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Complete pathological response in locally advanced non-small-cell lung cancer patient: A case report

World Journal of Clinical Cases 2021年第20期9卷 5540-5546页

作者： Elisabetta Parisi Donatella Arpa Giuglia Ghigi simona Micheletti Elisa Neri Luca Tontini Martina Pieri Antonino Romeo Radiotherapy Unit IRCCS Istituto Scientifico Romagnolo per lo Studio dei Tumori(IRST)"Dino Amadori"Meldola 47014Italy

BACKGROUND Chemotherapy and radiotherapy followed by durvalumab is currently the standard treatment for locally advanced node-positive non-small-cell lung cancer(NSCLC).We describe the case of a patient with locally advanced node-positive NSCLC(LA-NSCLC)treated in a phase II prospective protocol with chemotherapy,accelerated hypofractionated radiotherapy(AHRT)and surgery in the preimmunotherapy *** SUMMARY A 69-year-old male,ex-smoker(20 PY),with a Karnofsky performance status of 90,was diagnosed with locally advanced squamous cell lung *** was staged by total body computed tomography(CT)scanning,and integrated 18Ffluorodeoxyglucose positron emission tomography/CT scan[cT4 cN3 cM0,stage IIIC according to TNM(tumor-node-metastasis)8th edition]and received AHRT between chemotherapy cycles,in accordance with the study protocol(EudractCT registration 2008-006525-14).At the end of the study the patient underwent surgery,which was not part of the protocol,and showed a complete pathological *** This case report confirms that AHRT can be used successfully to treat primary LA-NSCLC with bilateral mediastinal lymph node *** case is of particular interest because of the pathological response after AHRT and the lack of surgical *** hypothesize that this radiotherapeutic approach,with its proven efficacy,could be delivered as a short course reducing treatment costs,increasing patient compliance and reducing *** are currently investigating the possibility of combining hypofractionation,chemotherapy and immunotherapy for patients with LA-NSCLC.

关键词： Locally advanced non-small-cell lung cancer Hypofractionated radiotherapy Chemoradiotherapy Complete pathological response Immunotherapy Case report

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Male gender and increased body mass index independently predicts clinically relevant morbidity after spleen-preserving distal pancreatectomy

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World Journal of Gastrointestinal Surgery 2018年第8期10卷 84-89页

作者： Traian Dumitrascu Mihai Eftimie ANDra Aiordachioae Cezar Stroescu simona Dima Mihnea Ionescu Irinel Popescu Department of General Surgery and Liver Transplant Fundeni Clinical Institute

AIM To identify risk factors for clinically relevant complications after spleen-preserving distal pancreatectomy(SPDP). No previous studies explored potential predictors of morbidity after *** The data of 41 patients who underwent a SPDP in a single surgical center between 2000 and 2015 were retrospectively reviewed from a prospectively maintained electronic database established in our Department of Surgery. The database included demographic, clinical, bioumoral, pathological, intraoperative and postoperative parameters. Uni-and multivariate ana-lyses were performed to assess potential predictors of clinically relevant morbidity. Postoperative morbidity was defined as in-hospital complications and mortality was assessed at 90 d. Clinically relevant morbidity was defined as complication ≥ grade 2 *** Overall morbidity rate was 34.1%(14 patients): grade Ⅰ(6 patients, 14.6%), grade Ⅱ(2 patients, 4.8%), grade Ⅲa(1 patient, 2.4%), and grade Ⅲb(5 patients, 12.2%). A number of 5 patients(12.2%) required re-laparotomy for postoperative complications. There was no postoperative mortality. Thus, at least one clinically relevant complication occurred in 8 patients(19.5%). Univariate analysis identified male gender(P = 0.034), increased body mass index(P = 0.002) and neuroendocrine pathology(P = 0.013) as statistically significant risk factors. Multivariate analysis identified male gender [odds ratio(OR): 1.29, 95%CI: 1.07-1.55, P = 0.005] and increased body mass index(OR: 23.18, 95%CI: 1.72-310.96, P = 0.018) as the only independent risk factors of clinically relevant morbidity after *** Male gender and increased body mass index are independently associated with increased risk of clinically relevant morbidity after SPDP. These findings may assist a surgeon in clinical decision-making to better select patients suitable for SPDP.

