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Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages

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Science China Life Sciences 2025年

作者： Liu Guo Junfei Xu Wenyue Zhou sisi chen Hanjing Shi Mengmeng Han Zekun Yang Yehui Duan Weijun Pang Yulong Yin Fengna Li Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences University of Chinese Academy of Sciences Laboratory of Animal Fat Deposition and Muscle Development College of Animal Science and Technology Northwest A&F University College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity, aging and metabolic disease. Since obese and lean pigs are ideal models for metabolic research. Here, we compared metabolome and transcriptome of Longissimus dorsi(LD) muscle between Taoyuan black(TB, obese) and Duroc(lean) pigs at different ages. We defined the “window phase” of intramuscular fat(IMF) deposition in TB pig, which has significantly higher IMF than Duroc pig. Our results displayed discrepant lipid composition and different expression genes(DEGs) enriched in lipid metabolism, and both metabolome and transcriptome analyses revealed stronger energy expenditure and more active amino acid and protein metabolism in Duroc pig. 10 up-and 51 down-regulated biomarker metabolites with age-and breed-specificity were identified. Potential secretory metabolites, including organic acid(fumaric acid, succinate,malic acid, and gamma-aminobutyric acid), amino acid(L-lysine, and L-glutamic acid), lipid(2-hydroxyisovaleric acid, and L-carnitine) were demonstrated a significant correlation with IMF deposition. Our research highlights the huge difference of metabolic spectrum in skeletal muscle between obese and lean model and muscle-derived secretory metabolites might act as an ambassador of intercellular communication to regulate systematic metabolism.

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Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

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Science China Technological Sciences 2025年

作者： sisi chen Jiemin ZHANG Nan chenG Wenbo LI Jing LIU Hongfei XIE Jie ZHANG Yueying chenG Xiaotong ZHAO Meng SU Yanlin SONG Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (ICCAS) University of Chinese Academy of Sciences Weiyang College Tsinghua University Department of Cardiovascular Surgery First Medical Center PLA General Hospital AECC Beijing Institute of Aeronautical Materials Beijing Institute of Graphene Technology Beijing Engineering Research Centre of Graphene Application School of Integrated Circuit & Beijing National Research Center for Information Science and Technology (BNRist) Tsinghua University

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors, optical and mechanical bi-modal sensors provide improved precision, enhanced safety,and robustness of human-machine interaction systems. Here, the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing capabilities. The printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition functionality. The combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing capabilities. Thus, the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor, as well as contact mechanical sensing capabilities to detect touch force applied by the hand. It provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

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Effects of sludge age on anaerobic acidification of waste activated sludge: Volatile fatty acids production and phosphorus release

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Journal of Environmental Sciences 2021年第7期33卷 11-21页

作者： sisi chen Xiaohu Dai Dianhai Yang Bin Dong State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Effects of sludge age on volatile fatty acids (VFAs) production and Phosphorus (P) release during anaerobic acidification of waste activated sludge (WAS) were *** batch reactors (SBR) fed with simulating domestic sewage were applied to produce WAS of different sludge ages,and batch tests were used for anaerobic *** maximum dissolved total organic carbon,release of PO_(4)^(3+)-P,and accumulation of acetate (C2),propionate (C3),butyrate (C4),and valerate (C5) decreased by 56.2%,55.8%,52.6%,43.7%,82.4%and 84.8%,respectively,as the sludge age of WAS increased from 5 to 40 *** degradation of protein played a dominating role in decreasing DTOC and VFAs ***,the increase in molecular weight of organics and organic nitrogen content in the supernatant after acidification suggested that the refractory protein in WAS increased as sludge age *** the production of C2,C3,C4,and C5 from WAS decreased as the sludge age increased,the proportions of C2 and C3 in VFAs increased,which might be due to the declined production of C5 from protein and the faded genus *** sludge age of WAS at a relatively low level (<10 days) is more appropriate for anaerobic acidification of WAS as internal carbon sources and P resource.

关键词： Sludge age Waste activated sludge Acidification Volatile fatty acids Microbial community

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New insights into the evaluation of anaerobic properties of sludge:Biodegradability and stabilization

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Journal of Environmental Sciences 2021年第2期33卷 158-166页

作者： Jun Gao Xiaoyan Zhao sisi chen Bin Dong Xiaohu Dai State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Evaluating anaerobic biodegradability of sludge and then identifying the stabilization of digestate is necessary in sludge treatment and disposal.48 sludge samples from 24 typical waste water treatment plants(WWTPs)in 11 provinces in China were selected to investigate the relationship between Biochemical Acidogenic Potential(BAP)test and Biochemical Methane Potential(BMP)*** volatile fatty acid(VFA)production obtained from BAP tests was found linearly related to the ultimate methane production from corresponding BMP *** results were obtained with Pearson correlation coefficient as 0.929 and R^2 value as ***,the physio-chemical characteristics(FCI,SUVA254,E 4/E 6)of supernatant,which were associated with humic-like substances(HS),were investigated before and after BMP *** which a new criterion(FCI>1.50,SUVA 254>1.10,E 4/E 6<4.0)was proposed to evaluate the stabilization level of anaerobic digested sludge.

