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Epidemiology of Cancer.in Systemic Scler.sis—Systematic r.view and Meta-Analysis of Cancer.Incidence, Pr.dictor. and Mor.ality

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Open Jour.al of r.eumatology and Autoimmune Diseases 2013年第4期3卷 231-245页

作者： Tatiana Nevskaya Shelly Chandr.n Adr.enne M. r.os Chr.stopher.r. Pasar.kovski Amie Kr.n Cathy Chau sindhu r. johnson Tor.nto Scler.der.a Pr.gr.m Division of Rheumatology Mount Sinai and Toronto Western Hospitals University of Toronto Toronto Canada Tor.nto Scler.der.a Pr.gr.m Division of Rheumatology Mount Sinai and Toronto Western Hospitals University of Toronto Toronto Canada

Objectives: The study was conducted to impr.ve our.under.tanding of the epidemiology of cancer.in systemic scler.sis (SSc) by evaluating the incidence, pr.valence, r.lative r.sk of over.ll and site-specific malignancies, pr.dictor. and cancer.attr.butable mor.ality. Methods: MEDLINE, CINAHL, EMBASE and Cochr.ne Libr.r. (inception-May 2012) wer. sear.hed. Estimates wer. combined using a r.ndom effects model. Consistency was evaluated using the I2 statistic. r.sults: 4876 citations wer. sear.hed to identify 60 ar.icles. The aver.ge incidence of malignancy in SSc was 14 cases/1000 per.on-year.;the pr.valence r.nged between 4%-22%. Cancer.was the leading cause of non-SSc r.lated deaths with a mean of 38%. Over.ll SIr.for.all-site malignancy r.sk was 1.85 (95%CI 1.52, 2.25;I276%). Ther. was a gr.ater.r.sk of lung (SIr.4.69, 95%CI 2.84, 7.75;I293%) and haematological (SIr.2.58, CI 95% 1.75, 3.81;I20%) malignancies, including non-Hodgkin’s lymphoma (SIr.2.55, 95%CI 1.40, 4.67;I20%). SSc patients wer. at a higher.r.sk of leukemia (SIr.2.79, 95%CI 1.22, 6.37;I20%), malignant melanoma (SIr.2.92, 95%CI 1.76, 4.83;I235%), liver.(SIr.4.75, 95%CI 3.09, 7.31;I20%), cer.ical (SIr.2.28, 95%CI 1.26, 4.09;I254%) and or.phar.ngeal (SIr.5.0, 95%CI 2.18, 11.47;I258%) cancer.. r.sk factor. include a-r.AP I/III ser.positivity, male sex, and late onset SSc. Smoking and longstanding inter.titial lung disease incr.ase the r.sk of lung cancer.Bar.ett’s esophagus and a positive family histor. of br.ast cancer. r.spectively, incr.ase the r.sk of esophageal adenocar.inoma and br.ast cancer. Conclusions: SSc patients have a two-fold incr.ase in all-site malignancy, and gr.ater.r.sk of lung and haematological malignancies that contr.bute significantly to mor.ality. Vigilance should be consider.d in SSc patients with r.sk factor. for.cancer.

关键词： Systemic Scler.sis Neoplasms Epidemiology r.sk Factor. Mor.ality

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Investigation of ductile ir.n casting pr.cess par.meter. using Taguchi appr.ach and r.sponse sur.ace methodology

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China Foundr. 2016年第5期13卷 352-360页

作者： A. johnson Santhosh A. r. Lakshmanan Dept of Mechanieal Engineer.ng PPG Institute of Technology Coimbatore India Dept of Mechanical Engineer.ng PSG College of Technology Coimbatore India

To find the optimized levels of var.ous casting par.meter. in the ductile ir.n casting, var.ous casting defects and the r.jection r.te wer. obser.ed fr.m a medium scale foundr.. The contr.lled values of differ.nt casting par.meter. such as pour.ng temper.tur., inoculation, car.on equivalent, moistur. content, gr.en compr.ssion str.ngth, per.eability and mould har.ness wer. selected. Thr.e differ.nt melts of metal with 0.4wt.%, 0.6wt.%, and 0.8wt.% inoculation （Fe-Si-Mg alloy and post inoculant） wer. pr.duced using a 1-ton capacity cor.less medium fr.quency induction fur.ace. L-27 or.hogonal ar.ay with 3-level settings wer. chosen for.the analysis. r.sponses for.each r.n wer. obser.ed. The signal-to-noise （S/N） r.tio for.each r.n was calculated using the Taguchi appr.ach, and the optimized levels of differ.nt casting par.meter. wer. identified based on the SIN r.tio. The analysis of var.ance for.the casting acceptance per.entage concludes that inoculation is the most significant factor.affecting the castings＇ quality with a contr.bution per.entage of 44%; an incr.ase in inoculation r.sults in a significant impr.vement in acceptance per.entage of ductile ir.n castings. The exper.ment r.sults showed that with the optimized par.meter., the r.jection r.te was r.duced fr.m 16.98% to 6.07%.

