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Epidemiology of Cancer.in Systemic Scler.sis—Systematic r.view and Meta-Analysis of Cancer.Incidence, Pr.dictor. and Mor.ality

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Open Jour.al of r.eumatology and Autoimmune Diseases 2013年第4期3卷 231-245页

作者： Tatiana Nevskaya Shelly Chandr.n Adr.enne M. r.os Chr.stopher.r. Pasar.kovski Amie Kr.n Cathy Chau sindhu r. johnson Tor.nto Scler.der.a Pr.gr.m Division of Rheumatology Mount Sinai and Toronto Western Hospitals University of Toronto Toronto Canada Tor.nto Scler.der.a Pr.gr.m Division of Rheumatology Mount Sinai and Toronto Western Hospitals University of Toronto Toronto Canada

Objectives: The study was conducted to impr.ve our.under.tanding of the epidemiology of cancer.in systemic scler.sis (SSc) by evaluating the incidence, pr.valence, r.lative r.sk of over.ll and site-specific malignancies, pr.dictor. and cancer.attr.butable mor.ality. Methods: MEDLINE, CINAHL, EMBASE and Cochr.ne Libr.r. (inception-May 2012) wer. sear.hed. Estimates wer. combined using a r.ndom effects model. Consistency was evaluated using the I2 statistic. r.sults: 4876 citations wer. sear.hed to identify 60 ar.icles. The aver.ge incidence of malignancy in SSc was 14 cases/1000 per.on-year.;the pr.valence r.nged between 4%-22%. Cancer.was the leading cause of non-SSc r.lated deaths with a mean of 38%. Over.ll SIr.for.all-site malignancy r.sk was 1.85 (95%CI 1.52, 2.25;I276%). Ther. was a gr.ater.r.sk of lung (SIr.4.69, 95%CI 2.84, 7.75;I293%) and haematological (SIr.2.58, CI 95% 1.75, 3.81;I20%) malignancies, including non-Hodgkin’s lymphoma (SIr.2.55, 95%CI 1.40, 4.67;I20%). SSc patients wer. at a higher.r.sk of leukemia (SIr.2.79, 95%CI 1.22, 6.37;I20%), malignant melanoma (SIr.2.92, 95%CI 1.76, 4.83;I235%), liver.(SIr.4.75, 95%CI 3.09, 7.31;I20%), cer.ical (SIr.2.28, 95%CI 1.26, 4.09;I254%) and or.phar.ngeal (SIr.5.0, 95%CI 2.18, 11.47;I258%) cancer.. r.sk factor. include a-r.AP I/III ser.positivity, male sex, and late onset SSc. Smoking and longstanding inter.titial lung disease incr.ase the r.sk of lung cancer.Bar.ett’s esophagus and a positive family histor. of br.ast cancer. r.spectively, incr.ase the r.sk of esophageal adenocar.inoma and br.ast cancer. Conclusions: SSc patients have a two-fold incr.ase in all-site malignancy, and gr.ater.r.sk of lung and haematological malignancies that contr.bute significantly to mor.ality. Vigilance should be consider.d in SSc patients with r.sk factor. for.cancer.

关键词： Systemic Scler.sis Neoplasms Epidemiology r.sk Factor. Mor.ality

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Compar.son of a Spectr.l Bin and Two Multi-Moment Bulk Micr.physics Schemes for.Super.ell Simulation:Investigation into Key Pr.cesses r.sponsible for.Hydr.meteor.Distr.butions and Pr.cipitation

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Advances in Atmospher.c Sciences 2024年第5期41卷 784-800页

作者： Mar.us johnson Ming XUE Youngsun JUNG Center.for.Analysis and Pr.diction of Stor.s University of OklahomaNormanOK 73072USA School of Meteor.logy University of OklahomaNormanOK 73072USA Office of Science and Technology Integr.tion National Weather ServiceSilver SpringMD 20910USA

