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Hearing loss and tinnitus associated with COVID-19 vaccines:An analysis from the national pharmacovigilance database in Malaysia

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 289-295,I0002-I0004页

作者： sing chet lee Wee Kee Wo Hee Sheong Yeoh Sim Mei Choo Azuana Ramli National Pharmaceutical Regulatory Agency(NPRA) Ministry of HealthMalaysia

Objective:To compare the reporting pattern of hearing loss and tinnitus across different vaccines brands used in Malaysia(BNT162b2,CoronaVac,ChAdOx1,***2-S and BBIBP-CorV).Methods:This retrospective study included all reports of hearing loss and tinnitus occurring after COVID-19 vaccination that were received in the national pharmacovigilance database,QUEST,from February 24,2021 through July 31,*** given causality consistent or indeterminate were ***:There were 21 cases of hearing loss,with overall reporting rate of 0.29 cases per million *** rate was similar across BNT162b2,CoronaVac and *** tinnitus,35 cases were reported,with the overall reporting rate of 0.49 cases per million doses,and the highest rate was reported for *** both events,most cases aged 30 to 49 *** gender disparity was *** events were mainly reported to have occurred after the primary doses,with a median time-to-onset of two *** were no statistically significant differences in the reporting patterns for both events across BNT162b2,CoronaVac and ChAdOx1 by age group,gender,race,and dose ***:Despite the low reporting rates and insufficient evidence to confirm its relationship,hearing loss and tinnitus following vaccinations should not be ignored due to its disabling potential and impact on one’s quality of *** reporting is encouraged for better signal characterization in the future.

关键词： COVID-19 vaccines Hearing loss Tinnitus Adverse events following immunization

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Water balance prediction in stormwater infiltration basins using 2-D modeling:An application to evaluate the clogging process

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International Journal of Sediment Research 2018年第4期33卷 371-384页

作者： Patrice Cannavo Anas Coulon Sylvain Charpentier Béatrice Béchet Laure Vidal-Beaudet Agrocampus Ouest Institute for Research on Urban Sciences and Techniques (IRSTV) Research Unit Environmental Physics and Horticulture Research(EPHor) Bretagne Loire University French Institute of Science and Technology for Transport Development and Networks (IFSTTAR) IRSTV Geotechnical engineeringEnvironment Natural hazards and Earth sciences Department (GERS) Water and Environment Laboratory (LEE)

Sustainable urban drainage systems are built along roads and in urban areas to collect urban runoff and avoid flooding, and to filter water pollutants. Sediment collected by runoff is deposited in the stormwater basin and progressively reduces water infiltration efficiency, leading to the clogging of the basin. To help stormwater basin managers and stakeholders better understand and predict clogging rates in order to elaborate maintenance plans and schedules, water transport prediction models are necessary. However,because of the heterogeneous sediment hydrodynamic properties inside the stormwater basin, a twodimensional(2-D) water flow model is required to predict water levels and possible overflow as accurately as possible. Saturated hydraulic conductivity(Ks) and sediment water retention curves were measured in the overall sediment layer of the stormwater basin, in addition to sediment layer thickness and organic matter content(11 sampling points). Sediment depth was used to predict organic matter(OM) content, and the OM was used to predict Ks. Water height in the basin was modeled with the HYDRUS-2 D model by taking into account the sediment hydrodynamic properties distribution. The HYDRUS-2 D model gave a satisfactory representation of the measured data. Scenarios of the hydraulic properties of stormwater basin sediment were tested over time, and hydraulic resistance, R, was calculated to assess the stormwater basin performance. Presently, after 20 years of functioning, the stormwater basin still ensures efficient water infiltration, but the first outflow(Hydraulic resistance,R > 24 h)) is expected to appear in the next 5 years, and clogging(R > 47 h) in the next 13 years. This 2-D water balance model makes it possible to integrate the hydrodynamic heterogeneity of a stormwater basin. It gives interesting perspectives to better predict 2-D/3-D contaminant transport.

关键词： 2-D water transport Hydraulic conductivity Sediment water retention Stormwater basin efficiency

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