关键词： Spleen-preserving distal pancreatectomy Morbidity Male gender Body mass index

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Gender specific medicine in liver diseases:a point of view

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World Journal of Gastroenterology 2014年第9期20卷 2127-2135页

作者： Marilena Durazzo Paola Belci Alessandro Collo Vanessa Prandi Erika Pistone Maria Martorana Roberto Gambino simona Bo Department of Medical Sciences University of Turin 10126 Turin Italy

Gender medicine focuses on the patho-physiological, clinical, prevention and treatment differences in diseases that are equally represented in men and women. The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence. The concept of “gender” includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women, including risk factors, protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women. It is very important to consider all the biological, physiological, functional, psychological, social and cultural characteristics to provide patients with individualized disease management. Herein, we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies: primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis, non alcoholic fatty liver disease and alcoholic liver disease, and viral chronic hepatitis B and C. The last section addresses hemochromatosis, which is a prevalent iron overload disorder in the Caucasian population. This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy, management during pregnancy and delivery, and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications.

关键词： Gender Liver disease Primary biliary cirrhosis Autoimmune hepatitis Viral chronic hepatitis B Viral chronic hepatitis C Non alcoholic fatty liver disease Alcoholic liver disease

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硼酸盐熔珠-X射线荧光光谱法分析高合金钢

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冶金分析 2012年第9期32卷 22-25页

作者： ROLLET simona FRANCISCONO Andrea 科涅特殊钢有限公司

采用直读光谱法(OES-Spark)、X射线荧光光谱法(XRF)以及电感耦合等离子体发射光谱法(ICP-OES)测定高合金钢中高含量的元素时,吸收增强效应、晶粒尺寸效应、冶金相组成的不同点、元素间干扰(OES-Spark、XRF)以及较低精密度(ICP-OES)等相... 详细信息

采用直读光谱法(OES-Spark)、X射线荧光光谱法(XRF)以及电感耦合等离子体发射光谱法(ICP-OES)测定高合金钢中高含量的元素时,吸收增强效应、晶粒尺寸效应、冶金相组成的不同点、元素间干扰(OES-Spark、XRF)以及较低精密度(ICP-OES)等相关因素都会影响结果的准确性。将样品制备成硼酸盐熔珠后进行检测可以带来很多优势,例如消除相组成和冶金晶粒尺寸效应的影响、对夹杂物(氧化物,氮化物,碳化物)以及任何形状和任何数量的样品进行处理时的高均匀性。本研究开发了一种样品制备的新方法,并将该方法应用于高合金钢标准样品(CRM)的XRF测定中。

关键词：高合金钢熔珠 X射线荧光光谱法硼酸盐夹杂物

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CSF biomarkers in multiple sclerosis:beyond neuroinflammation

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Neuroimmunology and Neuroinflammation 2021年第1期8卷 14-41页

作者： simona Toscano Francesco Patti Department"GF Ingrassia" Section of NeurosciencesMultiple Sclerosis CenterUniversity of CataniaCatania 95123Italy

For many years,quantifiable biomarkers in neurological diseases have represented a hot *** multiple sclerosis(MS),cerebrospinal fluid biomarkers have played a diagnostic role since the introduction of Poser's criteria in 1983,with IgG oligoclonal bands playing a supporting role in an epoch prior to magnetic resonance imaging and a complementary one after the introduction of McDonald criteria in ***,that supporting role has turned into a main one in substituting for dissemination in time and defining the diagnosis of MS in patients with a first clinical event,according to the 2017 revised McDonald *** kappa free light chains,N-CAM,chitinase 3-like protein 1 and IgM oligoclonal bands,not yet implemented in clinical practice,could similarly gain importance in the near ***,the increasing knowledge of molecular mechanisms leading to chronic inflammation has enhanced interest in looking for biomarkers of disease activity,better defining the MS phenotype and patients with highly active ***,myelin proteins,intermediate filaments,metalloproteinases and other molecules involved in the inflammatory cascade,are currently under ***,it has long been known that axonal loss occurs from the early phases,leading to a progressive neurological *** established criteria to assess treatment failure and transition to progressive forms are still lacking,both treatment response and prognostic biomarkers would be useful to predict MS course,and neurofilaments seem to have this *** purpose of this review article was to illustrate biomarkers that have been already validated or require further validation after proving to be useful in exploratory studies and potentially could prove useful in clinical practice in the coming years.

