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Antibacterial, Antioxidant Activities and GC-MS Analysis of Dichrostachys cinera (L.) Ethanolic Leaves Extract

Pharmacology & Pharmacy 2022年第12期13卷 545-557页

作者： sitelbanat yassin Mohamed Abubker Anwar Mohamed Selma Omer Salah Humeada Elhadi M. M. Ahmed Mirghani Abd Alrahman Department of Pharmaceutics (Pharmaceutical Microbiology) University of Gezira Wad Madani Sudan Department of Pharmaceutical Chemistry University of Gezira Wad Madani Sudan Central Laboratory University of Gezira Wad Madani Sudan Department of Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Madani Sudan Department of Chemistry Faculty of Education West Kordofan University Kordofan Sudan Department of Pharmacognosy University of Gezira Wad Madani Sudan Medicinal and Aromatic Plants Research Center University of Gezira Wad Madani Sudan Department of Clinical Pharmacy and Pharmacy Practice University of Gezira Wad Madani Sudan

Traditional medicinal plants are one of the potential sources of antimicrobial drugs and there is a great concern in the use and development of herbal medicine for the treatment of various infections. This study aimed to evaluate the antibacterial, and antioxidant activities of Dichrostachys cinera ethanolic leaves extract and to determine the components of the crude extract. D. cinera extract was evaluated against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. The antibacterial, antioxidant activities and active constituents were determined using standard methods. Antibacterial activity of the crude extract findings showed that all bacterial candidates were susceptible where S. aureus represent MIC at 12.5 mg/ml and MBC at 25 mg/ml, E. coli and P. aeruginosa both showed MIC 25 mg/ml and MBC 50 mg/ml. In the free radical scavenging assay of the extract and the standard quercetin at concentrations of 250 μg/ml, 125 μg/ml, 50 μg/ml, 10 μg/ml, and 5 μg/ml. The radical scavenging activity for the extract was about 92%, 89.6%, 86.8%, 82.8% and 37.8% respectively, compared to quercetin which gave 89.7%, 85.8%, 62.1%, 55.5%, and 45% radical scavenging activity. The GC-Ms analysis of the total constituents demonstrated that 1,6-Anhydro-2,4-dideoxy-.beta.-D-ribo-hexo (21.26%) with different peaks, followed by Glycerin (11.56%), 1,2,3-Cyclopentanetriol (10.18%), 8,11,14-Eicosatrienoic acid, (Z,Z,Z)-(6.18%), 1H-Pyrrole, 1-methyl-(6.08%), Phytol (5.91%) and 7-Bromo-6-(2-diethylaminoethoxy)-2,3-dihyd (5.44%) as major components in the extract. Finally, this study provided useful information on the therapeutic potential of D. cinera as an antibacterial agent and recommended to be evaluated against a wide range of Bacterial and fungal strains using different solvents and different parts from the plant.

关键词： Dichrostachys cinera Antibacterial Activity Antioxidant GC MS Analysis

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Frequency and Antimicrobials Susceptibility Pattern of <i>Staphylococcus aureus</i>Associated with Wound Infections in Surgery Department, Wad Madani Teaching Hospital, Sudan

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Pharmacology & Pharmacy 2021年第12期12卷 334-343页

作者： Sanaa M. Yousif Adam D. Abakar Bakri Y. M. Nour Salma O. Ibrahim Omer M. Abu Elhasan Mirgani A. Yousif sitelbanat yassin Hajer M. Hussien Mohamed Taj-Eldin Elhadi A. Ahmed National Blood Bank Ministry of Health Khartoum Sudan Department of Medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Medical Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Wad-Madani College of Medical Sciences and Technology Wad Medani Sudan Faculty of Pharmacy University of Gezira Wad Medani Sudan

Background: Most community and hospital acquired infections are due to Staphylococcus aureus, these infections involve both local suppurative and systemic conditions. There is an increase in the incidence rates of acquiring resistant strains of Staphylococcus aureus in hospitals and community in Sudan. This study aims to detect frequency of Staphylococcus aureus isolated from surgical-sites infections (SSIs) and traumatic wounds, and to determine susceptibility to commonly used drugs. Methods: Prospective cross-sectional laboratory based study was followed, 250 patients admitted to Surgery Departments at Wad Madani Teaching Hospitals during 2019 and 2020 were recruited;with clinical manifestation of SSIs and or/traumatic wounds. Swab sample was taken from each participant and incubated aerobically on mannitol salt agar. Biochemical tests and 16rRNA gene used for Staphylococcus aureus identification. Antimicrobial susceptibility was accomplished using Kirby Bauer disc diffusion technique. Results: Infection rate of wounds in males and females equal 71% (17/250) and 29% (73/250), while infection rate in the age group of 41 to 60 y

关键词： Staphylococcus aureus Surgical-Sites Wounds Meropeneme Sudan

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Antibacterial, Antioxidant Activities and GC-MS Analysis of Dichrostachys cinera (L.)Ethanolic Leaves Extract

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Pharmacology & Pharmacy（药理与制药） 2022年第12期

作者： sitelbanat yassin Mohamed Abubker Anwar Mohamed Selma Omer Salah Humeada Elhadi M. M. Ahmed Mirghani Abd Alrahman

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