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Essential biology Neil A. Campbell, jane B. Reece, Eric j. simon. 2nd ed.

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Essential biology Neil A. Campbell, Jane B. Reece, Eric J. S...

Structural Basis of Interaction of Bipartite Nuclear Localization Signal from Agrobacterium VirD2 with Rice Importin-o

2004年

作者： Neil A. Campbell jane B. Reece Eric j. simon.

Student CD-ROM includes: Activities, process of sciences, quizzes, flashcards, glossary.

ISBN: (纸本)0805374957

Student CD-ROM includes: Activities, process of sciences, quizzes, flashcards, glossary.

关键词： Biology.

来源：畅想之星图书光盘版（南... 评论

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Molecular Plant 2014年第6期7卷 1061-1064页

作者： Chiung-Wen Chang simon j. Williams Rafael Miguez Couñago Bostjan Kobe School of Chemistry and Molecular Biosciences Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre University of Queensland Brisbane Qld 4072 Australia

Dear Editor, In the eukaryotic cell, the nuclear envelope separates genomic DNA from the rest of the cell, but ensures a molecu- lar communication between the nucleus and the cytoplasm through the nuclear pore complexes （NPCs）. Nuclear trans- port of macromolecules is an energy-dependent process, exemplified by the classical nuclear import pathway. In the cytoplasm, proteins containing classical nuclear localization signals （cNLSs） are recognized by a hetero-dimeric transport receptor （importin-α （Impα）：importin-β （Impl3） complex）. Impa is employed as an adaptor protein that specifically rec-ognizes the classical nuclear localization signal （cNLS） from the cargo protein （Marfori et al., 2011）. Translocation of the trimeric cargo：transport receptor import complex through the NPCs is mediated by transient interactions between Impβ and nucleoporins in the NPC. The directionality of the trans- port is imparted by the asymmetric distribution, between the cytoplasm and the nucleus, of the distinct nucleotide-bound （GTP/GDP） states of the small GTPase Ran （Tran et al., 2007）.

关键词： CRYSTAL-STRUCTURE TRANSFORMATION

High Q and sub-wavelength THz electric field confinement in ultrastrongly coupled THz resonators

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光子学研究:英文版 2023年第7期11卷 1203-1216页

作者： simon MESSELOT SOLEN COEYMANS jEROME TIGNON SUKHDEEP DHILLON jULIETTE MANGENEY Laboratoire de Physique de l’Ecole Normale Supérieure Ecole normale supérieurePSL UniversitySorbonne UniversitéUniversitéParis DiderotSorbonne Paris CitéCNRS24 rue Lhomond75005 ParisFrance

The control of light–matter coupling at the single electron level is currently a subject of growing interest for the development of novel quantum devices and for studies and applications of quantum *** the terahertz(THz)spectral range,this raises the particular and difficult challenge of building electromagnetic resonators that can conciliate low mode volume and high quality ***,we report on hybrid THz cavities based on ultrastrong coupling between a Tamm cavity and an LC circuit metamaterial and show that they can combine high quality factors of up to Q=37 with a deep-subwavelength mode volume of V=3.2×10^(-4)λ^(3).Our theoretical and experimental analysis of the coupled mode properties reveals that,in general,the ultrastrong coupling between a metamaterial and a Fabry–Perot cavity is an effective tool to almost completely suppress radiative losses and,thus,ultimately limit the total losses to the losses in the metallic *** Tamm cavity-LC metamaterial coupled resonators open a route toward the development of single photon THz emitters and detectors and to the exploration of ultrastrong THz light–matter coupling with a high degree of coherence in the few to single electron limit.

关键词： coupling cavity coupled

A simultaneous approach for integration of thermal energy storages in industrial processes using multiperiod heat integration

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Energy Storage and Saving 2022年第2期1卷 117-128页

作者： simon Möhren Christian Schäfer jörg Meyer Hartmut Krause SWK E2 Institute for Energy Technology and Energy Management Hochschule Niederrhein University of Applied ScienceKrefeld47805Germany Institute of Thermal Engineering TU Bergakademie FreibergFreiberg09599Germany

