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孕早期末游离人绒毛膜促性腺激素β亚基、母体妊娠相关血浆蛋白A和颈部半透明厚度与胎儿宫内发育迟缓及其他妊娠不良结局的相关性研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 20-21页

作者： Krantz D. Goetzl l. simpson j.l. 侯巍

The purpose of this study was to determine the association between first trimester trisomy 21 screening markers (free human chorionic gonadotropin- β ., pregnancy associated plasma protein A , and nuchal translucency) and adverse pregnancy outcome. This was a cohort study of 8012 patients enrolled in a National Institute of Child Health and Human Development sponsored study of first trimester trisomy 21 and 18 screening. Trisomy 21 and 18 risk results and individual marker levels in unaffected pregnancies and pregnancies with adverse outcomes were evaluated. PAPP- A le (OR 5.4, 95% CI 2.8- 10.3) and PAPP- A le (OR 2.7, 95% CI 1.9- 3.9) and free β - hCG le (OR 2.7, 95% CI 1.3- 5.9) were associated with increased risk of intrauterine growth restriction (IUGR) with positive predictive values of 24.1% , 14.1% , and 14.3% , respectively. PAPP- A le (OR 2.3 95% CI 1.1- 4.7) and nuchal translucency >99th percentile (OR 3.5, 95% CI 1.1- 11.3) were associated with increased risk of preterm delivery before 34 weeks. Increased risk at screening for trisomy 21 and 18 identified 16 of the 29 other chromosomal abnormalities (55% ). low free β - hCG, low PAPP- A, and increased nuchal translucency were all associated with an increased rate of fetal abnormality. Extreme values of first trimester free β - hCG, PAPP- A, and nuchal translucency are all associated with adverse outcomes. The especially high predictive value for IUGR of PAPP- A levels below the 1st percentile suggests that patients within this group may benefit from increased surveillance for this condition.

关键词：妊娠不良结局染色体异常异常染色体筛查指标百分位数畸形发生率指标水平周前预测价值人类发展学

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.l.e Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

A MICROMECHANICAl MODEl FOR γ-TiAl BASE PST CRYSTAlS

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Acta Metallurgica Sinica(English letters) 2005年第6期18卷 686-694页

作者： j.l. Su G.K. Hu School of Mechanics-Electrics Engineering Fujian Agriculture and Forestry University Fuzhou 350002 China Department of Applied Mechanics Beijing Institute of Technology Beijing 100081 China

An analytical micromechanical method is proposed to examine the dependence of plastic deformation on the microstructure for a PST crystal. The sub-domain microstructure of the γ phase and the effect of the α2 phase are taken into account by a proper micromechanical formulation, the dislocation slip and twinning deformation mechanisms are considered in the context of crystal plasticity. The model can well predict the dependence of stress-strain relations on loading angle with respect to the microstructure. The influence of the twinning and lamellar spacing on the deformation behavior and biaxial yield surfaces for PST crystals are also examined.

关键词： TiAI alloy crystal plasticity micromechanical model yield surface

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

A Note on the Relationship Between Temperature and Water Vapor over Oceans, Including Sea Surface Temperature Effects

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Advances in Atmospheric Sciences 2006年第1期23卷 141-148页

作者： C.-l. SHIE W.-K. TAO j. simpson Goddard Earth Sciences and Technology Center University of MarylandBaltimore CountyBaltimoreMaryland 21250USA Laboratory for AtmospheresNASA Goddard Space Flight CenterGreenbeltMaryland 20771USA laboratory for Atmospheres NASA Goddard Space Flight CenterGreenbeltMaryland 20771USA

An ideal and simple formulation is successfully derived that well represents a quasi-linear relationship found between the domain-averaged water vapor, Q （ram）, and temperature, T （K）, fields for the three tropical oceans （i.e., the Pacific, Atlantic and Indian Oceans） based on eleven GEOS-3 [Goddard Earth Observing System （EOS） Version-3] global re-analysis monthly products. A Q - T distribution analysis is also performed for the tropical and extra-tropical regions based on in-situ sounding data and numerical simulations [GEOS-3 and the Goddard Cumulus Ensemble （GCE） model]. A similar positively correlated Q - T distribution is found over the entire oceanic and tropical regions; however, Q increases faster with T for the former region. It is suspected that the tropical oceans may possess a moister boundary layer than the Tropics. The oceanic regime falls within the lower bound of the tropical regime embedded in a global, curvilinear Q - T relationship. A positive correlation is also found between T and sea surface temperature （SST）; however, for one degree of increase in T, SST is found to increase 1.1 degrees for a warmer ocean, which is slightly less than an increase of 1.25 degrees for a colder ocean. This seemingly indicates that more （less） heat is needed for an open ocean to maintain an air mass above it with a same degree of temperature rise during a colder （warmer） season [or in a colder （warmer） region]. Q and SST are also found to be positively correlated. Relative humidity （RH） exhibits similar behaviors for oceanic and tropical regions. RH increases with increasing SST and T over oceans, while it increases with increasing T in the Tropics. RH, however, decreases with increasing temperature in the extratropics. It is suspected that the tropical and oceanic regions may possess a moister local boundary layer than the extratropics so that a faster moisture increase than a saturated moisture increase is favored for the former regions. T, Q, saturated water v

关键词： moisture temperature relationship quasi-equilibrium states Tropics oceans

Diorgano, Dichloro-tin (IV) Complexes of 4-X-Benzohydroxamic Acid (X=Cl, OCH_3): Synthesis, Characterization, Antitumor Activity in Vitro and the Crystal Structure of trans- [Me_2Sn (l_2) _2]

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Chinese Chemical letters 2003年第8期14卷 840-843页

作者： jing Hua ZHAO Tai Gang lIANG Qing Shan lI Armando j.l. Pombeiro SchoolofPharmaceuticalScience ShanxiMedicalUniversityTaiyuan030001

A series of diorganotin (IV) derivatives of R2Snl2 (R = Me, Et, n-Bu, ph or Cl; l = l1 or l2) and their corresponding mixed-ligand complexes R2Sn (l1)(l2) have been prepared and the structure of trans-Me2Sn (l2) 2 was characterized by FT-IR, 1H, 13C and 119Sn NMR spectroscopies, MS, elemental analysis, melting points and X-ray diffraction. The structure-activity relationships were discussed.

关键词： Diorganotin X-ray diffraction antitumor activity synthesis.

NUMERICAl STUDY OF TURBUlENT IMPINGING jET WITH A REFINED k-ε MODEl

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journal of Hydrodynamics 2000年第4期12卷 8-15页

作者： Xu, j.l. Xu, Z. Huang, S.j. Zhang, K.Y. Xiao, M. 2nd Dep. Nanjing Univ. of Aeron. and Astron. Nanjing 210016 China

A refined k-Ε model re-considering the fluctuating pressure diffusion term in the dissipation rate equation (Ε-equation) is provided and used in the numerical study of circular semi-confined turbulent impinging jet. The results are compared with those of the standard k-Ε model and show that the predicting ability of the refined k-Ε model is much improved, especially for the turbulent kinetic energy k. So it is necessary to consider the effect of the fluctuating pressure diffusion term and to model this term correctly and exactly in the near wall region with the great adverse pressure gradient, where the effect of the pressure fluctuating is important. Therefore we can conclude that the new modeling idea expressed in this paper is correct and effective.

关键词： Computer simulation jets Mathematical models Turbulence

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell lines

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： Edward simpson Steven Chen j.l. l.Reiter Yunlong liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBGlM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ElAVl RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBGlM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine