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Open Journal of Ecology（生态学期刊） 2024年第5期 419页

作者： Dandan Zhang Faujiah Nurhasanah Ritonga Tuya siqin Runxian Song Zicheng Zhang Mingwei Tang Peilin Sun Wa Gao

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梅毒患者住院费用及其影响因素的通径分析

中国病案 2024年第8期25卷 32-35页

作者：林金雄索斯琴郑举敦申树群南方医科大学皮肤病医院(广东省皮肤病医院) 广东省广州市510091 南方医科大学卫生管理学院广东省广州市510515

目的研究梅毒住院患者次均住院费用现状并分析其影响因素,为合理有效率控制医院住院费用上涨、减轻患者就医负担提供科学性建议。方法收集广东省某三级皮肤病专科医院2015年1月1日-2019年12月31日538例梅毒住院患者病例资料,运用描述性... 详细信息

目的研究梅毒住院患者次均住院费用现状并分析其影响因素,为合理有效率控制医院住院费用上涨、减轻患者就医负担提供科学性建议。方法收集广东省某三级皮肤病专科医院2015年1月1日-2019年12月31日538例梅毒住院患者病例资料,运用描述性分析、单因素t检验、通径分析及中介效应检验等方法对梅毒住院患者住院费用基本状况进行描述,并探究各影响因素与住院费用间相关关系。结果梅毒患者平均住院费4931.33元,平均住院天数5.99天,通径分析显示住院天数(β=0.538,P<0.001)、是否使用抗菌药物(β=0.227,P=0.006)、是否医保(β=0.147,P<0.001)、是否手术(β=0.223,P<0.001)会直接影响总费用,其中性别(β=0.029,P=0.005)、是否使用抗菌药物(β=0.417,P<0.001)、是否手术(β=-0.036,P=0.003)通过影响住院天数间接影响住院费用。结论影响住院费用的因素主要是住院天数、是否使用抗菌药物、是否手术。

关键词：梅毒住院费用影响因素通径分析中介效应

A new synonym of the species Falsomesosella truncatipennis Pic,1944(Coleoptera:Cerambycidae:Lamiinae:Mesosini)

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Zoological Systematics 2021年第4期46卷 342-343页

作者： Meiying Lin Andreas Weigel siqin Ge Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing100101China Am Schloβgarten 10 07381 WernburgGermany

The genus Falsomesosella Pic,1925 currently includes two subgenera,with 36 species/subspecies described in the nominate subgenus(Tavakilian&Chevillotte,2021).Among them,10 species were recorded from China(Lin&Tavakilian,2019).Recently,Lazarev(2021)described the 37 th species from Shaanxi Province of ***,it was based on four specimens of Falsomesosella truncatipennis Pic,1944,herein we propose the new synonym.

关键词： China. also meso

补肾健脾通络方结合五行健骨操对老年骨质疏松脾肾两虚证患者骨密度、骨代谢及炎症水平的影响

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陕西中医 2024年第4期45卷 485-489页

作者：姜凤依施丹季思勤鲍晓敏史晓上海中医药大学附属岳阳中西医结合医院上海200437

目的:观察补肾健脾通络方结合五行健骨操对老年骨质疏松脾肾两虚证患者骨密度、骨代谢及炎症水平的影响。方法:选取100例老年骨质疏松脾肾两虚证患者,采用简单随机法分为两组。西药组给予碳酸钙D_(3)联合骨化三醇治疗,综合组在西药组基... 详细信息

目的:观察补肾健脾通络方结合五行健骨操对老年骨质疏松脾肾两虚证患者骨密度、骨代谢及炎症水平的影响。方法:选取100例老年骨质疏松脾肾两虚证患者,采用简单随机法分为两组。西药组给予碳酸钙D_(3)联合骨化三醇治疗,综合组在西药组基础上给予补肾健脾通络方结合五行健骨操干预。比较两组治疗前后动态平衡、骨密度、骨代谢、炎症水平及中医症候积分差异,统计不良反应。结果:综合组治疗后睁眼和闭眼的动态平衡参数低于西药组(均P0.05)。结论:补肾健脾通络方结合五行健骨操可减轻老年骨质疏松脾肾两虚证患者炎症反应,改善骨密度和骨代谢,提高平衡功能。

