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Progress in the development of vaccines for hepatitis C virus infection

World Journal of Gastroenterology 2015年第42期21卷 11984-12002页

作者： Faezeh Ghasemi sina rostami Zahra Meshkat Department of New Sciences and Technology Faculty of Medicine Mashhad University of Medical Sciences Department of Biology Faculty of Sciences Ferdowsi University of Mashhad The Influenza Centre Department of Clinical Science University of Bergen Antimicrobial Resistance Research Center Faculty of Medicine Mashhad University of Medical Sciences

The hepatitis C virus(HCV), first described in 1989, is now a leading cause of liver cirrhosis and hepatocellular carcinoma. With more than 170 million people infected globally, this virus is a major public health issue. The current standard therapy is based on interferon in combination with ribavirin. This costly therapy often fails to completely clear the infection and is associated with adverse side effects. Recent anti-HCV therapies are interferon-free direct-acting antiviral(DAA) regimens for HCV, including simeprevir, sofosbuvir, and ledipasvir, which have effects on non-structural proteins. DAA regimens have several advantages, such as specifically targeting HCV viral replication, accompanied by very high sustained virological response rates and lower side effects like flu-like syndrome. These facts plus the fact that most HCV cases progress to chronic infection suggest the potential need for an efficient HCV vaccine. Different innovative methods, including methods based on peptide, recombinant protein, DNA, vector-based, and virus-like particles, have been introduced for the development of HCV vaccines. An extensive number of studies have been published on these vaccines, and some vaccines were even tested in clinical trials. In the current review, progress in the development of preventive and therapeutic vaccines against the HCV is reviewed in the context of peptide vaccines, recombinant protein vaccines, HCV-like particle, DNA vaccines and viral vectors expressing HCV genes.

关键词： Preventive vaccine Therapeutic vaccine Hepatitis C

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Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第11期14卷 500-506页

作者： Samira Behrad sina Pourranjbar Mohammad Pourranjbar Saeid Abbasi-Maleki Samira rostami Mehr Reza Hossein Gholizadeh Salmani Nasrollah Moradikor Department of Oral and Maxillofacial Pathology Dental SchoolSemnan University of Medical SciencesSemnanIran Faculty of Medicine Kerman University of Medical SciencesKermanIran Department and Neuroscience Research Center Kerman University of Medical SciencesKermanIran Pharmaceutical Sciences Research Center Health InstituteKermanshah University of Medical SciencesKermanshahIran Department of Basic Sciences Faculty of Veterinary MedicineUrmia UniversityUrmiaIran International Center for Neuroscience Research Institute for Intelligent ResearchTbilisiGeorgia

Objective:To evaluate the effect of Grifola frondosa polysaccharides(GFP)in a rat model of Alzheimer’s disease(AD).Methods:Seventy-five rats were divided into five groups:the normal control group and the AD group treated with or without GFP(100,200,and 400 mg/kg).Behavioral responses in the open field test and elevated plus maze test were ***,the levels of malondialdehyde and ferric-reducing ability of plasma,and the mRNA expressions of TNF-α,IL-6,and IL-1βin the hippocampus were ***:Treatment with GFP significantly improved AD-induced behavioral changes in the open field test and elevated plus maze test(P<0.05).In addition,the level of malondialdehyde and the mRNA expressions of TNF-α,IL-6,and IL-1βwere decreased by GFP treatment in a dose-dependent manner in AD rats(P<0.05),while the level of ferric-reducing ability of plasma was significantly increased(P<0.05).Conclusions:Oral administration of GFP can reduce inflammation and oxidative stress,as well as improve behavioral responses associated with AD,suggesting its potential use in AD ***,additional studies are needed to elucidate its underlying mechanisms and efficacy.

