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Data-Drive. Discove.y in Mine.alogy: Re.e.t Advance. in Data Re.ource., Analysis, and Visualization

e.gine.ring 2019年第3期5卷 397-405页

作者： Robe.t M. Haze. Robe.t T. Downs Ahme. e.e.sh Pe.e. Fox Olivie. C. Gagné Joshua J. Golde. e.ward S. Gre. Danie. R. Humme. Gre.he.Hystad Se.ge. V. Krivoviche. Congrui Li Chao Liu Xiaogang Ma Shaunna M. Morrison Fe.fe. Pan Ale.ande. J. Pire. Anirudh Prabhu Jolyon Ralph simone e. runyon Hao Zhong Ge.physical Laboratory Carnegie Institution for Science Washington DC 20015 USA De.artme.t of Ge.logy and Ge.physics University of Wyoming Laramie WY 82071-2000 USA De.artme.t of Ge.scie.ce. The University of Arizona Tucson AZ 85721-0077 USA Te.he.le.s World Conste.lation Rensselaer Polytechnic Institute Troy NY 12180 USA School of e.rth and Climate.Scie.ce. University of Maine Orono ME 04469 USA De.artme.t of Ge.logy Southern Illinois University Carbondale IL 62901 USA Mathe.atics Statistics and Computer Science Purdue University Northwest Hammond IN 46323-2094 USA Kola Scie.ce.Ce.tre.of the.Russian Acade.y of Scie.ce. Apatity Murmansk Region 184209 Russia De.artme.t of Compute. Scie.ce University of Idaho Moscow ID 83844-1010 USA *** Mitcham CR4 4FD UK

Large.and growing data re.ource. on the.dive.sity, distribution, and prope.tie. of mine.als are.ushe.ing in a ne. e.a of data-drive. discove.y in mine.alogy. The.most compre.e.sive.inte.national mine.al database.is the.IMA database. which include. information on more.than 5400 approve. mine.al spe.ie. and the.r prope.tie., and the.*** data source. which contains more.than 1 million spe.ie./locality data on mine.als found at more.than 300 000 localitie.. Analysis and visualization of the.e.data with dive.se.te.hnique.—including chord diagrams, cluste. diagrams, Kle. diagrams, skyline.diagrams, and varie. me.hods of ne.work analysis—are.le.ding to a gre.te. unde.standing of the.co-e.olving ge.sphe.e.and biosphe.e. Ne. data-drive. approache. include.mine.al e.olution, mine.al e.ology, and mine.al ne.work analysis—me.hods that colle.tive.y conside. the.distribution and dive.sity of mine.als through space.and time. The.e.strate.ie. are.foste.ing a de.pe. unde.standing of mine.al co-occurre.ce. and, for the.first time. facilitating pre.ictions of mine.al spe.ie. that occur on e.rth but have.ye. to be.discove.e. and de.cribe..

关键词： Mine.al e.olution e.ology Skyline diagrams Ne.work analysis Cluste. Chord Kle.

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Statistical analysis of physico-me.hanical parame.e.s of sandstone. occurring in oroge.ic se.tings

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Journal of Mountain Scie.ce 2024年第4期21卷 1388-1402页

作者： PAPPALARDO Giovanna CARBONe.Se.afina MONACO Carme.o ZOCCO Giordana MINe. simone Dipartime.to Di Scie.ze.Biologiche Geologiche E AmbientaliUniversitàDegli Studi Di CataniaCorso Italia 5795129 CataniaItaly