关键词：骨质疏松补肾健脾通络方五行健骨操脾肾两虚证骨密度骨代谢

The structure of the compound eyes and phototaxis in two phenotypes of the bean pest Callosobruchus maculatus(Coleoptera:Bruchinae)

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动物分类学报:英文版 2023年第3期48卷 193-205页

作者： Zhong Du Tianhao Zhang Fengming Wu Zulong Liang Xiaokun Liu Muinde Jacob Weili Fan Lei Jiang Lijie Zhang siqin Ge Guohong wang College of Life Sciences Fujian Normal UniversityProvincial University Key Laboratory of Cellular Stress Response and Metabolic RegulationCollege of Life SciencesFuzhou 350108China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Science and Technical Research Center of China Customs Beijing 100026China University of Chinese Academy of Sciences Beijing 100049China

Callosobruchus maculatus(Fabricius,1775)(Coleoptera:Bruchinae)is a destructive agricultural pest that is harmful to beans worldwide and an important quarantine pest in *** was divided into two phenotypes based on polyphenism:normal and flight *** this study,we first compared the morphological structures of the compound eyes of the two *** to the results of scanning electron microscopy(SEM),transmission electron microscopy(TEM),microcomputed tomography(micro-CT),and computer three-dimensional reconstruction,there are no differences in the structures of the compound eyes between the normal and flight forms except for the number of *** the internal structure,the compound eyes have a biconvex cornea with open rhabdom and acone eye,crystalline cone directly connected with rhabdom,and no clear *** is a kind of apposition *** facets range in shape from quadrilateral to hexagonal and some irregular *** electroretinograms(ERGs),the normal and flight forms showed different spectral sensitivities:the normal form had the strongest response to ultraviolet light,whereas the flight form had the strongest response to white *** assays revealed that the normal and flight forms showed completely opposite phototaxis behaviors;the flight form exhibited positive phototaxis,whereas the normal form exhibited negative *** study not only enriches our knowledge on coleopteran compound eyes but also provides a foundation for in-depth research on the photoreceptor mechanisms of compound eyes,which may be useful in pest control management.

关键词： Polyphenism cowpea weevil morphology photopreference electroretinogram

脑卒中患者肺部感染风险预测模型的建立及应用研究

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现代医药卫生 2024年第18期40卷 3090-3096,3103页

作者：刘思琴彭燕肖红司元华张小燕徐祖才遵义医科大学附属医院神经内科贵州遵义563000

目的构建脑卒中患者肺部感染的风险预测模型,并验证其临床预测效果。方法采用便利抽样法,选择2021年1月至2023年1月在贵州省某三级甲等医院住院的750例脑卒中患者为研究对象,根据是否发生肺部感染分为肺部感染组(n=267)和非肺部感染组... 详细信息

目的构建脑卒中患者肺部感染的风险预测模型,并验证其临床预测效果。方法采用便利抽样法,选择2021年1月至2023年1月在贵州省某三级甲等医院住院的750例脑卒中患者为研究对象,根据是否发生肺部感染分为肺部感染组(n=267)和非肺部感染组(n=483),对2组患者相关资料进行比较分析,应用logistic回归分析建立风险预测模型,应用Hosmer-Lemeshow(H-L)检验模型的拟合优度及受试者工作特征曲线(ROC曲线)下面积判断模型的预测效果。另选取2023年2-8月符合标准的145例患者进行模型预测效果验证。结果经单因素及多因素分析发现,吞咽障碍[比值比(OR)=10.462]、合并肺部基础疾病(OR=6.046)、低钾血症(OR=2.266)、低钠血症(OR=3.807)、低血红蛋白(OR=4.036)、入院时美国国立卫生研究院卒中量表(NISSH)评分(OR=38.135)、入院时日常生活能力(ADL)评分(OR=12.942)、住院时间(OR=8.992)是脑卒中患者发生肺部感染的独立危险因素(P<0.05)。风险预测模型公式:Logit(P)=-4.761+2.348×(吞咽障碍的赋值)+1.799×(合并肺部基础疾病的赋值)+0.818×(低钾血症的赋值)+1.337×(低钠血症的赋值)+1.395×(低血红蛋白的赋值)+3.641×(NISSH评分的赋值)+2.560×(ADL评分的赋值)+2.196×(住院时间的赋值)。建模组ROC曲线下面积为0.953[95%可信区间(95%CI)0.940~0.967,P<0.001],约登指数为0.762,灵敏度为0.880,特异度为0.882,H-L检验的P值为0.553。模型验证结果显示:验模组ROC曲线下面积0.946(95%CI:0.927~0.987,P<0.001),灵敏度为0.898,特异度为0.875,正确率为88.3%,H-L检验P值为0.510。结论构建的脑卒中发生肺部感染风险预测模型预测效能良好,可为临床医护人员早期识别脑卒中发生肺部感染的高危人群提供参考,为及时采取预防性管理措施提供借鉴。

