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Target Therapy in Platinum-Refractory/Resistant Ovarian Cancer:From Preclinical Findings to Current Clinical Practice

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Journal of Cancer Therapy 2013年第5期4卷 1005-1017页

作者： Nicoletta Staropoli Cirino Botta Domenico Ciliberto Lucia Fiorillo Antonina Maria De Angelis Caterina Viscomi simona gualtieri Angela Salvino Pierfrancesco Tassone Pierosandro Tagliaferri Medical Oncology Unit Department of Experimental and Clinical MedicineMagna Graecia University and Tommaso Campanella Cancer CenterCampus Salvatore VenutaCatanzaroItaly

Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in adjuvant setting, is represented by carboplatin/paclitaxel combination. Conversely, the second-line treatment is not well defined. The response to platinum is the major prognostic factor for survival. In this review we discuss the current views on platinum-refractory/resistant patient treatment only, which includes patients progressing or relapsing within 6 months from the last platinum-based course. Concerning this subgroup, the activity of several conventional drugs was confirmed in different trials without a significant impact in terms of overall survival. In the last years particular emphasis was given to targeted anti-angiogenetic therapy which produced a survival improvement with an acceptable toxicity profile. New “ad hoc” approaches, with a major attention to outcome-predictive factors, are eagerly awaited.

关键词： Ovarian Cancer Systemic Chemotherapy Platinum Sensitivity Status

AI for conceptual architecture:Reflections on designing with text-to-text,text-to-image,and image-to-image generators

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Frontiers of Architectural Research 2024年第3期13卷 593-612页

作者： Anca-simona Horvath Panagiota Pouliou Research Laboratory for Art and Technology Aalborg UniversityAalborg 9000Denmark Lighting Design Lab Aalborg UniversityCopenhagen 2450Denmark

In this paper we present a research-through-design study where we employed text-to-text,text-to-image,and image-to-image generative tools for a conceptual architecture project for the eVolo skyscraper *** trained these algorithms on a dataset that we collected and curated,consisting of texts about and images of *** describe our design process,present the final proposal,reflect on the usefulness of such tools for early-stage design,and discuss implications for future research and *** analysing the results from training the text-to-text generators we could establish a specific design brief that informed the final *** results from the image-to-image generator gave an overview of the shape grammars of previous *** results were intriguing and can assist creativity and in this way,the tools were useful for gaining insight into historical architectural data,helped shape a specific design brief,and provoked new *** reflecting on our design process,we argue that the use of language when employing such tools takes a new role and that three layers of language intertwined in our work:architectural discourse,programming languages,and *** present a map that unfolds how these layers came together as a contribution to making machine learning more explainable for creatives.

关键词： Machine learning StyleGAN2-ADA RNN TensorFlow VQGAN+clip AD journal eVolo Conceptual design Architectural design

A review on plasma-based CO_(2) utilization:process considerations in the development of sustainable chemical production

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Plasma Science and Technology 2024年第9期26卷 1-16页

作者： Sirui LI Giulia De FELICE simona EICHKORN Tao SHAO Fausto GALLUCCI Department of Chemical Engineering and Chemistry Eindhoven University of TechnologyEindhoven 5612 AZthe Netherlands Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190People’s Republic of China

Plasma-based processes,particularly in carbon capture and utilization,hold great potential for addressing environmental challenges and advancing a circular carbon *** significant progress has been made in understanding plasma-induced reactions,plasma-catalyst interactions,and reactor development to enhance energy efficiency and conversion,there remains a notable gap in research concerning overall process *** review emphasizes the critical need for considerations at the process level,including integration and intensification,to facilitate the industrialization of plasma technology for chemical *** centered on the development of plasma-based processes are made with a primary focus on CO_(2) conversion,offering insights to guide future work for the transition of the technology from laboratory scale to industrial *** of current research gaps,especially in upscaling and integrating plasma reactors with other process units,is the key to addressing critical *** review further delves into relevant research in process evaluation and assessment,providing methodological insights and highlighting key factors for comprehensive economic and sustainability ***,recent advancements in novel plasma systems are reviewed,presenting unique advantages and innovative concepts that could reshape the future of process *** review provides essential information for navigating the path forward,ensuring a comprehensive understanding of challenges and opportunities in the development of plasma-based CCU process.

