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Prioritizing Indicators for Rapid Response in Global Health Security: A Bayesian Network Approach

INTERNATIONAL JOURNAL OF DISASTER RISK SCIENCE 2024年第4期15卷 536-551页

作者： Qazi, Abroon simsekler, mecit can emre Al-Mhdawi, M. K. S. Amer Univ Sharjah Sch Business Adm Sharjah 26666 U Arab Emirates Khalifa Univ Sci & Technol Dept Management Sci & Engn Abu Dhabi 127788 U Arab Emirates Teesside Univ Sch Comp Engn & Digital Technol Middlesbrough TS1 3BX England

This study explored a Bayesian belief networks (BBNs) approach, developing two distinct models for prioritizing the seven indicators related to the "rapid response to and mitigation of the spread of an epidemic" category within the context of both the specific category and the Global Health Security Index (GHS index). Utilizing data from the 2021 GHS index, the methodology involves rigorous preprocessing, the application of the augmented naive Bayes algorithm for structural learning, and k-fold cross-validation. Key findings show unique perspectives in both BBN models. In the mutual value of information analysis, "linking public health and security authorities" emerged as the key predictor for the "rapid response to and mitigation of the spread of an epidemic" category, while "emergency preparedness and response planning" assumed precedence for the GHS index. Sensitivity analysis highlighted the critical role of "emergency preparedness and response planning" and "linking public health and security authorities" in extreme performance states, with "access to communications infrastructure" and "trade and travel restrictions" exhibiting varied significance. The BBN models exhibit high predictive accuracy, achieving 83.3% and 82.3% accuracy for extreme states in "rapid response to and mitigation of the spread of an epidemic" and the GHS index, respectively. This study contributes to the literature on GHS by modeling the dependencies among various indicators of the rapid response dimension of the GHS index and highlighting their relative importance based on the mutual value of information and sensitivity analyses.

关键词： Bayesian belief networks Global health security Indicators Mitigation Policy implications Rapid response RISK DISEASE

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An integrative risk assessment approach to enhancing patient safety in Continuous Renal Replacement Therapy (CRRT)

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JOURNAL OF SAFETY SCIENCE AND RESILIENCE 2024年第3期5卷 344-354页

作者： Saad, Ahmed Alsadi, Juman Al-Absi, Dima Tareq Almulla, Muhra simsekler, mecit can emre Sadeq, Ahmed Adel Omar, Fahad Basha, Mazhar Khatab, Islam Abu Khater, Noha Molesi, Andrea Anwar, Siddiq Khalifa Univ Sci & Technol Dept Management Sci & Engn POB 127788 Abu Dhabi U Arab Emirates Sheikh Shakhbout Med City Dept Pharm Abu Dhabi U Arab Emirates Sheikh Shakhbout Med City Crit Care Dept Abu Dhabi U Arab Emirates Sheikh Shakhbout Med City Dept Internal Med Abu Dhabi U Arab Emirates

Continuous Renal Replacement Therapy (CRRT) serves as an intervention strategy for the management of acute kidney injury (AKI) in critically ill patients. However, owing to its complex nature and the potential for complications, the implementation of CRRT demands continuous monitoring to prevent patient safety risks. This study aims to identify and validate prevalent risks linked to CRRT within a real-world clinical setting, intending to propose preventive measures grounded in expert insights. To systematically categorize and visually depict the risks, their consequences, preventive measures, and recovery controls, our study employed the Bowtie method in conjunction with the Systems Engineering Initiative for Patient Safety (SEIPS) model. In addition to considering patient-related factors that exhibit variability among critically ill individuals, our key findings showed that the most influential risks impacting the effective delivery of CRRT are incidents of clotted filters, bleeding risks arising from the necessity of anticoagulation for filter efficacy, vascular catheter-related bloodstream infections, variations in proficiency levels among healthcare professionals regarding CRRT modalities, especially in operating the CRRT machines, high nursing workload, frequent nursing turnover, occurrences of hypophosphatemia, variability in CRRT prescribing patterns, and issues related to communication among stakeholders. This research sheds light on the primary risks associated with CRRT and provides practical and viable strategies for effective management. Furthermore, the Bowtie diagram developed as part of this study serves as a valuable tool for visually representing the healthcare system and facilitating the identification of system-related risks within healthcare settings.

