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Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma

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World Journal of Gastroenterology 2010年第37期16卷 4697-4703页

作者： Kawin Leelawat siriluck narong Jerasak Wannaprasert Thawee Ratanashu-ek Department of Surgery Rajavithi Hospital College of Medicine Department of Surgery Rangsit University

AIM: To determine whether the serum level of matrix metalloproteinase-7 (MMP7) has the potential to diagnosis cholangiocarcinoma from benign biliary tract diseases. METHODS: This study was performed according to the PRoBE (a prospective-specimen-collection, retrospectiveblinded-evaluation) design. A total of 187 patients with obstructive jaundice were consecutively enrolled. After the diagnostic status of these patients was ascertained, their levels of serum MMP7 were assayed and compared with serum carbohydrate antigen 19-9 (CA19-9). This was conducted in a blinded case (cholangiocarcinoma)control (benign biliary tract disease) setup. RESULTS: MMP7 and CA19-9 serum levels were significantly elevated in cholangiocarcinoma patients (P < 0.001). The area under the curve (AUC) from a receiver operating characteristic (ROC) curve analysis for thediagnosis of cholangiocarcinoma, using MMP7 was more accurate than CA19-9 (AUC = 0.84, 95% CI: 0.778-0.903 for MMP7 and AUC = 0.79, 95% CI: 0.708-0.868 for CA19-9). The sensitivity and specificity of serum MMP7 (cut-off value of 5.5 ng/mL) was 75% and 78%, respectively, while the sensitivity and specificity of serum CA19-9 (cut-off value of 100 U/mL) was 68% and 87%, respectively. CONCLUSION: Serum values of MMP7 and CA19-9 appear to be useful biomarkers for differentiating cholangiocarcinoma from benign biliary tract obstructive diseases.

关键词： Carbohydrate antigen 19-9 Cholangiocarcinoma Matrix metalloproteinase-7 Sensitivity Specificity Tumor marker

Strong expression of CD133 is associated with increased cholangiocarcinoma progression

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World Journal of Gastroenterology 2011年第9期17卷 1192-1198页

作者： Kawin Leelawat Taweesak Thongtawee siriluck narong Somboon Subwongcharoen Sa-ad Treepongkaruna Department of Surgery Rajavithi Hospital College of Medicine Rangsit University

AIM:To determine the role of CD133 in cholangiocarcinoma progression. METHODS:CD133 protein expression was evaluated by immunohistochemistry in 34 cholangiocarcinoma *** addition,proliferation,chemoresistance and invasive properties of CD133-enriched(CD133 + ) and CD133-depleted(CD133 )RMCCA1 cholangiocarcinoma cells were studied and compared. RESULTS:Strong CD133 expression was observed in 67.6%(23/34)of the cholangiocarcinoma specimens. Strong expression of CD133 was significantly associated with nodal metastasis(P=0.009)and positive surgical margin status(P=0.011).In the in vitro study, both the CD133 + and CD133 cells had similar proliferation abilities and resistance to chemotherapeutic ***,the CD133 + cells had a higher invasive ability compared with CD133 cells. CONCLUSION:CD133+cells play an important role in the invasiveness of *** of the CD133+cells may be a useful approach to improve treatment against cholangiocarcinoma.

关键词： CD133 Cholangiocarcinoma Immunohistochemistry Invasion Metastasis

Prognostic relevance of circulating CK19 mRNA in advanced malignant biliary tract diseases

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World Journal of Gastroenterology 2012年第2期18卷 175-181页

作者： Kawin Leelawat siriluck narong Wandee Udomchaiprasertkul Jerasak Wannaprasert Sa-ard Treepongkaruna Somboon Subwongcharoen Tawee Ratanashu-ek Department of Surgery Rajavithi Hospital Bangkok 10400 Thailand College of Medicine Rangsit University Bangkok 10400 Thailand Cancer Molecular Therapeu-tics Unit Chulabhorn Hospital Bangkok 10110 Thailand