In northe.ste.n Sicily(Italy),sandstone.rock masse. wide.y crop out as cove. de.osits ove. crystalline.te.rains be.onging to the.oroge.ic *** be.ng part of the.same.ge.logical formation,the.e.sandstone. are.characte.ize. by highly diffe.e.t fe.ture. in te.ms of te.ture.and physico-me.hanical *** pose. a scie.tific que.tion on the.possibility of tracing the.e.rocks to a single.statistical mode.,which could be.re.re.e.tative.of the.r main e.gine.ring ge.logical ***,it is worth inve.tigating on the.possible.re.sons of such diffe.e.ce.,that should be.se.rche. e.the. in the.curre.t ge.graphical sandstone.distribution or in the.rock *** this study,sandstone.sample. we.e.colle.te. from diffe.e.t site. and we.e.analyze. at both the.hand and thin se.tion *** sandstone.type. we.e.re.ognize.,characte.ize. by a diffe.e.t ***,the.laboratory characte.ization allowe. e.timating the.r main physico-me.hanical and ultrasonic prope.tie.,such as porosity,de.sity,me.hanical stre.gth,de.ormability,and ultrasonic *** rock me.hanical stre.gth prove. linke. to the.rock compactne.s and to the.pre.e.ce.of lithic fragme.ts,while.pore. and a pse.do-matrix be.we.n grains re.re.e.t we.ke.ing *** data we.e.also statistically analyze. by grouping the.spe.ime.s according to a ge.graphical crite.ion,with re.pe.t to the.r sampling are.,but no link was found be.we.n location and rock ***,with the.aim of achie.ing mathe.atical laws that could be.use. to pre.ict some.rock prope.tie. from othe.s,use.ul for practical purpose. whe. de.ling with such a high prope.ty variability,single.and multiple.re.re.sion analyse. we.e.carrie. *** show that the.Uniaxial Compre.sive.Stre.gth,porosity,and P-wave.ve.ocity are.the.be.t pre.ictors for a quick,indire.t e.timation of the.main physico-me.hanical *** me.hodological approach de.e.ope. for this re.e.rch can be.take. as re.e.e.ce.to study othe. world

关键词： Sandstone Laboratory te.t Uniaxial Compre.sive.Stre.gth Porosity Rocks

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Final re.ults of the.first phase.of the.PROTO-SPHe.A e.pe.ime.t: obtainme.t of the.full curre.t stable.scre. pinch and first e.ide.ce. of the.je. + torus combine. plasma configuration

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Plasma Scie.ce.and Te.hnology 2024年第2期26卷 31-43页

作者： Paolo MICOZZI Franco ALLADIO Ale.sandro MANCUSO Vince.zo ZANZA Ge.arda APRUZZe.e.France.ca BOMBARDA Luca BONCAGNI Paolo BURATTI France.co FILIPPI Giuse.pe.GALATOLA Te.A France.co GIAMMANCO e.mondo GIOVANNOZZI Andre. GROSSO Matte. IAFRATI Ale.sandro LAMPASI Viole.a LAZIC simone MAGAGNINO simone MANNORI Paolo MARSILI Vale.io PIe.GOTTI Giuliano ROCCHI Ale.sandro SIBIO Be.e.e.to TILIA Onofrio TUDISCO FSN Dipartime.to Fusione.e.te.nologie.pe. la Sicure.za Nucle.re ENEA Agenzia Nazionale per Le Nuove Tecnologie Energia e lo Sviluppo Economico SostenibileFrascati(Rome)00044Italy IAPS Istituto di Astrofisica e.Plane.ologia Spaziali INAF Istituto Nazionale di AstrofisicaRome O133Italy Physics De.artme.t University of Pisa Faculty of Natural Sciences Mathematics and PhysicsPisa 56127 Italy

In astrophysics, the.boundary conditions for plasma phe.ome.a are.provide. by nature.and the.astronome. face. the.proble. of unde.standing the. from a varie.y of obse.vations [He.te. J J e. al 1996 Astrophys. J. 456 225], on the.othe. hand, in laboratory plasma e.pe.ime.ts the.e.e.tromagne.ic boundary conditions be.ome.a major proble. in the.se.-up of the.machine.that produce. the.plasma, an issue.that has to be.inve.tigate. ste. by ste. and to be.modifie. and adapte. with gre.t patie.ce. in particular in the.case.of an innovative.plasma confine.e.t e.pe.ime.t. The.PROTO-SPHe.A machine.[Alladio F e. al 2006 Nucl. Fusion 46 S613] is a magne.ic confine.e.t e.pe.ime.t, that e.ulate. in the.laboratory the.je. + torus plasma configurations ofte. obse.ve. in astrophysics: an inne. magne.ize. je. of plasma ce.te.e. on the.approximate. axis of symme.ry and surrounde. by a magne.ize. plasma torus orthogonal to this je.. The.PROTO-SPHe.A plasma is simply conne.te., i.e., no me.al curre.t conducting rod is linke. to the.plasma torus, while.inste.d it is the.inne. magne.ize. plasma je.(in the.following always calle. the.plasma ce.te.post) that is linke. to the.torus. It is mandatory that no spurious plasma curre.t path modifie. the.optimal shape.of the.plasma ce.te.post. More.ve., as the.plasma torus is produce. and sustaine., in abse.ce.of any applie. inductive.e.e.tric fie.d, by the.inne. plasma ce.te.post through magne.ic re.onne.tions [Taylor J B and Turne. M F 1989 *** 29 219], it is re.uire. as we.l that spurious curre.t paths do not surround the.torus on its outboard, in orde. not to lowe. the.e.ficie.cy of the.magne.ic re.onne.tions that maintain the.plasma torus at the.e.pe.se.of the.plasma ce.te.post. Boundary conditions have.be.n corre.te.,up to the.point that the.first sustainme.t in ste.dy state.has be.n achie.e. for the.combine. plasma.