关键词：脑卒中肺部感染危险因素风险预测预测模型

PCOS患者血清维生素D与同型半胱氨酸的表达及相关性

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现代医药卫生 2024年第19期40卷 3281-3284,3290页

作者：邹文毕廖美艳廖思钦池青黄光秀佛山市三水区人民医院广东佛山528100

目的探讨血清维生素D与同型半胱氨酸(Hcy)在多囊卵巢综合征(PCOS)诊断中的价值及其相关性。方法选取2022年1-12月于该院生殖中心门诊就诊或住院的18~40岁育龄期PCOS患者54例作为PCOS组,同时纳入50例18~40岁健康体检女性作为对照组。检... 详细信息

目的探讨血清维生素D与同型半胱氨酸(Hcy)在多囊卵巢综合征(PCOS)诊断中的价值及其相关性。方法选取2022年1-12月于该院生殖中心门诊就诊或住院的18~40岁育龄期PCOS患者54例作为PCOS组,同时纳入50例18~40岁健康体检女性作为对照组。检测所有受试者血清维生素D与Hcy水平,比较PCOS组和对照组的差异。采用受试者操作特征(ROC)曲线分析单独或联合维生素D和Hcy对PCOS的诊断效能。采用Pearson相关分析探究对照组、PCOS组维生素D水平低于cut-off值(47.16 nmol/L)的人群(低维生素D组)中血清维生素D与Hcy的相关性。结果PCOS组患者的体重[(66.98±11.27)kg]、身体质量指数(BMI)[(26.98±3.79)kg/m^(2)]和血清Hcy水平[(11.10±2.59)μmol/L]显著高于对照组[(61.26±6.66)kg、(24.04±4.28)kg/m^(2)、(9.16±1.75)μmol/L],而血清维生素D水平[(44.45±13.49)nmol/L]显著低于对照组[(71.57±15.71)nmol/L],差异有统计学意义(P<0.05)。ROC曲线分析结果显示,单独应用指标进行诊断时,体重的灵敏度为44.4%,特异度为88.0%;BMI的灵敏度为59.3%,特异度为78.0%;维生素D的灵敏度为75.9%,特异度为94.0%;Hcy的灵敏度为68.9%,特异度为60.0%;4项指标进行联合诊断的灵敏度为88.9%,特异度为92.0%。此外,对照组、PCOS组及低维生素D组患者中,血清维生素D与Hcy呈负相关[相关系数(r)=-0.4291、-0.7516、-0.9182,P<0.05]。结论4项指标联合诊断PCOS的灵敏度和特异度均优于单一指标。PCOS患者血清维生素D与Hcy呈负相关。因此,临床上可以考虑使用多项指标联合检测用于PCOS的诊断。

关键词：多囊卵巢综合征维生素D 同型半胱氨酸联合诊断

A study of the genus Xylotrechus Chevrolat(Coleoptera:Cerambycidae)from Beijing,China

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Entomotaxonomia 2021年第3期43卷 205-224页

作者： Meiying LIN siqin GE Nengwen XIAO Engineering Research Center for Forest and Grassland Disaster Prevention and Reduction Mianyang Normal UniversityMianyangSichuan 621000China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