关键词： optimized levels casting par.meter. S/N r.tio Taguchi appr.ach ANOVA ‘F’-Test

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FOCUS： PUNITIVE DAMAGES IN CHINA PUNITIVE DAMAGES, CHINESE TOr. LAW, AND THE AMEr.CAN EXPEr.ENCE

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Fr.ntier. of Law in China-Selected Publications fr.m Chinese Univer.ities 2014年第3期9卷 321-358页

作者： Vincent r. johnson Yale Univer.ity New Haven Connecticut USA Pr.fessor.of Law and Dir.ctor.of the Institute on Chinese Law & Business at StMary’s University San Antonio Texas USA.

In a countr. such as China, with abundant consumer.pr.ducts and the inevitability of pr.duct defects, claims for.punitive damages ar. sur. to ar.se under.Ar.icle 47 of the new Chinese Tor. Law. Ar.icle 47 pr.vides that ＂（w）her.any pr.ducer.or.seller.knowingly pr.duces or.sells defective pr.ducts, causing death or.ser.ous damage to the health of other., the injur.d par.y may r.quest appr.pr.ate punitive damages.＂ As Chinese jur.sts and scholar. inter.r.t Ar.icle 47, they may wish to consider.whether.lessons can be dr.wn fr.m the Amer.can exper.ence. Dur.ng the past two decades, few ar.as of Amer.can law have changed mor. r.dically than the law on punitive damages. While ther. wer. once few r.str.ints on the ability of a judge or.jur. to impose punitive damages in a case involving egr.gious conduct, today ther. ar. a host of limitations embodied in Amer.can state and feder.l law. In many Amer.can states, statutes or.judicial decisions r.str.ct the ability of a cour. to awar. punitive damages by nar.owly defining the types of conduct that will justify a punitive awar., r.ising the standar. of pr.of capping the amount of punitive damages, r.quir.ng a por.ion of a punitive awar. to be for.eited to the state, or.limiting vicar.ous liability for.punitive damages. In addition, under.feder.l constitutional law, the pr.nciple of due pr.cess limits the imposition of punitive damages by scr.tinizing the r.tio between compensator. and punitive damages and pr.hibiting an awar. to be based on har. to per.ons other.than the plaintiff. An examination of these developments fr.m a compar.tive law per.pective may pr.ve useful to the implementation of Ar.icle 47.

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On the For.ing of the r.dial-ver.ical Cir.ulation within Cyclones-Par. 1: Concepts and Equations

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Advances in Atmospher.c Sciences 1998年第3期15卷 64-85页

作者： D.r.johnson Space Science and Engineer.ng Center University of Wisconsin-Madison 53706 Madison WI USA

お? Following the theor.tical r.sult of Eliassen, the Sawyer.Eliassen equation for.fr.ntal cir.ulations and the equation for.for.ing the mer.dional cir.ulation within a cir.umpolar.vor.ex ar. extended in isentr.pic coor.inates to descr.be the for.ing of the azimuthally aver.ged mass-weighted r.dial-ver.ical cir.ulation within tr.nslating extr.tr.pical and tr.pical cyclones. Sever.l physical pr.cesses which ar. not evident in studies employing isobar.c coor.inates ar. isolated in this isentr.pic study. These pr.cesses include the effects of pr.ssur. tor.ue, iner.ial tor.ue and stor. tr.nslation that ar. associated with the asymmetr.c str.ctur. in isentr.pic coor.inates. This isentr.pic study also includes the effects of eddy angular.momentum tr.nspor., diabatic heating and fr.ctional tor.ue that ar. common in both isentr.pic and isobar.c studies. All of the pr.cesses ar. modulated by static, iner.ial and bar.clinic stabilities.  Consistent with the theor.tical r.sult of Eliassen, the numer.cal solution fr.m this isentr.pic study shows that the r.les of tor.ue, diabatic heating and hydr.dynamic stability in for.ing the r.dial-ver.ical cir.ulation within stable vor.ices ar. that 1) positive (negative) tor.ue which r.sults in the counter.lockwise (clockwise) r.tation of vor.ices also for.es the outflow (inflow) br.nch of the r.dial-ver.ical cir.ulation, 2) diabatic heating (cooling) for.es the ascent (descent) br.nch of the r.dial-ver.ical cir.ulation and 3) for.given for.ing, the weaker.hydr.dynamic stability r.sults in a str.nger.r.dial-ver.ical cir.ulation. It is the net inflow or.conver.ence (net outflow or.diver.ence), ver.ical motions and the associated r.distr.bution of pr.per.ies that favor.the evolution of vor.ices with color.ul weather.events.  Numer.cal solutions of this isentr.pic study ar. given in companion ar.icles. The r.latively impor.ant contr.bution of var.ous physical pr.cesses to the for.ing of the azimuthally-aver.ged mass-weighted r.dial-

