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Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian krötz Alexander Hennrich Michael Spannagl simone köppel Erik Gaitzsch Markus Wörnle Medizinische klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and Munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

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Biologically Inspired Girder Structure for the Synchrotron Radiation Facility PETRA IV

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Journal of Bionic Engineering 2023年第5期20卷 1996-2017页

作者： simone Andresen Norbert Meyners Daniel Thoden Markus körfer Christian Hamm Bionic Lightweight Design&Functional Morphology Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI)Am Handelshafen 1227570BremerhavenGermany Deutsches Elektronen-Synchrotron(DESY) Notkestraße 8522607HamburgGermany

Lightweight structures are widely used across different industry ***,they get easily excited by external influences,such as *** high vibration amplitudes can be avoided by shifting the structural eigenfrequencies,which can be achieved adapting the structural design considering optimisation procedures and structures primarily inspired by *** procedures has been applied to the development process of a girder structure installed in a synchrotron radiation facility to support heavy magnets and other *** objective was to design a 2.9 m long girder structure with high eigenfrequencies,a high stiffness and a low *** on a topology optimisation result,a parametric beam–shell model including biologically inspired structures(e.g.,Voronoi combs,ribs,and soft and organic-looking transitions)was built *** subsequent cross-sectional optimisation using evolutionary strategic optimisation revealed an optimum girder structure,which was successfully manufactured using the casting *** measurements validated the numerical *** changes in the specifications can be implemented in the bio-inspired development process to obtain adapted girder structures.

关键词： Biomimetics Eigenfrequency maximisation Evolutionary structural optimisation Lightweight design Topology optimisation Voronoi combs

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Nonlinear Damped Oscillators on Riemannian Manifolds:Fundamentals

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Journal of Systems Science & Complexity 2016年第1期29卷 22-40页

作者： FIORI simone Dipartimento di Ingegneria dell'Informazione Facolta di IngegneriaUniversita Politecnica delle Marche

The classical theory of mass-spring-damper-type dynamical systems on the ordinary flat space R^3 may be generalized to higher-dimensional Riemannian manifolds by reformulating the basic underlying physical principles through differential *** dynamical systems have been studied in the scientific literature because they arise naturally from the modeling of complex physical structures and because such dynamical systems constitute the basis for several modern applications such as the secure transmission of *** flows of nonlinear dynamical systems may evolve over time in complex,non-repeating(although deterministic) *** focus of the present paper is on formulating the general equations that describe the dynamics of a point-wise particle sliding on a Riemannian manifold in a coordinate-free *** paper shows how the equations particularize in the case of some manifolds of interest in the scientific literature,such as the Stiefel manifold and the manifold of symmetric positive-definite matrices.

关键词： Nonlinear(active/passive) damping nonlinear oscillator Riemannian manifold

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Comparing rockfall hazard and risk assessment procedures along roads for different planning purposes

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Journal of Mountain Science 2020年第3期17卷 653-669页

作者： MINEO simone Department of Biological Geological and Environmental SciencesUniversity of CataniaCorso Italia 5795129CataniaItaly

Hazard and risk assessment procedures of different types of rockfall were analyzed to compare their outcomes when they are applied to the same case *** numerous methodologies are available in literature,rockfall hazard and risk analyses are often limited to standard estimations,affected by a margin of uncertainty,especially when relevant engineering projects are about to be *** on the design purpose,different types of approaches can be chosen among the qualitative and quantitative ones available in literature,which allow different levels of *** of the main criticisms related to rockfall events is the risk affecting linear structures,such as road or railways,due both to their strategic relevance for trade and communications and to the great entity of the exposed value(traffic units)traveling along *** this perspective,a comparison between the qualitative method known as Evolving Rockfall Hazard Assessment(EHRA),the semi-quantitative modified Rockfall Hazard Rating System(RHRS)and the quantitative Rockfall Risk Management(RoMa)approach is herein commented according to a practical application to a case *** is the case of the rockfall threat along slopes crossed by a strategic road connecting two of the most known spots of eastern Sicily(Italy),at the Taormina tourist *** were retrieved from both recent literature and technical surveys on *** results highlight how the approaches are affected by a different level of detail and uncertainty,arising also by some necessary assumption that must be taken into account,especially when mitigation measures or territory planning have to be *** results can be also taken into account for similar studies worldwide,in order to choose the most suitable procedure based on the design *** is indeed crucial in the perspective of the optimization of time and economic resources in the territorial planning practice.

