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Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho Sousa Isabella Fernandes da Silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo JoseFigueiredo Mendes Joao Francisco Silva Rodrigues Jaqueline Pessoa Pontes simone aparecida teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-Souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos Ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de Souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em Saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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Search for naive human pluripotent stem cells

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World Journal of Stem Cells 2015年第3期7卷 649-656页

作者： simone aparecida Siqueira Fonseca Roberta Montero Costas Lygia Veiga Pereira National Laboratory of Embryonic Stem Cell Department of Genetics and Evolutionary Biology University of Sao Paulo Sao Paulo 05508-090 Brazil

Normal mouse pluripotent stem cells were originally derived from the inner cell mass(ICM) of blastocysts and shown to be the in vitro equivalent of those pre-implantation embryonic cells, and thus were called embryonic stem cells(ESCs). More than a decade later, pluripotent cells were isolated from the ICM of human blastocysts. Despite being called human ESCs, these cells differ significantly from mouse ESCs, including different morphology and mechanisms of control of pluripotency, suggesting distinct embryonic origins of ESCs from the two species. Subsequently, mouse pluripotent stem cells were established from the ICMderived epiblast of post-implantation embryos. These mouse epiblast stem cells(Epi SCs) are morphological and epigenetically more similar to human ESCs. This raised the question of whether cells from the human ICM are in a more advanced differentiation stage than their murine counterpart, or whether the available culture conditions were not adequate to maintain those human cells in their in vivo state, leading to a transition into Epi SC-like cells in vitro. More recently, novel culture conditions allowed the conversion of human ESCs into mouse ESC-like cells called nave(or ground state) human ESCs, and the derivation of nave human ESCs from blastocysts. Here we will review the characteristics of each type of pluripotent stem cells, how(and whether) these relate to different stages of embryonic development, and discuss the potential implications of nave human ESCs in research and therapy.

关键词： Naive pluripotent stem cells Epiblast stem cells X chromosome inactivation Human embryonic stem cells

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Challenges in the diagnosis of intestinal neuronal dysplasia type B:A look beyond the number of ganglion cells

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World Journal of Gastroenterology 2021年第44期27卷 7649-7660页

作者： simone Antunes Terra Anderson Cesar Gonçalves Pedro Luiz Toledo de Arruda Lourenção Maria aparecida Marchesan Rodrigues Department of Pathology Faculty of MedicineSão Paulo State University(UNESP)Botucatu 18618687São PauloBrazil Department of Surgery and Orthopedics Botucatu Medical School-São Paulo State University(UNESP)Botucatu 18618970São PauloBrazil

Intestinal neuronal dysplasia type B(IND-B)is a controversial condition among gastrointestinal neuromuscular *** is its most common clinical manifestation in *** intense scientific research,there are still knowledge gaps regarding the diagnostic criteria for IND-B in the histopathological analysis of rectal *** guidelines published in the past three decades have directed diagnostic criteria for quantifying the number of ganglion cells in the nervous plexus of the enteric nervous ***,it is very complex to distinguish numerically what is pathological from what is normal,mainly because of the difficulty in determining a reliable control group composed of healthy children without intestinal ***,a series of immunohistochemical markers have been proposed to assist in the histopathological analysis of the enteric nervous *** of these markers facilitate the identification of other structures of the enteric nervous system,in addition to ganglion *** structures may be related to the etiopathogenesis of IND-B and represent new possibilities for the histopathological diagnosis of this disease,providing a view beyond the number of ganglion *** review critically discusses the aspects related to the disease definitions and diagnostic criteria of this organic cause of constipation.

关键词： Intestinal neuronal dysplasia type B Constipation Diagnosis Gastrointestinal neuromuscular diseases

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Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

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Neural Regeneration Research 2020年第11期15卷 2067-2072页

作者： Caroline Dani Isabel teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da Silva simone Nique Vera Striebel Daniela Pochmann Viviane Rostirola Elsner Programa de Pos Graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Curso de Fisioterapia do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Programa de Pos Graduacao em Ciencias Biologicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Programa de Pos Graduacao em Farmacologia e Terapeutica Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil

Parkinson's disease is a neurodegenerative *** stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this *** exercise can regulate oxidative *** purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's *** aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise *** results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's *** with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first *** results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme *** results could better help understand the target of oxidative stress in Parkinson's *** study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).