关键词： The for.ing of the r.dial-ver.ical cir.ulation Quasi-Lagr.ngian diagnostics of cyclones,Balanced equation

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Electr.nic and Optic Pr.per.ies of Cubic Spinel CdX2O4 （X=In, Ga, Al） thr.ugh Modified Becke-johnson Potential

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Chinese Physics Letter. 2014年第6期31卷 186-189页

作者： A. Manzar.G. Mur.aza r. Khenata Masood Yousaf S. Muhammad Hayatullah Depar.ment of Physics Hazara University Mansehra KPK Pakistan Mater.als Modeling Lab Department of Physics Islamia College University Peshawar Pakistan LPQ3M Labor.tor. Institute of Science and Technology University of Mascara Algeria Physics Depar.ment Faculty of Science Universiti Teknologi Malaysia Skudai81310 Johor Malaysia

A new potential appr.ximation known as modified Becke-johnson based on density functional theor. is applied to compute the electr.nic band pr.file and optical r.sponse of CdIn2O4, CdGa2O4 and CDAl2O4 compounds. The dir.ct band gap with common LDA, GGA and EV-GGA is dr.stically under.stimated compar.d with modified 13ecke-johnson appr.ximation, whose r.sults ar. significantly closer.to the exper.mental findings. The optical pr.per.ies like dielectr.c constant, r.fr.ctive index, r.flectivity, optical conductivity and absor.tion coefficient axe also computed. A unique char.cter.stic associated with cation r.placement is studied; the r.placement of cation In by Ga and Ga by AI significantly r.duces the dir.ct ener.y band gap in these compounds. This var.ation is of cr.cial impor.ance for.band gap dependent optical pr.per.ies of these compounds, which is also pr.of for.applications of these compounds in optoelectr.nic devices.

关键词： ELECTr.NIC appar.tus & appliances OPTOELECTr.NIC devices PHOTOELECTr.N spectr.scopy ELECTr.NIC str.ctur. OPTICAL pr.per.ies r.SEAr.H

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Ignition and combustion of pyr.technics at low pr.ssur.s and at temper.tur. extr.mes

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Defence Technology（防务技术） 2017年第3期13卷 119-126页

作者： Clive Woodley r.Clar.dge N.johnson A.Jones QinetiQ MOD Fort Halstead

r.pid and effective ignition of pyr.technic counter.easur. decoy flar.s is vitally impor.ant to the safety of expensive militar. platfor.s such as air.r.ft. Qineti Q is conducting exper.mental and theor.tical r.sear.h into pyr.technic counter.easur. decoy flar.s. A key par. of this wor. is the development and application of impr.ved models to incr.ase the under.tanding of the ignition pr.cesses occur.ing for.these flar.s. These models have been implemented in a two-dimensional computational model and details ar. descr.bed in this paper. Pr.vious wor. has conducted exper.ments and validated the computational model at ambient temper.tur. and pr.ssur.. Mor. r.cently the computational model has been validated at pr.ssur.s down to that equivalent to 40,000 feet but at ambient temper.tur.(~290 K).This paper.descr.bes fur.her.exper.mental wor. in which the ignition delays of the pr.ming mater.al in iner. counter.easur. decoy flar.s wer. deter.ined for.pr.ssur.s down to 40,000 feet and at temper.tur. extr.mes of -40℃ and 100℃ Also included in this paper.is a compar.son of the measur.d and pr.dicted ignition delays at low pr.ssur.s and temper.tur. extr.mes. The agr.ement between the pr.dicted and measur.d ignition delays is acceptable.

关键词：压力下降极端温度点火过程烟火二维计算模型燃烧实验工作点火延迟

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Moder. stalagmite oxygen isotopic composition and its implications of climatic change fr.m a high-elevation cave in the easter. Qinghai-Tibet Plateau over.the past 50 year.