In times of increasing global warming,enormous efforts are required to rapidly reduce greenhouse gas(GHG)*** to the EU’s target of climate neutrality by 2050 and the even more ambitious goal of becoming climate-neutral in Germany by 2045,it is necessary to systematically increase energy efficiency and decarbonize the industrial heat *** methods of heat integration can be used to exploit existing potentials for waste heat utilization and to integrate renewable technologies for heating and *** using a non-stationary,multiperiod approach,additional energy savings can be achieved by integrating a thermal energy storage(TES)that enables heat transportation over *** paper presents a simultaneous approach for thermal energy storage integration into multiperiod heat integration *** approach can be used to minimize energy demand,costs and CO 2 emissions and is demonstrated in two case *** case study 1,it is shown that the presented approach is capable of integrating a TES properly into a simple multiperiod heat integration problem with two *** case study 2,a simplified example from a cosmetics manufactory is *** total utility demand can be reduced by up to 44.3%due to TES integration and the energetic optimal storage size can be determined as 125 m *** savings are strongly dependent on the constellation of heat flows between the periods,on the temperature levels and on the storage *** reductions of energy demand,costs and CO 2 emissions can be achieved with TES being properly integrated into a suitable operating environment.

关键词： Multiperiod heat integration Thermal energy storage Waste heat utilization Heat exchanger network Energy efficiency

Celiac disease:Management of persistent symptoms in patients on a gluten-free diet

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World journal of Gastroenterology 2012年第12期18卷 1348-1356页

作者： David H Dewar Suzanne C Donnelly simon D McLaughlin Matthew W johnson H julia Ellis Paul j Ciclitira King's College London Division of Diabetes and Nutritional SciencesDepartment of GastroenterologyThe Rayne InstituteSt Thomas' HospitalLondon SE1 7EHUnited Kingdom

AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued ***:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo *** individuals were investigated to establish the eitiology of their continued *** patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody *** were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where ***,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms *** clinical progress was followed over a minimum of 2 ***:One hundred and twelve consecutive patients were referred with *** were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting *** colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal *** 2 years,78 patients remained well,eight had continuing symptoms,and four had ***:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading *** propose an algorithm for investigation.

关键词： Celiac disease Non-responsive celiac disea-se Refractory celiac disease Gluten Gluten-free diet

Tracking the Cretaceous transcontinental Ceduna River through Australia:The hafnium isotope record of detrital zircons from offshore southern Australia

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Geoscience Frontiers 2016年第2期7卷 237-244页

作者： jarred Lloyd Alan S.Collins justin L.Payne Stijn Glorie simon Holford Anthony j.Reid Centre for Tectonics Resources and Exploration(TRaX)Department of Earth SciencesThe University of Adelaide Centre for Tectonics Resources and Exploration(TRaX)School of Built and Natural EnvironmentsThe University of South Australia Centre for Tectonics Resources and Exploration(TRaX)Australian School of PetroleumThe University of Adelaide Geological Survey of South Australia Department of State DevelopmentGovernment of South Australia

The middle-upper Cretaceous Ceduna River system traversed continental Australia from the NE coast to the centre of the southern coast. At its mouth, it formed a vast delta system that is similar in scale to the Niger delta of West Africa. The delta system is composed of two main lobes that represent different phases of delta construction. A recent hypothesis has challenged the traditional idea that both lobes of the delta were derived from a transcontinental river system by suggesting that the upper lobe （Santonian -Maastrichtian） is instead derived from a restricted catchment within southern Australia. Hf isotopic data presented here fingerprint the original source of the upper delta lobe zircons to NE Australia, with data comparing well with similar U-Pb and Lu-Hf isotopic data from the Lachlan Orogen, the New England Orogen, the eastern Musgraves Province and the northern Flinders Ranges. These data do not preclude a model where the lobe is derived from recycled Eromanga Basin sediments during a phase of late Cretaceous inland Australian uplift, but when coupled with reconnaissance low-temperature thermochronometry from the region of the Ceduna River course indicating widespread Triassic-jurassic exhumation, and comparisons with detrital zircon data from the Winton Formation upstream of any proposed uplift, we suggest that both lobes of the Ceduna Delta are likely to be derived from a transcontinental Ceduna River.