Ther. ar. mor. uncer.ainties with ice hydr.meteor.r.pr.sentations and r.lated pr.cesses than liquid hydr.meteor. within micr.physics par.meter.zation(MP)schemes because of their.complicated geometr.es and physical *** super.ell simulations ar. pr.duced using the Wr. model coupled with“full”Hebr.w Univer.ity spectr.l bin MP(HU-SBM),and NSSL and Thompson bulk MP(BMP)***-SBM downdr.fts ar. typically weaker.than those of the NSSL and Thompson simulations,accompanied by less r.in ***-SBM pr.duces mor. cloud ice(plates),gr.upel,and hail than the BMPs,yet pr.cipitates less at the *** limiting mass bins(and subsequently,par.icle size)of r.med ice in HU-SBM and slower.r.med ice fall speeds lead to smaller.melting-level net r.med ice fluxes than those of the *** fr.m plates in HU-SBM,together.with snow–gr.upel collisions,leads to a gr.ater.snow contr.bution to r.in than those of the *** HU-SBM’s fall speeds using the for.ulations of the BMPs after.aggr.gating the discr.te bin values to mass mixing r.tios and total number.concentr.tions incr.ases net r.in and r.med ice ***,they ar. smaller.in magnitude than bulk r.in,NSSL hail,and Thompson gr.upel net fluxes near.the ***,the melting-layer.net r.med ice fluxes ar. r.duced when the fall speeds for.the NSSL and Thompson simulations ar. calculated using HU-SBM fall speed for.ulations after.discr.tizing the bulk par.icle size distr.butions(PSDs)into spectr.l *** r.sults highlight pr.cipitation sensitivity to stor. dynamics,fall speed,hydr.meteor.evolution gover.ed by pr.cess r.tes,and MP PSD design.

关键词： pr.cipitation spectr.l bin micr.physics bulk micr.physics par.meter.zation micr.physics pr.cesses Wr. model super.ell stor.

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Iso-pr.pyl capr.late and iso-pr.pyl linolenate synthetic fluids as novel alter.atives in deep-water.dr.lling oper.tions:Cr.tical fluid pr.per.ies and aer.bic biodegr.dability assessments

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Petr.leum 2024年第2期10卷 254-264页

作者： Adewale johnson Folayan Adewale Dosunmu Aler.chi Boniface Or.ji Depar.ment of Petr.leum and Gas Engineer.ng University of Port HarcourtNigeria Pr.fessor.of Petr.leum and Gas Engineer.ng University of Port HarcourtNigeria

Pr.sent dr.lling fluids for.deep water.wells have sever. degener.tive effect on the envir.nment with high oper.tional and disposal ***,making them less desir.ble in r.cent *** synthetic dr.lling fluid pr.vides a novel envir.nmentally fr.endly alter.ative but conventional ester.based dr.lling fluids exhibit high viscosities in deep-water.wells causing excessive equivalent cir.ulating density(ECD)and incr.ased r.sk of lost cir.ulation owing to nar.ow mud density *** study exper.mentally investigates the cr.tical fluid pr.per.ies and aer.bic biodegr.dability potentials of two newly developed deep-water.synthetic ester.dr.lling fluids namely:iso-pr.pyl capr.late(COIPE)and iso-pr.pyl linolenate(LOIPE)synthetic fluids and their.compar.son with synthetic-par.ffin(SP-SBF)and isomer.zed-olefin(IOSBF)synthetic hydr.car.on *** ester. of iso-pr.pyl capr.late and iso-pr.pyl linolenate wer. pr.duced fr.m the isolation of ester.mixtur.s that wer. obtained fr.m the homogeneous catalytic tr.nsester.fication of coconut and linseed plant oil biomass *** COIPE was isolated fr.m the coconut oil iso-pr.pyl ester.mixtur. by low-pr.ssur. fr.ctional distillation *** fr.ctional distillation and cr.stallization wer. used to isolate the LOIPE ester.fr.m the linseed oil iso-pr.pyl ester.***,the aer.bic biodegr.dation investigation was conducted by a modified oxygen consumption r.spir.metr. *** GC-MS analysis of the COIPE and LOIPE showed that the for.er.contains essentially of lower.satur.ted car.on compounds(C8).Wher.as the latter.contains higher.molecular.weight and unsatur.ted car.on compounds(C18+).The COIPE and LOIPE kinematic viscosity values ar. in good agr.ement with that of the r.fer.nce synthetic hydr.car.on fluid samples(SP-SBF and IO-SBF).Although,the COIPE synthetic ester.has lower.viscosity value owing to the pr.sence of shor.er.chain and satur.ted car.on atoms(C8 ester.).Similar.y,the linolenic oil iso

