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Reviewing the insights of SARS-CoV-2:Its epidemiology,pathophysiology,and potential preventive measures in traditional medicinal system

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Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 96-110页

作者： Munish sharma Amit Kumar sharma simran sharma Arvind Kumar sharma Munish sharma Kamal Kant sharma Munit sharma Department of Plant Sciences Central University of Himachal PradeshShahpurKangra176206Himachal PradeshIndia Department of Animal Science Central University of Himachal PradeshShahpur Campus176206KangraIndia Department of Earth and Environmental Sciences Central University of Himachal PradeshShahpur Campus176206KangraIndia Department of Zoology and Environmental Science Gurukula Kangri(Deemed to be University)Haridwar249404UttarakhandIndia Department of Botany and Microbiology Gurukula Kangri(Deemed to be University)Haridwar249404UttarakhandIndia Department of Botany Thakur P.G.College of EducationDhaliara177103DehraHimachal PradeshIndia

Background:The severe acute respiratory syndrome Coronavirus-2 causing COVID-19 viral infection was first reported in late December 2019,spreading swiftly across all over the *** declared it a pandemic by March *** problems emerged worldwide healthcare system and economic burden due to viral *** transmission rate and infectious nature make COVID-19 *** managing outbreak and controlling spread is *** valiant efforts to contain the COVID-19 outbreak,the situation has deteriorated to the point that there were no viable preventive therapies to treat this *** effective treatment for COVID-19 has been a complex and ongoing ***:The aim of this systematic review is to evaluate the structure,epidemiology,pathophysiology,po-tential therapeutic treatments,and preventive measures adopted in Traditional Chinese Medicine(TCM)in the management of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)***:A systematic methodology has been adopted in this study following PRISMA *** key-words like“COVID-19”“SARS-CoV-2”“Coronavirus”and“Traditional Chinese Medicine”were searched in var-ious databases like ScienceDirect,Google Scholar,PubMed,and ResearchGate during the time span of *** trials and studies relevant to this study were identified through a systematic search strategy fol-lowing PRISMA ***:In this systematic review,after careful evaluation and reviewing of literature through PRISMA guidelines,145 relevant studies were identified,reviewed and included in this systematic review.A detailed study has been summarized on virus structure,etiology,epidemiology characteristics,pathophysiology,and potential therapeutic treatments and preventive measures adopted in traditional medicinal system in the treatment of infected COVID-19 ***:SARS-CoV-2 transmission dynamics and pathogenesis were revealed by the etiology ***-

关键词： COVID-19 SARS-CoV-2 Structure Epidemiology Pathophysiology Traditional medicine

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Effect of Purified Paper Wasp Ropalidia marginata Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

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Advances in Enzyme Research 2023年第3期11卷 113-145页

作者： simran sharma Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present, investigation effects of sub-lethal dose of purified paper wasp Ropalidia marginata venom toxins were evaluated on important metabolic enzymes i.e. ALP ACP, GPT, GOT, LDH, and AchE enzyme activity in serum, liver, and gastrocnemius muscles of albino mice. Alkaline phosphatase was found to be increased up to 119.9% at the 6th hr of the toxin injection in comparison to control. This elevation may be due to cytolysis. Maximum increase i.e., 153.33% level of glutamate pyruvate transaminase (GPT) was found at 6 hrs of 40% of 24-h LD50 treatment while it was found to be 151.1% at 6 hrs of 24 hr 80% of LD50, venom injection. A significant elevation was observed in LDH activity in serum, liver, and muscles, while the activity of AchE was decreased in serum, liver, and gastrocnemius muscles of albino mice after injecting the sub-lethal dose of Ropalidia marginata venom. This increase in the activity of LDH produces liver damage, massive disintegration and necrosis of hepatic cells. This elevation in LDH level led to a significant increase in the glucose catabolism and elevated oxidative stress in muscle and liver cells. It also displays insufficient oxygen supply and consequently leads to cell death. In experimental animals, venom toxin treatment decreased AchE level, and animals showed muscular paralysis. When mice were treated with 40% and 80% of 24-h LD50 of purified venom caused a significant (p < 0.05) elevation in the level of ACP, GOT, GPT, and LDH while the reduction in ALP and AChE level. Present study will be useful in the development of prototypes for study of pharmacological and therapeutic effects of various venom toxins. For this purpose structure activity relationship of enzyme and venom toxin, its due interaction to various metabolic enzymes and receptors must be explored.