关键词： laboratory plasmas magne.ic confine.e.t astrophysical plasmas

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Ge.physical e.ide.ce.of large.scale.silica-rich fluid flow above.the.contine.tal subduction inte.face

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Scie.ce.China e.rth Scie.ce. 2024年第9期67卷 2796-2809页

作者： Yuantong MAO Liang ZHAO Marco G.MALUSA Ste.ano SOLARINO Silvia PONDRe.LI Baolu SUN Coralie.AUBe.T simone SALIMBe.I e.e.a e.A Stéphane.GUILLOT State.Ke. Laboratory of Lithosphe.ic and e.vironme.tal Coe.olution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Colle.e.of e.rth and Plane.ary Scie.ce. University of Chinese Academy of SciencesBeijing 100049China De.artme.t of e.rth and e.vironme.tal Scie.ce. University of Milano-BicoccaMilan 20126Italy Istituto Nazionale.di Ge.fisica e.Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale.di Ge.fisica e.Vulcanologia Sezione di BolognaBologna 40127Italy Unive.sité Gre.oble.Alpe. Université Savoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

Fluids in subduction zone. can have.major e.fe.ts on subduction ***,ge.physical constraints on the.scale.and impact of fluid flow during contine.tal subduction are.still *** we.analyze.the.VP/VS ratios in the.We.te.n Alpine.re.ion,hosting one.of the.be.t-pre.e.ve. fossil contine.tal subduction zone. worldwide.to inve.tigate.the.impact of fluid flow during contine.tal *** found a be.t of high VP/VS ratios>1.9 on the.uppe.-plate.side.of the.subduction zone.consiste.t with a partially se.pe.tinize. uppe.-plate.mantle.and a be.t of unusually low VP/VS ratiose.lowe.-plate.side.at de.ths shallowe. than 30 *** propose.that the.e.low VP/VS ratios re.ult from a wide.pre.d ne.work of silica-rich ve.ns,indicating past fluid flow along the.contine.tal subduction *** re.ults sugge.t that past fluid flow may have.re.uce. the.e.fe.tive.stre.s along the.subduction inte.face.thus favoring contine.tal subduction.

关键词： We.te.n Alps Crustal structure Re.e.ve. function Vp/Vs ratio Silica e.richme.t

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Clinical-base. phe.otype. in childre. with pe.iatric post-COVID-19 condition

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World Journal of Pe.iatrics 2024年第7期20卷 682-691页

作者： Lie.e.C.e.Noij Je.le.M.Blanke.tijn Coe. R.Lap Marlie. A.van Houte. Giske.Bie.broe. Anke.Hilse.Maitland-van de. Ze. Mahmoud I.Abde.-Aziz Johanne. B.van Goudoe.e. Mattijs W.Alse. Caroline.L.H.Bracke. Kim J.Oostrom simone Hashimoto Suzanne.W.J.Te.he.ge.-Lagro De.artme.t of Pe.iatric Pulmonology and Alle.gy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands De.artme.t of Pulmonary Me.icine Amsterdam UMCAmsterdamThe Netherlands De.artme.t of Pe.iatrics Spaarne GasthuisHoofddorpThe Netherlands De.artme.t of Pe.iatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands De.artme.t of Re.abilitation Me.icine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands De.artme.t of Pae.iatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands De.artme.t of Child and Adole.ce.t Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pe.iatric post coronavirus dise.se.2019(COVID-19)condition(PPCC)is a he.e.oge.e.us syndrome.which can significantly affe.t the.daily live. of *** study aime. to ide.tify clinically me.ningful phe.otype. in childre. with PPCC,to be.te. characte.ize.and tre.t this *** Participants we.e.childre. with physician-diagnose. PPCC,re.e.re. to the.acade.ic hospital Amste.dam UMC in the.Ne.he.lands be.we.n Nove.be. 2021 and March *** factors and information on post-COVID symptoms,comorbiditie.,and impact on daily life.we.e.*** cluste.s we.e.ide.tifie. using an unsupe.vise. and unbiase. approach for mixe. data *** Analysis of 111 patie.ts(age. 3–18 ye.rs)re.e.le. thre. distinct cluste.s within *** 1(n=62,me.ian age.15 ye.rs)pre.ominantly consiste. of girls(74.2%).The.e.patie.ts suffe.e. re.ative.y more.from e.e.cise.intole.ance.dyspne.,and sme.l *** 2(n=33,me.ian age.13 ye.rs)containe. patie.ts with an e.e. ge.de. distribution(51.5%girls).The. suffe.e. from re.ative.y more.sle.p proble.s,me.ory loss,gastrointe.tinal symptoms,and *** 3(n=16,me.ian age.11 ye.rs)had a highe. proportion of boys(75.0%),suffe.e. re.ative.y more.from fe.e.,had significantly fe.e. symptoms(me.ian of 5 symptoms compare. to 8 and 10 for cluste.s 1 and 2 re.pe.tive.y),and e.pe.ie.ce. a lowe. impact on daily *** This study ide.tifie. thre. distinct clinical PPCC phe.otype.,with variations in se.,age.symptom patte.ns,and impact on daily *** findings highlight the.ne.d for furthe. re.e.rch to unde.stand the.pote.tially dive.se.unde.lying me.hanisms contributing to post-COVID symptoms in childre..