关键词： Detrital zircon Hf U-Pb Ceduna sub-basin Bight basin Australia

Plasticity of Xyloglucan Composition in Bean （Phaseolus vulgaris）-Cultured Cells during Habituation and Dehabituation to Lethal Concentrations of Dichlobenil

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Molecular Plant 2010年第3期3卷 603-609页

作者： A. Alonso-simon L. Neumetzler R Garcia-Angulo A.E. Encina j.L. Acebes j.M. Alvarez T. Hayashi Area de Fisiologia Vegetal Universidad de Leon E-24071 Leon Spain Max Planck Institute of Molecular Plant Physiology 14476 Golm Germany Kyoto University RISH Gokasho Uji Kyoto 611-0011 Japan

Bean cells that have been habituated to grow in a lethal concentration （12 μM） of 2,6-dichlorobenzonitrile （dichlobenil or DCB, a cellulose biosynthesis inhibitor） are known to have decreased cellulose content in their cell walls. Xyloglucan, which is bound to cellulose and together with it forms the main loading network of plant cell walls, has also been described to decrease in habituated cells, but whether the change on cellulose affects the xyloglucan structure besides its abundance has not been analyzed. Fragmentation analysis with xyloglucan-specific endoglucanase （XEG） and endocellulase revealed that habituation to DCB caused a change in the fine structure of xyloglucan, namely a decrease in fucosyl residues attached to the galactosyl-xylosyl residues along the glucan backbone. After the removal of herbicide from the medium （dehabituated cells）, xyloglucan recovered its fucosyl residues. In addition, some cello-oligosaccharides could be detected only in habituated cells＇ xyloglucan digested by XEG and endocellulase, corresponding to a glucan co- valently bound or co-precipitated with the hemicelluloses. These results show that structural flexibility of cell walls relies in part on the plasticity of xyloglucan composition and opens up new perspectives to further research in this field.

关键词： Bean 2,6-dichlorobenzonitrile habituation and dehabituation OLIMP (Oligosaccharides Mass Profiling) xyloglucan.

3D-QSAR analysis of a new type of acetylcholinesterase inhibitors

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Science China(Life Sciences) 2007年第6期50卷 726-730页

作者： LEE simon M. Y Institute of Chinese Medical Sciences University of Macao Av. Padre Tomas Pereira S. J. Taipa Macao China

Acetylcholinesterase (AChE) inhibitors are an important class of medicinal agents used for the treatment of Alzheimer’s disease. A screening model of AChE inhibitor was used to evaluate the inhibition of a series of phenyl pentenone derivatives. The assay result showed that some compounds displayed higher inhibitory effects. In order to study the relationship between the bioactivities; the structures, 26 compounds with phenyl pentenone scaffold were analyzed. A 3D-QSAR model was constructed using the method of comparative molecular field analysis (CoMFA). The results of cross-validated R[2]cv=0.629, non-cross-validated R[2]=0.972, SE=0.331,; F=72.41 indicate that the 3D-model possesses an ability to predict the activities of new inhibitors,; the CoMFA model would be useful for the future design of new AChE inhibitors.

关键词： acetylcholinesterase (AChE), comparative molecular field analysis (CoMFA), phenyl pentenone derivatives

Mate-recognition and species boundaries in the ascomycetes

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Fungal Diversity 2013年第1期58卷 1-12页

作者： simon H.Martin Emma T.Steenkamp Michael j.Wingfield Brenda D.Wingfield Department of Genetics Forestry and Agricultural Biotechnology InstituteUniversity of PretoriaPretoria 0002South Africa Department of Microbiology and Plant Pathology Forestry and Agricultural Biotechnology InstituteUniversity of PretoriaPretoria 0002South Africa

Reproductive gene evolution is commonly invoked as a source of reproductive isolation during *** possibility has not been adequately explored in the Ascomycota,the most species-rich fungal *** mechanisms of mate-recognition in this group are relatively simple:a“mating type”locus determines reproductive mode and sexual compatibility,and two pheromone/receptor pairs control sexual ***,ascomycete reproductive genes can experience unique and interesting evolutionary forces,which could lead to rapid *** this review,we examine the mechanisms of sexual interaction in ascomycetes and explore current evidence as to whether these mechanisms allow for species-specificity in *** discuss the evolutionary forces that can drive reproductive gene divergence,how these may apply in the world of ascomycetes,and their possible consequences for speciation.

关键词： Ascomycota Speciation Mating type Pheromone Receptor