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Modeling of environmental influence in structural health assessment for reinforced concrete buildings

Earthquake Engineering and Engineering Vibration 2010年第2期9卷 295-306页

作者： Ka-Veng Yuen sin-chi kuok Department of Civil and Environmental Engineering Univeristy of Macao

One branch of structural health monitoring (SHM) utilizes dynamic response measurements to assess the structural integrity of civil infrastructures. In particular,modal frequency is a widely adopted indicator for structural damage since its square is proportional to structural stiffness. However,it has been demonstrated in various SHM projects that this indicator is substantially affected by fluctuating environmental conditions. In order to provide reliable and consistent information on the health status of the monitored structures,it is necessary to develop a method to filter this interference. This study attempts to model and quantify the environmental influence on the modal frequencies of reinforced concrete buildings. Daily structural response measurements of a twenty-two story reinforced concrete building were collected and analyzed over a one-year period. The Bayesian spectral density approach was utilized to identify the modal frequencies of this building and it was clearly seen that the temperature and humidity fluctuation induced notable variations. A mathematical model was developed to quantify the environmental effects and model complexity was taken into consideration. Based on a Timoshenko beam model,the full model class was constructed and other reduced-order model class candidates were obtained. Then,the Bayesian modal class selection approach was employed to select the one with the most suitable complexity. The proposed model successfully characterizes the environmental influence on the modal frequencies. Furthermore,the estimated uncertainty of the model parameters allows for assessment of the reliability of the prediction. This study not only improves the understanding about the monitored structure,but also establishes a systematic approach for reliable health assessment of reinforced concrete buildings.

关键词： Bayesian inference model selection reinforced concrete building structural health monitoring temperature and humidity effects Timoshenko beam

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Study of the attenuation relationship for the Wenchuan M_s 8.0 earthquake

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Earthquake Engineering and Engineering Vibration 2015年第1期14卷 1-11页

作者： sin-chi kuok Iok-Tong Ng Ka-Veng Yuen Faculty of Science and Technology University of Macao

Prediction of peak ground acceleration is an essential element in engineering seismology and it has received great attention in last few decades. In this paper, a comprehensive database of the strong-motion records of the 2008 great Wenchuan Ms 8.0 earthquake is analyzed to investigate the seismic attenuation relationship and the directivity effects. In contrast to most existing seismic attenuation models, the proposed model considers explicitly the directivity effect which has primary influence on the magnitude of ground motion. Bayesian model updating is used to obtain the model parameters and the associated uncertainty. Comparative study is performed with the well-known Boore-Joyner-Fumal empirical formula. Results show that consideration of the directivity effect is vital in modeling the seismic attenuation relationship.

关键词： Bayesian inference Boore-Joyner-Fumal attenuation relationship directivity peak ground acceleration seismic attenuation model

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Spatiotemporal distribution,environmental risk and carbon emission reduction potential of livestock manure in Shaanxi Province,china

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 381-396页

作者： Mengyuan QIAO Jianchun ZHU Ronghua LI Junting PAN Ran XIAO Hailong WANG kuok Ho Daniel TANG Zengqiang ZHANG College of Humanities&Social Development Northwest A&F UniversityYangling 712100China College of Natural Resources and Environment Northwest A&F UniversityKey Laboratory of Low-carbon Green Agriculture in Northwestern ChinaMinistry of Agriculture and Rural AffairsYangling 712100China Key Laboratory of Non-point Source Pollution of Ministry of Agricultural and Rural Affairs Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Interdisciplinary Research Center for Agriculture Green Development in Yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400715China Biochar Engineering Technology Research Center of Guangdong Province School of Environmental and Chemical EngineeringFoshan UniversityGuangdong 528000China Department of Environmental Science University of ArizonaTucsonAZ 85721USA

Shaanxi is a leading province in animal husbandry(AH)in ***,the lack of provincial information on the characteristics and utilization potential of livestock manure(LM)hinders crucial management ***,we investigated the spatiotemporal distribution,availability and biogas potential of LM in Shaanxi,and examine the carbon emission reduction potential of *** has been a 1.26-fold increase in LM quantities in Shaanxi over the past 35 years,reaching 4635.6×10^(4)t by *** was mainly concentrated in northern Shaanxi and the eastern part of *** and pig manure were the primary sources of LM,with the average LM land-load of 14.57 t·ha^(−1)in *** the overall AH in Shaanxi has not exceeded the environmental capacity,the actual scales of AH in Ankang and Hanzhong have already surpassed the respective environmental capacities,posing a higher risk of N and P *** 2021,the estimated biogas energy potential of LM was 1.2×10^(11)*** 2012 to 2021,the average carbon emission reduction potential in Shaanxi was 22%,with an average potential scale of 10%.The results of this research provide valuable data and policy recommendations for promoting the intensive use of LM and reducing carbon emissions in Shaanxi.

