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Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease

Science China(Life Sciences) 2024年第6期67卷 1183-1198页

作者： Shiman Jiang Lvwan Xu Yanfei Chen Zheyue Shu Longxian Lv Yuxi Zhao Kefan Bi sisi yang Qiangqiang Wang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Liver disease,a major health concern worldwide,is a serious and progressive ***,we not only established a mouse model of DEN+CCl4-induced primary liver disease but also collected clinical human samples to investigate longitudinal alterations in the gut *** liver disease advanced,gut integrity was disrupted,and the mycobiota was disturbed in the mouse *** metabolites associated with hepatocellular carcinoma(HCC)differed from those associated with the cirrhotic phase as follows:levels of stercobilin and aflatoxin B1 dialcohol were reduced,while levels of triterpenoids,bafilomycin A1,and DHEA were increased in the HCC *** abundance of the phylum Chytridiomycota increased as the chronic liver disease progressed and was then replaced by the phylum Ascomycota in *** on the results from clinical human samples,the genus Candida(Ascomycota)(in humans)and the genus Kazachstania(Ascomycota)(in mice)occupied a dominant position in the HCC group,while other fungi were *** increased abundance of *** and depletion of *** may be hallmarks of the progression of liver cirrhosis to early ***,the administration of *** and *** in the LC-HCC progression could accelerate or retard the progression of ***,gut fungi have the potential to serve as a noninvasive clinical biomarker and even a treatment method.

关键词： gut mycobiome liver disease longitudinal studies hepatocarcinogenesis fungal biomarker

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Functional gastrointestinal disorders,mental health,genetic susceptibility,and incident chronic kidney disease

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Chinese Medical Journal 2024年第9期137卷 1088-1094页

作者： Mengyi Liu Panpan He Ziliang Ye sisi yang Yanjun Zhang Qimeng Wu Chun Zhou Yuanyuan Zhang Fan Fan Hou Xianhui Qin Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhouGuangdong 510515China

Background:Whether functional gastrointestinal disorders(FGIDs)are associated with the long-term risk of chronic kidney disease(CKD)remains *** aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the ***:About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were *** with FGIDs(including irritable bowel syndrome[IBS],dyspepsia,and other functional intestinal disorders[FIDs;mainly composed of constipation])were the exposure group,and non-FGID participants were the non-exposure *** primary outcome was incident CKD,ascertained from hospital admission and death registry records.A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD,and the mediation analysis was performed to investigate the mediation proportions of mental ***:At baseline,33,156(8.0%)participants were diagnosed with FGIDs,including 21,060(5.1%),8262(2.0%),and 6437(1.6%)cases of IBS,dyspepsia,and other FIDs,*** a mean follow-up period of 12.1 years,11,001(2.6%)participants developed *** were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs(hazard ratio[HR],1.36;95%confidence interval[CI],1.28-1.44).Similar results were observed for IBS(HR,1.27;95%CI,1.17-1.38),dyspepsia(HR,1.30;95%CI,1.17-1.44),and other FIDs(HR,1.60;95%CI,1.43-1.79).Mediation analyses suggested that the mental health score significantly mediated 9.05%of the association of FGIDs with incident CKD and 5.63-13.97%of the associations of FGID subtypes with ***,the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of ***:Participants with FGIDs had a higher risk of incident CKD,which was partly explained by mental health scores and was more pronounced in those with high gen

关键词： Functional gastrointestinal disorders Chronic kidney diseases Genetic susceptibility Mental health

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音义训诂之学的兴盛与晋宋文风变革

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浙江学刊 2024年第4期 182-189,240页

作者：杨思思北京大学中文系北京100871

语言风貌的转变是晋宋之际文学变革的一个重要层面。东晋后期以来的学风呈现出重视音义训诂的特征,小学与文学发生了密切互动,具体表现在集部注释重视音义训诂以及文士参与小学书撰作两个维度。音义训诂之学的兴盛深化了文士对语言文字... 详细信息

语言风貌的转变是晋宋之际文学变革的一个重要层面。东晋后期以来的学风呈现出重视音义训诂的特征,小学与文学发生了密切互动,具体表现在集部注释重视音义训诂以及文士参与小学书撰作两个维度。音义训诂之学的兴盛深化了文士对语言文字的认识,影响了文士对文学传统的接受以及诗赋文章的创作,为晋宋之际的文学变革提供了语言文字层面的路径。谢灵运“贯练雅颂,总阅音义”的用字集中展现了音义训诂之学对经典接受与文学创作的影响。