关键词： Sludge Anaerobic digestion Biodegradability Stabilization Biochemical acidogenic potential Physio-chemical characteristics

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Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

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Chemical Research in Chinese Universities 2022年第4期38卷 847-855页

作者： chen sisi ZHANG Lei YUAN Quan TAN Jie Molecular Science and Biomedicine Laboratory(MBL) Institute of Chemical Biology and Nanomedicine(ICBN)State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha410082P.R.China

The interaction between biomolecules with their target ligands plays a great role in regulating biological *** are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological *** the past ten years,aptamers have made great progress in target biomolecule recognition,becoming a powerful tool to regulate biological *** present,there are many reviews on aptamers applied in biomolecular recognition,but few reviews pay attention to aptamer-based regulation of biological ***,we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity,cellular immunity and cellular ***,this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation,aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.

关键词： functions. complementarity enzymatic

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A case-control study on family environment characteristics of accidentprone children

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Family Medicine and Community Health 2014年第4期2卷 26-31页

作者： sisi chen Leshan Zhou School of Nursing Central South UniversityChangshaHunan 410013P.R.China Central South University ChangshaHunan 410013P.R.China

Objective:The purpose of the current study was to determine the family environment charac-teristics of accident-prone children,and the influencing factors to provide a reference for accident prevention and intervention for these ***:One hundred forty-seven cases of accident-prone children were screened out from a cross-sectional survey as the case group,and another 147 cases of non-accidentally-injured chil-dren served as the control *** Chinese version of the Family Environment Scale(FES-CV)was applied to evaluate the family environment characteristics of subjects from both ***:The incidence of accident-prone children was 9.42%.Comparing the scores of all factors in the FES-CV,the contradiction score of the case group was higher than the control group,while the scores of other factors was lower than the control *** between the two groups with respect to intimacy,emotional expression,contradiction,independence,and success scores were statistically significant,but differences in informative and entertaining scores were *** with respect to family type,financial status,education,guardian,age of guardian,marital status,and health status were statistically *** revealed by regression analysis,intimacy(OR=0.530),emotional expression(OR=0.749),and independence(OR=0.732)were protective factors for accident proneness,while rigorous education(OR=2.101)and indulgence or indifference/violence(OR=7.629)were risk factors for accident ***:Family environment influence child accident proneness,thus preventive interventions should be provided according to the characteristics of the family environment.

关键词： Children Accident proneness Family environment

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A star-like photodetector for angle-based light sensing in 3D space

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Nano Research 2024年第8期17卷 7567-7573页

作者： Qi Pan sisi chen Hongfei Xie Qiling Xu Meng Su Yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450051China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of three-dimensional(3D)space light angle detection is vital in optical technology for applications such as 3D imaging,computer vision,and augmented *** methods involve advanced sensors and algorithms,including time-offlight cameras,which need multiple cameras and light sources to improve ***,it is a great challenge to integrate these complex components into compact *** semiconductor structures offer optical resonance characteristics,enabling precise light–matter interaction regulation.A 3D star-like photodetector,fabricated using a template assistant printing strategy,demonstrates optical resonances of the subwavelength facade and the shielding effect of spatial *** achieves light angle detection with the resolution of 10°in vertical space and the resolution of 36°in horizontal space,making it a promising prototype for various applications.

关键词： photodetector light angle detection printing subwavelength structure shielding effect

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Parameterization and Explicit Modeling of Cloud Microphysics:Approaches, Challenges, and Future Directions

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Advances in Atmospheric Sciences 2023年第5期40卷 747-790页

作者： Yangang LIU Man-Kong YAU Shin-ichiro SHIMA Chunsong LU sisi chen Environmental and Climate Sciences Department Brookhaven National LaboratoryUptonNY11973USA Department of Atmospheric Sciences McGill UniversityMontrealH3A 0B8Canada Graduated School of Information Science University of HyogoKobe 650-0047Japan College of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China National Center for Atmospheric Research BoulderCO80307USA

