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Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence

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Asian Journal of Andrology 2021年第5期23卷 441-449页

作者： sinda mahbouli Charlotte Dupont Yaelle Elfassy Eric Lameignere Rachel Levy FabLife 104 Avenue Albert lerRueil-Malmaison 92500France Sorbonne University Saint Antoine Research CentreINSERM Genetic and Acquired Lipodystrophies TeamReproductive Biology and CECOSAP-HPTenon HospitalParis F-75020France Reproductive Biology and CECOS AP-HPTenon HospitalParis F-75020France

Infertility affects about 15%of the world's *** 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains *** clinical data show that lifestyle interventions may contribute to male reproductive *** of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male *** analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male *** these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane *** studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been *** review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.

关键词： energy metabolism genetic polymorphisms idiopathic male infertility lifestyle factors nutrition oxidative stress semen quality

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Geodynamic significance and genesis of chromitites from the Islahiye ophiolite(Gaziantep,SE Anatolia)as constrained by platinum group element(PGE)compositions and mineral chemistry characteristics

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Acta Geochimica 2022年第5期41卷 741-752页

作者： Nil Yapici Gael Calo sinda Ngbangandimbo Nusret Nurlu Department of Mining Engineering University ofÇukurovaAdanaTurkey Department of Geological Engineering University ofÇukurovaAdanaTurkey Mühendislik Fakültesi Jeoloji Mühendisliği BölümüÇukurovaÜniversitesi01330 BalcalıAdanaTurkey

Chromitites associated with intensely altered dunites and harzburgites from fourteen dif ferent localities in the Islahiye ophiolites(SE Anatolia)is reported here for the first *** chromitites were observed as lenticular and banded bodies with disseminated and massive textures and containing magnesiochromite grains with the following composition:CrO=58.91–59.74 wt%,Al_(2)O_(3)=10.85–11.20 wt%,and TiO=0.09–0.13 wt%.The Mg#[Mg/(Mg+Fe)]values of magnesiochromite from the Islahiye ophiolite range between 0.52 and 0.60 and their Cr#[Cr/(Cr+Al)]values vary from 0.7802 to *** contents vary with a constant pattern,coincident with the estimated parental liquids that have originated from the derivative of a single bulk of boninitic magma together with Al,Ti-poor,and Cr-rich initial *** chromitites are serpentinised in almost all parts of the study area,and harzburgite and dunite can be observed in different *** the overall composition of platinum group elements(PGE)in most examined chromitites varies between 97 and 191 ppb,three chromitites from the Islahiye region present enrichments in overall PGE(up to 214 ppb).The mineralogical and geochemical features of chromitites from the Islahiye region exhibit a robust similarity to podiform chromitites in the mantle fragment of supra–subduction zone type ophiolitic *** estimated parental magmas of the investigated chromites are consistent with the diff erentiation of arcrelated melts and do not suggest an oceanic spreading centre tectonic *** Islahiye chromites are enriched in IPGE(Ir,Os,Ru),with the occasional presence of Ru and Ir and higher Os contents in ***,we did not find any platinum group minerals(PGM)associated with the serpentine silicate sample matrix,which would have stated a secondary enrichment in *** chromitites in the investigated region have high Cr and low Ti values,are defined as magnesiochromite and were crystallised from a characte

关键词： Chromite Platinum group element Platinum group mineral Ophiolite Mineral chemistry

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Diagnosing Kearns-Sayre Syndrome Requires Genetic Confirmation

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Chinese Medical Journal 2016年第18期129卷 2267-2268页

作者： Josef Finsterer sinda Zarrouk-Mahjoub 1Krankenanstalt Rudolfstiftung 1030 Vienna Austria Genomics Platform Pasteur Institute of Tunis 1002 Tunis Tunisia

To the Editor： With interest, we read the article by Kwon et al. about a single patient with Kearns-Sayre syndrome （KSS）, who successfully and without complications underwent peripheral nerve block for multiple mus... 详细信息

关键词： Diagnosing Kearns-Sayre Syndrome Requires

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Pathogenicity of the Homoplasmic m.8701A〉 G Variant Requires Confirmation

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Chinese Medical Journal 2016年第15期129卷 1889-1890页

作者： Josef Finsterer sinda Zarrouk-Mahjoub Krankenanstalt Rudolfstiftung Vienna Austria Genomics Platform Pasteur Institute of Tunis Tunis Tunisia

