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Assessment of gastrointestinal stromal tumors with computed tomography following treatment with imatinib mesylate

World Journal of Gastroenterology 2008年第6期14卷 892-898页

作者： sith phongkitkarun Cholada Phaisanphrukkun Janjira Jatchavala Ekaphop Sirachainan Department of Radiology Faculty of Medicine Ramathibodi Hospital Mahidol University Rama Ⅵ Rd. Ratchathewi Bangkok 10400 Thailand Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Rama Ⅵ Rd. Ratchathewi Bangkok 10400 Thailand

AIM: To evaluate and characterize the patterns of disease progression of metastatic or unresectable gastrointestinal stromal tumor (GIST) treated with imatinib mesylate, and to determine the prognostic significance associated with disease progression. METHODS: Clinical data and computed tomography (CT) images were retrospectively reviewed in 17 GIST patients who were treated with imatinib mesylate from October 2002 to October 2006. Apart from using size measurement for evaluation of tumor response [Response Evaluation Criteria in Solid Tumors (RECIST) criteria], patterns of CT changes during treatment were evaluated and correlated with clinical data. RESULTS: There were eight non-responders and nine responders. Five patterns of CT change during treatment were found: focal progression (FP), generalized progression (GP), generalized cystic change (GC), new cystic lesion (NC) and new solid lesion (NS). At the end of study, all non-responders showed GP, whereas responders showed cystic change (GC and NC) and response according to RECIST criteria. Overall survival was significantly better in patients with cystic change or response within the RECIST criteria compared with GP patients (P = 0.0271). CONCLUSION: Various patterns of CT change in patients with GIST who responded to imatinib mesylate were demonstrated, and might determine the prognosis of the disease. A combination of RECIST criteria and pattern of CT change are proposed for response evaluation in GIST.

关键词：胃肠基质肿瘤 X线检查甲磺酸盐药物治疗

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Added value of hepatobiliary phase gadoxetic acid-enhanced MRI for diagnosing hepatocellular carcinoma in high-risk patients

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World Journal of Gastroenterology 2013年第45期19卷 8357-8365页

作者： sith phongkitkarun Kuruwin Limsamutpetch Penampai Tannaphai Janjira Jatchavala Department of Diagnostic and Therapeutic Radiology Faculty of Medicine Ramathibodi Hospital Mahidol University Ratchatewi Bangkok 10400 Thailand

AIM:To determine the added value of hepatobiliary phase(HBP)gadoxetic acid-enhanced magnetic resonance imaging(MRI)in evaluating hepatic nodules in high-risk ***:The institutional review board approved this retrospective study and waived the requirement for informed *** study included 100 patients at high risk for hepatocellular carcinoma(HCC)and 105hepatic nodules that were larger than 1 cm.A blind review of two MR image sets was performed in a random order:set 1,unenhanced(T1-and T2-weighted)and dynamic images;and set 2,unenhanced,dynamic20-min and HBP *** diagnostic accuracy,sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were compared for the two image *** and multivariate analyses were performed on the MR characteristics utilized to diagnose ***:A total of 105 hepatic nodules were identified in 100 ***-nine nodules were confirmed to be *** diameter of the 59 HCCs ranged from1 to 12 cm(mean:1.9 cm).The remaining 46 nodules were benign(28 were of hepatocyte origin,nine were hepatic cysts,seven were hemangiomas,one was chronic inflammation,and one was focal fat infiltration).The diagnostic accuracy significantly increased with the addition of HBP images,from 88.7%in set 1to 95.5%in set 2(P=0.002).In set 1 vs set 2,the sensitivity and NPV increased from 79.7%to 93.2%and from 78.9%to 91.8%,respectively,whereas the specificity and PPV were not significantly *** hypointensity on the HBP images was the most sensitive(93.2%),and typical arterial enhancement followed by washout was the most specific(97.8%).The multivariate analysis revealed that typical arterial enhancement followed by washout,hyperintensity on T2-weighted images,and hypointensity on HBP images were statistically significant MRI findings that could diagnose HCC(P<0.05).CONCLUSION:The addition of HBP gadoxetic acidenhanced MRI statistically improved the diagnostic accuracy in HCCs larger than

关键词： Magnetic resonance imaging Liver Gadoxetic acid Hepatobiliary phase Hepatocellular carcinoma

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Lymphomatous involvement of gastrointestinal tract: Evaluation by positron emission tomography with ^(18)F-fluorodeoxyglucose

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世界胃肠病学杂志：英文版 2005年第46期11卷 7284-7289页

作者： sith phongkitkarun Vithya Varavithya Toshiki Kazama Silvana C Faria Martha V Mar Donald A Podoloff Homer A Macapinlac Departments of Diagnostic Radiology and Nuclear MedicineBox 057 The University of Texas MDAnderson Cancer Center1515 Holcombe Blvd.HoustonTXUnited States