Cloud microphysical processes occur at the smallest end of scales among cloud-related processes and thus must be parameterized not only in large-scale global circulation models(GCMs)but also in various higher-resolution limited-area models such as cloud-resolving models(CRMs)and large-eddy simulation(LES)*** of giving a comprehensive review of existing microphysical parameterizations that have been developed over the years,this study concentrates purposely on several topics that we believe are understudied but hold great potential for further advancing bulk microphysics parameterizations:multi-moment bulk microphysics parameterizations and the role of the spectral shape of hydrometeor size distributions;discrete vs“continuous”representation of hydrometeor types;turbulence-microphysics interactions including turbulent entrainment-mixing processes and stochastic condensation;theoretical foundations for the mathematical expressions used to describe hydrometeor size distributions and hydrometeor morphology;and approaches for developing bulk microphysics *** presented are the spectral bin scheme and particle-based scheme(especially,super-droplet method)for representing explicit *** advantages and disadvantages are elucidated for constructing cloud models with detailed microphysics that are essential to developing processes understanding and bulk microphysics ***-resolved direct numerical simulation(DNS)models are described as an emerging technique to investigate turbulence-microphysics interactions at the most fundamental level by tracking individual particles and resolving the smallest turbulent eddies in turbulent *** challenges and future research directions are explored as well.

关键词： cloud microphysics parameterizations systems theory bin microphysics particle-based microphysics particleresolved direct numerical simulations

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Life-cycle assessment of two sewage sludge-to-energy systems based on different sewage sludge characteristics:Energy balance and greenhouse gas-emission footprint analysis

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Journal of Environmental Sciences 2022年第1期34卷 380-391页

作者： Renjie chen Shijie Yuan sisi chen Hanlin Ci Xiaohu Dai Xiankai Wang Chong Li Dianchang Wang Bin Dong School of Environmental Science and Engineering.Tongji University Shanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China YANGTZE Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China

Anaerobic digestion and incineration are widely used sewage sludge(SS)treatment and disposal approaches to recovering energy from SS,but it is difficult to select a suitable technical process from the various *** this study,life-cycle assessments were adopted to compare the energy-and greenhouse gas-(GHG)emission footprints of two sludge-to-energy *** system uses a combination of AD with incineration(the AI system),whereas the other was simplified by direct incineration(the DI system).Comparison between three SS feedstocks(VS/TS:57.61-73.1 ds.%)revealed that the AI system consistently outperformed the DI *** results of sensitivity analyses showed that the energy and GHG emission performances were mainly affected by VS content of the SS,AD conversion efficiency,and the energy consumption of sludge ***,the energy and GHG emission credit of the two systems increased remarkably with the increase in the VS content of the *** the high-organic-content sludge(VS/TS:55%–80%),the energy and GHG emission credit of the AI system increase with the increase of AD conversion ***,for the low organic content sludge(VS/TS:30%–55%),it has the opposite *** terms of energy efficiency and GHG performance,the AI system is a good choice for the treatment of high-organic-content sludge(VS/TS>55%),but DI shows superiority over AI when dealing with low organic content sludge(VS/TS<55%).

关键词： Life cycle assessment Incineration Anaerobic digestion Energy recovery Environmental sustainability

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Near-infrared spectroscopy as a promising tool in stroke:Current applications and future perspectives

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Journal of Innovative Optical Health Sciences 2021年第6期4卷 19-41页

作者： Jinyan Sun Richong Pang sisi chen Hucheng chen Yuanrong Xie Dandan chen Kai Wu Jianbin Liang Kecheng Yan Zhifeng Hao Department of Biomedical Engineering School of Medicine Foshan UniversityFoshan 528000P.R.China Department of Electronic Information School of Mechatronic Engineering and Automation Foshan University Foshan 528000P.R.China Seventh Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518107P.R.China Department of Biomedical Engineering School of Material Science and Engineering South China University of Technology Guangzhou 510006P.R.China School of Mathematics and Big Data Foshan University Foshan 528000 P.R.China

Stroke is caused by an acute focal disruption of the vasculature in the central nervous ***-related functional deficits are the most devastating consequences for stroke *** signals from stroke patients can reflect the functional statuses of patients and provide insights into the neuronal recovery mechanism for functioning,which could be used as the basis for designing optimal treatment ***-infrared spectroscopy(NIRS)is a low-cost,noninvasive,easily operated neuroimage method and it is compatible with various rehabilitative *** advantages make NIRS an excellent candidate in research for stroke ***,we focused on the brain functions and recovery for stroke patients at stable status,conducted a systematic literature review about NIRS applications in stroke since 2000 and identified a total of 72 references through ScienceDirect and PubMed database *** NIRS studies in stroke include resting-state function and its recovery,motor function and itsrecovery,motor and cognition interference,cognitive function and its recovery,language function and its recovery,emotional function and its recovery and other *** on the results of the quality assessment,we identified some study gaps from the previous research and provided suggestions for some methodological improvement in the *** trend of NIRS gives a boost to its application in stroke,and the potential research directions for NIRS in stroke are pros-pected,including multi-center clinical research,treatment efficacy prediction research and brain-muscle coupling ***,limitations of NIRS are discussed.

关键词： Near-infrared spectroscopy stroke function deficits recovery

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