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In vivofluorescenceflow cytometry reveals that the nanoparticle tumor vaccine OVA@HA-PEI effectively clears circulating tumor cells

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 107-123页

作者： Wei Jin Yuting Fu sisi Ge Han Sun Kai Pang Xunbin Wei The Department of Biomedical Engineering Institute of Advanced Clinical Medicine Peking University Beijing 100191P.R.China Institute of Medical Technology Peking University Health Science Center Beijing 100191 P.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142P.R.China School of Instrument Science and Opto-Electronics Engineering Beijing Information Science&Technology University Beijing 100192 P.R.China

Tumor vaccine therapy offers significant advantages over conventional treatments,including reduced toxic side ***,it currently functions primarily as an adjuvant treatment modality in clinical oncology due to limitations in tumor antigen selection and delivery *** vaccines often fail to elicit a su±ciently robust immune response against progressive tumors,thereby limiting their clinical e±*** this study,we developed a nanoparticle-based tumor vaccine,OVA@HA-PEI,utilizing ovalbumin(OVA)as the presenting antigen and hyaluronic acid(HA)and polyethyleneimine(PEI)as adjuvants and *** formulation significantly enhanced the proliferation of immune cells and cytokines,such as CD3.CD8,interferon-,and tumor necrosis factor-,in vivo,effectively activating an immune response against B16–F10 *** vivofluorescenceflow cytometry(IVFC)has already become an effective method for monitoring circulating tumor cells(CTCs)due to its direct,noninvasive,and long-term detection *** study utilized a laboratory-constructed IVFC system to monitor the immune processes induced by the OVA@HA-PEI tumor vaccine and an anti-programmed death-1(PD-1)*** results demonstrated that the combined treatment of OVA@HA-PEI and anti-PD-1 antibody significantly improved the survival time of mice compared to anti-PD-1 antibody treatment ***,this combination therapy substantially reduced the number of CTCs in vivo,increased the clearance rate of CTCs by the immune system,and slowed tumor *** greatly enhance the clinical application prospects of IVFC and tumor vaccines.

关键词： Tumor vaccines circulating tumor cells in vivofluorescenceflow cytometry.

The Influential Mechanisms of Theory of Mind on Prosocial Behavior and the Effect of Mindfulness Intervention

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International Journal of Mental Health Promotion 2024年第9期26卷 679-695页

作者： sisi Li Nailiang Zhong Qingke Guo Department of Psychology Guangxi Normal UniversityGuilin541006China School of Teacher Education Hechi UniversityHechi546300China South China Normal University Liru Senior High School Xinyi525300China

Background:Theory of Mind(ToM)and empathy are crucial cognitive and emotional capacities that influence social *** their role in promoting prosocial behavior has been established,the potential moderating effect of mindfulness on this relationship remains *** these complex interactions is vital for developing effective interventions to foster prosocial behavior among college *** study examines the influence of ToM on college students’prosocial behavior and explores the moderating role of mindfulness in this ***:A mixed-methods approach combining questionnaires and experimental design was *** 1:A survey of 759 college students(mean age 22.03.years;477 females)was conducted using the ToM Scale,Interpersonal Reactivity Index,Prosocial Behavior Tendency Scale,and Mindfulness Awareness *** were analyzed using correlation and moderated mediation *** 2:An 8-week mindfulness attention training program was implemented for the intervention group and compared with a control *** training served as a moderating variable to validate Model 59 from Study ***:*** 1 found:(a)ToM was significantly positively correlated with prosocial behavior(r=0.3.,p<0.01).(b)Empathy partially mediated the relationship between ToM and prosocial behavior(β=0.10,p<0.001,95%CI[0.06,0.14]).(c)Mindfulness negatively moderated the direct path between ToM and three dimensions of prosocial behavior,as well as the indirect path between empathy and kin altruism and reciprocal ***,high levels of mindfulness weakened the direct impact of ToM on prosocial *** levels of mindfulness also weakened the indirect influence of ToM on prosocial behavior through *** 2 results showed:(a)The intervention group had significantly higher levels of trait mindfulness compared to the control group(t=2.56,p<0.05).(b)The validity of the moderated mediation model 59 from Study 1 w

