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Green Synthesis of Silver Nanoparticles and Their Reduced Graphene Oxide Nanocomposites as Antibacterial Agents:A Bio-inspired Approach

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Acta Metallurgica Sinica(English Letters) 2017年第1期30卷 45-52页

作者： Edreese Alsharaeh Sarah Alazzam Faheem Ahmed Nishat Arshi Mohammed Al-Hindawi Garwin Kim sing College of Science & General Studies Alfaisal UniversityRiyadhSaudi Arabia

In this paper, silver nanoparticles （AgNPs） and AgNPs/reduced graphene oxide （RGO） nanocomposites were prepared using.lemon juice under microwave irradiation （MWI） and UV light irradiation. AgNPs with face-centered cubic structure RGO peaks were observed by X-ray diffraction. The UV-Vis spectrum showed modifications in the absorption peaks of the AgNPs with the concentration of the precursor solution and irradiation time, and the optimized condition was obtained for 20 min MWI and 60 s of UV light. Raman analysis confirmed the presence of RGO as D and G bands in the spectrum. Transmission electron microscopy analyses confirmed that the AgNPs of size ranging from 3 to 8 nm were anchored onto the RGO sheets. The antibacterial properties of the AgNPs/RGO nanocomposites were investigated using.gram-negative bacteria. The results revealed that AgNPs/RGO nanocomposites consisting of approximately 5 wt% AgNPs can achieve antibacterial performance similar to that of neat AgNPS. This method can be useful for the applications of AgNPs-based nanocomposites, where minute amount of silver will be utilized.

关键词： Silver nanoparticles (AgNPs) Nanocomposites Reduced graphene oxide Antibacterial

Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosus

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Chinese Medical Journal 1998年第7期 84-89页

作者： Lau Chak sing. Yuen Yung, Chan Hung and Wong Raymond Woon sing

Objectives Systemic lupus erythematosus (SLE) is a multifactorial disease. Environmental factors such as viral infection(s) have been proposed as pathaetiological factors. There are particular interests in studying lymphotropic viruses such as the Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Although previous case reports and in vitro studies suggested that they may have a role, there is no direct evidence that onset of SLE or disease exacerbation is associated with active infection by these viruses. Using.the very sensitive polymerase chain reaction (PCR) technique, we tried to find out evidence of active replication of these viruses in patients with SLE. Methods Thirty-four patients with SLE were compared with matched normal controls. Eleven patients were newly diagnosed to have SLE and 18 of the 34 patients had active disease as determined by a SLE Disease Activity Index (SLEDAI) score of ≥10 at the time of study. Results Our results showed no evidence of active replication or reactivation of EBV in the leucocytes amongst the newly diagnosed SLE patients, established SLE patients, patients with SLEDAI ≥10, patients with SLEDAI <10, and control subjects. There was no evidence of CMV infection in any of the subjects studied. The IgG and IgA responses against EBV early antigen (EA) and viral capsid antigen (VCA) were also studied. The IgG and IgA responses against VCA of EBV were increased in patients with SLE when compared with controls. However, there were no differences in these responses among different subgroups of patients. The mechanism of these responses was not apparent but may represent non-specific hyperimmune responses in these patients. There were no differences in the titre of IgG and IgA against EBV EA between the patient groups and *** There is no direct evidence that either EBV or CMV plays a direct role in the onset and/or exacerbation of SLE.

关键词： Lack of evidence of active lytic replication of Epstein-Barr and cytomegaloviruses in patients with systemic lupus erythematosus

Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese

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World Journal of Gastroenterology 2005年第6期11卷 797-802页

作者： May-Jen Huang Sien-sing.Yang Min-Shung Lin Ching-Shan Huang Department of Laboratory Medicine Department of Liver Unit Department of Family Medicine School of Medicine and Health Sciences