AIM: To determine the role of circulating tumor cells (CTCs) in prediction of the overall survival of patients with advanced malignant biliary tract obstruction. METHODS: We investigated the prognostic value of CTCs by examining two markers, cytokeratin (CK) 19 and human telomerase reverse transcriptase (hTERT) mRNA, in 40 patients diagnosed with advanced malig- nant biliary tract diseases. Quantitative real-time re- verse transcription polymerase chain reaction was used to detect CK19 and hTERT mRNA in the peripheral blood of these patients. Overall survival was analyzed using the Kaplan-Meier method and Cox regression ***: Positive CK19 and hTERT mRNA expression was detected in 45% and 60%, respectively, of the 40 patients. Univariable analysis indicated that positive CK19 mRNA expression was significantly associated with worse overall survival (P = 0.009). Multivariable analysis determined that positive CK19 mRNA expres- sion, patient's age and serum bilirubin were each inde- pendently associated with overall survival. CONCLUSION: CK19 mRNA expression levels in pe- ripheral blood appear to provide a valuable marker to predict the overall survival of patients with advanced malignant biliary tract obstruction.

关键词： Circulating tumor cells Cytokeratin 19 Human telomerase reverse transcriptase Malignant biliary tract obstruction Overall survival

当归芍药散联合西药治疗轻度阿尔茨海默病临床观察

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中国中医药现代远程教育 2024年第3期22卷 106-109页

作者：尚娜荣山东省东明县中医医院内科山东菏泽274500

目的分析当归芍药散联合西药治疗轻度阿尔茨海默病的效果。方法选取2020年3月—2021年3月在山东省东明县中医医院就诊的90例轻度阿尔茨海默病患者,运用随机数字表法分为参照组和研究组,各45例。参照组患者予盐酸多奈哌齐片治疗,研究组... 详细信息

目的分析当归芍药散联合西药治疗轻度阿尔茨海默病的效果。方法选取2020年3月—2021年3月在山东省东明县中医医院就诊的90例轻度阿尔茨海默病患者,运用随机数字表法分为参照组和研究组,各45例。参照组患者予盐酸多奈哌齐片治疗,研究组予当归芍药散联合西药治疗,观察、比较2组患者的临床疗效和治疗前后的阿尔茨海默病评估量表-认知量表(ADAS-cog)评分。结果研究组患者的治疗总有效率为95.56%(43/45),高于参照组的77.78%(35/45),差异有统计学意义(P<0.05);治疗后,研究组患者的ADAS-cog积分低于参照组,差异有统计学意义(P<0.05)。结论对于轻度阿尔茨海默病患者来说,给予当归芍药散联合西药治疗,能够取得良好的效果、改善患者的临床症状,值得推广。

关键词：阿尔茨海默病当归芍药散中西医结合疗法

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Synthesis, characterization and magnetic properties of KFeO_(2) nanoparticles prepared by a simple egg white solution route

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International Journal of Minerals,Metallurgy and Materials 2022年第1期29卷 128-135页

作者： Thongsuk Sichumsaeng Nutthakritta Phromviyo Supree Pinitsoontorn Pinit Kidkhunthod narong Chanlek Santi Maensiri School of Physics Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima30000Thailand SUT CoE on Advanced Functional Materials Suranaree University of TechnologyNakhon Ratchasima30000Thailand Research Network NANOTEC-SUT on Advanced Nanomaterials and Characterization Suranaree University of TechnologyNakhon Ratchasima30000Thailand Department of Physics Faculty of ScienceKhon Kaen UniversityKhon Kaen40002Thailand Synchrotron Light Research Institute(Public Organizer Nakhon Ratchasima30000Thailand

Nanoparticles of potassium ferrite(KFeO_(2))in this work were synthesized by a simple egg white solution method upon calcination in air at 773,873,and 973 K for 2 *** effects of calcination temperature on the structural and magnetic properties of the synthesized KFeO_(2) nanoparticles were *** varying the calcination temperature,X-ray diffraction and transmission electron microscopy results indicated the changes in crystallinity and morphology including particle size,***,the reduction in particle size of the synthesized KFeO_(2) was found to have a remarkable influence on the magnetic *** room temperature,the synthesized KFeO_(2) nanoparticles prepared at 873 K exhibited the highest saturation magnetization(M_(S))of 2.07×10^(4) A·m^(−1).In addition,the coercivity(H_(C))increased from 3.51 to 16.89 kA·m^(−1) as the calcination temperature increased to 973 *** zero-field cooled(ZFC)results showed that the blocking temperatures(T_(B))of about 125 and 85 K were observed in the samples calcined at 773 and 873 K,***,this work showed that the egg white solution method is simple,cost effective,and environmentally friendly for the preparation of KFeO_(2) nanoparticles.