关键词： Multiple sclerosis biomarkers cerebrospinal fluid neurofilaments oligoclonal bands disease activity

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Italy’s Fiscal Response to the COVID-19 Crisis

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Belt and Road Initiative Tax Journal 2022年第2期3卷 16-18页

作者： simona Massai International Organisations Unit Italian Revenue Agency

This article focuses on measures envisaged and adopted by the Italian Revenue Agency during the COVID-19 pandemic to prevent the spread of virus and to support businesses and individuals in mitigating the worst economic impact of the *** particular,measures such as suspension of tax payments and processing,grants allocation,tax credits and increased use of digital services have been adopted to re-cover and relaunch the financial *** a member state of the European Union,Italy has also submitted its recovery and resilience plan that is committed to boosting a sustainable growth while fostering the digital and green transition.

关键词： Tax incentive Tax credit Recovery and resilience COVID-19 Digital-isation Grants allocation

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博洛尼亚Bonfiglioli总部大楼

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现代装饰 2024年第3期 24-31页

作者： Peter Pichler(设计) Silvana Ordinas(设计) Niklas Knap(设计) simona Alu(设计) Ugo Licciardi(设计) Cem Ozbasaran(设计) Filippo Ogliani(设计) Giovanni Paterlini(设计) Domenico Calabrese(设计) Nathalia Rotelli(设计) Angela Ferrari(设计) Alessandro Cardellini(设计) Simone Valbusa(设计) Gustav Willeit(摄影) 范嘉苑(编译) 不详

Peter Pichler Architecture近期落成的Bonfiglioli总部大楼现已揭幕,该项目位于意大利博洛尼亚的Calderara di Reno地区。新总部设计旨在打造一座高效且功能齐全的办公建筑,以此展现出这家意大利企业的专业性、创新性以及引以为傲的历... 详细信息

Peter Pichler Architecture近期落成的Bonfiglioli总部大楼现已揭幕,该项目位于意大利博洛尼亚的Calderara di Reno地区。新总部设计旨在打造一座高效且功能齐全的办公建筑,以此展现出这家意大利企业的专业性、创新性以及引以为傲的历史。创立于1956年,Bonfiglioli公司是一家拥有领先地位的制造商以及供应商,产品门类涵盖齿轮电动机、驱动系统、减速齿轮箱和变频器等。Bonfiglioli的产品解决方案在全球范围内的自动化、移动机械和可再生能源领域都具有强有力的推动作用。

关键词：产品门类减速齿轮箱移动机械可再生能源博洛尼亚总部大楼办公建筑产品解决方案

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Associations between y-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: A possible implication for oxidative stress

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World Journal of Gastroenterology 2005年第45期11卷 7109-7117页

作者： simona Bo Roberto Gambino Marilena Durazzo Sabrina Guidi Elisa Tiozzo Federica Ghione Luigi Gentile Maurizio Cassader Gian Franco Pagano Department of Internal Medicine Diabetic Clinic

AIM: To examine the relationships between γ -glutamyltransferase (GGT), alanine-aminotransferase (ALT),aspartate-aminotransferase (AST) and various metabolic parameters, C-reactive protein (CRP) and an oxidative stress marker (nitrotyrosine, NT) in subjects without any metabolic abnormalities from a population-based ***: Two hundred and five subjects with normal body mass index (BMI), glucose tolerance, and without any metabolic abnormality were studied out of 1339subjects, without known liver diseases, alcohol abuse or use of hepatotoxic drugs, who are representative of the 45-64 aged population of Asti (north-western Italy).RESULTS: In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference,hs-CRP, triglyceride values, and GGT levels. In these subjects, male sex, higher hs-CRP and glucose levels are associated with GGT levels in a multiple regression model, after adjustments for multiple *** the same model, median NT levels are significantly associated with the increasing GGT tertile (β = 1.06;95%CI 0.67-1.45), but not with the AST and ALT *** a multiple regression model, after adjusting for age,sex, BMI, waist, smoking, and alcohol consumption, both NT (β = 0.05; 95%CI 0.02-0.08) and hs-CRP levels (β =0.09; 95%CI 0.03-0.15) are significantly associated with fasting ***: GGT, an easy, universally standardized and available measurement, could represent an early marker of sub-clinical inflammation and oxidative stress in otherwise healthy individuals. Prospective studies are needed to establish if GGT could predict future diabetes in these subjects.

