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Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model

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Neural Regeneration Research 2015年第2期10卷 266-270页

作者： Ibrahim Erkutlu Mehmet Alptekin sirma geyik Abidin Murat geyik Inan Gezgin Abdulvahap G?k Department of Neurosurgery Faculty of Medicine University of Gaziantep Department of Neurology Faculty of Medicine University of Gaziantep Department of Neurosurgery Sanko University Department of Neurosurgery Private Park Hospital

Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potas-sium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug in-jection injury. This study aimed to assess the time-dependent efifcacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by cyclosporine-A administration （30 minutes, 8 or 24 hours）. The compound muscle action potentials were recorded pre-injury, early post-injury （within 1 hour） and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant im-provement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury （P 〈 0.05）; at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin G potassium injection.

关键词： nerve regeneration peripheral nerve injury injection injury cyclosporine A penicillin G potassium Wallerian degeneration neuroelectrophysiology neural regeneration

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