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Nuclear receptors and pathogenesis of pancreatic cancer

World Journal of Gastroenterology 2014年第34期20卷 12062-12081页

作者： simone Polvani Mirko Tarocchi Sara Tempesti Andrea Galli Department of Experimental and Clinical Biomedical Sciences University of Florence50134 FlorenceItaly

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a median overall survival time of 5 mo and the five years survival less than 5%, a rate essentially unchanged over the course of the years. A well defined progression model of accumulation of genetic alterations ranging from single point mutations to gross chromosomal abnormalities has been introduced to describe the origin of this disease. However, due to the its subtle nature and concurring events PDAC cure remains elusive. Nuclear receptors (NR) are members of a large superfamily of evolutionarily conserved ligand-regulated DNA-binding transcription factors functionally involved in important cellular functions ranging from regulation of metabolism, to growth and development. Given the nature of their ligands, NR are very tempting drug targets and their pharmacological modulation has been widely exploited for the treatment of metabolic and inflammatory diseases. There are now clear evidences that both classical ligand-activated and orphan NR are involved in the pathogenesis of PDAC from its very early stages; nonetheless many aspects of their role are not fully understood. The purpose of this review is to highlight the striking connections that link peroxisome proliferator activated receptors, retinoic acid receptors, retinoid X receptor, androgen receptor, estrogen receptors and the orphan NR Nur, chicken ovalbumin upstream promoter transcription factor II and the liver receptor homologue-1 receptor to PDAC development, connections that could lead to the identification of novel therapies for this disease.

关键词： Peroxisome proliferator activated receptor Pancreatic intraepithelial neoplasia COUP-TFⅡ Nuclear receptors Orphan nuclear receptor Nuclear receptors 4A2 Nuclear receptors 2F2 Pancreatic cancer Retinoid X receptor Testicular receptor 3

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Entanglement and discord assisted entropic uncertainty relations under decoherence

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Science China(Physics,Mechanics & Astronomy) 2014年第9期57卷 1703-1711页

作者： YAO ChunMei CHEN ZhiHua MA ZhiHao SEVERINI simone SERAFINI Alessio Department of Physics and Electronic Science Hunan University of Arts and Science Department of Physics and Astronomy University College London Department of Science Zhijiang College Zhejiang University of Technology Centre for Quantum Technologies National University of Singapore Department of Mathematics Shanghai JiaoTong University Department of Computer Science University College London Gower Street

The uncertainty principle is a crucial aspect of quantum *** has been shown that quantum entanglement as well as more general notions of correlations,such as quantum discord,can relax or tighten the entropic uncertainty relation in the presence of an ancillary *** explored the behaviour of entropic uncertainty relations for system of two qubits—one of which subjects to several forms of independent quantum noise,in both Markovian and non-Markovian *** uncertainties and their lower bounds,identified by the entropic uncertainty relations,increase under independent local unital Markovian noisy channels,but they may decrease under non-unital *** behaviour of the uncertainties(and lower bounds)exhibit periodical oscillations due to correlation dynamics under independent non-Markovian *** addition,we compare different entropic uncertainty relations in several special cases and find that discord-tightened entropic uncertainty relations offer in general a better estimate of the uncertainties in play.

关键词： entropic uncertainty relation entanglement quantum discord decoherence Markovian and non-Markovian reservoirs

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Antiapoptotic activity of 30 kDa lipoproteins family from fat body tissue of silkworm, Bombyx moil

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Insect Science 2015年第5期22卷 629-638页

作者： Britto Cathrin Pakkianathan Nitin Kumar Singh simone Konig Muthukalingan Krishnan Department of Environmental Biotechnology Bharathidasan University Tiruchirappalli India and Integrated Functional Genomics Interdisciplinary Center for Clinical Research University of MEmster Germany