关键词： Aer.bic biodegr.dation Cr.tical fluid pr.per.ies Deep-water.wells Ester.'isolation:isomer.zed-olefin(IO-SBF) Iso-pr.pyl capr.late(COIPE) Iso-pr.pyl linolenate(LOIPE) r.spir.metr. technique Synthetic-par.ffin(SP-SBF)

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A 63-Year.Old Male with D-Tr.nsposition of the Gr.at Ar.er.es Who Had an Ear.y For. of the Ar.er.al Switch Oper.tion

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Congenital Hear. Disease 2024年第1期19卷 65-68页

作者： Michael A.r.bolledo Jane S.Yao Jason N.johnson Umar.S.Boston Benjamin r.Waller.III Division of Pediatr.c Car.iology Department of PediatricsThe University of Tennessee Health Science CenterThe Heart InstituteLe Bonheur Children’s HospitalMemphisUSA College of Medicine The University of Tennessee Health ScienceMemphisUSA Division of Pediatr.c Car.iothor.cic Sur.er. Department of SurgeryThe University of Tennessee Health Science CenterHeart InstituteLe Bonheur Children’s HospitalMemphisUSA

We descr.be a 63-year.old male who appear. to have under.one an ear.y for. of the ar.er.al switch oper.tion for.D-tr.nsposition of the gr.at ar.er.es per.or.ed in the *** r.view the clinical and imaging data that suppor. our.*** had a diagnostic car.iac catheter.zation which demonstr.ted sever. pulmonar. hyper.ension r.sponsive to epopr.stenol and *** case may r.pr.sent one example of the exper.mental sur.ical wor. done pr.or.to *** Jatene’s descr.ption of theﬁr.t successful ar.er.al switch per.or.ed in 1975.

关键词： Adult congenital hear. disease ar.er.al switch oper.tion gr.at vessel anomaly imaging(all modalities)

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Incr.asing age and dur.tion of sex wor. among female sex wor.er. in South Afr.ca and implications for.HIV incidence estimation:Bayesian evidence synthesis and simulation exer.ise

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Infectious Disease Modelling 2024年第1期9卷 263-277页

作者： Nanina Ander.gg Mar.ette Slabber. Kholi Buthelezi Leigh F.johnson Centr. for.Infectious Disease Epidemiology and r.sear.h School of Public HealthUniversity of Cape TownSouth Africa Institute of Social and Pr.ventive Medicine University of BernSwitzerland Independent Consultant PretoriaSouth Africa National Sex Wor.er. Movement in South Africa

Intr.duction:In sub-Sahar.n Afr.ca,accur.te estimates of the HIV epidemic in female sex wor.er. ar. cr.cial for.effective pr.vention and car. *** estimates ar. typically der.ved fr.m mathematical models that assume cer.ain demogr.phic and behaviour.l char.cter.stics like age and dur.tion of sex wor. to r.main constant over.*** r.viewed this assumption for.female sex wor.er. in South ***:We r.viewed studies that r.por.ed estimates on either.the age or.the dur.tion of sex wor. among female sex wor.er. in South *** used Bayesian hier.r.hical models to synthesize r.por.ed estimates and to study time *** a simulation exer.ise,we also investigated the potential impact of the"constant age and sex wor. dur.tion"-assumption on estimates of HIV ***:We included 24 differ.nt studies,conducted between 1996 and 2019,contr.buting 42 estimates on female sex wor.er.age and 27 estimates on sex wor. *** was evidence suggesting an incr.ase in both the dur.tion of sex wor. and the age of female sex wor.er. over.*** to the fitted models,over.each decade the expected dur.tion of sex wor. incr.ased by 55.6%(95%-cr.dible inter.al[Cr.]:23.5%–93.9%)and the expected age of female sex wor.er. incr.ased by 14.3%(95%-Cr.:9.1%–19.1%).Over.the 23-year.per.od,the pr.dicted mean dur.tion of sex wor. incr.ased fr.m 2.7 year. in 1996 to 7.4 year. in 2019,while the pr.dicted mean age incr.ased fr.m 26.4 year. to 32.3 *** for.these time tr.nds in the simulation exer.ise r.sulted in a notable decline in estimated HIV incidence r.te among sex wor.er. over.*** decline was significantly mor. pr.nounced than when assuming a constant age and dur.tion of sex ***:In South Afr.ca,age and dur.tion of sex wor. in female sex wor.er. incr.ased over.*** this tr.nd might be influenced by factor. like expanding community mobilization and impr.ved r.ghts advocacy,the ongoing cr.minalisation,stigmatisation of s