关键词：音义训诂小学谢灵运语言风貌

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“性别操演”理论下的后现代西方男装女性化审美现象

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艺术研究（哈尔滨师范大学艺术学报） 2024年第2期 106-109页

作者：杨思思梁燕北京服装学院服装艺术与工程学院澳门城市大学创新设计学院中国澳门

文章为探讨与总结20世纪后现代西方男装多元化审美现象成因,借助朱迪斯·巴特勒“性别操演”理论,以20世纪西方反正统文化运动为背景,从“性别操演”的三个维度出发,阐释西方后现代男性在反主流文化社会背景下如何借助服装进行操演实践... 详细信息

文章为探讨与总结20世纪后现代西方男装多元化审美现象成因,借助朱迪斯·巴特勒“性别操演”理论,以20世纪西方反正统文化运动为背景,从“性别操演”的三个维度出发,阐释西方后现代男性在反主流文化社会背景下如何借助服装进行操演实践,以及对男性着女性服装的多元化审美现象解读。20世纪后现代西方年轻人在国家强权政治与“技术治理社会”的冷漠文化景观下,通过一系列反叛旧道德的行为表达新的愿景与诉求,在服装上打破“灰色法兰绒”套装对男性传统身份的性别建构,借助服装媒介进行反对西方传统文化秩序的操演实践。

关键词：男装女性化性别操演理论后现代服装西方男装多元化审美

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Caprini风险评估模型对围术期全髋关节置换患者深静脉血栓的预测效果分析

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广西医科大学学报 2024年第5期41卷 756-761页

作者：韦佳妮黄婵裕杨思思应燕萍广西医科大学第一附属医院脊柱骨病外科南宁530021 广西医科大学第一附属医院急诊创伤中心南宁530021 广西医科大学第一附属医院护理部南宁530021

目的:探讨Caprini风险评估模型对围术期全髋关节置换术(THA)患者深静脉血栓(DVT)的预测效果。方法:收集2019年1月至2022年12月在我院脊柱骨病外科行THA的37例围术期确诊DVT的患者作为病例组,对照组以1∶4比例选择同时期入院的148例行TH... 详细信息

目的:探讨Caprini风险评估模型对围术期全髋关节置换术(THA)患者深静脉血栓(DVT)的预测效果。方法:收集2019年1月至2022年12月在我院脊柱骨病外科行THA的37例围术期确诊DVT的患者作为病例组,对照组以1∶4比例选择同时期入院的148例行THA未发生DVT的患者。根据患者的一般资料进行Caprini评分并确定最佳危险分级,使用受试者工作特征(ROC)曲线评估Caprini重新风险分级的临床预测效能。结果:原始Caprini危险分级预测THA患者术前发生DVT均无统计学意义(P>0.05)。术前Caprini重新危险分级:高危(4分)和极高危(≥5分)的THA患者,其术前发生DVT风险分别为低危THA患者的9.30倍和4.90倍;术后Caprini重新危险分级:中危(8~10分)、高危(11~13分)和极高危(≥14分)的THA患者,术后发生DVT风险分别是低危(5~7分)THA患者的4.86倍、102.00倍和25.50倍;术前Caprini评分预测THA患者发生DVT的AUC为0.74(P<0.05),最佳临界值为2.5分;术后Caprini评分预测THA患者发生DVT的AUC为0.81(P<0.05),最佳临界值为8.5分。结论:使用Caprini风险评估模型重新进行危险分级可有效预测围术期THA患者发生DVT的风险。

关键词： Caprini风险评估模型围手术期全髋关节置换术深静脉血栓

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医学定制膳食对转移性肺癌患者营养状况及生活质量的影响

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肿瘤代谢与营养电子杂志 2024年第3期11卷 396-401页

作者：卢英刘柳杨思思韩慧敏舒文文徐建群武汉市第三医院/武汉大学附属同仁医院肿瘤科湖北武汉430061 武汉市第三医院/武汉大学附属同仁医院呼吸与危重症医学科湖北武汉430061