关键词： Ropalidia marginata Serum Liver and Rectus Abdominis Gastrocnemius Muscle Atria and Ventricle Acid Phosphatase (ACP) Alkaline Phosphatase (ALP) Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) Lactic Dehydrogenase (LDH) Acetylcholinesterase (AchE)

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Effect of Purified Paper Wasp Ropalidia marginata Venom Toxins on Different Biomolecules in Mice Serum

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Journal of Biosciences and Medicines 2023年第5期11卷 55-75页

作者： simran sharma Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

This study evaluated the effects of purified paper wasp Ropalidia marginata venoms on various biomolecules in the blood serum of albino mice. Changes in the concentration of some important macromolecules, i.e., proteins, free amino acids, uric acid, cholesterol, pyruvic acid, total lipids and glucose were noted down. These alterations were measured after intraperitoneal injection of 40% and 80% 24-hour LD50 purified Ropalidia marginata venom toxin. Serum total protein levels were found to decrease to 78% after 6 hrs, while serum free amino acid levels were significantly increased to 117% 6 hrs after venom injection compared to control. It was also found that serum uric acid levels increased to 138% after 8 hrs of venom injection compared to control. The increase in serum cholesterol i.e. (101% and 106%) and pyruvic acid increased significantly to a maximum value of 106% after 6 hrs of treatment at 40% LD50. Glycogen levels in the gastrocnemius muscle were found to decrease significantly (p-0.05) to 43% and 92% at LD50 after injection of purified Ropalidia marginata venom after 8 h and 80% at LD50 compared to control. Moreover, up to 71% and 81% were obtained at 10 hrs of treatment with the same dose. In the present study, the purified toxins significantly changed the levels of biomolecules in blood serum, indicating their wider effects on cellular physiology due to toxic effects and stress on the animal. These toxins can be good antigens and stimulate immune responses in experimental mice.

关键词： Paper Wasp Venom and Toxin Lethal Effects Blood Serum Biomolecules

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Data mining-based algorithm for assortment planning

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Journal of Management Analytics 2020年第3期7卷 443-457页

作者： Praveen Ranjan Srivastava Satyendra sharma simran Kaur Information Technology Indian Institute of Management(IIM)RohatakRohtakIndia Operation and Supply Chain Birla Institute of Technology and Science(BITS)PilaniPilaniRajasthanIndia Computer Science Birla Institute of Technology and Science(BITS)PilaniPilaniRajasthanIndia

With increasing varieties and products,management of limited shelf space becomes quite difficult for ***,an efficient product assortment,which in turn helps to plan the organization of various products across limited shelf space,is extremely important for *** can be distinguished based on quality,price,brand,and other attributes,and decision needs to be made about an assortment of the products based on these *** efficient assortment planning improves the financial performance of the retailer by increasing profits and reducing operational *** techniques can be very effective in grouping products,stores,*** help managers solve the problem of assortment *** paper proposes data mining approaches for assortment planning for profit maximization with space,and cost constraints by mapping it into well-known knapsack problem.

关键词： Retail assortment SKU rationalization data mining

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A review on re-emerging bacteriophage therapy in the era of XDR

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生物细胞(英文) 2023年第9期47卷 1915-1930页

作者： POOJA BHADORIYA RICHA sharma REKHA MEHROTRA simran KAUR ISHA SRIVASTAVA MUKUL JAIN PRASHANT KAUSHIK Department of Microbiology Shaheed Rajguru College of Applied Sciences for WomenUniversity of DelhiVasundhara EnclaveNew Delhi110096India Lab-209 Cell&Developmental biology labCenter of Research for DevelopmentParul UniversityVadodara391760GujaratIndia Instituto de Conservacióny Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaValencia46022Spain

In the present medicine world antibiotic resistance is one of the key threats to universal health *** continue to work hard to combat this global health *** therapy,an age-old practice during the early twentieth century,was outshined by the discovery of *** the advent of widespread antibiotic resistance,phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria *** side effects,the ability to migrate to different body organs,a distinct mode of action,and proliferation at the infection site,make phages a profitable candidate to replace conventional *** progressive outcome of numerous in vitro studies and case reports has validated the clinical efficacy of phage *** bright perspective of using phages to treat bacterial infections has fueled enormous medical research to exploit their potential as *** gaps in the information about phages and the lack of consent for clinical trials is major hurdle for consideration of phage *** phage therapy as a reality in medicine requires a coordinated effort from different *** this review,we aim to emphasize the importance of phage therapy in modern *** review explains their historical journey,basic phage biology,cross-talk with the host immunity,obstacles with phage therapy,and their possible *** data on the various significant clinical trials of phage therapy has been *** evaluated the efficacy of antibiotics and phage therapy in part and in combination,along with recent progress and future perspectives of phage therapy.

关键词： Bacteriophages Antibiotic resistance Phage biology Phage therapy Phage therapy clinical trials Phage therapy in India

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CFOA Based Band Pass and Band Stop Ladder Filter—A New Configuration

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Circuits and Systems 2016年第1期7卷 29-42页

作者： Praween K. Sinha Neelam sharma simran Agarwal Sudipto Saha Electronics and Communication Department Maharaja Agrasen Institute of Technology New Delhi India

A new technique for the conversion of ladder based filter into CFOA based filter has been proposed. The technique uses signal flow graph and converts the existing LC ladder based filter into band pass & band stop configurations. The design of band pass and band stop filter has been realized using the proposed technique. The proposed configuration is implemented using CFOA as an active device and all the capacitors are grounded. CFOA based circuits have greater linearity, high dynamic rate, high slew rate and high signal bandwidth. Simulation has been carried out using simulation software P Spice (v10.1). The simulation results have been demonstrated and discussed.

关键词： CFOA-Current Feedback Operational Amplifier Ladder Filter Signal Flow Graph Current Mode Voltage Mode Band Pass Filter Band Stop Filter

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