关键词： Adole.ce.ts Cluste.s Long COVID Pe.iatric Phe.otype. Post-COVID syndrome

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Particle.e.asticity influe.ce. polyme.ic artificial antige. pre.e.ting ce.l e.fe.tive.e.s in vivo via CD8+T ce.l activation,macrophage.uptake.and the.prote.n corona

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Nano Re.e.rch 2024年第10期17卷 9052-9064页

作者： Savannah e.e.t-Witte.Sydne. R.Shannon De.nis H.Gong Kaitlyn G.Calabre.i Jawaun J.Harris Kaitlyn Storm e.win J.Yoo Arie. Isse. Vive. P.Jani Natalie.K.Livingston Mary O.Omotoso Ke.ly Rhode. e.ana Be.-Akiva Randall A.Me.e. Zoe.T.Hsie. simone Sidoli Ste.hany Y.Tze.g Jonathan P.Schne.k Jordan J.Gre.n Translational Tissue.e.gine.ring Ce.te. Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute.for Ce.l e.gine.ring Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA De.artme.t of Bioche.istry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive.ce.l the.apy(ACT)is an immunothe.apy strate.y for cance. that has se.n wide.pre.d clinical *** ACT,patie.t-de.ive. lymphocyte. are.stimulate. with the.antige. of inte.e.t e. vivo,prolife.ate.,the. re.urne. to the.patie.t to initiate.an antige.-spe.ific antitumor *** e.fe.tive.this proce.s is re.ource.inte.sive.and logistically impossible.for many *** artificial antige. pre.e.ting ce.ls(aAPCs)offe. a pote.tial“off-the.she.f”alte.native.to e. vivo *** particulate.aAPCs pe.form we.l in vitro,the. have.had limite. succe.s in vivo due.to poor bioavailability afte. *** to bioavailability include.rapid cle.rance.unfavorable.biodistribution,and inade.uate.inte.actions with CD8+T ce.ls at site. of *** prope.tie. such as e.asticity have.be.n shown to vastly impact the.bioavailability and particle.ce.l inte.actions,but this has ye. to be.inve.tigate. in the.conte.t of aAPCs for in vivo T-ce.l *** lite.ature.like.ise.indicate. that biomate.ial prope.tie.,e.pe.ially e.asticity,can modulate.T-ce.l activation in *** the.goal of cre.ting a more.biomime.ic,ne.t-ge.e.ation particulate.aAPC,we.de.e.ope. a poly(e.hyle.e.glycol hydroge. particle.platform with tunable.e.asticity to inve.tigate.the.impact of e.asticity on antige.-spe.ific T ce.l activation for in vivo adoptive.*** this knowle.ge.we.we.e.able.to gain more.pre.ise.control ove. in vivo T ce.l activation and inve.tigate.possible.me.hanisms including the.e.fe.ts of aAPC e.asticity on T ce.l binding,macrophage.uptake.and the.prote.n corona.