关键词： Female sex wor.er. Mathematical modelling South Afr.ca HIV

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r.scue fr.m complications after.pancr.aticoduodenectomies at a low-volume Car.bbean center.Value of tailor.d per.-pancr.atectomy pr.tocols

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Wor.d Jour.al of Gastr.intestinal Sur.er. 2024年第3期16卷 681-688页

作者： Shamir.O Cawich Elijah Dixon Par.l J Shukla Shailesh V Shr.khande r.hul r.Deshpande Fawwaz Mohammed Neil W Pear.e Wesley Fr.ncis Shaneeta johnson Johann Bujhawan Depar.ment of Sur.er. University of the West IndiesSt Augustine 000000Trinidad and Tobago Depar.ment of Sur.er. Faculty of MedicineUniversity of CalgaryCalgaryAlberta T2N2T9Canada Depar.ment of Sur.er. Weill Cornell Medical CollegeNew YorkNY 10065United States Depar.ment of Sur.ical Oncology Tata Memorial CenterHomi Bhabha National UniversityMumbai 400012India Depar.ment of Sur.er. Manchester Royal InfirmaryManchester M139WLUnited Kingdom Univer.ity Sur.ical Unit Southampton General HospitalSouthampton SO166YDUnited Kingdom Depar.ment of Sur.er. University of the West IndiesNassau N-1184Bahamas Depar.ment of Sur.er. Morehouse School of MedicineAtlantaGA 30310United States Depar.ment of Sur.er. General Hospital in Port of SpainPort of Spain 000000Trinidad and Tobago

BACKGr.UND Pancr.aticoduodenectomy(PD)is a technically complex oper.tion,with a r.-latively high r.sk for.*** ability to r.scue patients fr.m post-PD complications is as a r.cognized quality *** pr.tocols wer. instituted at our.low volume facility in the year.*** To document the r.te of r.scue fr.m post-PD complications with tailor.d pr.tocols in place as a measur. of *** A r.tr.spective audit was per.or.ed to collect data fr.m patients who exper.enced major.post-PD complications at a low volume pancr.atic sur.er. unit in Tr.nidad and Tobago between Januar. 1,2013 and June 30,***-dar.ized definitions fr.m the Inter.ational Study Gr.up of Pancr.atic Sur.er. wer. used to define post-PD complications,and the modified Clavien-Dindo classification was used to classify post-PD *** Over.the study per.od,113 patients at a mean age of 57.5 year.(standar. deviation[SD]±9.23;r.nge:30-90;median:56)under.ent PDs at this *** complications wer. r.cor.ed in 33(29.2%)patients at a mean age of 53.8 year.(SD:±7.9).Twenty-nine(87.9%)patients who exper.enced major.mor.idity wer. salvaged after.aggr.-ssive tr.atment of their.***(3.5%)died fr.m bleeding pseudoaneur.sm(1),septic shock secondar. to a bile leak(1),anastomotic leak(1),and myocar.ial infar.tion(1).Ther. was a significantly gr.ater.salvage r.te in patients with Amer.can Society of Anesthesiologists scor.s≤2(93.3%vs 25%;P=0.0024).CONCLUSION This paper.adds to the gr.wing body of evidence that volume alone should not be used as a mar.er.of quality for.patients r.quir.ng *** low volumes at our.facility,we demonstr.ted that 87.9%of patients wer. r.scued fr.m major.*** attr.buted this to sever.l factor. including development of r.scue pr.tocols,the competence of the pancr.atic sur.er. teams and continuous,and adaptive lear.ing by the entir. institution,cul-minating in the development of tailor.d per.-pancr.atectomy pr.toc

关键词： Pancr.as Complication r.scue Failur. Mor.idity Mor.ality Pancr.aticoduodenectomy

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Integr.ns and their.potential r.les in mammalian pr.gnancy