The family of 30kDa lipoproteins （LP1-5） is abundant in silkworm pupa fat body （FB） and hemolymph. One of its members, the 29 kDa protein decreased in concentration from peripheral （PP） FB tissue but was sustained in perivisceral （PV） FB tissue at the time of apoptosis. This study investigated the correlation of the 30kDa proteins with FB apoptosis. Two protein fractions were purified, a 29 and a 30/31 kDa protein fraction, and they were used to test for activity against actinomycin D-induced apoptosis in the FB tissues. Concentrations as little as 50/zg/mL of the 29 kDa protein fraction efficiently inhibited apoptosis. Less antiapoptotie activity was detected for the higher MW fraction; DNA fragmentation was observed in FB tissue treated with 50 #g/mL of the 30/31 kDa fraction. The viability of the cells in the 29 kDa protein-supplemented culture was 40% higher than in the 31 kDa protein-supplemented culture. However, the 30 kDa lipoproteins were not able to prevent scheduled FB degeneration during silkworm metamorphosis. Thus, it is hypothesized that the antiapoptotic 29 kDa protein needs to be proteolytically degraded by a regulatory mechanism to allow programmed cell death of FB tissue.

关键词： actinomycin D apoptosis Bombyx mori fat body tissue 30 kDa proteins

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Large-scale Data Collection and Analysis via a Gamified Intelligent Crowdsourcing Platform

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International Journal of Automation and computing 2019年第4期16卷 427-436页

作者： simone Hantke Tobias Olenyi Christoph Hausner Tobias Appel Bjorn Schuller ZD.B Chair of Embedded Intelligence for Health Care and Wellbeing University of Augsburg Germany Machine Intelligence & Signal Processing Group Technische Universitat München München Germany audEERING GmbH Gilching Germany Group on Language Audio & Music (GLAM) Department of Computing Imperial College London SW7 2AZ UK

In this contribution, we present iHEARu-PLAY, an online, multi-player platform for crowdsourced database collection and labelling, including the voice analysis application (VoiLA), a free web-based speech classification tool designed to educate iHEARu-PLAY users about state-of-the-art speech analysis paradigms. Via this associated speech analysis web interface, in addition, VoiLA encourages users to take an active role in improving the service by providing labelled speech data. The platform allows users to record and upload voice samples directly from their browser, which are then analysed in a state-of-the-art classification pipeline. A set of pre-trained models targeting a range of speaker states and traits such as gender, valence, arousal, dominance, and 24 different discrete emotions is employed. The analysis results are visualised in a way that they are easily interpretable by laymen, giving users unique insights into how their voice sounds. We assess the effectiveness of iHEARu-PLAY and its integrated VoiLA feature via a series of user evaluations which indicate that it is fun and easy to use, and that it provides accurate and informative results.

关键词： Human computation speech analysis crowdsourcing gamified data collection survey

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Microbiota shaping — the effects of probiotics, prebiotics, and fecal microbiota transplant on cognitive functions: A systematic review

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World Journal of Gastroenterology 2021年第39期27卷 6715-6732页

作者： simone Baldi Tiziana Mundula Giulia Nannini Amedeo Amedei Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy SOD of Interdisciplinary Internal Medicine Azienda Ospedaliera Universitaria CareggiFlorence 50134Italy

BACKGROUND Dementia is a chronic progressive neurological disease affecting millions of people worldwide,and represents a relevant economic burden for healthcare *** its pathogenesis is still unknown,recent findings have reported that a dysregulated gut-brain axis communication,a fundamental relationship mediated by several host and microbial molecules,is associated with cognitive *** addition,gut microbiota manipulation reduces neuroinflammation,improving cognitive function by restoring the functional gut-brain *** To better define the effects of probiotics,prebiotics,synbiotics,and fecal microbiota transplant(FMT)on cognitive *** We performed a literature search of human randomized clinical trials to examine the effects of the administration of probiotics,prebiotics,synbiotics,or FMT on cognition outcomes in healthy or sick people of every age,sex,and *** systematically searched Embase,Medline/PubMed,Cochrane Library,central and *** databases with a combination of comprehensive terms related to cognition and gut microbiota *** we carefully reviewed and synthesized the data by type of study design and setting,characteristics of the studied population,kind of intervention(strain type or mixture type,dosage,and frequency of administration),control treatment,inclusion and exclusion criteria,follow-up duration,and cognitive or memory *** After examining the titles and abstracts,the initial literature screening identified 995 articles,but we added 23 papers in our systematic *** analyses of these selected studies highlighted that both probiotic supplementation and FMT improved cognitive function regardless of the type and posology of administration and the adopted cognitive tests and *** found that most of the studies conducted in healthy people showed a significant positive effect of the intervention on at least one of the performed cognitive ***