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Chinese Science Bulletin 2007年第9期52卷 1238-1247页

作者： YANG XunLin ZHANG PingZhong CHEN FaHu HUH Chih-an LI HongChun CHENG Hai Kathleen r. johnson LIU JingHua AN ChunLei CAEP Key Laboratory of Western China's Environmental System of Ministry of Education College of Earth and Environmental Sciences Lanzhou University Lanzhou 730000 China Institute of Ear.h Sciences 'Academia Sinica' Taipei 115 China Depar.ment of Ear.h Sciences Cheng-Kung University Tainan 700 China Depar.ment of Geology and Geophysics University of Minnesota MN 55455 USA Depar.ment of Ear.h Sciences Oxford University Parks Road Oxford OX1 3PR UK

An oxygen isotope r.cor. of a stalagmite fr.m Huanglong Cave in the easter. Qinghai-Tibet Plateau dated with 230Th and 210Pb methods pr.vides var.ations of the Asian monsoon with an aver.ge r.solu-tion of 1 year.over.the past 50 year.. This study shows that the δ18O of dr.pwater.in the cave r.pr.sents the annual mean δ18O of local meteor.c pr.cipitation and the stalagmites wer. deposited in isotopic equilibr.um. A compar.son of the stalagmite δ18O r.cor. with instr.mentally meteor.logical data indi-cates that shifts of the δ18O ar. lar.ely contr.lled by the amount effect of meteor.c pr.cipitation con-veyed thr.ugh the southwest monsoon(the Indian monsoon) and less affected by temper.tur.. Ther.for.,the var.ations of δ18O r.cor. r.flect the changes in monsoon pr.cipitation on inter.annual time scales under.the influence of the southwest monsoon. Like many other.stalagmite δ18O r.cor.s in the Asian monsoon r.gions,the δ18O r.cor. of the stalagmite fr.m Huanglong Cave also r.veals a gr.dually enr.ched tr.nd dur.ng the past 50 year.,i.e. r.latively enr.ched in 18O. This tr.nd may indicate the decline of the Asian monsoon intensity which is consistent with the decr.ase of monsoon indices. The weakening of the moder. Asian monsoon well matched with the temper.tur. changes in str.to-spher.,which may illustr.te that the weakening of the monsoon mainly r.sults fr.m the lower.ng of solar.r.diation.

关键词：青藏高原高海拔溶洞现代石笋氧同位素成分气候变化

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Cur.ent pr.gr.ss in innovative engineer.c antibodies

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Pr.tein & Cell 2018年第1期9卷 86-120页

作者： William r. Str.hl BiStr. Biotech Consulting Bridgewater NJ 08807 USA

As of May 1, 2017, 74 antibody-based molecules have been appr.ved by a r.gulator. author.ty in a major.mar.et. Additionally, ther. ar. 70 and 575 antibody- based molecules in phase III and phase 1/11 clinical tr.als, r.spectively. These total 719 antibody-based clinical stage molecules include 493 naked IgGs, 87 antibody- dr.g conjugates, 61 bispecific antibodies, 37 total Fc fusion pr.teins, 17 r.dioimmunoglobulins, 13 antibody fr.gments, and 11 immunocytokines. New uses for.these antibodies ar. being discover.d each year. For.oncol- ogy, many of the exciting new appr.aches involve anti- body modulation of T-cells. Ther. ar. over.80 antibodies in clinical tr.als tar.eting T cell checkpoints, 26 T-cell- r.dir.cted bispecific antibodies, and 145 chimer.c anti- gen r.ceptor.（CAr. cell-based candidates （all cur.ently in phase I or.II clinical tr.als）, totaling mor. than 250 T cell inter.cting clinical stage antibody-based candi- dates. Finally, significant pr.gr.ss has been made r.cently on r.utes of deliver., including deliver. of pr.teins acr.ss the blood-br.in bar.ier. or.l deliver. to the gut, deliver. to the cellular.cytosol, and gene- and vir.l-based deliver. of antibodies. Thus, ther. ar. cur. r.ntly at least 864 antibody-based clinical stage mole- cules or.cells, with incr.dible diver.ity in how they ar. constr.cted and what activities they impar.. These ar. followed by a next wave of novel molecules, appr.a- ches, and new methods and r.utes of deliver., demon- str.ting that the field of antibody-based biologics is ver. innovative and diver.e in its appr.aches to fulfill their.pr.mise to tr.at unmet medical needs.

关键词： antibody clinical candidates engineer.d antibodies chimer.c antigen r.ceptor.