关键词： antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress Parkinson's disease

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Genotype-environment interaction in Cordia trichotoma(Vell.)Arrá*** *** in two different soil conditions

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Journal of Forestry Research 2022年第1期33卷 309-319页

作者： Wanderley dos Santos Bruno Marchetti de Souza Daniele Fernanda Zulian Gilberto Terra Ribeiro Alves João Bosco Vasconcellos Gomes Mário Luiz teixeira de Moraes Valderês aparecida de Sousa Ananda Virginia de Aguiar Faculdade de Engenharia de Ilha Solteira Universidade Estadual Paulista“Júlio Mesquita Filho”Ilha Solteira 15385-000Brazil Sucupira Agroflorestas Fazenda SucupiraValença 45400-000Brazil EMBRAPA Florestas Empresa Brasileira de Pesquisa AgropecuáriaColombo 83411-000Brazil

Investment in silvicultural techniques is noticeably lacking,especially in breeding programs for non-conventional wood *** genotype×environment interaction(G×E)is essential to the development of breeding ***,this study aimed to estimate genetic diversity of and the effects of G×E interaction on two progeny tests of Cordia trichotoma,including the estimation of genetic gain and genetic diversity after *** the experiment,30 progenies of *** were tested at two sites with differing soil *** at breast height(1.30 m above soil surface,dbh-cm),total height,diameter at 30 cm from the soil,first branch height,and survival were all monitored for four *** deviance,best linear unbiased estimator,and harmonic mean of relative performance of genetic values(MHPRVG)were all calculated to predict breeding values,estimate genetic parameters,and analyze *** quantified traits varied significantly among progenies by soil type,with greatest variation recorded for genetic *** of the progenies led to predictions of genetic gain,ranging from 7.73 to 15.45%,for dbh at four years of *** calculated decrease in genetic diversity after selection showed that this parameter should be monitored in subsequent breeding cycles.G×E was low for all *** best-performing progenies proved most stable and best adapted to the different environmental conditions tested.

关键词： Effective population number Native species Productivity Stability and adaptability Tree improvement

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Characterization of Brazilians Students with Dyslexia in Handwriting Proficiency Screening Questionnaire and Handwriting Scale

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Psychology Research 2016年第10期6卷 590-597页

作者： Giseli Donadon Germano Catia Giaconi simone aparecida Capellini Sao Paulo State University "Ju1io deMesquita Filho" UNESP Sao Paulo Brazil University of Macerata Macerata Italia Sao Paulo State University "Julio deMesquita Filho" UNESP Sao Paulo Brazil

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Systematic Review Study on the Impact of the Pandemic on Literacy:Experiences of Parents and Teachers

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Psychology Research 2022年第10期12卷 813-823页

作者： Liliane da Veiga Silva Amorim simone aparecida Capellini Giseli Donadon Germano São Paulo State University“Júlio de Mesquita Filho”(UNESP) MaríliaBrazil

With the COVID-19 pandemic,it was necessary to carry out public health measures,including the adoption of remote teaching and modification of the educational practices and experiences of parents and ***,the objective of this study was to conduct a systematic review and analyze the impact of the pandemic on the learning of schoolchildren in the early years of literacy,according to the experiences and practices of parents and *** systematic review is based on the PRISMA method(Preferred Reporting Items for Systematic Reviews and Meta-Analyses)and the guiding questions of the PICO strategy(Population,Intervention,Comparison,Outcome).The PubMed,LILACS,Scopus,SciELO,Embase,and Web of Science databases were *** selection criteria involved the descriptors elementary school AND COVID-19,elementary school AND pandemic,and elementary school AND SARS-CoV-2.A total of 130 studies were selected,and after applying the criteria,only six studies were *** studies used interviews and questionnaires aimed at parents,teachers,and students and were carried out in various countries:one in Saudi Arabia,two in Indonesia,one in the United States of America,one in Canada,and one in *** studies were classified as Evidence Level 4(clinical outcome studies).As common points,most parents were stressed,overloaded,and unprepared to support their children during remote *** also mentioned difficulties,such as the lack of support and training,which affected their *** studies should be carried out to verify the educational and social impacts resulting from remote teaching.