AIM: To demonstrate the 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) findings in patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal (GI) tract and the clinical utility of modality despite of the known normal uptake of FDG in the GI ***: Thirty-three patients with biopsy-proven gastrointestinal NHL who had undergone FDG-PET scan were included. All the patients were injected with 10-15 mCi FDG and scanned approximately 60 min later with a CTI/Siemens HR (+) PET scanner. PET scans were reviewed and the maximum standard uptake value (SUVmax) of the lesions was measured before and after the treatment,if data were available and compared with histologic ***: Twenty-five patients had a high-grade lymphoma and eight had a low-grade lymphoma. The stomach was the most common site of the involvement (20 patients). In high-grade lymphoma, PET showed focal nodular or diffuse hypermetabolic activity. The average SUVmax±SD was 11.58±5.83. After the therapy,the patients whose biopsies showed no evidence of lymphoma had a lower uptake without focal *** SUVmax±SD decreased from 11.58±5.83 to 2.21±0.78. In patients whose post-treatment biopsies showed lymphoma, the SUVmax±SD was 9.42±6.27. Low-grade follicular lymphomas of the colon and stomach showed diffuse hypermetabolic activity in the bowel wall (SUVmax 8.2 and 10.3, respectively). The SUVmax was 2.02-3.8 (mean 3.02) in the stomach lesions of patients with MALT ***: 18F-FDG PET contributes to the diagnosis of high-grade gastrointestinal non-Hodgkin's lymphoma,even when there is the normal background FDG activity. Furthermore, the SUV plays a role in evaluating treatment response. Low-grade NHL demonstrates FDG uptake but at a lesser intensity than seen in high-grade NHL.

关键词：放射治疗氟去氧葡萄糖胃肠疾病淋巴瘤

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Tafel scan schemes for microbiologically influenced corrosion of carbon steel and stainless steel

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Journal of Materials Science & Technology 2022年第35期130卷 193-197页

作者： Di Wang Pruch Kijkla Mazen A.Saleh sith Kumseranee Suchada Punpruk Tingyue Gu Shenyang National Lab for Materials Science Northeastern UniversityShenyang 110819China Department of Chemical and Biomolecular EngineeringInstitute for Corrosion and Multiphase TechnologyOhio UniversityAthens 45701United States Department of Chemical and Biomolecular Engineering Institute for Corrosion and Multiphase TechnologyOhio UniversityAthens 45701United States PTT Exploration and ProductionBangkok 10900Thailand Research and Development Center Saudi Arabian Oil CompanyDhahran 31311Saudi Arabia PTT Exploration and Production Bangkok 10900Thailand Department of Chemical and Biomolecular Engineering Institute for Corrosion and Multiphase TechnologyOhio UniversityAthens 45701United States

*** Microbial biofilms cause microbiologically influenced corrosion(MIC),which is one of the operational risks that can lead to equipment failures in the oil and gas industry and other industries [1-4].Mitigation measures such as biocide treatment and corrosion monitoring programs are implemented to ensure vital equipment integrity [5,6].The mechanism investigations in MIC can assist case analyses,field detections and biocide treatment strategies [7-9].

关键词： corrosion steel treatment

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Mitigating microbiologically influenced corrosion of an oilfield biofilm consortium on carbon steel in enriched hydrotest fluid using 2,2-dibromo-3-nitrilopropionamide(DBNPA) enhanced by a 14-mer peptide

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Journal of Materials Science & Technology 2020年第22期54卷 146-152页

作者： Di Wang Mahmoud Ramadan sith Kum seranee Suchada Punpruk Tingyue Gu Department of Chemical&Biomolecular Engineering Institute for Corrosion and Multiphase TechnologyOhio UniversityAthens 45701USA PTT Exploration and Production Bangkok 10900Thailand

In the oil and gas industry,microbiologically influenced corrosion(MIC) is a major threat to hydrotest,a procedure which is required to certify whether a pipeline can be *** is frequently used as a hydrotest *** this bio film prevention lab study,an oilfield biofilm consortium was grown in an enriched artificial seawater anaerobically at 37℃ for 60 *** combination of 100 ppm(w/w) 2,2-dibromo-3-nitrilopropionamide(DBNPA)+100 nM(180 ppb) Peptide A(a biofilm dispersal agent) led to extra SRB(sulfate reducing bacteria),APB(acid producing bacteria) and GHB(general heterotrophic bacteria) sessile cell count reductions of 0.9-log,0.8-log and 0.6-log,respectively,compared with the outcome obtained by using 100 ppm DBNPA *** Peptide Aenhancement also led to extra reductions of 44 % in weight loss,43 % in maximum pit depth,and 54 % in corrosion current density.