关键词： Livestock manure emission estimation N and P loads biogas potential carbon emission reduction

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An unusual etiology of subarachnoid hemorrhage,basilar artery perforator aneurysms,in Macao:Three case reports and review of literature

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World Journal of Clinical Cases 2024年第20期12卷 4337-4347页

作者： Ieong-Chon Man Tam-Man Pan kuok-Cheong U Department of Radiology Hospital Conde S.JanuárioMacao SAR 999078China

BACKGROUND Subarachnoid hemorrhage is a severe neurological condition that requires prompt and appropriate treatment to prevent *** are the most common cause of spontaneous subarachnoid ***,basilar artery perforator aneurysms(BAPAs)are a rare *** is no consensus on the optimal management of ruptured BAPAs in the acute *** SUMMARY We present a case series of 3 patients with ruptured BAPAs who were treated at our *** patients had a modified Fisher grade of I,and one had a grade of IV on initial *** aneurysms were detected by computed tomography angiography in two cases and conventional angiography in one *** 3 patients underwent endovascular treatment with Guglielmi detachable ***-treatment,the patients had good clinical outcomes,and follow-up brain computed tomography scans showed reduced subarachnoid hemorrhage without any new ***,one patient experienced a cerebral infarction 2 months later and eventually succumbed to the *** other 2 patients showed progressive recovery,and no aneurysm recurrence was observed at the 2-year *** Endovascular treatment may be a preferable approach for managing ruptured BAPAs compared with surgical intervention or conservative *** detection and prompt treatment is important to achieve favorable patient outcomes.

关键词： Basilar artery Intracranial aneurysm Endovascular treatment Subarachnoid hemorrhage Case report

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Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： kuok-Tong Lei Yun-Xia Wu Yun Lu Zi-Shan Wang Thi-Huong Nguyen Qiu-Ying Cai Wen Zhu Yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional chinese medicine primary Sjogren’s syndrome NF-κB RELA

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Efficacy of Pudilan Xiaoyan Oral Liquid in the treatment of pneumonia induced by drug-resistant Pseudomonas aeruginosa

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Infectious Diseases Research 2024年第3期5卷 22-29页

作者： Jing Ma Yan-Yan Bao Xiao-Rui Wang kuok Kuantai Leong-Man Chon Xiao-Lan Cui Ju-Ying Zhong Yu-Jing Shi Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Conde S.Januário Hospital(CHCSJ) pharmacy departmentMacao 999078China Lin Fong Charities Traditional chinese Medicine Treatment Centre Macao 999078China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China

Background:Pudilan Xiaoyan Oral Liquid(PDL)is a chinese patent medicine with notable pharmacological properties,including anti-inflammatory and antibacterial ***-resistant Pseudomonas aeruginosa infection is a common and refractory bacterial infection in clinical *** to its high drug resistance,it brings great challenges to *** study aimed to assess the therapeutic efficacy of PDL in a murine model of pneumonia induced by drug-resistant Pseudomonas ***:Three different doses of PDL(11 mL/kg/d,5.5 mL/kg/d,2.75 mL/kg/d)were used to observe lung tissue pathology and inflammatory cytokine levels in pneumonia mouse models induced by multidrug-resistant Pseudomonas aeruginosa(MDR-PA).Additionally,the protective efficacy of PDL against mortality in infected mice was evaluated using a death model caused by *** sub-MIC concentration of levofloxacin was used to induce drug-resistant mice pneumonia model to evaluate the role of PDL in reversing drug *** data are expressed as mean±standard *** significance was determined by one-way analysis of variance followed by Tukey’s multiple-comparisons ***:Treatment effect of PDL on MDR-PA pneumonia:the medium and small doses of PDL can significantly reduce the lung index of multi-drug resistant bacteria infected pneumonia model mice(P<0.05),the lung index inhibition rates for these groups were 55.09%and 58.43%,and improve the degree of lung tissue lesions of mice;The expression of serum cytokines keratinocyte chemoattractant,tumor necrosis factor-αand monocyte chemoattractant protein-1 could be decreased in the three dosage groups of PDL(P<0.01).PDL treatment not only lowered the mortality but also extended the survival duration in mice infected with *** was found after sub-MIC concentration of levofloxacin induced resistance of Pseudomonas aeruginosa to pneumonia in *** with the model group,the lung index of mice in high

关键词： pudilan Pseudomonas aeruginosa drug resistance mice model

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A Note on 3-Divisibility of Class Number of Quadratic Field

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chinese Annals of Mathematics,Series B 2022年第2期43卷 307-318页

作者： Jianfeng XIE kuok Fai CHAO Wu Wen-Tsun Key Laboratory of Mathematics School of Mathematical SciencesUniversity of Science and Technology of ChinaHefei 230026China Lui Che Woo College University of MacaoMacaoChina

In this paper,the authors show that there exists infinitely many family of pairs of quadratic fields Q(√D)and Q((√D+n)(1/2))with D,n∈Z whose class numbers are both divisible by 3.