关键词： Rockfall Risk Rockfal hazard Event Tree Analysis Evolving Rockfall Hazard Assessment(EHRA) Rockfall Hazard Rating System(RHRS),Rockfall Risk Management(RoMa)

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A simplified Parisi ansatz

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Communications in Theoretical Physics 2021年第5期73卷 92-101页

作者： simone Franchini Sapienza Universita di Roma 1 Piazza Aldo Moro00185 RomaItaly

Based on simple combinatorial arguments,we formulate a generalized cavity method where the Random Overlap Structure(ROSt)probability space of Aizenmann,Sims and Starr is obtained in a constructive way,and we use it to... 详细信息

关键词： Sherrington–kirkpatrick model cavity methods Parisi formula

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Measurements of Non-reacting and Reacting Flow Fields of a Liquid Swirl Flame Burner

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Chinese Journal of Mechanical Engineering 2015年第2期28卷 394-401页

作者： CHONG Cheng Tung HOCHGREB simone Faculty of Mechanical Engineering Universiti Teknologi Malaysia Department of Engineering University of Cambridge

The understanding of the liquid fuel spray and flow field characteristics inside a combustor is crucial for designing a fuel efficient and low emission *** of the flow field of a model gas turbine liquid swirl burner is performed by using a2-D particle imaging velocimetry（PIV）*** flow field pattern of an axial flow burner with a fixed swirl intensity is compared under confined and unconfined conditions,i.e.,with and without the combustor *** effect of temperature on the main swirling air flow is investigated under open and non-reacting *** result shows that axial and radial velocities increase as a result of decreased flow density and increased flow *** flow field of the main swirling flow with liquid fuel spray injection is compared to non-spray swirling *** of liquid fuel spray changes the swirl air flow field at the burner outlet,where the radial velocity components increase for both open and confined *** reacting condition,the enclosure generates a corner recirculation zone that intensifies the strength of radial *** reverse flow and corner recirculation zone assists in stabilizing the flame by preheating the *** flow field data can be used as validation target for swirl combustion modelling.

关键词： flow field swirl flame gas turbine burner particle imaging velocimetry(PIV)

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A Bioinspired Robot Growing like Plant Roots

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Journal of Bionic Engineering 2023年第5期20卷 2044-2058页

作者： Giovanni Bianchi Aldo Agoni simone Cinquemani Department of Mechanics Politecnico di MilanoVia La Masa 1Milano20156LombardiaItaly

Plants are usually considered static organisms,but they can perform a wide range of movements that can be a source of inspiration for *** roots’growing motion is the most noteworthy since they are excellent diggers that can move in unstructured environments and navigate past ***,root growth has a high energy efficiency since it penetrates the soil at its tip,adding new material without displacing the already grown portion,minimizing the energy dissipation due to friction and lowering the inertia.A robot inspired by the growth of roots could be used in search and rescue or environmental *** design of a soft robot inspired by root growth is presented in this *** robot body consists of a cylindrical plastic membrane folded inside *** robot body is inflated,and its tip is everted,expanding its length as air is blown from the *** straps are placed on the membrane’s exterior surface to keep it *** head is positioned inside the tip,which houses the mechanism that controls the growth *** consists of housing for two balloons that are selectively inflated,and their expansion applies pressure on the exterior surface,opening the Velcro straps and determining the growth *** robot was constructed,and a kinematic model of its motion in the plane was created and compared with experimental *** error in predicting the turning angle is only 5%,and the resulting predicted position differs on average by 55 mm on a total length of 850 mm.