目的探索医学定制膳食(HDMTM)对转移性肺癌患者营养状况、疲劳感及生活质量的影响。方法前瞻性选取武汉市第三医院2021年6月至2023年6月期间收治的108例转移性肺癌患者,根据随机数字表法分为两组,对照组54例采用常规营养支持,干预组54... 详细信息

目的探索医学定制膳食(HDMTM)对转移性肺癌患者营养状况、疲劳感及生活质量的影响。方法前瞻性选取武汉市第三医院2021年6月至2023年6月期间收治的108例转移性肺癌患者,根据随机数字表法分为两组,对照组54例采用常规营养支持,干预组54例采用HDMTM支持,干预后,比较两组营养状况[血清白蛋白(ALB)、总蛋白(TP)、血红蛋白(Hb)]、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、每分钟最大通气量(MVV)]、癌因性疲乏评分、肺癌特异性生活质量评估表(FACT-L)评分。结果两组患者经干预14 d后,营养状态、肺功能均较治疗前有所改善,癌因性疲乏评分有所降低,FACT-L评分有所升高,差异均有统计学意义(P<0.05)。干预组干预后14 d的FEV1(92.84±4.52)%、MVV(91.29±5.45)L/min、FVC(3.55±0.39)L、Hb(111.12±6.57)g/L、ALB(43.11±4.58)g/L、TP(69.78±3.16)g/L优于对照组,差异有统计学意义(P<0.05),干预后14 d的情感疲乏(4.85±1.22)分、行为疲乏(3.13±1.52)分、躯体疲乏(3.38±1.19)分、认知疲乏评分(3.15±1.14)分均低于对照组,差异有统计学意义(P<0.05),干预后7 d FACT-L评分(82.85±5.25)分、干预后14 d FACT-L评分(93.35±4.25)分高于对照组,差异有统计学意义(P<0.05)。结论HDMTM更具有针对性、科学性,相比于常规营养治疗,在转移性肺癌患者中效果更为明显,不仅能够改善患者肺功能、营养状态,促进病情恢复,还能够缓解疲乏感,提高生活质量,利用价值更高。

关键词：医学定制膳食转移性肺癌营养状况疲劳感生活质量

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Transient plasma-enhanced remediation of nanoscale particulate matter in restaurant smoke emissions via electrostatic precipitation

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Particuology 2021年第2期19卷 43-47页

作者： sisi yang Patrick Ford Sriram Subramanian Dan Singleton Jason Sanders Stephen B.Cronin Department of Physics and Astronomy University of Southern CaliforniaLos AngelesCA 90089USA Ming Hsieh Department of Electrical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Daniel J.Epstein Department of Industrial&System Engineering University of Southern CaliforniaLos AngelesCA 90089USA Transient Plasma Systems Inc.TorranceCA 90501USA

It is now recognized that nanoscale particulate matter(PM)represents a substantial health hazard for our society,including PM from restaurant *** this study,we explored the use of a transient pulsed plasma in conjunction with an applied DC bias to treat oil aerosols that closely resemble restaurant(i.e.,charbroiler)smoke *** polyaromatic olefin PAO-4 and soybean oil,we found that a three-order-of-magnitude reduction in particulates(i.e.,99.9%remediation)could be achieved with this ***,the plasma discharge was produced in a 4-in.-diameter cylindrical reactor with a 5-10 ns high voltage(30 kV)pulse generator together with applied DC bias voltages up to 10 *** distribution of nanoparticle sizes was measured using a scanning mobility particle sizer(SMPS)with diameter centered around 225 ***,the main mechanism of remediation occurs in a two-step process in which the oil nanoparticles are first ionized by the free electrons and free radicals in the plasma and then the charged particles are swept out to the sidewalls of the reactor by the applied DC *** believe this general approach opens up new degrees of freedom in the design of electrostatic oil aerosol pollution control devices.