关键词： adoptive.ce.l the.apy artificial antige. pre.e.ting ce.ls particle.drug de.ive.y e.asticity prote.n corona poly(e.hyle.e.glycol)

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Lowe. limb balance.ankle.dorsifle.ion,orofacial tissue.pre.sure.and occlusal force.of rugby playe.s

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Sports Me.icine.and He.lth Scie.ce 2024年第2期6卷 173-178页

作者： Rafae. R.Machado Marce.o Palinkas Paulo B.de.Vasconce.os Sara Gollino Ve.idiana W.Arnoni Marcos Vinicios R.Prandi Isabe.a H.Re.alo Se.ma Sie.se.e.simone C.H.Re.alo School of De.tistry of Ribe.rao Pre.o University of Sao PauloBrazil National Institute.for Translational Me.icine.INCT-TM) Ribeirao PretoBrazil

This cross-se.tional study e.amine. the.lowe. limb balance.ankle.dorsifle.ion,orofacial tissue.pre.sure.and occlusal stre.gth of rugby ***-six participants we.e.divide. into groups:rugby playe.s(n=13)and he.lthy se.e.tary adults(n=13).Participants unde.we.t an analysis of lowe. limb balance.using a composite.score.Y-Balance.Te.t).Ankle.dorsifle.ion was me.sure. using the.Lunge.*** Iowa Oral Pe.formance.Instrume.t was e.ploye. to me.sure.orofacial tissue.*** force.was me.sure. with a dynamome.e.,and T-Scan asse.se. occlusal contact *** we.e.analyze. using the.t-te.t(pe.and we.ght as covariate.,whe.e.it is possible.to ve.ify that the.e.factors did not influe.ce.the.re.ults *** diffe.e.ce. we.e.obse.ve. in the.balance.of the.right(p=0.07)and le.t(p=0.02)lowe. limbs,whe.e.rugby playe.s had lowe. composite.*** we.e.significant diffe.e.ce. in the.right(p=0.005)and le.t(p=0.004)lunge.,with rugby playe.s showing lowe. value.,as we.l as lowe. tongue.pre.sure.p=0.01)and highe. lip pre.sure.p=0.03),with significant diffe.e.ce. to se.e.tary *** was no significant diffe.e.ce.in molar bite.force.and distribution occlusal contacts be.we.n *** se.ms to re.uce.lowe. limb displace.e.t,cause.ankle.hypomobility,le.d to change. in orofacial tissue.,particularly the.tongue.and *** study is significant for ide.tifying significant diffe.e.ce. be.we.n rugby playe.s and se.e.tary individuals,providing ne. insights into the.impact of rugby on he.lth and pe.formance.which can be.e.it sports training and injury pre.e.tion.

关键词： Rugby Y-balance.te.t Lunge.te.t Orofacial tissue. Occlusal force

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大陆俯冲界面之上大规模硅富集流体的地球物理学证据

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中国科学：地球科学 2024年第9期54卷 2848-2863页

作者：毛元彤赵亮 Marco G.MALUSÀ Ste.ano SOLARINO Silvia PONDRe.LI 孙宝璐 Coralie.AUBe.T simone SALIMBe.I e.e.a e.A Stéphane.GUILLOT 中国科学院地质与地球物理研究所岩石圈演化与环境演变全国重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049 De.artme.t of e.rth and e.vironme.tal Scie.ce. University of Milano-BicoccaMilan 20126Italy Istituto Nazionale.di Ge.fisica e.Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale.di Ge.fisica e.Vulcanologia Sezione di BolognaBologna 40127Italy Unive.sitéGre.oble.Alpe. UniversitéSavoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地... 详细信息

俯冲带中的流体可能对俯冲过程产生重要影响.然而,关于大陆俯冲期间流体规模及其作用的地球物理约束仍然有限.西阿尔卑斯造山带是全球保存最完好的大陆俯冲带之一,为认识大陆俯冲过程中流体作用的影响提供了重要的参考.本文综合多种地球物理方法分析了西阿尔卑斯造山带地区的V_(P)/V_(S)比值,发现在俯冲区的上盘侧存在高V_(P)/V_(S)(>1.9)带,与部分蛇纹岩化的上覆地幔楔位置一致;而在下盘侧存在异常低的V_(P)/V_(S)(<1.7)带,异常深度浅于30km.本文认为,观测到的低V_(P)/V_(S)比值异常是由地壳内广泛分布的富硅岩脉导致,指示了在俯冲时期大陆俯冲界面之上可能存在的富硅流体流动.本文的结果暗示俯冲时期的流体流动可能降低了俯冲界面的有效应力,从而促进了大陆俯冲.

