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Growth, Duplication and Lateral Mutual Compressive Deformation of Akouemma hemisphaeria on the Seafloor of Okondja Basin at 2.2 Ga (Gabon)

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International Journal of Geosciences 2017年第9期8卷 1172-1191页

作者： Ambroise Edou-Minko Mathieu Moussavou Tomohiko Sato Yusuke Sawaki simplice ndong ondo Richard Maire Guillaume Fleury Michel Mbina Mounguengui Anders Kaestner Richard Ortega Stéphane Roudeau Asuncion Carmona Makaya Mvoubou Benjamin Musavu Moussavou Osamu Sasaki Shigenori Maruyama Université des Sciences et Techniques de Masuku Franceville Gabon Earth-Life Science Institute (ELSI) Tokyo Institute of Technology Tokyo Japan Department of Earth Science and Astronomy Graduate School of Arts and Sciences The University of Tokyo Tokyo Japan UMR 5319 Passages Maison des Suds CNRS-Université Bordeaux-Montaigne Pessac France Muséum d’Histoire Naturelle de Toulouse Toulouse France Laboratory for Neutron Scattering and Imaging Paul Scherrer Institut Villigen Switzerland CENBG Univ. Bordeaux CNRS IN2P3 UMR 5797 Gradignan France Tohoku University Museum Université de Tohoku Sendai Japan

A colony of macro-fossils Akouemma hemisphaeria has been described in the Paleoproterozoic sedimentary basin of Okondja, Gabon. These fossils are classified into two groups according to their spheroidal or elongated forms. The spheroidal shapes are similar, have a tripartite structure with two hemispheres and a median disc and gradually pass to the elongated forms. These elongated forms have a pronounced bipartite tendency to two “hemispheres” separated by a median surface, and often have several ovoid “pieces” attached. The elongated specimens show both lateral growth marks and signs of fission. Growth marks are characterized by unidirectional homogeneous side elongations and lateral bud-like protuberances. The signs of fission are marked by circular furrows perpendicular to the direction of elongation, called “constriction furrows” with varying depths depending on the degree of fission of the specimen and internal vertical “division planes”. All of these ovoid and elongated specimens have undergone significant initial deformations due mainly to mutual lateral compressions in tabular beds. The Akouemma hemisphaeria macro-organisms, which were primitive probably sessile organisms, lived on the seafloor. They provide the oldest known record of macro-organisms on Earth having vegetative growth and asexual reproduction by budding, lateral elongation and fission. Their mutual lateral deformations would result from their growth.

关键词： Paleoproterozoic Francevillian Group Okondja Basin Akouemma hemisphaeria Growth Duplication

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Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 209-216页

作者： Cédric Sima Obiang Rick Léonid Ngoua Meye Misso Guy Roger ndong Atome Joseph Privat ondo Louis Clément Obame Engonga Edouard Nsi Emvo Laboratory of Research in Biochemistry University of Sciences and Technology of Masuku Laboratory of Natural Substances and Organometallic Synthesis University of Sciences and Technology of Masuku

Objective: To evaluate the phytochemical constituents, antimicrobial and antioxidant activities of the extracts of Distemonanthus benthamianus(D. benthamianus) stem bark and Solanum torvum(S. torvum) fruit which have been used as traditional medicinal herbs in Gabon. Methods: Plant extracts were subjected to a qualitative study(phytochemical screening) and a quantitative(dosing) study of secondary metabolites. Antioxidant activity was tested by 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid assay. Bacteria and fungi susceptibility tests were performed on Mueller Hinton medium and solid Sabouraud, respectively, using the diffusion method, while minimum inhibitory concentration, minimum fungicidal concentration and minimum bactericidal concentration were evaluated by microdilution ***: The total phenol and tannin contents were significantly higher in the water-ethanol extract compared to the other extracts of D. benthamianus and S. torvum. The water-ethanol and water-acetone extracts showed significantly higher antioxidant activity than the aqueous extracts of the two medicinal plants. However, the extracts presented weak antioxidant activities compared to standards(Vitamin C, BHA). The water-acetone and water-ethanol extracts of S. torvum showed the highest antimicrobial activity against Bacillus cereus LMG 13569 BHI, Shigella dysenteriae 5451 CIP, Shigella dysenteriae and Neisseria gonorrhoeae. Conclusions: Our results show that D. benthamianus and S. torvum can be promising sources of natural products with potential antimicrobial and antioxidant activities.