关键词： Quadratic field Class number Hilbert class field

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Duplex kidneys and the risk of urinary tract infection in children

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World Journal of Pediatrics 2022年第2期18卷 144-146页

作者： Chon In kuok Wun Fung Hui Winnie Kwai Yu Chan Department of Paediatrics Queen Elizabeth Hospital30 Gascoigne RoadKowloonHong KongChina

Duplex kidney,also known as duplicated kidney or renal duplication,is a form of congenital anomaly of kidney and urinary tract(CAKUT)characterized by the presence of two pelvicalyceal systems,dividing a kidney into up... 详细信息

关键词： kidney Duplex urinary

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Identification and expression analysis of mical family genes in zebrafish

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Journal of Genetics and Genomics 2010年第10期37卷 685-693页

作者： Yulin Xue chikin kuok An Xiao Zuoyan Zhu Shuo Lin Bo Zhang Key Laboratory of Cell Proliferation and Differentiation Center of Developmental Biology and Genetics College of Life Sciences Peking University Ministry of Education Beijing 100871 China Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095-1606 USA

Mical （molecule interacting with CasL） represent a conserved family of cytosolic multidomain proteins that has been shown to be as- sociated with a variety of cellular processes, including axon guidance, cell movement, cell-cell junction formation, vesicle trafficking and cancer cell metastasis. However, the expression and function of these genes during embryonic development have not been comprehen- sively characterized, especially in vertebrate species, although some limited in vivo studies have been carried out in neural and muscula- ture systems of Drosophila and in neural systems of vertebrates. So far, no mical family homologs have been reported in zebrafish, an ideal vertebrate model for the study of developmental processes. Here we report eight homologs of mical family genes in zebrafish and their expression profiles during embryonic development. Consistent with the findings in Drosophila and mammals, most zebra_fish mical family genes display expression in neural and musculature systems. In addition, five mical homologs are detected in heart, and one, mi- call2a, in blood vessels. Our data established an important basis for further functional studies of mical family genes in zebrafish, and suggest a possible role for mical genes in cardiovascular development.

关键词： mical micall2a expression pattern blood vessel heart

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Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway

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chinese Journal of Natural Medicines 2019年第5期17卷 346-354页

作者： WANG Han-Qing WANG Sha-Sha chiufai kuok WANG Qi CHENG Xiao-Lan College of Pharmacy Ningxia Medical University School of Rehabilitation Medicine Binzhou Medical University School of Health Sciences Macao Polytechnic Institute Nanjing Dorra Pharmaceutical Co. Ltd. Laboratory of Cellular and Molecular Biology Jiangsu Province Academy of Traditional Chinese Medicine

Diabetic nephropathy(DN) is a leading cause of renal failure, contributing to severe morbidity and mortality in diabetic patients. Umbelliferae(Umb) has been well characterized to exert protective effects in diabetes. However, the action and mechanism of Umb in DN remains unclear. In this work, we studied the effect of Umb in a streptozotocin(STZ)-induced DN rat model and explore its underlying mechanism. DN rats were treated with Umb(20, 40 mg·kg^(-1)) or irbesartan(15 mg·kg^(-1)) for 4 weeks. Levels of serum glucose, insulin, blood uric acid, creatinine, triglycerides(TG) and total cholesterol(TC) were measured by commercial assay kits,respectively. Histopathological changes and inflammatory cytokine levels including IL-6, IL-1β and TNF-α in the kidney were also evaluated. Alterations in the expression of podocin, CD2 AP and TLR/NF-κB were assessed by western blotting. Our results showed that Umb reduced renal injury in DN rat model, as evidenced by the decrease in blood glucose, 24 h urinary protein, serum creatinine,and blood uric acid. Umb also significantly ameliorated the renal histopathological alteration, and down-regulated the expression of epithelial-to-mesenchymal transition-related molecular markers podocin and CD2AP. Moreover, Umb inhibited TLR2, TLR4, MyD88 expressions, NF-κB activation and considerably reduced levels of other downstream inflammatory molecules(TNF-α, IL-6, IL-1β).These findings indicated that Umb improved renal function through regulating inflammation and TLR/NF-κB pathway, suggesting the potential efficacy of Umb in DN treatment.

关键词： Diabetic nephropathy Umbelliferone Streptozotocin Inflammation TLR/NF-κB pathway

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