关键词： non-thermal plasma carbon capture and utilization process integration process intensification techno-economic analysis life cycle analysis

The sea bass Dicentrarchus labrax as a marine model species in immunology:Insights from basic and applied research

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Aquaculture and Fisheries 2024年第2期9卷 136-143页

作者： Andrea Miccoli Francesco Buonocore simona Picchietti Giuseppe Scapigliati Department for Innovation in Biological Agro-food and Forest SystemsUniversity of TusciaViterbo01100Italy

This review summarizes the current knowledge on immune defence activities of the European sea bass Dicentrarchus labrax by reporting the consistent amount of work done on this economically-important species.A draft genome sequence is available for this species,together with whole transcriptomes from lymphoid and non-lymphoid *** full-length coding sequences of many immunoregulatory and immune-related genes allow for targeted quantitative PCR analysis,nowadays needed for-omics data verification,ex vivo and in *** first anti-T cells monoclonal antibody teleost-wise was obtained in sea bass,followed by several monoclonal and polyclonal markers of lymphocyte populations,namely T cells(pan-T,CD3ε,TcRγ,CD45),and B cells(IgM,IgT,IgD).The combined use of molecular and biochemical tools enabled investigations on innate and acquired immune responses of sea bass in unstimulated/stimulated fish,along the development and under variable environmental conditions and food *** overview of sea bass viral and bacterial pathogens and available vaccines against these microorganisms is also *** knowledge accumulated in the past 25 years validates the European sea bass as a reference marine model in the field of fish immunology.

关键词： Sea bass Dicentrarchus labrax Fish immunology Acquired immunity Innate immunity Evolutionary immunology

Metabolic dysfunction-associated steatotic liver disease-associated fibrosis and cardiac dysfunction in patients with type 2 diabetes

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World Journal of Cardiology 2024年第10期16卷 580-594页

作者： simona Cernea Danusia Onișor Andrada Larisa Roiban Theodora Benedek Nora Rat Department M3/Internal Medicine I George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTârgu Mureş540142Romania Diabetes Nutrition and Metabolic Diseases Outpatient UnitEmergency County Clinical HospitalTârgu Mureş540136Romania Department ME2/Internal Medicine VII George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureşTârgu Mureş540142Romania Gastroenterology Clinic MureșCounty Clinical HospitalTârgu Mureş540103Romania Diabetes Compartment MediașMunicipal HospitalMediaș551030Romania Doctoral School of Medicine and Pharmacy George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department M3/Internal Medicine VI George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department of Cardiology Emergency County Clinical HospitalTârgu Mureş540136Romania

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepatic interaction in the context type 2 diabetes mellitus(T2DM)is not fully *** To evaluate the changes in cardiac morphology and function in patients with T2DM and MASLD-associated liver *** T2DM patients with MASLD underwent a medical evaluation that included an assessment of lifestyle,anthropometric measurements,vital signs,an extensive laboratory panel,and a standard *** fibrosis was evaluated using two scores[Fibrosis-4(FIB4)and Non-alcoholic fatty liver disease-Fibrosis Score(NFS)],and subjects were classified as having advanced fibrosis,no fibrosis,or an indeterminate *** correlations between structural and functional cardiac parameters and markers of liver fibrosis were evaluated through bivariate and multiple regression *** significance was set at P<*** Data from 267 T2DM-MASLD subjects with complete assessment was *** with scores indicating advanced fibrosis exhibited higher interventricular septum and left ventricular(LV)posterior wall thickness,atrial diameters,LV end-systolic volume,LV mass index(LVMi),and epicardial adipose tissue thickness(EATT).Their mean ejection fraction(EF)was significantly lower(49.19%±5.62%vs 50.87%±5.14%vs 52.00%±3.25%;P=0.003),and a smaller proportion had an EF≥50%(49.40%vs 68.90%vs 84.21%;P=0.0017).Their total and mid LV wall motion score indexes were higher(P<0.05).Additionally,they had markers of diastolic dysfunction,with a higher E/e’ratio[9.64±4.10 vs 8.44(2.43-26.33)vs 7.35±2.62;P=0.026],and over 70%had lateral e’values<10 cm/second,though without significant differences between *** multiple regression analyses,FIB4 correlated with left atrium diameter(LAD;β=0.044;P<0.05),and NFS with both LAD(β=0.039;P<0.05)and right

