的可靠性,本文进一步展开了苯硫酚光解非绝热动力学模拟.动力学计算得到的S_(1)振电态0^(0)和3^(1)的寿命与实验和之前的理论结果均吻合,验证了基于激发态运动方程耦合簇绝热能量构建的非绝热势能面的可靠精确性,并可进一步应用到实际大分子体系中.

关键词：神经网络透热势能矩阵光解动力学

在线全文

学校读者我要写书评

暂无评论

神经网络方法构建苯硫酚三维非绝热势能面

Chinese Journal of Chemical Physics 2021年第6期34卷 825-832,I0003页

作者：李超凡侯思婷谢长建西北大学现代物理研究所西安710127 陕西省理论物理前沿重点实验室西安710127

本文利用神经网络方法构建了苯硫酚三维的基态(S0)绝热势能面以及激发态1ππ^(*)和1πσ^(*)耦合的非绝热势能面.特别地,1ππ^(*)和1πσ^(*)非绝热势能面的透热化是通过神经网络拟合实现的,拟合仅基于其绝热势能,但对非绝热势能矩阵... 详细信息

本文利用神经网络方法构建了苯硫酚三维的基态(S0)绝热势能面以及激发态1ππ^(*)和1πσ^(*)耦合的非绝热势能面.特别地,1ππ^(*)和1πσ^(*)非绝热势能面的透热化是通过神经网络拟合实现的,拟合仅基于其绝热势能,但对非绝热势能矩阵的非对角元施加了对称性的正确限制.神经网络拟合的3个态的势能面的拟合均方根误差都非常小(<4 meV),体现了神经网络方法的高精度.在神经网络构建的势能面上计算得到了S0态的低位能级和S_(1)态0^(0)的寿命,结果均与早前非绝热势能面上的结果吻合,验证了神经网络方法构建的绝热和非绝热势能面的高精度和可靠性.

关键词：非绝热势能面神经网络光解

间作菠萝模式下不同品种椰子根际土壤微生物多样性及群落结构特征

在线全文

学校读者我要写书评

暂无评论

中国南方果树 2023年第3期52卷 84-93页

作者：刘莹莹卢丽兰谢淑云陈思婷王玉萍杨伟波中国地质大学(武汉)地球科学学院武汉430074 中国热带农业科学院椰子研究所/海南省热带油料作物生物学重点实验室海南文昌571339

为探究椰子间作栽培管理模式,设置文椰4号间作菠萝、文椰3号间作菠萝、文椰2号间作菠萝1、文椰2号间作菠萝2及文椰3号单作(对照)处理,采集椰子植株根际土壤测定其理化性质,并采用Illumina高通量测序技术检测土壤微生物组成与多样性,分... 详细信息

为探究椰子间作栽培管理模式,设置文椰4号间作菠萝、文椰3号间作菠萝、文椰2号间作菠萝1、文椰2号间作菠萝2及文椰3号单作(对照)处理,采集椰子植株根际土壤测定其理化性质,并采用Illumina高通量测序技术检测土壤微生物组成与多样性,分析土壤理化性质与根际土壤微生物群落特征的相关性。结果表明,间作处理的椰子根际土壤含水量、电导率,氮、磷、钾、有效钙和有效镁含量均显著高于单作,间作处理的土壤pH值明显下降。间作处理的根际土壤细菌多样性比单作高,而真菌多样性则低于单作。根际土壤中优势细菌门依序为变形菌门Proteobacteria、酸杆菌门Acidobacteria、拟杆菌门Bacteroidetes等,优势真菌门依次为子囊菌门Ascomycota、担子菌门Basidiomycota、Rozellomycota等。间作与单作之间细菌和真菌种类组成差异较大,文椰2号间作1、文椰2号间作2、文椰4号间作与文椰3号间作的细菌和真菌群落分别聚为一类,文椰3号单作的细菌和真菌群落分别单独聚为一类。不同处理的椰子根际土壤微生物多样性与土壤理化性质之间有不同程度的相关性。说明不同品种椰子间作菠萝对根际土壤微生物组成产生较大影响,间作很大程度上能够提高椰子根际土壤养分和改善微生物群落结构及多样性。

关键词：椰子菠萝间作根际微生物多样性优势菌门

非医学专业学生对海姆立克急救法认知现状的调查

在线全文

学校读者我要写书评

暂无评论

中国急救复苏与灾害医学杂志 2023年第10期18卷 1379-1382,1394页

作者：谢雨宏王思婷黄佳英韦亚善苏幼美袁林玲广西中医药大学护理学院广西南宁530200

目的调查非医学专业学生对海姆立克急救法的认知现状及其影响因素,为非医学院校开展院前急救培训及普及提供参考。方法采用便利抽样方法选择508名非医学专业学生,采用自行设计的调查问卷对海姆立克急救法认知现状进行调查研究。结果508... 详细信息

目的调查非医学专业学生对海姆立克急救法的认知现状及其影响因素,为非医学院校开展院前急救培训及普及提供参考。方法采用便利抽样方法选择508名非医学专业学生,采用自行设计的调查问卷对海姆立克急救法认知现状进行调查研究。结果508名非医学专业学生中,只有167名(32.87%)比较了解海姆立克急救法;对于海姆立克急救法的操作要点作答中,海姆立克急救法的操作要点整体作答正确率不足50.00%,非医学专业学生对海姆立克急救法的认知不高;大部分的学生具有一定的学习意愿,492名(96.85%)学生认为海姆立克急救法的学习是重要的、470(92.52%)名学生认为是有必要学习的;超过一半(52.95%)的非医学专业学生所在学校没有开设过有关急救的课程;78.74%学生表示没有权威组织宣传及引导,因此影响到其学习海姆立克急救法的意识和动机。结论建议非医学专业院校搭建急救知识与技能的学习平台,为非医学专业学生开放延续性急救应急培训;在非医学专业人才培养方案的课程设置中增加应急救护能力培养的内容,采用选修课或者第二课堂的形式,加大急救知识和相关技能的宣传力度和普及程度,培养非医学专业学生的急救意识,形成应急抢救的使命感和责任感。

关键词：海姆立克急救法认知非医学专业学生