关键词： egg white solution method potassium ferrite nanoparticles magnetic properties ferromagnetism

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Mangosteen peel-derived activated carbon for supercapacitors

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Progress in Natural Science:Materials International 2022年第5期32卷 570-578页

作者： Jessada Khajonrit Thongsuk Sichumsaeng Ornuma Kalawa Suphawi Chaisit Atchara Chinnakorn narong Chanlek Santi Maensiri School of Physics Institute of Science Suranaree University of Technology SUT-NANOTEC RNN on Nanomaterials and Advanced Characterizations Suranaree University of Technology SUT Center of Excellence on Advanced Functional Materials Suranaree University of Technology Synchrotron Light Research Institute (Public Organization)

This work reports the effects of activation temperatures on the porous development and electrochemical performance of activated carbons. Herein, activated carbons were prepared from the biowaste of mangosteen peel by using KOH activation at temperatures of 400, 600, and 800°C. The results demonstrate that the specific surface area increases with increasing the activation temperatures in which the well-developed porous structure after KOH activation at 800°C provides the highest specific surface area of 1039 m2g-1. At 600°C, the activated carbon delivers the highest specific capacitance value of 182 F g-1at a current density of 0.5 A g-1in 3 M KOH aqueous electrolyte. This is correlated well with its high micropore fractions(99%). Moreover, it was found that the activation temperature changes the major contribution of oxygen-containing functional group on surface of activated carbon, which is beneficial for the enhancement of the specific capacitance value of activated carbon at the temperature of 600°C. This work suggests that the activation temperature is a key to optimizing the electrochemical performance of activated carbons. Overall, our activated carbons can be considered as a strong candidate for use as electrode materials in supercapacitors.

关键词： Mangosteen peel KOH activation Porous carbon Oxygen-containing functional group Supercapacitor

Influence of polymer solution on the morphology and local structure of NH_(4)ZnPO_(4)powders synthesized by a simple precipitation method at room temperature

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International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 298-304页

作者： Santi Phumying Thongsuk Sichumsaeng Pinit Kidkhunthod narong Chanlek Jessada Khajonrit Somchai Sonsupap Santi Maensiri School of Physics Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima 30000Thailand Synchrotron Light Research Institute(Public Organizer Nakhon Ratchasima 30000Thailand SUT-NANOTEC RNN on Nanomaterials and Advanced Characterizations Suranaree University of TechnologyNakhon Ratchasima 30000Thailand

NH_(4)Zn PO_(4)powders were synthesized using a simple precipitation method at room *** effects of polyvinyl pyrrolidone(PVP),polyvinyl alcohol(PVA),glucose,and hexadecyltrimethylammonium bromide(CTAB)solutions on the morphology and structure of the prepared samples were *** phase composition and morphology of the prepared samples were characterized using X-ray diffraction and scanning electron microscopy,*** on the polymer sources,the hexagonal structure prepared using non-surfactant of water completely changed to monoclinic structure when CTAB was added.X-ray absorption near-edge structure(XANES)and X-ray photoelectron spectroscopy(XPS)were performed to study the local structure and surface electronic structure of the prepared samples,confirming that the oxidation states of P and Zn ions are^(5+)and^(2+),*** the basis of the results of inductively coupled plasma atomic emission spectroscopy(ICP-OES),the NH_(4)Zn PO_(4)powders can be classified as a slow-release fertilizer where less than 15%of the ions were released in 24 h.A simple precipitation method using water,PVP,PVA,sucrose,and CTAB as a template can be used to synthesize NH4 Zn PO4 *** addition,this method may be extended for the preparation of other oxide materials.