关键词： Grifola frondosa Polysaccharides Dementia Behavioral responses Inflammation Alzheimer’s disease

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Geology,geochemistry,fluid inclusions and O-H stable isotope constraints on genesis of the Lake Siah Fe-oxide±apatite deposit,NE Bafq,Central Iran

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Acta Geochimica 2020年第6期39卷 920-946页

作者： Ebrahim TaleFazel Mahin rostami Department of Geology Faculty of Science.Bu-Ali Sina UniversityHamedanIran

The Lake Siah iron±apatite deposit is situated in the Bafq Mining District(BMD),Central *** iron±apatite orebodies are hosted by a succession of rhyolite,rhyolitie tuff,trachyandesite,and andesite of Lower Cambrian *** host rock has undergone wide-spread alteration and mineralization stages including Na(albite-quartz),followed by Na-Ca(albite-calcite--am-phibole-magnetite±quartz±epidote),magnetite-ap-atite,K(biotite±K-feldspar),hydrolytic(sericite-quartz),and argillic(kaolinite--montmorillonite±dickite),*** microprobe analyses(EPMA)from mag-netite and hematite show significant variations of trace *** on Ni/Cr+Mn and Ca+Al+Mn ver-sus Ti+V diagrams,the majority of magnetite samples belong to Kiruna-type *** least,three generations of fluid inclusions,including solid-bearing(L+V+S)(Type I),liquid-rich(L+V)(Type II-A),vapor-rich(L+V)(Type II-B),and liquid or vapor mono-phase(Type II),are recognized in quartz and *** solid-bearing fluid inclusions in quartz completely homogenized at temperatures of 150 to>530℃with salinities of 30--58 wt%NaCl ***-rich fluid inclusions in apatite homogenized to a liquid phase at 175--210℃,whereas the vapor-rich fuid inclusions homogenized to a vapor at 335-350°*** isotope analysis was carried out on quartz and *** hydrogen and oxygen isotopic compositions of quartz(8"Onuid values of 7.57-11.04%)show that with progress in time the ore-forming solutions gradually evolved from a magmatic to meteoric-dominated source.

关键词： Iron oxide-apatite Lower Cambrian Kirunatype Bafq Mining District Lake Siah

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p-Toluenesulfonyl chloride as a new and effective catalyst for acetylation and formylation of hydroxyl compounds under mild conditions

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Chinese Chemical Letters 2010年第12期21卷 1430-1434页

作者： Ardeshir Khazaei Amin rostami Fatemeh Mantashlo Faculty of Chemistry Bu-Ali Sina UniversityHamedan ***Iran Department of Chemistry Faculty of ScienceUniversity of KurdistanSanandaj 66135Iran

The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is *** structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-toluenesulfonyl chloride under solvent-free *** reactions were carried out in short reaction time and in good to excellent yields at room temperature.

关键词： p-Toluenesulfonyl chloride Hydroxyl compounds Acetylation Forrnylation

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Predictor homotopy analysis method for nanofluid flow through expanding or contracting gaps with permeable walls

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International Journal of Biomathematics 2015年第4期8卷 145-159页

作者： Navid Freidoonimehr Behnam rostami Mohammad Mehdi Rashidi Young Researchers and Elite Club Hamedan Branch Islamic Azad University Hamedan Iran Shanghai Key Lab of Vehicle Aerodynamics and Vehicle Thermal Management Systems4800 Cao An Rd. Jiadong Shanghai 201804 P. R. China ENN-Tongji Clean Energy Institute of Advanced Studies Shanghai P. R. China Mechanical Engineering DepartmentEngineering Faculty of Bu-Ali sina University Hamedan Iran

In this paper a definitely new analytical technique, predictor homotopy analysis method （PHAM）, is employed to solve the problem of two-dimensional nanofluid flow through expanding or contracting gaps with permeable walls. Moreover, comparison of the PHAM results with numerical results obtained by the shooting method coupled with a Runge- Kutta integration method as well as previously published study results demonstrates high accuracy for this technique. The fluid in the channel is water containing different nanoparticles： silver, copper, copper oxide, titanium oxide, and aluminum oxide. The effects of the nanoparticle volume fraction, Reynolds number, wall expansion ratio, and different types of nanoparticles on the flow are discussed.