关键词： Dementia Cognitive disorders Gut microbiota Probiotics Prebiotics Fecal microbiota transplant

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p38α MAPK pathway:A key factor in colorectal cancer therapy and chemoresistance

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World Journal of Gastroenterology 2014年第29期20卷 9744-9758页

作者： Valentina Grossi Alessia Peserico Tugsan Tezil Cristiano simone Division of Medical Genetics Department of Biomedical Sciences and Human Oncology (DIMO)University of Bari "Aldo Moro" National Cancer Institute IRCCS Oncologico Giovanni Paolo Ⅱ Fondazione Mario Negri Sud Santa Maria Imbaro 66030 (CH)Italy

Colorectal cancer (CRC) remains one of the most common malignancies in the world. Although surgical resection combined with adjuvant therapy is effective at the early stages of the disease, resistance to conventional therapies is frequently observed in advanced stages, where treatments become ineffective. Resistance to cisplatin, irinotecan and 5-fluorouracil chemotherapy has been shown to involve mitogen-activated protein kinase (MAPK) signaling and recent studies identified p38α MAPK as a mediator of resistance to various agents in CRC patients. Studies published in the last decade showed a dual role for the p38α pathway in mammals. Its role as a negative regulator of proliferation has been reported in both normal (including cardiomyocytes, hepatocytes, fibroblasts, hematopoietic and lung cells) and cancer cells (colon, prostate, breast, lung tumor cells). This function is mediated by the negative regulation of cell cycle progression and the transduction of some apoptotic stimuli. However, despite its anti-proliferative and tumor suppressor activity in some tissues, the p38α pathway may also acquire an oncogenic role involving cancer related-processes such as cell metabolism, invasion, inflammation and angiogenesis. In this review, we summarize current knowledge about the predominant role of the p38α MAPK pathway in CRC development and chemoresistance. In our view, this might help establish the therapeutic potential of the targeted manipulation of this pathway in clinical settings.

关键词： p38 mitogen-activated protein kinase Chemoresistance Molecularly-targeted drugs Colorectal cancer Cell death

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From blood to breath: New horizons for esophageal cancer biomarkers

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World Journal of Gastroenterology 2016年第46期22卷 10077-10083页

作者： Roger Yazbeck simone E Jaenisch David I Watson Department of Surgery Flinders Centre for Innovation in Cancer Flinders University

Esophageal cancer is a lethal cancer encompassing adenocarcinoma and squamous cell carcinoma subtypes. The global incidence of esophageal cancer is increasing world-wide, associated with the increased prevalence of associated risk factors. The asymptomatic nature of disease often leads to late diagnosis and five-year survival rates of less than 15%. Current diagnostic tools are restricted to invasive and costly endoscopy and biopsy for histopathology. Minimally and non-invasive biomarkers of esophageal cancer are needed to facilitate earlier detection and better clinical management of patients. This paper summarises recent insights into the development and clinical validation of esophageal cancer biomarkers, focussing on circulating markers in the blood, and the emerging area of breath and odorant biomarkers.

