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Influence of urban air pollution on the population in the Klang Valley,Malaysia:a spatial approach

Ecological Processes 2022年第1期11卷 126-141页

作者： siti haslina mohd shafie Mastura Mahmud Suzani Mohamad Nor Lita Fadilah Rameli Ramdzani Abdullah Ahmad Fariz Mohamed Centre for Research in Development Social and Environment(SEEDS)Faculty of Social Sciences and HumanitiesUniversiti Kebangsaan MalaysiaBangiSelangorMalaysia Department of Environment Faculty of Forestry and Envi-ronmentUniversiti Putra MalaysiaSerdangSelangorMalaysia Institute for Environment and Development(LESTARI) Universiti Kebangsaan MalaysiaBangiSelangorMalaysia.

Background:Urban air pollution resulting from economic growth as well as urbanization impacts the health of *** study aims to examine the spatial distribution of particulate matter(PM_(10))and the risk of exposure for the population in the Klang Valley,an urban conglomeration centred in Kuala Lumpur,***:The inverse distance weighted(IDW)interpolation technique in the ArcGIS platform was used to map the air quality from five air monitoring *** statistics of the Global Moran’s I Spatial Autocorrelation and Optimized Hot Spot Analysis were used to estimate the spatial clustering of PM_(10).The population-weighted exposure level(PWEL)technique was used to calculate the population density susceptible to PM_(10)and the AirQ+model was applied to estimate the proportion of the adult population at risk of chronic bronchitis due to long-term exposure to PM_(10)concentrations in the Klang ***:The highest annual mean PM_(10)concentrations at the Klang station ranged between 80 and 100μg/m^(3)from 2000 to 2009 and exceeded the New Malaysia Ambient Air Quality Standard(NMAAQS)and the World Health Organi-zation Air Quality Guidelines(WHOAQG)levels of 40 and 20μg/m^(3),*** Moran’s I results indicated that the statistically significant clusters of high PM_(10)in Klang present a health risk to the local *** PWEL results showed that levels of PM_(10)in Petaling Jaya exceeded the WHOAQG limits,potentially posing a health risk to the high-density *** AirQ+model found Klang to be a significantly high-risk area for chronic bronchitis among the adult population with 804,240 people(with a relative risk of 1.85)in ***:These high-risk values are due to rapid urbanization and high motor vehicle usage in the Klang Valley and therefore the impact of PM_(10)on the population needs to be *** situation should be taken seriously by the Department of Environment and Kuala Lumpur City Hall in addre

关键词： Population Urban air pollution Spatial distribution PM_(10) Adult chronic bronchitis risk

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Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer

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Cancer Biology & Medicine 2018年第1期15卷 14-28页

作者： Muhammad Khairi Ahmad Nur Ainina Abdollah Nurul Husna shafie Narazah mohd Yusof siti Razila Abdul Razak Oncological and Radiological Sciences Cluster Advanced Medical and Dental Institute Universiti Sains Malaysia Department of Nutrition and Dietetics Faculty of Medicine and Health SciencesUniversiti Putra Malaysia Regenerative Medicine Cluster Advanced Medical and Dental Institute Universiti Sains Malaysia

Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome.

关键词： Dual-specificity phosphatase 6 MAPK signaling cancer chemoresponsiveness chemoresistance

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Radiative Blood-Based Hybrid Copper-Graphene Nanoliquid Flows along a Source-Heated Leaning Cylinder

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1017-1037页

作者： siti Nur Ainsyah Ghani Noor Fadiya mohd Noor Institute of Mathematical Sciences Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia Center for Data Analytics Consultancy&Services(UM-CDACS) Faculty of ScienceUniversiti MalayaKuala Lumpur50603Malaysia