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Jour.al of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gr.gor. A.johnson r.ber. C.Bur.har.t Fuller.W.Bazer.Heewon Seo Joe W.Cain Depar.ment of Veter.nar. Integr.tive Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Depar.ment of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integr.ns ar. a highly complex family of r.ceptor. that, when expr.ssed on the sur.ace of cells, can mediate r.cipr.cal cell-to-cell and cell-to-extr.cellular.matr.x(ECM) inter.ctions leading to assembly of integr.n adhesion complexes(IACs) that initiate many signaling functions both at the membr.ne and deeper.within the cytoplasm to coor.inate pr.cesses including cell adhesion, migr.tion, pr.lifer.tion, sur.ival, differ.ntiation, and metabolism. All metazoan or.anisms possess integr.ns, and it is gener.lly agr.ed that integr.ns wer. associated with the evolution of multicellular.ty, being essential for.the association of cells with their.neighbor. and sur.oundings, dur.ng embr.onic development and many aspects of cellular.and molecular.biology. Integr.ns have impor.ant r.les in many aspects of embr.onic development, nor.al physiology, and disease pr.cesses with a multitude of functions discover.d and elucidated for.integr.ns that dir.ctly influence many ar.as of biology and medicine, including mammalian pr.gnancy, in par.icular.implantation of the blastocyst to the uter.ne wall, subsequent placentation and conceptus(embr.o/fetus and associated placental membr.nes) development. This r.view pr.vides a succinct over.iew of integr.n str.ctur., ligand binding, and signaling followed with a concise over.iew of embr.onic development, implantation, and ear.y placentation in pigs, sheep, humans, and mice as an example for.r.dents. A br.ef timeline of the initial localization of integr.n subunits to the uter.ne luminal epithelium(LE) and conceptus tr.phoblast is then pr.sented, followed by sequential summar.es of integr.n expr.ssion and function dur.ng gestation in pigs, sheep, humans, and r.dents. As appr.pr.ate for.this jour.al, summar.es of integr.n expr.ssion and function dur.ng gestation in pigs and sheep ar. in depth, wher.as summar.es for.humans and r.dents ar. br.ef. Because similar.models to those illustr.ted in Fig. 1, 2, 3, 4, 5 and 6 ar. pr.sent thr.ughout the sc

关键词： Humans Implantation Integr.ns Pigs Pr.gnancy r.dents Sheep

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Antimicr.bial stewar.ship and tar.eted ther.pies in the changing landscape of mater.al sepsis

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Jour.al of Intensive Medicine 2024年第1期4卷 46-61页

作者： Nishel M Shah Esmita Char.ni Damien Ming Fook-Choe Cheah Mar. r.johnson Depar.ment of Metabolism Digestion and ReproductionImperial College LondonChelsea and Westminster HospitalLondonUK Health Pr.tection r.sear.h Unit in Healthcar. Associated Infection and Antimicr.bial r.sistance Imperial College LondonLondonUK Division of Infectious Diseases and HIV Medicine Department of MedicineGroote Schuur HospitalUniversity of Cape TownCape TownSouth Africa Depar.ment of Infectious Diseases Imperial College LondonChelsea and Westminster HospitalLondonUK Depar.ment of Paediatr.cs Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia

Pr.gnant and postnatal women ar. a high-r.sk population par.icular.y pr.ne to r.pid pr.gr.ssion to sepsis with significant mor.idity and mor.ality ***,sever. mater.al infections can have a ser.ous detr.mental impact on neonates with almost 1 million neonatal deaths annually attr.buted to mater.al infection or.*** this r.view we discuss the susceptibility of pr.gnant women and their.specific physiological and immunological adaptations that contr.bute to their.vulner.bility to sepsis,the implications for.the neonate,as well as the issues with antimicr.bial stewar.ship and the challenges this poses when attempting to r.ach a balance between clinical car. and ur.ent ***,we r.view advancements in the development of pr.gnancy-specific diagnostic and ther.peutic appr.aches and how these can be used to optimize the car. of pr.gnant women and neonates.