关键词： Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes mellitus Liver fibrosis Cardiac dysfunction Sex-hormone binding protein

Herpes Simplex Virus Encephalitis Complicated by Acute Ischemic Stroke

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Advances in Infectious Diseases 2024年第2期14卷 387-392页

作者： simona Zlatanova Oliana Boykinova Clinic of Infectious Diseases Parasitology University Hospital St George Plovdiv Bulgaria Department of Infectious Diseases Parasitology and Tropical Medicine Medical Faculty Medical University Plovdiv Plovdiv Bulgaria

Introduction: Herpes simplex virus is the most common etiology for life-threatening sporadic encephalitis worldwide. Antiviral therapy with acyclovir has been shown to reduce mortality and should be started promptly in patients with clinically suspected viral encephalitis before serological confirmation of the diagnosis. Despite antiviral treatment, it is associated with significant mortality and a wide range of neurologic sequelae or neuropsychiatric disorders. Clinical presentation includes fever, headache, altered mental status, and focal or generalized seizures. In some cases, it can present with focal neurological deficits, such as an acute stroke. The aim of this study is to identify rare complications of HSVE. Presentation: We present a case of a 71-year-old female patient with herpes virus encephalitis and an ischemic cerebral accident. The findings of CT scan of the brain revealed an extensive right temporal hypodensity. CSF findings include an elevated protein level, normal glucose level and pleocytosis with lymphocyte predominance. The lumbar tap confirmed the presence of herpes simplex virus type 1 with polymerase chain reaction (PCR) in the CSF. Neurological manifestations include focal neurological deficit with left-sided hemiparesis and coma. After 40 days of complex therapy, an improvement in the mental state was observed. Conclusion: There are varying degrees of neurologic sequelae among survivors in children and adults despite the antiviral treatment. Herpes simplex encephalitis has significant morbidity and high mortality due to the lack of prophylactic treatment and preventable strategies.

关键词： Herpes Virus Encephalitis Focal Neurological Deficit Altered Mental Status Stroke Chameleon Persistently Positive CSF

Characterization of the molecular dysfunctions occurring in Aicardi-Goutieres syndrome patients with mutations in ADAR1

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Genes & Diseases 2024年第3期11卷 116-119页

作者： Sofan Al wardat Loredana Frasinlli Elisa Orecchini Federica Rey Silvia Anna Ciafre Silvia Galardi Jessica Garau Stella Gagliardi simona Orcesi Davide Tonduti Stephana Carelli Cristina Cereda Ernesto Picardi Alessandro Michienzi Department of Biomedicine and Prevention University of Rome Tor VergataRome 00133Italy Pediatric Clinical Research Center"Romeo ed Enrica Invernizzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children's HospitalMilano20154Italy Department of Child Neurology and Psychiatry IRccs Mondino FoundationPavia 27100Italy Unit of Pediatric Neurology C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Department of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostructures and Biosystems National Institute(INBB) Rome00136Italy Institute of Biochemistry and Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis.^(1) ADAR1,one of the genes mutated in AGS(AGS6),encodes for an enzyme that belongs to the ADAR family(ADAR1,ADAR2,and ADAR3)that catalyzes the conversion of adenosine to inosine within double-stranded RNAs(dsRNAs)(RNA editing A-to-1).