Variant graphene,graphene oxides(GO),and graphene nanoplatelets(GNP)dispersed in blood-based copper(Cu)nanoliquids over a leaning permeable cylinder are the focus of this *** forms of graphene are highly beneficial in the biological and medical fields for cancer therapy,anti-infection measures,and drug *** non-Newtonian Sutterby(blood-based)hybrid nanoliquid flows are generalized within the context of the Tiwari-Das model to simulate the effects of radiation and heating *** governing partial differential equations are reformulated into a nonlinear set of ordinary differential equations using similar transformational *** equations are then transformed into boundary value problems through a shooting technique,followed by the implementation of the bvp4c tool in *** influences of various parameters on the model’s nondimensional velocity and temperature profiles,reduced skin friction,and reduced Nusselt number are presented for detailed *** results indicated that Cu-GNP/blood and Cu-GO/blood hybrid nanofluids exhibit the lowest and highest velocity distributions,respectively,for increased nanoparticles volume fraction,curvature parameter,Sutterby fluid parameter,Hartmann number,and wall permeability ***,opposite trends are observed for the temperature distribution for all considered parameters,except the mixed convection *** in the reduced skin friction magnitude and the reduced Nusselt number with higher values of graphene/GO/GNP nanoparticle volume fraction are also ***,GNP is identified as the superior heat conductor,with an average increase of approximately 5%and a peak of 7.8%in the reduced Nusselt number compared to graphene and GO nanoparticles in the Cu/blood nanofluids.

关键词： Hybrid nanofluid sutterby fluid tiwari-das model thermal radiation graphene graphene oxides graphene nanoplatelets

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Effects of Hibiscus sabdariffa Linn. fruit extracts on α-glucosidase enzyme,glucose diffusion and wound healing activities

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 466-472页

作者： Raheem Mohssin Shadhan siti Pauliena mohd Bohari Department of Biotechnology and Medical Engineering Faculty of Biosciences and Medical EngineeringUniversiti Teknologi Malaysia81310UTMJohor BahruJohorMalaysia

Objective:To provide in vitro evidence for antidiabetic activity through potential inhibition of α-glucosidase enzyme,glucose diffusion and enhancement in the wound healing using methanolic extract and fractions from Hibiscus sabdariffa ***:The inhibitory action of methanolic extract and fractions of such fruit on aglucosidase enzyme and glucose movement through in vitro assay assessment was *** activities on wound healing were tested using the scratch ***:Ethyl acetate fraction at 50 mg/m L concentration exhibited significant aglucosidase inhibition(95.79 mg/m L) with P sitively.

关键词： α-Glucosidase Glucose diffusion Wound healing Hibiscus sabdariffa Linn

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Notch-δ-doped InP Gunn diodes for low-THz band applications

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Journal of Electronic Science and Technology 2023年第2期21卷 30-43页

作者： Duu Sheng Ong siti Amiera mohd Akhbar Kan Yeep Choo Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia

The viability of the indium phosphide(InP)Gunn diode as a source for low-THz band applications is analyzed based on a notch-δ-doped structure using the Monte Carlo *** presence of theδ-doped layer could enhance the current harmonic amplitude(A0)and the fundamental operating frequency(f0)of the InP Gunn diode beyond 300 GHz as compared with the conventional notch-doped structure for a 600-nm length *** its superior electron transport properties,the notch-δ-doped InP Gunn diodes outperform the corresponding gallium arsenide(GaAs)diodes with up to 1.35 times higher in f0 and 2.4 times larger in A0 under DC *** optimized InP notch-δ-doped structure is estimated to be capable of generating 0.32-W radio-frequency(RF)power at 361 *** Monte Carlo simulations predict a reduction of 44%in RF power,when the device temperature is increased from 300 K to 500 K;however,its operating frequency lies at 280 GHz which is within the low-THz *** shows that the notch-δ-doped InP Gunn diode is a highly promising signal source for low-THz sensors,which are in a high demand in the autonomous vehicle industry.