关键词： Prosocial behavior Theory of Mind trait mindfulness empathy mindfulness intervention

Synthesis and optical properties of highly efficient Na_(3.KMg_(7)(PO_(4))_(6):Eu^(2+)blue phosphor for full-spectrum white-light-emitting diodes:The role of Li_(2)CO_(3.flux

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Journal of Rare Earths 2024年第7期42卷 1217-1223,I0001页

作者： Zihao Wang sisi Liang Chenyang Zhan Kunyuan Xu Jie Hu Dejian Chen Liping Song Haomiao Zhu School of Physics and Materials Science Nanchang UniversityNanchang330000China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Research Center of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China

Full-spectrum phosphor-converted white-light-emitting diodes(pc-WLED)are emerging as a mainstream technology in semiconductor ***,high-performance blue phosphor which can be excited efficiently by a 400 nm NUV diode chip is still ***,we present a blue-emitting Na_(3.KMg_(7)(PO_(4))6:Eu^(2+)phosphor synthesized by the solid-reaction ***,we find that the using of Li_(2)CO_(3.as flux can significantly improve the crystal quality and thus the emission efficiency of the ***,the excitation peak of the phosphor shifts from 3.5 to 400 nm,which is pivotal for efficient NUV(400 nm)diode chip *** practical Eu^(2+)concentration is also enhanced by using Li_(2)CO_(3.as flux,and the absorption efficiency is greatly *** phosphor exhibits superior PL thermal stability,namely retains 94%integrated photoluminescence intensity at 150℃of that at 25℃.As a result,the optimized phosphor shows an emission band peaked at 43. nm with a bandwidth of 40 nm and a high external photoluminescence quantum yield of 51.7%.Finally,a pc-WLED was fabricated by using NKMPO:Eu^(2+)blue,Sr_(2)SiO_(4):Eu^(2+)green,CaAlSiN_(3.:Eu^(2+)red phosphors,and a 400 nm NUV diode *** shows a high color rendering index of R_(a)=96.4 and a correlated color temperature of 43.8 *** results prove that NKMPO:Eu^(2+)is a promising blue phosphor for full-spectrum WLED based on NUV diode chips.

关键词： Eu^(2+) Blue phosphor Na_(3.KMg_(7)(PO_(4))_(6) Full-spectrum white LEDs Rare earths

Advancing microarray fabrication:One-pot synthesis and highresolution patterning of UV-crosslinkable perovskite quantum dots

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Nano Research 2024年第9期17卷 8600-8609页

作者： Linfeng Yuan Dejian Chen Kun He Jiamin Xu Kunyuan Xu Jie Hu sisi Liang Haomiao Zhu CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Research Center of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021China

The development of highly efficient,solution-processable,and environmentally stable perovskite quantum dots(PQDs)is crucial for their accurate high-resolution patterning and subsequently enabling the practical deployment of PQD based emissive display *** study presents an innovative strategy for integrating all-inorganic PQDs and ultraviolet(UV)crosslinkable acrylate polymer at a structural and functional *** achievement is accomplished by meticulous design and one-pot synthesis of UV-crosslinkable CsPbX_(3.(X=Cl,Br,I)PQDs solution,which exhibit outstanding environmental *** the solution-processable characteristics of the resulting UV-crosslinkable PQDs,precise patterning of high-resolution(2μm,7608 pixels·in.^(-1))and colorful PQDs microarrays can be readily achieved through inkjet printing and high-throughput photolithography(~2μm in pitch line/space patterning).The UV cross-linked process guarantees a homogeneous distribution of PQDs,effectively mitigating coffee ring effect and improving the overall quality of stereoscopic *** photo-cured PQDs film,which undergoes free radical photopolymerization,displays an impressive photoluminescence quantum yield(PL QY)of up to 89.2%,reaching 98%of the value observed in the solution *** approach outlined in this research is both cost-effective and pragmatic,exhibiting tremendous promise for diverse system-level integrated optoelectronic devices,such as ultra-high-resolution micro-light-emitting device(micro-LED)displays.