关键词： ADAR1 interferon res

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QS2025世界大学排名解析--聚焦中国

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教育国际交流 2024年第4期 56-60页

作者： Ben Sowter Alice Wei Alex Berka simona Bizzozero Sally Zhang QS

英国QS世界大学排名是目前全球的三大权威大学排名之一,每年的排名发布都会吸引全球教育界的目光。2024年6月5日,QS发布了2025版世界大学排名,中国大学整体表现亮眼。本期编辑部特邀Ben Sowter高级副总裁及QS资深学术顾问团队对此次排... 详细信息

英国QS世界大学排名是目前全球的三大权威大学排名之一,每年的排名发布都会吸引全球教育界的目光。2024年6月5日,QS发布了2025版世界大学排名,中国大学整体表现亮眼。本期编辑部特邀Ben Sowter高级副总裁及QS资深学术顾问团队对此次排名进行独家分析,对中国高校的表现作出权威解读,并就“留学中国”的品牌建设提出专业建议。

关键词：学术顾问大学排名副总裁权威解读中国大学整体表现

Protein-S-100-beta is increased in patients with decompensated cirrhosis admitted to ICU

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Journal of Intensive Medicine 2024年第2期4卷 222-230页

作者： Nicolas Weiss simona Tripon Maxime Mallet Françoise Imbert-Bismut Mehdi Sakka Dominique Bonnefont-Rousselot Philippe Sultanik Sarah Mouri Marika Rudler Dominique Thabut Sorbonne Université AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreDépartement de NeurologieUnitéde Médecine Intensive RéanimationàOrientation NeurologiqueParisFrance Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et Fibro-Inflammatoire du FoieInstitute of Cardiometabolism and Nutrition(ICAN)ParisFrance Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université ParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreService d'hépato-GastroentérologieUnitéde Soins Intensifs d'HépatologieParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéService de Biochimie MétaboliqueHôpitaux Universitaires Pitié-Salpêtrière-Charles FoixDMU BioGeMParis F-75013France UniversitéParis Cité UFR de PharmacieCNRSInsermUTCBSParisFrance

Background Hepatic encephalopathy(HE)is highly prevalent in patients with liver *** pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic ***,some data suggest altered functioning of the blood–brain barrier(BBB).Assessing BBB function is challenging in clinical practice and at the ***-S-100 Beta(PS100-Beta)could be a useful peripheral marker of BBB permeability in *** study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit(ICU)with decompensated cirrhosis with and without overt *** We retrospectively evaluated a prospective cohort of cirrhotic patients admitted to the ICU from October 2013 to September 2015 that had an available plasmatic PS100-Beta *** with previous neurological impairment or limitation of intensive or resuscitative measures were *** HE was defined as West-Haven grades 2 to *** patients were compared to a control cohort of outpatient clinic cirrhotic and non-cirrhotic patients explored for isolated elevation of liver *** ICU discharge,the patients were followed for at least 3 months for the occurrence of overt *** outcomes(liver transplantation or death)were *** ability of PS100-Beta–in combination with other factors–to predict overt HE was evaluated in a multivariate analysis using logistic *** ratios were used to determine the effects and calculate odds ratios(OR).Survival analysis was performed by using the Kaplan–Meier method and survival between groups was compared using a Log-rank *** A total of 194 ICU patients and 207 outpatients were included in the *** levels of plasmatic PS100-Beta were detected in the ICU decompensated cirrhotic patients compared with the outpatients([0.15±0.01]mg/L vs.[0.08±0]mg/L,P<0.001).ICU patients with overt HE had higher levels of PS100-Beta([0.19±0.03]mg/L)compared with the

关键词： Cirrhosis Hepatic encephalopathy Blood-brain barrier PS100-Beta Liver disease