关键词： Breath analysis Cancer Micro RNA Noninvasive Esophageal cancer Biomarker

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Slug catcher finger-type CFD simulator for two-phase flow separation

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Petroleum 2019年第2期5卷 133-140页

作者： Alessio Pierro simone Spadoni Francesco Chiappetta Francesco Ferrini Techfem SpA Italy

Slug catcher is an important and costly equipment in the up-stream assets,but is the less supported by research or commercial simulation software in terms of design and sizing *** purpose of this paper is to present a simulation model based on the open-source software for computational fluid-dynamics OpenFOAM®,which can assist during the preliminary sizing,made by the usual simplified methods,proving the fluid-dynamic behaviour and drive the process engineers to an optimum final design by checking all the expected production profiles of the related oil/gas field,for a comprehensive and safe operation all along the reservoir *** slug catcher main function is to ensure the separation of the phases within the acceptance specifications dictated by the process units of downstream CPF(Central Production Facility).The optimization of the slug catcher could allow the reduction of the equipment overall dimensions,that is essential to reduce the capital expenditure and make the installation more *** graphic output is a strong tool in the hand of engineers,following the fluid-dynamic response of the slug catcher in the gas-liquid separation section,in function of the flow pattern at the entrance and superficial velocities of the phases.

关键词： Slug separation flow

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Upstream Operations in the Oil Industry： Rigorous Modeling ofan Electrostatic Coalescer

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Engineering 2017年第2期3卷 220-231页

作者： Francesco Rossi simone Colombo Sauro Pierucci Eliseo Ranzi Flavio Manenti Department of Chemistry Materials and Chemical Engineering "Giulio Natta" Polytechnic University of Milan Milan 20133 Italy Davidson School of Chemical Engineering Purdue University West Lafayette IN 47907-2100 USA

This paper deals with a first-principle mathematical model that describes the electrostatic coalescer unitsdevoted to the separation of water from oil in water-in-oil emulsions, which are typical of the upstreamoperations in oil fields. The main phenomena governing the behavior of the electrostatic coalescer are denscribed, starting from fundamental laws. In addition, the gradual coalescence of the emulsion droplets isconsidered in the mathematical modeling in a dynamic fashion, as the phenomenon is identified as a keystep in the overall yield of the unit operation. The resulting differential system with boundary conditionsis then integrated via performing numerical libraries, and the simulation results confirm the available lit-erature and the industrial data. A sensitivity analysis is provided with respect to the main parameters. Themathematical model results in a flexible tool that is useful for the purposes of design, unit behavior predic-tion. performance rnoniroring, and ontimization.

关键词： Upstream operations Electrostatic coalescer Desalter Rigorous modeling Water-oil emulsion

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A novel approach for manufacturing of layered,ultra-refractory composites using pliable,short fibre-reinforced ceramic sheets

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Journal of Advanced Ceramics 2023年第1期12卷 155-168页

作者： Matteo MOR Antonio VINCI simone FAILLA Pietro GALIZIA Luca ZOLI Diletta SCITI ISSMC-CNR Institute of ScienceTechnology and Sustainability for CeramicsVia Granarolo 6448018 Faenza(RA)Italy

A new additive technique for manufacturing of short fibre-reinforced ultra-refractory ceramics is *** technique allows the fabrication of solvent-free,thin(~100µm),flexible,and easy-to-handle sheets suitable for fabricating homogeneous or layered structures.A large range of compositions,in terms of matrix and fibre volumetric contents,from 0%to 100%is *** amount of short carbon fibres incorporated in the sheets ranged from 20 to 50 vol%,whereas the fibre length ranged from 3 to 5 *** matrix composition investigated with this technique consisted of ZrB_(2)/SiC/Y_(2)O_(3).By increasing the fibre amount from 35 to 50 vol%,an improvement of mechanical properties was ***-point flexural strength(σ)ranged from 107 to 140 MPa,depending on the amount of carbon fibres(Cf).The same holds true for the work of fracture,ranging from 108 to 253 J/m^(2).Functionally graded composites were fabricated by overlapping sheets with a fibre gradient(0%-50%).

关键词： ultra-high-temperature ceramics(UHTCs) ceramic matrix composites(CMCs) short carbon fibres mechanical properties

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