关键词： Patient safety Risk management CRRT Continuous Renal Replacement Therapy Acute kidney injury Bowtie method SEIPS CRITICALLY-ILL PATIENTS ANTICOAGULATION DESIGN

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Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： can-can Zhang Jun-Long Yang Ya-Jiang Huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

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Stereochemical editing:Catalytic racemization of secondary alcohols and amines

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Chinese Chemical Letters 2024年第5期35卷 17-31页

作者： Jun Zhang Zhiyao Zheng can Zhu Department of Chemistry Fudan UniversityShanghai 200438China Department of Organic Chemistry Arrhenius LaboratoryStockholm UniversityStockholm 10691Sweden

Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,agrochemicals,and food *** kinetic resolution(DKR)is an efficient strategy to deliver optically active alcohols and amines from their *** the development of DKR method,racemization catalyst plays as a crucial element with the requirement of compatibility with the kinetic resolution(KR)*** this paper,recent advance in the catalytic racemization of secondary alcohols and amines is summarized based on different types of racemizing intermediates,which are redox racemization via ketone/imine intermediates,racemization via radical intermediates,and racemization via carbocation *** racemization of secondary alcohols and amines is also enclosed.

关键词： Racemization Secondary alcohols Amines Kinetic resolution Dynamic kinetic resolution

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Ytterbium modified birnessite MnO_(2) for improving deep oxidation of toluene

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Journal of Rare Earths 2024年第4期42卷 668-675页

作者： Linjiang Sun Yan Cheng Yujie Liu can Yi Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu611756China

A series of rare earth metals modified birnessite manganese dioxides(RE-Mn)was synthesized by hydrothermal method and their catalytic degradation of toluene was ***-Mn shows the best toluene oxidation activity with the conversion of T50%and T99%at 196 and 226℃,*** physiochemical characterizations identified that the high catalytic performance and excellent stability of Yb-Mn are mainly associated with its higher molar ratios of Mn^(4+)/Mn^(3+),more lattice oxygen(Olatt),and better mobility of surface adsorbed oxygen(O_(ads)).Moreover,it is confirmed that introduction of Yb into birnessite MnO_(2) facilitates the production of acetic acid at lower *** results can aid the design of high-efficiency manganese oxide catalysts for the catalytic combustion of VOCs.

关键词： Manganese oxide Rare earth metal doping Toluene Catalytic combustion

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Performance of iron-air battery with iron nanoparticle-encapsulated C-N composite electrode

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Frontiers in Energy 2024年第1期18卷 42-53页

作者： can FANG Xiangmei TANG Jiaoyan WANG Qingfeng YI School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Xiangtan 411201China

Highly efficient and stable iron electrodes are of great significant to the development of iron-air battery(IAB).In this paper,iron nanoparticle-encapsulated C–N composite(NanoFe@CN)was synthesized by pyrolysis using polyaniline as the C–N *** performance of the NanoFe@CN in different electrolytes(alkaline,neutral,and quasi-neutral)was investigated via cyclic voltammetry(CV).The IAB was assembled with NanoFe@CN as the anode and IrO_(2)+Pt/C as the *** effects of different discharging/charging current densities and electrolytes on the battery performance were also *** K_(2)SO_(4)electrolyte can effectively suppress the passivation of iron electrode,and the battery showed a good cycling stability during 180 charging/discharging *** to the pure nano-iron(NanoFe)battery,the NanoFe@CN battery has a more stable cycling stability either in KOH or NH_(4)Cl+KCl electrolyte.

关键词： energy storage and conversion metallic composites nanocomposites iron-air battery iron anode

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Current status of early gastric cancer screening research

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cancer Biology & Medicine 2024年第3期21卷 218-222页

作者： can Hu Li Yuan Xiangdong Cheng Department of Gastric surgery Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Key Laboratory of Prevention Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang ProvinceHangzhou 310022China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract cancer Zhejiang Cancer HospitalHangzhou 310022China

Gastric cancer is a predominant threat to the health and well-being of China's residents. Data from the World Health Organization(WHO) in 2020 revealed that gastric cancer in China notably accounted for 44.0% of new c... 详细信息