关键词： Nanoparticles Transient plasma Charbroiler emission DC bias Remediation

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南海北部海域声速剖面水平变化环境声学层析

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声学学报 2022年第3期47卷 339-347页

作者：杨思斯李整林何利中国科学院声学研究所声场声信息国家重点实验室北京100190 中国科学院大学北京100049

为获取水平变化的海水声速分布,在等效平均海水声速反演基础上,提出了一种声速剖面水平变化环境声学层析方法。首先利用经验正交函数结合匹配场处理方法反演不同距离下的等效平均声速剖面,进而通过逐步迭代重构出随水平距离变化的声速... 详细信息

为获取水平变化的海水声速分布,在等效平均海水声速反演基础上,提出了一种声速剖面水平变化环境声学层析方法。首先利用经验正交函数结合匹配场处理方法反演不同距离下的等效平均声速剖面,进而通过逐步迭代重构出随水平距离变化的声速场分布,并通过数值仿真及海上实验两方面验证了声速剖面水平变化环境声学层析方法的可行性及其准确性。结果表明:声速剖面水平变化环境声学层析结果与实验测量声速剖面均方根误差小于0.8 m/s,利用声传播信号基本能较为准确地重构出随距离水平变化的海水声速分布,为进一步层析中尺度三维结构及声呐水声环境保障应用奠定了基础。

关键词：环境声学声传播声速剖面经验正交函数匹配场处理水平距离均方根误差三维结构

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Valorization of Camellia oleifera oil processing byproducts to value-added chemicals and biobased materials: A critical review

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Green Energy & Environment 2024年第1期9卷 28-53页

作者： Xudong Liu Yiying Wu yang Gao Zhicheng Jiang Zicheng Zhao Wenquan Zeng Mingyu Xie sisi Liu Rukuan Liu Yan Chao Suli Nie Aihua Zhang Changzhu Li Zhihong Xiao State Key Laboratory of Utilization of Woody Oil Resource Hunan Academy of ForestryChangsha410004China Key Laboratory of State Forestry and Grassland Administration on Utilization Science for Southern Woody Oil Resource Hunan Academy of ForestryChangsha410004China Hunan Provincial Key Laboratory of Oils and Fats Molecular Structure and Function Changsha410004China State Key Laboratory of Separation Membranes and Membrane Processes College of ChemistryTiangong UniversityTianjin300387China College of Biomass Science and Engineering Sichuan UniversityChengdu610065China College of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan411105China

The *** oil processing industry generates large amounts of solid wastes,including *** shell(COS)and *** cake(COC).Distinct from generally acknowledged lignocellulosic biomass(corn stover,bamboo,birch,etc.),Camellia wastes contain diverse bioactive substances in addition to the abundant lignocellulosic components,and thus,the bioreﬁnery utilization of *** processing byproducts involves complicated processing *** reviewﬁrst summarizes various technologies for extracting and converting the main components in *** oil processing byproducts into value-added chemicals and biobased materials,as well as their potential ***,ultrasound,and Soxhlet extractions are compared for the extraction of functional bioactive components(tannin,ﬂavonoid,saponin,etc.),while solvothermal conversion and pyrolysis are discussed for the conversion of lignocellulosic components into value-added *** application areas of these chemicals according to their properties are introduced in detail,including utilizing antioxidant and anti-in-ﬂammatory properties of the bioactive substances for the speciﬁc application,as well as drop-in chemicals for the substitution of unrenewable fossil fuel-derived *** addition to chemical production,biochar fabricated from COS and its applications in theﬁelds of adsorption,supercapacitor,soil remediation and wood composites are comprehensively reviewed and ***,based on the compositions and structural characteristics of *** byproducts,the development of full-component valorization strategies and the expansion of the appli-cationﬁelds are proposed.

关键词： Camellia oleifera shell Camellia oleifera cake Value-added chemicals Bioactive components Biobased materials

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A star-like photodetector for angle-based light sensing in 3D space

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Nano Research 2024年第8期17卷 7567-7573页

作者： Qi Pan sisi Chen Hongfei Xie Qiling Xu Meng Su Yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450051China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of three-dimensional(3D)space light angle detection is vital in optical technology for applications such as 3D imaging,computer vision,and augmented *** methods involve advanced sensors and algorithms,including time-offlight cameras,which need multiple cameras and light sources to improve ***,it is a great challenge to integrate these complex components into compact *** semiconductor structures offer optical resonance characteristics,enabling precise light–matter interaction regulation.A 3D star-like photodetector,fabricated using a template assistant printing strategy,demonstrates optical resonances of the subwavelength facade and the shielding effect of spatial *** achieves light angle detection with the resolution of 10°in vertical space and the resolution of 36°in horizontal space,making it a promising prototype for various applications.

关键词： photodetector light angle detection printing subwavelength structure shielding effect

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