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Advanced gastric cancer:what we know and what we stillhave to learn

World Journal of Gastroenterology 2016年第3期22卷 1139-1159页

作者： Federico Coccolini Giulia Montori Marco Ceresoli simona cima Maria Carla Valli Gabriela E Nita Arianna Heyer Fausto Catena Luca Ansaloni Department of General Surgery Papa Giovanni XXIII Hospital24127 BergamoItaly Radiation Oncology Center Department of ExperimentalDiagnostic and Specialty Medicine-DIMESSant’Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Maria Carla Valli Radiation Oncology UnitOncology Institute of Southern Switzerland6500 BellinzonaSwitzerland University of California BerkeleyCA 94720-5800United States Department of General and Emergency Surgery Maggiore hospital43100 ParmaItaly

Gastric cancer is a common neoplastic disease and, more precisely, is the third leading cause of cancer death in the world, with differences amongst geographic areas. The definition of advanced gastric cancer is still debated. Different stadiating systems lead to slightly different stadiation of the disease, thus leading to variations between the single countries in the treatment and outcomes. In the present review all the possibilities of treatment for advanced gastric cancer have been analyzed. Surgery, the cornerstone of treatment for advanced gastric cancer, is analyzed first, followed by an investigation of the different forms and drugs of chemotherapy and radiotherapy. New frontiers in treatment suggest the growing consideration for intraperitoneal administration of chemotherapeutics and combination of traditional drugs with new ones. Moreover, the necessity to prevent the relapse of the disease leads to the consideration of administering intraperitoneal chemotherapy earlier in the therapeutical algorithm.

关键词： Advanced gastric cancer Chemotherapy Hypertermic intraperitoneal chemotherapy Intraperitoneal Surgery Definition

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