关键词： Gunn diode δ-doped Monte Carlo Indium phosphide(InP) Terahertz source

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Modified 2 Satisfiability Reverse Analysis Method via Logical Permutation Operator

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Computers, Materials & Continua 2023年第2期74卷 2853-2870页

作者： siti Zulaikha mohd Jamaludin mohdAsyraf Mansor Aslina Baharum mohd Shareduwan mohd Kasihmuddin Habibah A.Wahab Muhammad Fadhil Marsani School of Mathematical Sciences Universiti Sains MalaysiaMindenPenang11800Malaysia School of Distance Education Universiti Sains MalaysiaMindenPenang11800Malaysia Faculty of Computing and Informatics Universiti Malaysia SabahJalan UMSKota Kinabalu88450SabahMalaysia School of Pharmaceutical Sciences Universiti Sains MalaysiaMindenPenang11800Malaysia

The effectiveness of the logic mining approach is strongly correlated to the quality of the induced logical representation that represent the behaviour of the ***,the optimum induced logical representation indicates the capability of the logic mining approach in generalizing the real datasets of different variants and *** main issues with the logic extracted by the standard logic mining techniques are lack of interpretability and the weakness in terms of the structural and arrangement of the 2 Satisfiability logic causing lower *** address the issues,the logical permutation serves as an alternative mechanism that can enhance the probability of the 2 Satisfiability logical rule becoming true by utilizing the definitive finite arrangement of *** work aims to examine and analyze the significant effect of logical permutation on the performance of data extraction ability of the logic mining approach incorporated with the recurrent discrete Hopfield Neural *** on the theory,the effect of permutation and associate memories in recurrent Hopfield Neural Network will potentially improve the accuracy of the existing logic mining *** validate the impact of the logical permutation on the retrieval phase of the logic mining model,the proposed work is experimentally tested on a different class of the benchmark real datasets ranging from the multivariate and timeseries *** experimental results show the significant improvement in the proposed logical permutation-based logic mining according to the domains such as compatibility,accuracy,and competitiveness as opposed to the plethora of standard 2 Satisfiability Reverse Analysis methods.

关键词： Logic mining logical permutation discrete hopfield neural network knowledge extraction

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Numerical Simulations of One-Directional Fractional Pharmacokinetics Model

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Computers, Materials & Continua 2022年第12期73卷 4923-4934页

作者： Nursyazwani Mohamad Noor siti Ainor mohd Yatim Nur Intan Raihana Ruhaiyem School of Distance Education Universiti Sains MalaysiaUSM PenangPenang11800Malaysia School of Computer Science Universiti Sains MalaysiaUSM PenangPenang11800Malaysia

In this paper,we present a three-compartment of pharmacokinetics model with irreversible rate *** compartment consists of arterial blood,tissues and venous ***’s principle and the law of mass action were used to develop the model based on the diffusion *** model is modified into a fractional pharmacokinetics model with the sense of Caputo *** existence and uniqueness of the model are investigated and the positivity of the model is *** behaviour of the model is investigated by implementing numerical algorithms for the numerical solution of the system of fractional differential *** software is used to plot the graphs for illustrating the variation of drug concentration concerning ***,the numerical simulations of the model are presented for different values ofαwhich verified the theoretical ***,we also observed the pattern of the simulations at the three-compartment of the model by using different values of initial conditions.

关键词： Pharmacokinetics model Irreversible rate Fractional order Numerical simulations

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XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians

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World Journal of Gastroenterology 2013年第23期19卷 3623-3628页

作者： Abdul Aziz Ahmad Aizat mohd Shahpudin siti Nurfatimah Mustapha mohd Aminudin Ravindran Ankathil Human Genome Centre School of Medical SciencesUniversiti Sains Malaysia Health Campus16150 Kubang Kerian Kelantan Malaysia

AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC ) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI. RESULTS: The frequency of the homozygous variant (Gln/Gln) genotype was significantly higher in cases compared with controls (16.0% vs 10.2%, P = 0.049). The Gln/Gln genotype of XPC showed a significantly higher association with the risk of CRC (OR = 1.884; 95%CI: 1.082-3.277; P = 0.025). In the case of allele frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI: 1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln variant genotype and were also cigarette smokers (OR = 3.409; 95%CI: 1.061-10.949; P = 0.032). CONCLUSION: The XPC Gln/Gln genotype alone and in combination with smoking increases the risk of CRC among Malaysians.