关键词： Antioxidants Phytochemical Antimicrobial Distemonanthus benthamianus Solanum torvum

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Hypospadias: Evaluation of Therapeutic Outcomes and Sexual Function in Adulthood in a University Hospital Setting

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Open Journal of Urology 2020年第9期10卷 245-252页

作者： El Hadji Malick Diaw Modou Ndiaye Ousmane Sow Abdoulaye Ndiath Alioune Sarr Boubacar Fall Babacar Sine Aboubacar Traore bdourahmane ndong Cyrille Ze ondo Amath Thiam Oumar Gaye Ndiaga Seck Ndour Ngor Mack Thiam Yaya Sow Babacar Diao Papa Ahmed Fall Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal Departement of Surgery Gaston Berger University Saint-Louis Senegal Urology-Andrology Department Dalal Jamm Hospital Dakar Senegal

Background: Hypospadias is a congenital malformation resulting from hypoplasia of the tissues forming the ventral face of the penis. It is associated to variable degrees with an ectopic urethral meatus, a penis curvature and a sapper’s apron foreskin [1]. The incidence of this malformation varies from country to country. It is estimated at 1/300 male births in France and 0.26/ 1000 in Mexico [1]. In Senegal, the prevalence of this malformation is unknown. Hypospadias surgery has improved significantly in recent years due to a better understanding of the anatomy on the one hand and the improvement of the instruments used during surgery on the other (suture material, surgical magnification, urethral catheter of suitable size). In sub-Saharan Africa and particularly in Senegal, hypospadias surgery remains a challenge due to the unavailability of adequate equipment (lack of microsurgical instruments and surgical loupes). Objective: To evaluate the outcomes of the treatment of hypospadias by the different surgical techniques used in our center as well as their sexual function in adulthood. Patients and Methods: This is a retrospective study, including all patients operated for hypospadias between January 2009 and December 2017 in Urology-Andrology department of Aristide Le Dantec hospital. The studied parameters were: frequency, age, clinical and therapeutic aspects, and their sexual function in adulthood after treatment. The outcomes of the treatment were judged good or poor depending of the quality of penile straightening, the aesthetic appearance of the penis, the position of the urethral neo-meatus, the permeability of the urethra and the existence or not of fistula. The sexual function was assessed by the International Index of Erectile Function 15 (IIEF) score. Results: Fifty-five patients were included. The median age was 6 years (P25 = 2.8 and P75 = 13 year

关键词： Urogenital Malformation Penile Enlargement Urethroplasty Urethrocutaneous Fistula

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Higher IL-8 Response to <i>Mycobacterium tuberculosis</i>Antigens in Women above 40 Years

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Journal of Tuberculosis Research 2021年第4期9卷 266-275页

作者： Marielle Leboueny Priscillia Virginie Liesse Mbourou Mensah Paulin N. Essone Anicet Christel Maloupazoa Siawaya Amel Kévin Alame-Emane Amandine Mveang Nzoghe Dimitri Ulrich Essamazokou Carene Anne ndong Sima Sima Ofilia Mvoundza Ndjindji Guy-Stéphane Padzys Joseph Privat ondo Brigitte Gicquel Joel Fleury Djoba Siawaya Service Laboratoire Centre Hospitalier Universitaire Mère Enfant Fondation Jeanne EBORI Libreville Gabon Département de chimie Faculté des Sciences Université des Sciences et Techniques de Masuku Franceville Gabon Centre de Recherches Médicales de Lambaréné BP 242 Lambaréné Gabon Unité des Recherche et de Diagnostic Spécialisé Laboratoire National de Santé Publique Libreville Gabon Department of Biomedical Sciences Division of Molecular Biology and Human Genetics Faculty of Medicine and Health Sciences Stellenbosch University Stellenbosch South Africa Département de Biologie Faculté des Sciences Université des Sciences et Techniques de Masuku Franceville Gabon Unité de Génétique Mycobactérienne Institut Pasteur Paris France

Objective: Circulating levels of sex hormones vary with age. Moreover, there is emerging evidence supporting that sex hormones have an influence on the immune response of women. Here, we investigated age-associated levels of sex hormones and Mycobacterium tuberculosis (Mtb) specific cytokines response in women. Design: Using immunoassay methods, we have measured and compared secretion levels of E2, P4 and Mtb specific secretion of 11 cytokines including Granulocyte-macrophage colony-stimulating factor (GM-CSF), Interferon gamma (IFN-γ), Interleukin 1 beta (IL-1β), IL-10, IL-12 (p70

关键词： IL-8 Mycobacterium tuberculosis Estradiol (E2) Progesterone (P4)

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