AIM: sing.e nucleotide polymorphisms (SNPs) of uridinediphosphoglucuro -nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this gene for Taiwan Chinese. METHODS: We collected blood samples from 112 healthy adults and 505 subjects carrying different genotypes of UGT1A1, and determined the promoter area and the entire sequence of UGT1A7 exon 1 by polymerase chain reaction. We designed appropriate primers and restriction enzymes to detect variant UGT1A7 genotypes found in the study subjects. RESULTS: Six SNPs at nucleotides 33, 387, 391, 392, 622, and 756 within the coding region of UGT1A7 exon 1 were found. The incidence of UGT1A7*l/*2 (N129R131W208/ K129K131W208) was predominant (35.7%) while that of UGT1A7 *3/*3 (K129K131R208/K129K131R208) was the least (2.7%). The allele frequency of UGT1A7*3, which exists in a considerable proportion of Caucasians (0.361) and Japanese (0.255), was identified only to be 0.152 in our study subjects. A novel variation at nucleotide -57 in the upstream was found, which was associated with SNPs at nucleotides 33, 387, 391, 392, and 622 in one of the variant haplotypes. The nucleotide changes at positions 387, 391, 392 and 756 were in linkage in another variant haplotype. The allele frequency of UGT1A7*3 was 0.018, 0.158, 0.242, 0.433, and 0.920 in subjects carrying wild, A(TA)6TAA/A(TA)7TAA, A(TA)7TAA/A(TA)7TAA, 211G/211A, and 211A/211A variants of UGT1A1 gene, respectively. By using.natural or mutagenesis primers, we successfully detected the variations at nucleotides -57, 33, 387, and 622 with the restriction enzymes HpyCH4 Ⅳ, TaqⅠ, AflⅡ, and Rsa Ⅰ, respectively. CONCLUSION: The results indicate that the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese. Carriage of the nucleotide 211- vari

关键词： UGT1A7 gene sing.e nudeotide polymorphisms Genotype Taiwan Chinese

Erastin-induced ferroptosis is a regulator forthe growth and function of humanpancreatic islet-like cell clusters

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Cell Regeneration 2020年第1期9卷 171-179页

作者： Xing Yu Li Po sing.Leung School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongShatinHong KongChina Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina

Ferroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactiveoxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently proposed forcancer treatment. Meanwhile, ROS generation and apoptosis are inherently consequent to cell apoptosis anddysfunction during islet cell preparation and transplantation. Whether ferroptosis induction is a regulator for cellviability and function in human pancreatic islet-cell clusters (ICCs) derived from pancreatic progenitor cells (PPCs)remains elusive. We thus sought to induce ferroptosis in our established cell culture system of human PPCs/ICCs,examine the effects of ferroptosis on ICCs, and explore the potential regulatory pathways involved. Our resultsshowed that ICCs were prone to the use of ferroptosis-inducing and inhibiting agents under our culture ***, a ferroptosis inducer, was found to trigger ferroptosis in ICCs, without the apparent detection of other typesof cell death involved, such as apoptosis and autophagy. In corroboration, the use of ferroptosis inhibitor,ferrostatin-1 (Fer-1), was found to enhance the cell viability of ICCs and prevent them from ferroptosis as well asimprove its function. Mechanistically, the erastin-induced ferroptosis in ICCs was probably mediated via activation ofJNK/P38/MAPK pathways and upregulation of NOX4 expression. Together, our findings may provide a scientificbasis of ferroptosis inhibition as a potential for the amelioration of ICC survival and functionality during islettransplantation in diabetic patients.

关键词： Apoptosis Autophagy Cell death Erastin Ferrostatin-1 Islets NOX4 p38

面向未来的新加坡高密度公共住房可持续设计策略与启示

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世界建筑导报 2024年第3期39卷 13-17页

作者：薛菲章倩刘昇陽刘少瑜深圳大学人因环境与可持续设计研究中心深圳518060 深圳大学建筑与城市规划学院深圳518060 浙江清华长三角研究院新加坡(东南亚)海纳创新中心新加坡068895 香港中文大学建筑学院中国香港999077

近年来,新加坡建屋发展局(HDB)通过“绿色家园计划”、“绿色城镇计划”等一系列政策指引,在高密度公共住房品质提升和环境可持续方面成为全球瞩目的典范。本文从绿色低碳、健康宜居、智慧管理三个视角对新加坡高密度公共住房的可持续... 详细信息

近年来,新加坡建屋发展局(HDB)通过“绿色家园计划”、“绿色城镇计划”等一系列政策指引,在高密度公共住房品质提升和环境可持续方面成为全球瞩目的典范。本文从绿色低碳、健康宜居、智慧管理三个视角对新加坡高密度公共住房的可持续设计策略和典型案例做了深度解析,旨在对我国未来的公共住宅发展提供有益参考。

关键词：绿色低碳健康宜居智慧管理高密度住区可持续设计

Synthesis and properties of poly(1-phenyl-1-octyne)s containing stereogenic and chromophoric pendant groups

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Science China Chemistry 2009年第10期52卷 1691-1702页

作者： LAM Jacky W.Y. JIM Cathy K.W. KWOK Hoi sing Department of Chemistry The Hong Kong University of Science & Technology Center for Display Research The Hong Kong University of Science & Technology

Poly(1-phenyl-1-octyne)s containing different stereogenic and chromophoric pendants {-[(C6H13)C= C(C6H4-p-CO2-R)] n -R = [(1S)-endo]-(?)-borneyl (P3), (1R,2S,5R)-(?)-menthyl (P4), -C6H4-p-(1R,2S,5R)-(?)-menthyl (P5), 2-napthyl (P6), 4-biphenylyl (P7)} have been designed and synthesized. The polymers are prepared in moderate yields by WCl6-Ph4Sn and possess high molecular weights (M w up to 64000). The structures and properties of the polymers are characterized and evaluated by NMR, TGA, UV, CD, PL, and EL analyses. All the polymers are thermally stable and their temperatures for 5% weight loss locate in the range of 300 to 416°C under nitrogen. The energy band gaps of all the polymers are ～3.0 eV. Polymers P4 and P5 show CD absorptions associated with the helicity of the polymer segments. Excitation of the THF solutions of P3–P7 by UV irradiation gives strong blue lights of ～485 nm with quantum yields higher than 20%. The thin films of the polymers also emit in the same spectral region, indicative of little aggregation-caused quenching of light emission. Multilayer EL devices with a configuration of ITO/Polymer:PVK/BCP/Alq3/LiF/Al are constructed, which emit blue lights of ～487 nm. The maximum luminance and external quantum efficiency vary with the pendant groups, with P6 exhibiting the highest external quantum efficiency of 0.16%. The spectra stability of the EL devices is outstanding and the EL peak maximum experiences little change with the applied voltage.

关键词： chiral photoluminescence polyacetylene electroluminescence helicity

GA-based nonlinear predictive switching control for a boiler-turbine system

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控制理论与应用（英文版） 2012年第1期10卷 100-106页

作者： Jie WU Jiong SHEN Mattias KRUG sing.Kiong NGUANG Yiguo LI School of Energy and Environment Southeast University Nanjing Jiangsu 210096 China Department of Electrical and Computer Engineering The University of Auckland Private Bag 92019 Auckland 1142 New Zealand

In this paper, the problem of designing a controller for a highly coupled constrained nonlinear boiler- turbine system is addressed with a predictive controller. First, a nonlinear predictive control is implemented by genetic algorithm. Second, to guarantee fast output stabilization, an H-infinity fuzzy state-feedback tracking control is applied with a designed switching principle. The success of such a control structure is based on taking advantage of the optimal input sequence derived from the nonlinear predictive control based on artificial intelligent while ensuring a fast decay of the steady state error. Simulation results of the proposed design are given to illustrate its effectiveness and compared to other control schemes.

关键词： Genetic algorithm (GA) Nonlinear receding horizon control Adaptive control Boiler-turbine Switching control

Crystallization of amorphous silicon beyond the crystallized polycrystalline silicon region induced by metal nickel

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Chinese Physics B 2017年第1期26卷 353-356页

作者： Dongli Zhang Mingxiang Wang Man Wong Hoi-sing.Kwok Department of Microelectronics Soochow University Suzhou 215006 China Center for Display Research Department of Electronic and Computer Engineering the Hong Kong University of Science and Technology Kowloon Hong Kong China

Crystallization of amorphous silicon（a-Si） which starts from the middle of the a-Si region separating two adjacent metal-induced crystallization（MIC） polycrystalline silicon（poly-Si） regions is observed. The crystallization is found to be related to the distance between the neighboring nickel-introducing MIC windows. Trace nickel that diffuses from the MIC window into the a-Si matrix during the MIC heat-treatment is experimentally discovered, which is responsible for the crystallization of the a-Si beyond the MIC front. A minimum diffusion coefficient of 1.84×10^-9cm^2/s at 550℃ is estimated for the trace nickel diffusion in a-Si.

关键词： metal-induced crystallization poly-Si nickel diffusion coefficient

Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions

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Neural Regeneration Research 2020年第4期15卷 739-747页

作者： Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic sing.Yian Chew School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Blizard Institute Barts&The London School of MedicineQueen Mary University of LondonLondonUK NUS Synthetic Biology for Clinical and Technological Innovation(SynCTI) Life Sciences InstituteNational University of SingaporeSingapore

MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific *** overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising.approach for nerve ***,nerve injuries in the CNS also involve other cell types,such as microglia and ***,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in *** found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte *** addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in ***,our results suggest miR-219/miR-338 as a promising.treatment for axonal remyelination in the CNS following nerve *** experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016.

关键词： central nervous system electrospinning gene silencing glia hydrogel myelination nanofibers oligodendroglial polycaprolactone spinal cord injury