关键词： Hydrotest Microbiologically influenced corrosion Anti-biofilm peptide Biocide enhancer 2 2-dibromo-3-nitrilopropionamide(DBNPA)

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Characteristics of Drug-induced Liver Injury in Chronic Liver Disease:Results from the Thai Association for the Study of the Liver(THASL)DILI Registry

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 88-96页

作者： Sakkarin Chirapongsathorn Wattana Sukeepaisarnjaroen Sombat Treeprasertsuk Roonguedee Chaiteerakij Pichaporn Surawongsin Chanunta Hongthanakorn sith Siramolpiwat Naichaya Chamroonkul Chalermrat Bunchorntavakul Watcharasak Chotiyaputta Kittiyod Poovorawan Rattana Boonsirichan Saranath Lawpoolsri Chinnavat Sutivana Abhasnee Sobhonslidsuk Division of Gastroenterology and Hepatology Department of MedicinePhramongkutklao Hospital and College of MedicineRoyal Thai ArmyBangkokThailand Division of Gastroenterology and Hepatology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Division of Gastroenterology Faculty of MedicineChulalongkorn UniversityBangkokThailand Division of Gastroenterology Bhumibol Adulyadej HospitalBangkokThailand Division of Gastroenterology Faculty of MedicineThammasat UniversityPratumthaniThailand Division of Gastroenterology and Hepatology Faculty of MedicinePrince of Songkla UniversitySongklaThailand Division of Gastroenterology and Hepatology Rajavithi HospitalCollege of MedicineRangsit UniversityBangkokThailand Division of Gastroenterology Faculty of MedicineSiriraj HospitalMahidol UniversityBangkokThailand Department of Clinical Tropical Medicine Faculty of Tropical MedicineMahidol UniversityBangkokThailand Division of Gastroenterology Faculty of MedicineVajira HospitalBangkokThailand Center of Excellence for Biomedical and Public Health Informatics(BIOPHICS) Faculty of Tropical MedicineMahidol UniversityBangkokThailand Division of Gastroenterology and Hepatology Faculty of MedicineRamathibodi HospitalMahidol UniversityBangkokThailand

Background and Aims:The impact of drug-induced liver injury(DILI)on patients with chronic liver disease(CLD)is *** are few reports comparing DILI in CLD and non-CLD *** this study,we aimed to determine the incidence and outcomes of DILI in patients with and without ***:We collected data on eligible individuals with suspected DILI between 2018 and 2020 who were evaluated systematically for other etiologies,causes,and the severity of *** compared the causative agents,clinical features,and outcomes of DILI among subjects with and without CLD who were enrolled in the Thai Association for the Study of the Liver DILI *** with definite,or highly likely DILI were included in the ***:A total of 200 subjects diagnosed with DILI were found in the *** those,41 had CLD and 159 had no evidence of CLD in their *** and alternative medicine(CAM)products were identified as the most common class of DILI *** 59%of DILI in the CLD and 40%in non-CLD group were associated with CAM *** with pre-existing CLD had similar severity including *** patients(6%)developed adverse outcomes related to DILI including seven(3.5%)deaths and five(2.5%)with liver *** was 4.88%in CLD and 3.14%in non-CLD subjects over median periods of 58(8–106)days and 22(1–65)days,***:In this liver disease registry,the causes,clinical presentation,and outcomes of DILI in subjects with CLD and without CLD patients were not *** study is required to confirm our findings.

关键词： Chronic liver disease Cirrhosis Drug-induced liver injury Druginduced liver injury network Toxicity Medication

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Transjugular intrahepatic portosystemic shunts and portal hypertension-related complications

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World Journal of Gastroenterology 2014年第45期20卷 16996-17010页

作者： sith Siramolpiwat Division of Gastroenterology Department of Internal Medicine Faculty of Medicine Thammasat University

Portal hypertension(PH)plays an important role in the natural history of cirrhosis,and is associated with several clinical *** introduction of transjugular intrahepatic portosystemic shunts(TIPS)in the 1980s has been regarded as a major technical advance in the management of the PH-related *** present,polytetrafluoroethylene-covered stents are the preferred option over traditional bare metal *** is currently indicated as a salvage therapy in patients with bleeding esophageal varices who fail standard ***,applying TIPS early(within 72 h after admission)has been shown to be an effective and life-saving treatment in those with high-risk variceal *** addition,TIPS is recommended as the second-line treatment for secondary *** bleeding gastric varices,applying TIPS was able to achieve hemostasis in more than 90%of *** trials are needed to clarify the efficacy of TIPS compared with other treatment modalities,including cyanoacrylate injection and balloon retrograde transvenous obliteration of gastric *** should also be considered in bleeding ectopic varices and refractory portal hypertensive *** patients with refractory ascites,there is growing evidence that TIPS not only results in better control of ascites,but also improves long-term survivalin appropriately selected *** addition,TIPS is a promising treatment for refractory hepatic ***,the role of TIPS in the treatment of hepatorenal and hepatopulmonary syndrome is not well *** advantage of TIPS is offset by a risk of developing hepatic encephalopathy,the most relevant postprocedural *** data are addressing the determination the optimal time and patient selection for TIPS placement aiming at improving long-term treatment *** review is aimed at summarizing the published data regarding the application of TIPS in the management of complications related to PH.

关键词： Transjugular intrahepatic portosystemic shunts Por

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