To the Editor： We read with interest the article by Zhu et al. about a family with dilated cardiomyopathy （dCMP） and arterial hypertension （AHT） in four members being attributed to the m.8701A〉G variant in the A... 详细信息

关键词： Variant Requires Confirmation

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Diagnosis of Kearns-Sayre Syndrome Requires Comprehensive Work-up

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Chinese Medical Journal 2016年第20期129卷 2518-2519页

作者： Josef Finsterer sinda Zarrouk-Mahjoub Krankenanstalt Rudolfstiftung 1030 ViennaAustria Genomics Platform Pasteur Institute of Tunis1002 TunisTunisia

To the Editor：With interest,we read the article by Yu et al.[1] about the clinical presentation and central nervous system （CNS） imaging in 19 patients with Kearns-Sayre syndrome （KSS）,of whom 12 were genetically *** have the following comments and concerns.@@The main disadvantage of the study was that the diagnosis was not genetically confirmed in all patients and mitochondrial DNA （mtDNA） deletion was detected in only 63% patients,[1] What was the reason for seven KSS patients not undergoing genetic testing？Did not all patients undergo muscle biopsy？

关键词： MITOCHONDRIAL-DNA

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Impaired Hearing in Mitochondrial Disorders

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Chinese Medical Journal 2015年第13期128卷 1839-1839页

作者： Josef Finsterer sinda Zarrouk-Mahjoub Krankenanstalt Rudolfstiftung Vienna Austria Genomics Platform Pasteur institute of Tunis Tunis Tunisia

To the Editor： With interest, we read the article reported by Liu et al. about the frequency of central and peripheral auditory system affection in 73 patients with a mitochondrial disorder （MID） due to mitochondri... 详细信息

关键词： Impaired Hearing Disorders

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Mitochondrial vasculopathy

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World Journal of Cardiology 2016年第5期8卷 333-339页

作者： Josef Finsterer sinda Zarrouk-Mahjoub Krankenanstalt Rudolfstiftung Genomics Platform Pasteur Institute of Tunis

Mitochondrial disorders(MIDs)are usually multisystem disorders(mitochondrial multiorgan disorder syndrome)either on from onset or starting at a point during the disease *** frequently affected tissues are those with a high oxygen demand such as the central nervous system,the muscle,endocrine glands,or the ***,it has been shown that rarely alsothe arteries may be affected(mitochondrial arteriopathy).This review focuses on the type,diagnosis,and treat-ment of mitochondrial vasculopathy in MID patients.A literature search using appropriate search terms was carried *** vasculopathy manifests as either microangiopathy or *** manifestations of mitochondrial microangiopathy include leukoencephalopathy,migraine-like headache,stroke-like episodes,or peripheral *** macroangiopathy manifests as atherosclerosis,ectasia of arteries,aneurysm formation,dissection,or spontan-eous rupture of *** diagnosis relies on the documentation and confirmation of the mitochondrial metabolic defect or the genetic cause after exclusion of non-MID *** is not at variance compared to treatment of vasculopathy due to non-MID *** vasculopathy exists and manifests as micro-or *** mitochondrial vasculopathy is crucial since appropriate treatment may prevent from severe complications.

关键词： Mitochondrial disorder Multisystem Mt DNA Phenotype Vasculopathy Arteriopathy Angiopathy Genotype

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Ethnobotany, Pharmacology and Phytochemical Investigations of the Seeds of <i>Pentaclethra macrophylla</i>Benth (Mimosaceae)

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Advances in Biological Chemistry 2021年第3期11卷 126-141页

作者： Pierre V. K. sinda Beaudelaire K. Ponou Borice T. Tsafack Jonas Kühlborn Roland T. Tchuenguem Rémy B. Teponno Jean P. Dzoyem Till Opatz Léon A. Tapondjou Research Unit of Environmental and Applied Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Chemistry Johannes Gutenberg University Duesbergweg Mainz Germany Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon

Phytochemical investigation of the seeds of Pentaclethra macrophylla led to the isolation of a mixture of two new aromatic monoterpene glycosides, pentamacrophylloside A (1a) and pentamacrophylloside B (1b), together with six known secondary metabolites: Comososide (2), secopentaclethroside (3), caffeoylputrescine (4), β-sitosterol-3-O-β-D-glucopyranoside (5), 2-hydroxymethyl-5-(2-hydroxypropan

关键词： Pentaclethra macrophylla Ethnobotany Pharmacology Aromatic Monoterpenoids Chemophenetic Significance Antimicrobial Activity

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