关键词： DNA repair Xeroderma pigmentosum group C Lys939Gln polymorphism Cigarette smoking Colorectal cancer Susceptibility risk

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A Preliminary Genetic Investigation of Rastrelliger Kanagurta Based on Random Amplified Polymorphic DNA and Mitochondrial ND2 Gene

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湿地科学 2008年第4期6卷 518-525页

作者： siti Azizah mohd Nor Abu Talib A mohd Ghows M A Samsudin B Aquaculture Research Group School of Biological Sciences University Sains Malaysia 11800 Minden Penang Malaysia Fisheries Research Institute 11900 Batu Maung Penang Malaysia

In a preliminary investigation, Random Amplified Polymorphic DNA (RAPD) analysis and partial mitochondrial ND2 gene sequencing were conducted to study the genetic variation of the Indian mackerel, Rastrelliger kanagurta along a 450 km stretch of its distribution on the west coast of Peninsular Malaysia. A total of 53 individuals from 6 populations were analyzed using 4 RAPD primers and a sub-sample of 15 individuals was chosen for sequencing of partial ND2 gene. Comparison between the 2 markers revealed genetic structuring in the RAPD results but genetic homogeneity for ND2 gene. Based on the former there may be at least 2 genetically differentiated groups of Rastrelliger kanagurta along this stretch.

关键词：基因 DNA分析分析方法生物技术水生生物

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Distribution of Chironomidae (Insecta: Diptera) in polluted rivers of the Juru River Basin, Penang, Malaysia

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Journal of Environmental Sciences 2010年第11期22卷 1718-1727页

作者： Salman A. Al-Shami Che Salmah Md Rawi Abu HassanAhmad siti Azizah mohd Nor School of Biological Sciences Universiti Sains Malaysia Centre for Marine and Coastal Studies Universiti Sains Malaysia

The influence of physical and chemical parameters on the abundance and diversity of chironomids was studied in six rivers with moderate to highly polluted water in the Juru River Basin. The rivers： Ceruk Tok Kun （CTKR） as reference site, and polluted rivers of Pasir （PR）, Juru （JR）, Permatang Rawa （PRR）, Ara （AR） and Kilang Ubi （KUR） were sampled over a period of five months （November 2007–March 2008）. Nine chirnomid species： Chironimus kiiensis, C. javanus, Polypedilum trigonus, Microchironomus sp., Dicrotendipes sp., Tanytarsus formosanus, Clinotanypus sp., Tanypus punctipennis and Fittkauimyia sp. were identified. Assessment of their relationships with several environmental parameters was performed using the canonical correspondence analysis （CCA）. Tanytarsus formosanus was the most dominant in the relatively clean CTKR and moderately polluted JR with mean densities of 19.66 and 25.32 m 2 , respectively while C. kiiensis was abundant in more polluted rivers. Tanytarsus formosanus, Dicrotendipes sp. and Microchironomus sp. were grouped under moderate to high water temperature, total organic matter （TOM）, total suspended solids （TSS）, velocity, pH, phosphates and sulphates. However, Tanypus punctipennis, Fittkauimyia sp., and Clinotanypus sp. were associated with high contents of river sediment such as TOM, Zn and Mn and water ammonium-N and nitrate-N and they were associated with higher dissolved oxygen （DO） content in the water. Chironomus kiiensis, C. javanus and P. trigonus showed positive relationships with TOM, ammonium-N and nitrate-N as well as trace metals of Zn, Cu and Mn. These three species could be considered as tolerant species since they have the ability to survive in extreme environmental conditions with low DO and high concentrations of pollutants. Based on the water parameter scores in all rivers, the highest diversity of chironomid larvae was reported in CTKR. With higher concentrations of organic and/or inorganic pollutants as reported in PPR, K

关键词： chironomid larvae Juru River physicochemical parameters canonical correspondence analysis

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