关键词： Nanofluid permeable walls porous channel non-dimensional wall dilationrate predictor homotopy analysis method.

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无溶剂中性条件下分子I_2或Fe(NO_3)_3·9H_2O/NaI原位生成的I_2催化醇与甲酸甲酰化反应(英文)

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催化学报 2011年第1期32卷 60-64页

作者： rostami AMIN[a] Khazaei ARDESHIR[b] Alavi-Nik HEIDAR ALI[b] Toodeh-Roosta ZAHRA[b] [a] Department of Chemistry Faculty of Science University of Kurdistan Zip Cod 66177-15175 Sanandaj Iran[b] Faculty of Chemistry Bu-Ali sina University Zip Cod 65178-38683 Hamadan Iran

Different alcohols were formylated by formic acid under solvent-free conditions in the presence of iodine as the catalyst with good-to-high yields at room temperature.I2 generated in situ from Fe(NO3)3·9H2O/NaI also catalyzed the formylation of the alcohols under solvent-free *** gives a green and efficient reaction at room temperature,in which the use of toxic and corrosive molecular I2 is avoided.

关键词： alcohol formic acid formylation iodine in situ iodine solvent-free

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Effects of neurofeedback on the short-term memory and continuous attention of patients with moderate traumatic brain injury： A preliminary randomized controlled clinical trial

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Chinese Journal of Traumatology 2017年第5期20卷 278-282页

作者： Reza rostami Payman Salamati Kourosh Karimi Yarandi Alireza Khoshnevisan Soheil Saadat Zeynab Sadat Kamali Somaie Ghiasi Atefeh Zaryabi Seyed Shahab Ghazi Mir Saeid Mehdi Arjipour Mohammad Saeid Rezaee-Zavareh Vafa Rahimi-Movaghar Department of Psychology Tehran University Tehran Islamic Republic of Iran sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Islamic Republic of Iran Department of Neurosurgery School of Medicine Shariati Hospital Tehran University of Medical Sciences TehranIran Department of Psychology Kharazmi University Tehran Islamic Republic of Iran Department of Clinical Psychology AUame Tabatabaei University Tehran Iran Students' Research Committee Baqiyatallah University of Medical Sciences Tehran Islamic Republic of Iran

Purpose： There are some studies which showed neurofeedback therapy （NET） can be effective in clients with traumatic brain injury （TBI） history. However, randomized controlled clinical trials are still needed for evaluation of this treatment as a standard option. This preliminary study was aimed to evaluate the effect of NET on continuous attention （CA） and short-term memory （STM） of clients with moderate TBI using a randomized controlled clinical trial （RCT）. Methods： In this preliminary RCT, seventeen eligible patients with moderate TBl were randomly allo- cated in two intervention and control groups. All the patients were evaluated for CA and STM using the visual continuous attention test and Wechsler memory scale-4th edition （WMS-IV） test, respectively, both at the time of inclusion to the project and four weeks later. The intervention group participated in 20 sessions of NFT through the first four weeks. Conversely, the control group participated in the same NF sessions from the fifth week to eighth week of the project. Results： Eight subjects in the intervention group and five subjects in the control group completed the study. The mean and standard deviation of participants＇ age were （26.75 ~ 15.16） years and （2Z60 ＋_ 8.17） years in experiment and control groups, respectively. All of the subjects were male. No significant improvement was observed in any variables of the visual continuous attention test and WMS-IV test between two groups （p _~ 0.05）. Conclusion： Based on our literature review, it seems that our study is the only study performed on the effect of NET on TBl patients with control group. NET has no effect on CA and STM in patients with moderate TBI. More RCTs with large sample sizes, more sessions of treatment, longer time of follow-up and different orotocols are recommended.

关键词： Neurofeedback Brain injuries Attention Short-term memory

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