关键词： cancer Gastric gastric

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Assessment of large-scale multiple forest disturbance susceptibilities with AutoML framework: an Izmir Regional Forest Directorate case

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Journal of Forestry Research 2024年第4期35卷 73-88页

作者： Remzi Eker Kamber can Alkiş Abdurrahim Aydın Department of Forest Engineering Faculty of ForestryIzmir KatipÇelebi University35620 IzmirTurkey Graduate School of Natural and Applied Sciences Izmir KatipÇelebi University35620 IzmirTurkey Department of Forest Engineering Faculty of ForestryDüzce University81620 DüzceTurkey

Disturbances such as forest fires,intense winds,and insect damage exert strong impacts on forest ecosystems by shaping their structure and growth dynamics,with contributions from climate ***,there is a need for reliable and operational methods to monitor and map these disturbances for the development of suitable management *** susceptibility assessment using machine learning methods has increased,most studies have focused on a single ***,there has been limited exploration of the use of“Automated Machine Learning(AutoML)”in the *** this study,susceptibility assessment for multiple forest disturbances(fires,insect damage,and wind damage)was conducted using the PyCaret AutoML framework in the Izmir Regional Forest Directorate(RFD)in *** AutoML framework compared 14 machine learning algorithms and ranked the best models based on AUC(area under the curve)*** extra tree classifier(ET)algorithm was selected for modeling the susceptibility of each disturbance due to its good performance(AUC values>0.98).The study evaluated susceptibilities for both individual and multiple disturbances,creating a total of four susceptibility maps using fifteen driving factors in the *** to the results,82.5%of forested areas in the Izmir RFD are susceptible to multiple disturbances at high and very high ***,a potential forest disturbances map was created,revealing that 15.6%of forested areas in the Izmir RFD may experience no damage from the disturbances considered,while 54.2%could face damage from all three *** SHAP(Shapley Additive exPlanations)methodology was applied to evaluate the importance of features on prediction and the nonlinear relationship between explanatory features and susceptibility to disturbance.

关键词： AutoML Forest disturbances Forest fire Insect Susceptibility Wind

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Cas13d-mediated gene knockdown in CAR T cells:towards off-the-shelf cancer treatment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1796-1798页

作者： Midori Johnston Nadine Urban can Dincer FIT Freiburg Centre for Interactive Materials and Bioinspired Technology University of FreiburgFreiburgGermany IMTEK-Department of Microsystems Engineering University of FreiburgFreiburgGermany

In a recent study published in Cell,Tieu et *** RfxCas13d to dynamically enhance performance and longevity of chimeric antigen receptor(CAR)T cells by massively multiplexed gene knockdown and thereby,move the treatmen... 详细信息

关键词： treatment shelf

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A visible-light-assisted Pd/TiO_(2)gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

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Rare Metals 2024年第1期43卷 257-266页

作者： can Liu Qiao-Qiao Zou Bin Liu Yong Zhang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Owing to the ppb-level detection standard toward the toxic and harmful gas,the detection of trace gases has become an important subject in the field of indoor environment ***,the traditional resistive gas sensors hardly meet the requirement due to the weak signal generated by trace gas molecules that are difficult to ***,a visible-light-assisted Pd/TiO_(2)gas sensor is proposed to endow the effective detection of trace formaldehyde(HCHO)gas without heating *** from the enhanced photocatalytic properties of TiO_(2)by Pd decoration,the visible-light-assisted Pd/TiO_(2)gas sensor can detect the HCHO gas as low as80×10^(–9)at room *** successful preparation of nanoscale TiO_(2)sensing layer is facilitated by the ultrathin carbon nanotube interdigital electrode in the gas sensor,which avoids the discontinuity of the sensing layer caused by the excessive thickness of the traditional metal *** addition,the whole preparation process of the Pd/TiO_(2)gas sensor with carbon nanotube electrodes is compatible with mainstream CMOS fabrication technology,which is expected to realize the batch fabrication and micro-integrated application of gas *** is expected that our work can provide a new strategy for the batch preparation of high-performance trace HCHO gas sensors and their future applications in portable electronic devices such as smartphones.

关键词： Visible-light-assisted gas sensor Pd/TiO_(2) Trace HCHO detection Carbon nanotubes electrodes

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