关键词： perovskite quantum dots microarrays cross-linking strategy Inkjet printing photolithography

Electrochemical biosensors and power supplies for wearable health-managing textile systems

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Interdisciplinary Materials 2024年第2期3卷 270-296页

作者： Changxin Li Kangkang Jia Qimin Liang Yingchun Li sisi He Shenzhen Key Laboratory of Flexible Printed Electronics Technology School of ScienceHarbin Institute of Technology(Shenzhen)University TownShenzhenGuangdongChina

In recent years,wearable electrochemical biosensors have received increasing attention,benefiting from the growing demand for continuous monitoring for personalized medicine and point-of-care medical *** electrochemical biosensing and corresponding power supply into everyday textiles could be a promising strategy for next-generation non-invasive and comfort interaction mode with *** review starts with the manufacturing and structural design of electrochemical biosensing textiles and discusses a series of wearable electrochemical biosensing textiles monitoring various biomarkers(e.g.,pH,electrolytes,metabolite,and cytokines)at the molecular *** fiber-shaped or textile-based solar cells and aqueous batteries as corresponding energy harvesting and storage devices are further introduced as a complete power supply for electrochemical biosensing ***,we discuss the challenges and prospects relating to sensing textile systems from wearability,durability,washability,sample collection and analysis,and clinical validation.

关键词： energy harvesting and storage fiber health monitoring smart textile wearable biosensor

In-situ sludge reduction based on Mn^(2+)-catalytic ozonation conditioning:Feasibility study and microbial mechanisms

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Journal of Environmental Sciences 2024年第1期135卷 185-197页

作者： Haozhe Huang Tingting Wei Hui Wang Bing Xue sisi Chen Xiankai Wang Haibin Wu Bin Dong Zuxin Xu College of Environmental Science and Engineering Tongji UniversityShanghai 200092China YANGTZE Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China

To improve the sludge conditioning efficiency without increasing the ozone dose,an in-situ sludge reduction process based on Mn^(2+)-catalytic ozonation conditioning was *** ozone conditioning alone as a control,a lab-scale sequencing batch reactor coupled with ozonated sludge recycle was evaluated for its operating performance at an ozone dose of 75 mg O_(3./g VSS and 1.5 mmol/L Mn^(2+)*** results showed a 3..4%reduction in MLSS and an observed sludge yield of 0.23. kg MLSS/kg COD for the O_(3.+Mn^(2+)group compared to the O_(3.group (15.3.and 0.292 kg MLSS/kg COD),accompanied by better COD,NH_(4)^(+)-N,TN and TP removal,improved effluent SS and limited impact on excess sludge ***,activity tests,BIOLOG ECO microplates and 16S rRNA sequencing were applied to elucidate the changing mechanisms of Mn^(2+)-catalytic ozonation related to microbial action:(1) Dehydrogenase activity reached a higher peak.(2) Microbial utilization of total carbon sources had an elevated effect,up to approximately 18%,and metabolic levels of six carbon sources were also increased,especially for sugars and amino acids most pronounced.(3. The abundance of Defluviicoccus under the phylum Proteobacteria was enhanced to 12.0%and dominated in the sludge,they had strong hydrolytic activity and metabolic *** bacteria of the genus Ferruginibacter also showed an abundance of 7.6%,they contributed to the solubilization and reduction of sludge *** results could guide researchers to further reduce ozonation conditioning costs,improve sludge management and provide theoretical support.

