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Molecular characteristics of primary pulmonary lymphoepithelioma-like carcinoma based on integrated genomic analyses

引用

Signal Transduction and Targeted Therapy 2021年第2期6卷 472-481页

作者： Bojiang Chen Yu Zhang sisi dail Ping Zhou Wenxin Luo Zhoufeng Wang Xuping Chen Peng Cheng Guoya Zheng Jing Ren Xiaodong Yang Weimin Li Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan UniversityNo.37Guo Xue Alley610041 ChengduSichuanChina Frontiers Science Center for Disease related Molecular Network West China HospitalSichuan UniversityChengdu SichuanChina Novogene Co LtdBeijingChina Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanChina Department of Respiratory and Critical Care Medicine Guangyuan Central HospitalNo.16Jing Jia AlleyLizhou DistrictGuangyuan628099 SichuanChina

Primary pulmonary lymphoepithelioma-like carcinoma(pLELC)is a rare non-small cell lung cancer(NSCLC)*** features have been described in our previous report,but molecular characteristics remain ***,pLELC genomic features were *** 41,574 lung cancers,128 pLELCS and 162 non-pLELC NSCLCS were *** cell death ligand 1(PD-L1)and protein 53(p53)expression was detected in 47 surgically resected pLELC samples by immunohistochemical *** genomic analyses,including whole-genome sequencing(WGS),RNA whole-transcriptome sequencing(RNA-seq),and Epstein-Barr virus(EBV)integration analyses,were performed on eight frozen pLELC tissues and compared with 50 lung adenocarcinomas(LUADs)and 50 lung squamous cell carcinomas(LUSCs)from The Cancer Genome Atlas(TCGA)and another 26 EBV-positive nasopharynx cancers(EBV+-NPCs).Progression-free survival(PFS)and overall survival(OS)of pLELC patients were better than those of non-pLELC *** PD-L1 or p53 expression was associated with extended disease free survival(DFS).pLELC had 14 frequently mutated genes(FMGs).Somatically mutated genes and enrichment of genetic lesions were found,which differed from observations in LUAD,LUSC,and EBV+-nasopharyngeal carcinoma(NPC).Three tumor associated genes,zinc finger and BTB domain-containing 16(ZBTB16),peroxisome proliferator activated receptor gamma(PPARG),and transforming growth factor beta receptor 2(TGFBR2),were downregulated with copy number variation(CNV)*** was prone to integrating into intergenic and intronic regions with two upregulated miR-BamH1-A rightward transcripts(BARTs),BART5-3P and *** findings reveal that pLELC has a distinct genomic *** tumor associated genes with CNV loss and two miR-BARTs might be involved in pLELC tumorigenesis.

关键词： lung NSCLC characteristics

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