关键词： ammonium zinc phosphate precipitation method morphology X-ray absorption spectroscopy ion release properties

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Enhancement of output power density in a modified polytetrafluoroethylene surface using a sequential O_(2)/Ar plasma etching for triboelectric nanogenerator applications

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Nano Research 2022年第1期15卷 272-279页

作者： Teerayut Prada Viyada Harnchana Anthika Lakhonchai Artit Chingsungnoen Phitsanu Poolcharuansin narong Chanlek Annop Klamchuen Prasit Thongbai Vittaya Amornkitbamrung Department of Physics Khon Kaen UniversityKhon Kaen 40002Thailand Institute of Nanomaterials Research and Innovation for Energy(IN-RIE) NANOTEC-KKU RNN on Nanomaterials Research and Innovation for EnergyKhon Kaen UniversityKhon Kaen 40002Thailand Technological Plasma Research Unit Department of PhysicsFaculty of ScienceMahasarakham UniversityMaha Sarakham 44150Thailand Synchrotron Light Research Institute(Public Organization) Naklwn Ratchasima 30000Thailand National Nanotechnology Center(NANOTEC) NSTDAPathum Thani 12120Thailand

In this work,the surface modification using a two-steps plasma etching has been developed for enhancing energy conversion performance in polytetrafluoroethylene(PTFE)triboelectric nanogenerator(TENG).Enhancing surface area by a powerful O_(2) and Ar bipolar pulse plasma etching without the use of CF_(4) gas has been demonstrated for the first *** with modified surface PTFE using a sequential two-step O_(2)/Ar plasma has a superior power density of 9.9 W·m^(-2),which is almost thirty times higher than that of a pristine PTFE *** synergistic combination of high surface area and charge trapping sites due to chemical bond defects achieved from the use of a sequential O_(2)/Ar plasma gives rise to the intensified triboelectric charge density and the enhancement of power output of PTFE-based *** effects of plasma species and plasma etching sequence on surface morphologies and surface chemical species were investigated by a field emission scanning electron microscopy(FESEM),atomic force microscopy(AFM),and X-ray photoelectron spectroscopy(XPS).The correlation of surface morphology,chemical structure,and TENG performance was *** addition,the applications of mechanical energy harvesting for lighting,charging capacitors,keyboard sensing and operating a portable calculator were demonstrated.

关键词： two-step plasma etching O_(2)and Ar plasma CF_(4)free triboelectric nanogenerator power output enhancement

Fabrication of fluoroalkylsilane/zeolitic imidazolate framework composites for highly efficient superhydrophobic coating

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Carbon Resources Conversion 2022年第1期5卷 26-34页

作者： Preyaphan Kheaw-in Chanatip Samart narong Chanlek Phakkhananan Pakawanit Prasert Reubroycharoen Guoqing Guan Suwadee Kongparakul Suda Kiatkamjornwong Department of Chemistry Faculty of Science and TechnologyThammasat UniversityPathumthani 12120Thailand Bioenergy and Biochemical Refinery Technology Program Faculty of Science and TechnologyThammasat University12120Thailand Synchrotron Light Research Institute(Public Organization) 111 University AvenueMuang DistrictNakhon Ratchasima 30000Thailand Department of Chemical Technology Faculty of ScienceChulalongkorn University254 Phyathai RoadWangmaiPatumwanBangkok 10330Thailand Institute of Regional Innovation Hirosaki UniversityAomori 030-0813Japan Office of University Research Affairs Chulalongkorn University254 Phyathai RoadWangmaiPatumwanBangkok 10330Thailand FRST Academy of ScienceOffice of the Royal SocietySanam Suea PaKhet DusitBangkok 10300Thailand

Superhydrophobic bagasse paper was successfully engineered by facile spray coating with a zeolitic imidazolate framework composite modified by 3,3,3-trifluoropropyltrimethoxysilane(FAS)and used as a filter membrane with special wettability for oil/water *** characteristics such as surface morphology,surface moieties,roughness,and wettability were *** addition of FAS decreased the apparent surface energy between solid surfaces and liquids with a polar contribution of surface free energy as low as 0 mN m−*** formation of the FAS layer was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy core-level ***-dimensional surface topography revealed an increase in the spray coating cycle that enhanced the hydrophobicity of the coated *** results confirmed that not only microstructures but also the presence of functional groups with low surface energy(such as FAS)can promote surface *** spray-coated paper with FAS/ZIF in the presence of a small amount of nanocellulose provided a superhydrophobic surface after the first spray *** separation efficiency was up to 85%and was slightly affected by oil ***,this can be used as a filter membrane for water-in-oil *** the present work,simple spray-coated paper is a promising candidate material for gravity-driven oil/water separation and water repellent coating.

关键词： Superhydrophobic surface Spray-coating Zeolitic imidazolate framework Oil/water separation