关键词： Activated sludge In-situ reduction Catalytic ozonation conditioning Dehydrogenase activity Carbon source utilization Microbial community

Identification and Analysis of the WRKY Transcription Factor Gene Family in Verbena bonariensis

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1875-1896页

作者： Dandan Yuan Ju Cai Tao Zhang sisi Wang Xiuliu Yang Yan Li The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) Guizhou UniversityGuiyang550025China

The WRKY transcription factor gene family is one of the unique gene families in *** plays an important role in response to abiotic stresses such as cold and drought,hormone signal transduction,regulation of biosynthesis,leaf senescence seed germination,***,little information is available about WRKY transcription factors in Verbena *** this study,70 VbWRKY genes were identified from the whole *** phylogenetic analysis of the WRKY gene family in *** and Arabidopsis shows that the WRKY genes in *** can be divided into three groups:I,II,and III,which contain 13.47,and 10 members,*** II can be further divided into five subclasses:IIa(5),IIb(10),IIc(18),IId(6),and IIe(8).Conservative motif analysis showed that 64 proteins encoded by the VbWRKY gene had conserved motifs 1,2 and 3.and the same subclass motif elements were approximately the *** collinearity analysis showed that there were 44 homologous gene pairs among the VbWRKYs,and these homologous gene pairs may have the same *** sequence analysis showed that the VbWRKY gene has multiple cis-acting elements,including not only cis-acting elements related to low-temperature and light responses,but also cis-acting elements related to hormone regulation,Among them,most VbWRKY genes contain response elements about low-temperature,and 3. VbWRKY genes contain low-temperature response elements(LTR),and 61 VbWRKY genes contain abscisic acid response elements(ABRE),indicating that VbWRKY plays a crucial role in plant growth and abiotic *** to the expression of VbWRKY in the cold stress and different tissues transcriptome,70 VbWRKY genes played their respective roles in various tissues and stages to regulate plant growth,Also,some of them participated in the process of cold stress tolerance,52 VbWRKYs showed significant differences in expression under cold stress,and 3. VbWRKY genes were up-regulated under cold stress.9 VbWRKY genes w

关键词： Verbena bonariensis WRKY gene family cold resistance

The Interrelationship between Culture and Capital Structure:Evidence from International Retailers

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Proceedings of Business and Economic Studies 2024年第2期7卷 66-72页

作者： sisi Xu Hangzhou Dianzi University Information Engineering College Hangzhou 311305ZhejiangChina

The present study investigates the influence of cultural factors in 2022 on the capital structure of global *** are sixteen retailers from eight countries in the *** recent times,numerous academicians have taken an interest in examining the capital structure and business model of retailers,owing to their swift and consistent ***,the fact that the majority of research originates from the retailers’host country gives rise to debate regarding the applicability of the capital structure of said retailers to countries with distinct cultural ***,academics have begun to investigate whether the capital structure of multinational retailers is impacted by the diversity of national cultures.

关键词： Cultural factors Capital structure Global retailers Business model National cultures

A cognitive spectrum allocation scheme for data transmission in smart distribution grids

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High-Confidence Computing

High-Confidence Computing 2024年第3期4卷 32-40页

作者： Zhongguo Zhou You Li Ziming Zhu Qinghe Gao sisi Xiao Tao Yan Yan Huo AoStar Information Technologies CO. LTD.Chengdu 610094China School of Electronics and Information EngineeringBeijing Jiaotong UniversityBeijing 100044China

As the communication needs in the smart distribution grid continue to rise,using existing resources to meet this growing demand poses a significant *** paper researches on spectrum allocation strategies utilizing cognitive radio(CR)*** consider a model containing strong time-sensitive and regular communication service requirements such as distribution terminal communication services,which can be seen as a user with primary data(PD)and weak time-sensitive services such as power quality monitoring,which can be seen as a user with secondary data(SD).To fit the diversity of services in smart distribution grids(SDGs),we formulate an optimization problem with two indicators,including the sum of SD transmission rates and the maximum latency of ***,we analyze the two convex sub-problems and utilize convex optimization methods to obtain the optimal power and frequency bandwidth allocation for the users with *** simulation results indicate that,when the available transmission power of SD is low,Maximization of Transmission Sum Rate(MTSR)achieves lower maximum transmit ***,when the available transmission power is high,the performance of Minimization of the Maximum Latency(MML)is better,compared with MTSR.

关键词： Cognitive radio technologies Smart distribution grids Spectrum allocation Convex optimization