关键词： Alanine aminotransferase Aspartate aminotransferase Body mass index C-reactive protein γ-Glutamyl transferase Metabolic syndrome Nitrotyrosine

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High-accuracy characterization of pyroelectric materials:A noncontact method based on surface potential measurements

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Journal of Advanced Dielectrics 2023年第4期13卷 52-59页

作者： Reinhard Schwödiauer simona Bauer-Gogonea Martin Kaltenbrunner Volodymyr Tkachenko Simonetta Grilli Soft Matter Physics Johannes Kepler UniversityAltenbergerstraße 694040 LinzAustria Institute of Applied Sciences&Intelligent Systems National Research Council(CNR-ISASI)Via Campi Flegrei 3480078 Pozzuoli(NA)Italy

The characterization of pyroelectric materials is essential for the design of pyroelectric-based *** current measurement is the commonly employed method,but can be complex and requires surface ***,we present noncontact electrostatic voltmeter measurements as a simple but highly accurate alternative,by assessing thermally-induced pyroelectric surface potential *** introduce a refined model that relates the surface potential variations to both the pyroelectric coefficient and the characteristic figure of merit(FOM)and test the model with square-shaped samples made from PVDF,LiNbO3 and *** characteristic pyroelectric coefficient for PVDF,LiNbO3 and LiTaO3 was found to be 33.4,59.9 and 208.4μC m−2 K−1,*** values are in perfect agreement with literature values,and they differ by less than 2.5%from values that we have obtained with standard pyroelectric current measurements for comparison.

关键词： Pyroelectric coefficient surface potential figure of merit

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A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients

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World Journal of Gastroenterology 2010年第2期16卷 167-175页

作者： Luca Gianotti Lorenzo Morelli Francesca Galbiati simona Rocchetti Sara Coppola Aldo Beneduce Cristina Gilardini Daniela Zonenschain Angelo Nespoli Marco Braga Department of Surgery Milano-Bicocca University San Gerardo Hopsital Department of Microbiology Università Cattolica Sacro Cuore Department of Surgery San Raffaele University

AIM:To investigate whether probiotic bacteria,given perioperatively,might adhere to the colonic mucosa, reduce concentration of pathogens in stools,and modulate the local immune function. METHODS:A randomized,double-blind clinical trial was carried out in 31 subjects undergoing elective colorectal resection for *** were allocated to receive either a placebo(group A,n=10),or a dose of 10 7 of a mixture of Bifidobacterium longum(BB536) and Lactobacillus johnsonii(La1)(group B,n=11),or the same mixture at a concentration of 10 9 (group C,n=10).Probiotics,or a placebo,were given orally 2 doses/d for 3 d before *** same treatment continued postoperatively from day two to day four. Stools were collected before treatment,during surgery (day 0)and 5 d after *** the operation, colonic mucosa samples were harvested to evaluate bacterial adherence and to assess the phenotype of dendritic cells(DCs)and lymphocyte subsets by surface antigen expression(flow cytometry).The presence of BB536 and La1 was evaluated by the random amplified polymorphism DNA method with specific polymerase chain reaction probes. RESULTS:The three groups were balanced for baseline and surgical ***536 was never found at any time-points *** day 0,La1 was present in 6/10(60%)patients in either stools or by biopsy in group C,in 3/11(27.2%)in group B,and none in the placebo group(P=0.02,C vs A).There was a linear correlation between dose given and number of adher- ent La1(P=0.01).The rate of mucosal colonization by enterobacteriacae was 30%(3/10)in C,81.8%(9/11) in B and 70%(7/10)in A(P=0.03,C vs B).The Enterobacteriacae count in stools was 2.4(log10 scale) in C,4.6 in B,and 4.5 in A(P=0.07,C vs A and B). The same trend was observed for colonizing enterococ- ***1 was not found at day+*** observed greater expression of CD3,CD4,CD8,and naive and memory lymphocyte subsets in group C than in group A with a dose response trend(C>B>A).Treatment didnot affect DC

关键词： Probiotic Dendritic cell Microbiota Colon cancer Lymphocyte Surgery Intestinal immunity

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