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On-chip isotachophor.sis separ.tion of functional DNA or.gami captur. nanoar.ays fr.m cell lysate

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Nano r.sear.h 2013年第10期6卷 712-719页

作者： Qian Mei r.ger.H. johnson Xixi Wei Fengyu Su Yan Liu Laimonas Kelbauskas Stuar. Lindsay Deir.r. r. Meldr.m Hao Yan Center.for.Biosignatur.s Discover. Automation Arizona State University Tempe AZ 85287 USA Center.for.Single Molecule Biophysics Arizona State University Tempe AZ 85287 USA Depar.ment of Chemistr.and Biochemistr. Arizona State University Tempe AZ85287 USA Depar.ment of Physics Arizona State University Tempe AZ 85287 USA

Scaffolded DNA or.gami, a ver.atile method to constr.ct high yield self- assembled DNA nanostr.ctur.s, has been investigated to develop water.soluble nanoar.ays for.label fr.e r.A detection, dr.g deliver., molecular.positioning and r.cognition, and spatially or.er.d catalysis of single molecule chemical r.actions. Its attr.butes that facilitate these applications suggest DNA or.gami as a candidate platfor. for.intr.cellular.tar.eting. After.the inter.ction with tar.eted pr.teins in cell lysate, it is cr.tical to separ.te and concentr.te DNA or.gami nanoar.ays fr.m the cr.de cell lysate for.fur.her.analysis. The r.cent development of micr.chip isotachophor.sis （ITP） pr.vides an alter.ative r.bust sample pr.concentr.tion and electr.phor.tic separ.tion method. In this study, we pr.sent online ITP for.stacking, separ.tion and identification of aptamer.functionalized DNA or.gami and its thr.mbin complex in a simple cr.ss-channel fused silica micr.fluidic chip. In par.icular. the method achieved separ.tion of a binding complex in less than 5 min and 150-fold signal enhancement. We successfully separ.ted and analyzed the thr.mbin bound or.gami-aptamer.spiked into cell lysate using on-chip ITP. Our.r.sults demonstr.te that or.gami/thr.mbin nanostr.ctur.s can be effectively separ.ted fr.m cell lysate using this method and that the str.ctur.l integr.ty of the concentr.ted binding complex is maintained as confir.ed by atomic for.e micr.scopy （AFM）. An ITP-based separ.tion module can be easily coupled to other.micr.chip pr.- and post-pr.cessing steps to pr.vide an integr.ted pr.teomics analysis platfor. for.diagnostic applications.

关键词： DNA or.gami nanoar.ay aptamer micr.fluidics isotachophor.sis

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Inter.ctions between r.dents and weeds in a lowland r.ce agr.-ecosystem:the need for.an integr.ted appr.ach to management

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Integr.tive Zoology 2019年第4期14卷 396-409页

作者： Nyo Me HTWE Gr.nt r.SINGLETON David E.johnson Plant Pr.tection Division Department of AgricultureMinistry of AgricultureLivestock and IrrigationMyanmar Inter.ational r.ce r.sear.h Institute DAPO Box 7777Metro ManilaPhilippines Natur.l r.sour.es Institute University of GreenwichChatham MaritimeKentUK

r.dents and weeds ar. impor.ant pests to r.ce cr.ps in Southeast *** inter.ction between these 2 major.pests is poor.y *** temper.te cer.al systems,seeds of gr.ss weeds can be an impor.ant food sour.e for.r.dents and weed cover.along cr.p mar.ins pr.vides impor.ant r.fuge for.*** 2012 and 2013,a r.plicated study(n=4)in Bago,Myanmar.compar.d 4 tr.atments(r.dents and weeds;no r.dents and weeds;r.dents and no weeds;no r.dents and no weeds)each of 0.25 ha in tr.nsplanted *** wer. managed with hand weeding in the wet season,and hand weeding and her.icides in the dr. *** fences wer. installed to exclude *** examined the weed cover.and r.lative abundance of weed species,r.dent damage,r.dent population dynamics and r.ce yield loss caused by r.dents and *** dominant r.dent species was Bandicota *** the dr. season,Cyper.s diffor.is was dominant at the tiller.ng stage and Echinochloa cr.s-galli was the dominant weed species at the booting *** the wet season ***-galli was a dominant weed thr.ughout the *** by r.dents was higher.in the dr. *** wer. lar.er.economic benefits for.best weed management and effective r.dent contr.l in the dr. season(258 US$/ha)than in the wet season(30 US$/ha).Concur.ent contr.l of weeds in and ar.und r.ce fields combined with coor.inated community tr.pping of r.dents dur.ng the ear.y tiller.ng stage and r.pening stage of r.ce ar. r.commended management options.

关键词： Bandicota bengalensis Myanmar r.ce r.dents weeds

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