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Preliminary pharmacological evaluation of Martynia annua Linn leaves for wound healing

Asian Pacific Journal of Tropical Biomedicine 2011年第6期1卷 421-427页

作者： Santram Lodhi singhai ak Department of Pharmaceutical Sciences Dr.H.S.Gour University SAGAR(M.P.)

Objective:To evaluate the wound healing potential of fractions from ethanol extract of Martynin annua(***) Linn ***:Ethanol extract of *** Linn leaves was fractionate into three different fractions(MAF-A,MAF-B and MAF-C) which were screened for wound healing potential using two models:excision and incision on *** thin layer chromatography(TLC) profile of all fractions were analysed and TLC of luteolin was also *** PovidoneIodine Ointment was used as reference for *** and incision wounds were created on dorsal portion of rats for *** contraction,biochemical parameters(protein level and hydroxyproline level) and histopathological study were performed in excision wound model whereas incision model was used for determination of tensile ***:The wound contraction and tensile strength of skin tissues were observed significantly greater in MAF-C fraction treated group than other two fractions(P<0.01).In excision wound method(on day 18) protein content and hydroxyproline were found significantly higher in MAF-C group than control group(P<0.01).Histopathological study also showed better angiogenesis,matured collagen fibres and fibroblast cells as compared with the control ***:In conclusion, our findings suggest that fiaction MAF-C from ethanol extract of *** leaves is found most effective in wound healing.

关键词： Martynia annua Wound healing Povidone-iodine ointment Incision Excision Luteolin TLC Wound contraction Tensile strength

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