Ten species of the genus Xylotrechus Chevrolat,1860 from Beijing are *** pekingensis Pic,1939 is reinstated from synonym of Xylotrechus yanoi Gressitt,1934,and newly recorded from Hebei and Shaanxi *** bifenestratus Pic,1916 is proposed as a new junior synonym of Xylotrechus polyzonus(Fairmaire,1888),both were described from Beijing,*** species,***(Gebler,1825),*** Bates,1873,and ***(Pic,1936),are reported from Beijing for the first *** new localities are added to the related species based on specimens examined.A key to the ten species of Xylotrechus Chevrolat,1860 from Beijing is provided.

关键词： Cerambycinae Clytini taxonomy new synonym new record

Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1416-1431页

作者： Yang Zhou Fan Tong Weilong Gu siqin He Xiaotong Yang Jiamei Li Yue-Dong Gao Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Core Technology Facility of Kunming Institute of Zoology Chinese Academy of SciencesKunming 650223China Chinese Academy of Sciences Territorial Core Facility of Kunming Biological Diversity Regional Center Kunming 650223China

Considering that photodynamic therapy(PDT)-induced oxygen consumption and microvascular damage could exacerbate hypoxia to drive more glycolysis and angiogenesis, a novel approach to potentiate PDT and overcome the resistances of hypoxia is avidly needed. Herein, morpholine-modified PEGylated bilirubin was proposed to co-deliver chlorin e6, a photosensitizer, and diclofenac(Dc). In acidic milieu, the presence of morpholine could enable the nanocarriers to selectively accumulate in tumor cells, while PDT-generated reactive oxidative species(ROS) resulted in the collapse of bilirubin nanoparticles and rapid release of Dc. Combining with Dc showed a higher rate of apoptosis over PDT alone and simultaneously triggered a domino effect, including blocking the activity and expression of lactate dehydrogenase A(LDHA), interfering with lactate secretion, suppressing the activation of various angiogenic factors and thus obviating hypoxia-induced resistance-glycolysis and angiogenesis. In addition, inhibition of hypoxia-inducible factor-1a(HIF-1a) by Dc alleviated hypoxia-induced resistance. This study offered a sequentially responsive platform to achieve sufficient tumor enrichment, on-demand drug release and superior anti-tumor outcomes in vitro and in vivo.

关键词： Bilirubin nanoparticles ROS-responsive drug release Charge reversal Photodynamic therapy Hypoxia Diclofenac LDHA inhibition HIF-1a inhibition

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2176-2187页

作者： Chuan Hu Yujun Song Yiwei Zhang siqin He Xueying Liu Xiaotong Yang Tao Gong Yuan Huang Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China

Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination ***,a kind of tumor cascade-targeted responsive liposome(NLG919@Lip-pep1)is developed by conjugating polypeptide inhibitor of PD-1 signal pathway(AUNP-12),which is also a targeted peptide that conjugated with liposome carrier through matrix metalloproteinase-2(MMP-2)cleavable peptide(GPLGVRGD).This targeted liposome is prepared through a mature preparation process,and indoleamine-2,3-dioxygenase(IDO)inhibitor NLG919 was encapsulated into ***,mediated by the enhanced permeability and retention effect(EPR effect)and AUNP-12,NLG919@Lip-pep1 first targets the cells that highly express PD-L1 in tumor *** the same time,the over-expressed MMP-2 in the tumor site triggers the dissociation of AUNP-12,thus realizing the precise block of PD-1 signal pathway,and restoring the activity of T *** exposure of secondary targeting moduleⅡVRGDC-NLG919@Lip mediated tumor cells targeting,and further relieved the immunosuppressive ***,this study offers a potentially appealing paradigm of a high efficiency,low toxicity,and simple intelligent responsive drug delivery system for targeted drug delivery in breast cancer,which can effectively rescue and activate the body's anti-tumor immune response and furthermore achieve effective treatment of metastatic breast cancer.

关键词： Immunotherapy Cascade targeting Liposome MMP-2 responsive Breast cancer ICBs IDO inhibitors Immunosuppressive microenvironment