关键词： Soft robot Pneumatic actuation Bioinspired robot Growing robot Plant root

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Nano-precision metrology of X-ray mirrors with laser speckle angular measurement

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Light(Science & Applications) 2021年第10期10卷 1915-1927页

作者： Hongchang Wang simone Moriconi kawal Sawhney Diamond Light Source Ltd Harwell Science and Innovation CampusDidcot OX110DEUK Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK

X-ray mirrors are widely used for synchrotron radiation,free-electron lasers,and astronomical *** short wavelength and grazing incidence impose strict limits on the permissible slope *** polishing techniques have already produced mirrors with slope errors below 50 nrad root mean square(rms),but existing metrology techniques struggle to measure ***,we describe a laser speckle angular measurement(SAM)approach to overcome such *** also demonstrate that the angular precision of slope error measurements can be pushed down to 20nrad rms by utilizing an advanced sub-pixel tracking ***,SAM allows the measurement of mirrors in two dimensions with radii of curvature as low as a few hundred ***,the instrument based on SAM is compact,low-cost,and easy to integrate with most other existing X-ray mirror metrology instruments,such as the long trace profiler(LTP)and nanometer optical metrology(NOM).The proposed nanometrology method represents an important milestone and potentially opens up new possibilities to develop next-generation super-polished X-ray mirrors,which will advance the development of X-ray nanoprobes,coherence preservation,and astronomical physics.

关键词： millimeter metrology speckle

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A combined technique of kalman filter, artificial neural network and fuzzy logic for gas turbines and signal fault isolation

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Chinese Journal of Aeronautics 2021年第2期34卷 124-135页

作者： simone TOGNI Theoklis NIkOLAIDIS Suresh SAMPATH Department of Power and Propulsion Cranfield UniversityCranfield MK-43United Kingdom

The target of this paper is the performance-based diagnostics of a gas turbine for the automated early detection of components malfunctions. The paper proposes a new combination of multiple methodologies for the performance-based diagnostics of single and multiple failures on a two-spool engine. The aim of this technique is to combine the strength of each methodology and provide a high success rate for single and multiple failures with the presence of measurement malfunctions. A combination of kF(kalman Filter), ANN(Artificial Neural Network) and FL(Fuzzy Logic) is used in this research in order to improve the success rate, to increase the flexibility and the number of failures detected and to combine the strength of multiple methods to have a more robust solution. The kalman filter has in his strength the measurement noise treatment, the artificial neural network the simulation and prediction of reference and deteriorated performance profile and the fuzzy logic the categorization flexibility, which is used to quantify and classify the failures. In the area of GT(Gas Turbine) diagnostics, the multiple failures in combination with measurement issues and the utilization of multiple methods for a 2-spool industrial gas turbine engine has not been investigated *** paper reports the key contribution of each component of the methodology and brief the results in the quantification and classification success rate. The methodology is tested for constant deterioration and increasing noise and for random deterioration. For the random deterioration and nominal noise of 0.4%, in particular, the quantification success rate is above 92.0%, while the classification success rate is above 95.1%. Moreover, the speed of the data processing(1.7 s/sample)proves the suitability of this methodology for online diagnostics.

关键词： Artificial neural network Data analytics Data filtering Diagnostics Fuzzy logic Gas turbine kalman filter Performance-based diagnostics

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Recent progress in polar metabolite quantification in plants using liquid chromatography-mass spectrometry

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Journal of Integrative Plant Biology 2014年第9期56卷 816-825页

作者： Zhiqian Liu simone Rochfort Department of Environment and Primary Industries Dairy Futures Co-operative Research Centre La Trobe University

Metabolite analysis or metabolomics is an important component of systems biology in the post-genomic *** separate liquid chromatography（LC） methods for quantification of the major classes of polar metabolites of plants have been available for decades,a single method that enables simultaneous determination of hundreds of polar metabolites is possible only with gas chromatography-mass spectrometry（GC-MS） *** rapid expansion of new LC stationary phases in the market and the ready access of mass spectrometry in many laboratories provides an excellent opportunity for developing LC-MS based methods for multitarget quantification of polar *** various LC-MS methods have been developed over the last 10 years with the aim to quantify one or more classes of polar compounds in different matrices,currently there is no consensus LC-MS method that is widely used in plant metabolomics *** most promising methods applicable to plant metabolite analysis will be reviewed in this paper and the major problems encountered *** aim of this review is to provide plant scientists,with limited to moderate experience in analytical chemistry,with up-to-date and simplified information regarding the current status of polar metabolite analysis using LC-MS techniques.

关键词： Aqueous normal phase chromatography hydrophilic interaction liquid chromatography liquid chromatography-mass spectrometry plants polar metabolites

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