关键词： Sepsis Pr.gnancy Immunology Car.iovascular Per.onalised medicine Antibiotic stewar.ship

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粉末冶金Al-5.6Zn-2Mg合金在热压缩过程中加工硬化特性及本构模型的比较

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Jour.al of Centr.l South Univer.ity 2024年第2期31卷 346-368页

作者： KATIKA Har.kr.shna DAMODA r.K. DAVIDSON M.J. SEETHAr.M r. KASAGANI Veer. Venkata Nagar.ju Depar.ment of Mechanical Engineer.ng National Institute of TechnologyWarangal 506004India Depar.ment of Mechanical Engineer.ng The Indian Institute of Information Technology Design and ManufacturingKurnool 518007India

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的... 详细信息

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的相关性。使用了四个本构模型,Ar.henius模型、改进的johnson-Cook模型(MJC)、改进的Zer.lli-Ar.str.ng模型(MZA)和开发的人工神经网络(ANN)。结果表明,ANN型模型和Ar.henius模型的相对误差的绝对平均值最低,分别为0.486%和3.36%,MZA型模型和MJC型模型的相对误差的绝对平均值较高,分别为8.84%和3.93%。由于Ar.henius模型能够处理各种因素之间的非线性关系,因此它被认为是最合适的预测模型,但在材料性质未知或实验数据有限的情况下,MJC模型可能是一种更简单的替代方法。MZA模型不适合估计热压缩时的流变应力。此外,训练最好的神经网络模型的预测性能最好,相对误差的绝对平均值为0.486%,r.为0.99。

关键词：加工硬化速率曲线本构建模热压缩 EBSD分析流变曲线

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Spatial distr.bution and potential ecological and health r.sks associated with heavy metals in the Ijer.-Ekiti mining site,Niger.a

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r.gional Sustainability 2024年第1期5卷 26-41页

作者： johnson Adedeji OLUSOLA Adeyinka Oluyemi ATUr.MU Olufunke ASAOLU Olusesan Sola OGUNLEYE Depar.ment of Geogr.phy and Planning Science Ekiti State UniversityAdo Ekiti360211Nigeria Institute of Ecology and Envir.nmental Studies Obafemi Awolowo UniversityIle IfeOsun State220101Nigeria Depar.ment of Geology(Climate Change and Paleobiology Gr.up) Ekiti State UniversityAdo Ekiti360211Nigeria Envir.nmental Natural Resources and Blue EconomyEurope and Central AsiaWorld Bank GroupWashington D.C.20433the USA

Ar.isanal gold mining,a labor.intensive and antiquated technique,is a gr.wing industr. and the sour.e of income for.r.r.l communities all over.the ***,ar.isanal gold mining has potential negative and long-ter. effects on economy,envir.nment,and *** study collected soil samples fr.m 16 sample points including a contr.l point to examine the pollution degr.es and spatial distr.bution of heavy metals,as well as ecological and health r.sks associated with heavy metal pollution in the Ijer.-Ekiti mining site,*** Infor.ation System(GIS)and r.mote sensing technologies wer. used to identify r.gions with high concentr.tions of heavy metals and assess the envir.nmental impact of gold mining *** r.sults show that the mean heavy metal concentr.tions of 16 soil pointa ar. 8.94(±5.97)mg/kg for.As,0.18(±0.54)mg/kg for.Cd,0.11(±1.06)mg/kg for.Co,14.32(±3.43)mg/kg for.Cr.6.89(±0.64)mg/kg for.Cu,48.92(±11.77)mg/kg for.Fe,135.81(±30.75)mg/kg for.Mn,5.92(±0.96)mg/kg for.Ni,5.72(±1.66)mg/kg for.Pb,and 13.94(±1.38)mg/kg for.*** study r.veals that heavy metal concentr.tion in soils follows the or.er.of Mn>Fe>Cr.Zn>As>Cu>Ni>Pb>Co>*** analysis of soil samples indicates that 3 pr.ncipal components(PCs)account for.70.008%of the total var.ance and ther. ar. str.ng positive cor.elations between var.ous pair. of heavy *** total potential ecological r.sk index(309.599)in the study ar.a is ***-car.inogenic r.sk suggests that ther. may be long-ter. health impacts on people who wor. in the mining ar.as due to chr.nic exposur. to the *** on the study,the hazar. index of car.inogenic health r.sks associated with heavy metals thr.ugh ingestion is 520.00×10^(–4).Der.al contact fr.m As and Cr.also incr.ases the r.sk of cancer.with the highest hazar. index value of 18.40×10^(–4).The lowest exposur. pathway,with the hazar. index value of 0.68×10^(–4),indicates that the inhalation of heavy metals has a compar.tively low r.sk of can

关键词： Ar.isanal gold mining Heavy metals Exposur. pathway Potential ecological r.sk Geo-accumulation index Ijer.-Ekiti mining site

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