关键词： pandemic elementary school COVID-19 online learning

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Shade and sapling size influence restoration of Araucaria angustifolia

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Journal of Forestry Research 2021年第5期32卷 1833-1841页

作者： simone aparecida Zolet Sasso JoséAbramo Marchese Amanda Pacheco Cardoso Moura Bruna Valéria Gil Anelise Tessari Perboni Joel Donazzolo Fabrícia Lorrane Rodrigues Oliveira Bruno Francisco Sant’Anna-Santos Angela Rohr Moeses Andrigo Danner Agronomy Department Universidade Tecnológica Federal do Paraná(UTFPR)Campus Pato BrancoVia do Conhecimentokm 01Pato BrancoParaná85503-390Brazil UTFPR Campus Dois VizinhosEstrada para Boa Esperançakm 04Dois VizinhosParaná85660-000Brazil Biological Sciences Department Universidade Federal do Paraná(UFPR)Avenida Coronel Francisco H.dos Santos100CuritibaParaná81531-980Brazil

Toward improving reforestation of Brazilian pine(Araucaria angustifolia),two contrasting sapling sizes in either full sun or in the shade of a mixed plantation and the effect of opening the canopy were evaluated for survival,growth,gas exchange,photosynthetic pigments,and leaf anatomy 18 months after being *** 23 months after planting,a partial opening was made in the canopy in the mixed plantation,then the saplings were evaluated again after 2 months for the same morphophysiological *** 18 months,saplings planted in the full sun had higher survival,growth,pigments,and photosynthesis compared to the shaded *** saplings had higher survival and growth compared to the small *** leaves were thinner and little differentiation of palisade parenchyma and *** opening of the canopy,photo synthetically active radiation was 10 times higher,and the saplings quickly grew in height due to increased ***,although the species can tolerate shade,growth in the shade is *** recommend that for reforestation purposes of Brazilian pine,large saplings should be selected and planted in the open for better development.

关键词： Brazilian pine Luminosity Gas exchanges Photosynthetic pigments Leaf anatomy

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Payment for Ecosystem Services Markets and Rural Development in BrazilmA Co-evolutionary Approach

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Journal of Environmental Science and Engineering(B) 2013年第5期2卷 276-288页

作者： Shigeo Shiki simone de Faria Narciso Shiki Patricia Lopes Rosado Elaine aparecida Fernandes Economics Department Federal University of Viqosa Vigosa-MG 36570 000 Brazil Economic Sciences Department Federal University of S6o Jo6o Del Rei S6o Jo6o Del Rei-MG 3630 7372 Brazil

The article discusses the payment for ecosystem or environmental services markets in Brazil with a critical review, based on the ecological economics literature and focused on the concept of co-evolution. It is argued that the mainstream approach which considers ecosystem services as an externality has many shortcomings and fails to consider institutional and political aspects---all very critical for the design and implementation of a PES （Payment for ecosystem services） project or program. The complexity and the diversity of co-evolutionary relations between ecosystem services and socioeconomic activities are spatially or territorially specific. In this sense, different types of PES market have to adapt and coevolve with different ongoing development processes.

关键词： Payment for ecosystem services co-evolutionary approach rural development.

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Significance Analysis of RTI Tier 2 Metaphonological and Alphabetic Principle Program for Brazilian Schoolchildren at Risk for Dyslexia

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Psychology Research 2022年第7期12卷 552-561页

作者： Melissa Pinotti Marguti Alexandra Beatriz Portes de Cerqueira César simone aparecida Capellini São Paulo State University“Júlio de Mesquita Filho”(UNESP) MariliaSão PauloBrazil

Aim:to analyze the significance of RTI Tier 2 metaphonological and alphabetic principle program for Brazilian schoolchildren at risk for ***:a bibliographic review was carried out in the Scielo and Pubmed databases using the descriptors“intervention studies”,“reading”,“dyslexia”,and“learning”in Portuguese and English for the elaboration of RTI Tier 2 metaphonological and alphabetic principle program for schoolchildren at risk for *** program was designed based on the selection of strategies for metaphonological skills,knowledge of the alphabet,and grapheme-phoneme correspondence described in national and international *** stimuli(real words)and visual stimuli(pictures)were selected to be used in the intervention program *** stimuli were selected from a word bank according to length,regularity,and *** intervention program designed was composed of the following skills:letter-sound knowledge,syllable knowledge,syllabic segmentation,phonemic segmentation,syllabic addition,phonemic addition,syllabic subtraction,phonemic subtraction,syllabic substitution,phonemic substitution,syllabic combination,and phonemic *** program was structured with collective strategies and was applied in small groups of four to five schoolchildren aged six years and 11 months to seven years and 11 months in 50-minute ***:The results revealed that there was a change in the response pattern,showing better performance in the skills of the Early Identification of Reading Problems Protocol,demonstrating significance and positive change in post-testing situations when compared to ***:the program developed in this study proved to be effective and,in this way,it can be used as an intervention instrument based on scientific evidence that helps in the acquisition of skills necessary for the development of reading.

关键词： dyslexia literacy metaphonological skills predictors for literacy clinical significance

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