关键词：西阿尔卑斯造山带地壳精细结构接收函数 V_(P)/V_(S)波速比硅富集

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Dysfunction of the.adhe.ion G prote.n-couple. re.e.tor latrophilin 1(ADGRL1/LPHN1)incre.se. the.risk of obe.ity

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Signal Transduction and Targe.e. The.apy 2024年第5期9卷 2298-2311页

作者： He.a ZabriTorste. Schöne.e.g AndréNguye. Die.zsch Hadi Al-Hasani Joachim Altschmie. Katharina Botte.mann Jana Bre.dle. Judith Hae.de.e. Susanne.Horn Isabe.l Kaczmare. Antje.Körne. Ke.stin Krause.Kathrin Landgraf Diana Le.Duc Laura Le.mann Ste.an Le.r Ste.hanie.Pick Albe.t Ricke. Re.e.Schnorr Ange.a Schulz Martina Strnadová Akhil Ve.luva He.a Zabri Torste. Schöne.e.g Dore.n Thor simone Pröme. Rudolf Schönhe.me. Institute.of Bioche.istry Medical FacultyLeipzig UniversityLeipzigGermany Institute.for Clinical Bioche.istry and Pathobioche.istry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany Ge.man Ce.te. for Diabe.e. Re.e.rch(DZD e.V.) Munich-NeuherbergGermany Cardiovascular De.e.e.ation Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Re.e.rch Institute.CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute.of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute.of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Ce.te. for Pe.iatric Re.e.rch Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany He.mholtz Institute.for Me.abolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany De.artme.t of e.docrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute.of Human Ge.e.ics Leipzig University Medical CenterLeipzigGermany Institute.of Ce.l Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Me.icine University of Global Health EquityKigaliRwanda

Obe.ity is one.of the.dise.se. with se.e.e.he.lth conse.ue.ce. and rapidly incre.sing worldwide.*** the.comple. ne.work of food intake.and e.e.gy balance.re.ulation is an e.se.tial pre.e.uisite.for pharmacological inte.ve.tion with obe.ity.G prote.n-couple. re.e.tors(GPCRs)are.among the.main modulators of me.abolism and e.e.gy ***,for instance.re.ulate.appe.ite.and satie.y in ce.tain hypothalamic ne.rons,as we.l as glucose.and lipid me.abolism and hormone.se.re.ion from *** in some.GPCRs,such as the.me.anocortin re.e.tor type.4(MC4R),have.be.n associate. with e.rly-onse. ***,we.ide.tifie. the.adhe.ion GPCR latrophilin 1(ADGRL1/LPHN1)as a me.be. of the.re.ulating ne.work gove.ning food intake.and the.mainte.ance.of e.e.gy *** of the.highly conse.ve. re.e.tor in mice.re.ults in incre.se. food consumption and se.e.e.obe.ity,accompanie. by dysre.ulation of glucose.***,we.ide.tifie. a partially inactivating mutation in human ADGRL1/LPHN1 in a patie.t suffe.ing from ***,we.propose.that LPHN1 dysfunction is a risk factor for obe.ity de.e.opme.t.

关键词： obe.ity me.abolism intake

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From blood to bre.th: Ne. horizons for e.ophage.l cance. biomarke.s

引用

World Journal of Gastroe.te.ology 2016年第46期22卷 10077-10083页

作者： Roge. Yazbe.k simone e.Jae.isch David I Watson De.artme.t of Surge.y Flinders Centre for Innovation in Cancer Flinders University

e.ophage.l cance. is a le.hal cance. e.compassing ade.ocarcinoma and squamous ce.l carcinoma subtype.. The.global incide.ce.of e.ophage.l cance. is incre.sing world-wide. associate. with the.incre.se. pre.ale.ce.of associate. risk factors. The.asymptomatic nature.of dise.se.ofte. le.ds to late.diagnosis and five.ye.r survival rate. of le.s than 15%. Curre.t diagnostic tools are.re.tricte. to invasive.and costly e.doscopy and biopsy for histopathology. Minimally and non-invasive.biomarke.s of e.ophage.l cance. are.ne.de. to facilitate.e.rlie. de.e.tion and be.te. clinical manage.e.t of patie.ts. This pape. summarise. re.e.t insights into the.de.e.opme.t and clinical validation of e.ophage.l cance. biomarke.s, focussing on circulating marke.s in the.blood, and the.e.e.ging are. of bre.th and odorant biomarke.s.

关键词： Bre.th analysis Cance. Micro RNA Noninvasive e.ophage.l cance. Biomarke.

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