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Cost-effectiveness analysis of treatments for metastatic castration resistant prostate cancer

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Asian journal of Urology 2017年第1期4卷 37-43页

作者： Matthew E.Pollard Alan j.Moskowitz Michael A.Diefenbach simon j.Hall Department of Urology UCLA School of MedicineLos AngelesCAUSA Department of Health Evidence and Policy Mount Sinai School of MedicineNew YorkNYUSA Smith Institute for Urology Hofstra Northwell School of MedicineLake SuccessNYUSA

Objective:Treatment options for metastatic castration resistant prostate cancer(mCRPC)have expanded rapidly in recent *** the significant economic burden,we sought perform a cost-effectiveness analysis(CEA)of the contemporary treatment paradigm for ***:We devised a treatment protocol consisting of sipuleucel-T,enzalutamide,abiraterone,docetaxel,radium-223,and *** estimated number and length of treatments for each therapy using dosing schedules or progression free survival data from published clinical *** estimated treatment cost using billing data and Medicare reimbursement values and performed a *** analysis assumed US$100,000 per life year saved(LYS)as the threshold societal willingness to ***:Incremental cost-effectiveness ratios(ICER)for strategies incorporating sipuleucel-T that were not eliminated by extended dominance exceeded the societal threshold willingnessto-pay of US$100,000 per LYS,the lowest of which was sipuleucel-T+enzalutamide+abiraterone+docetaxel at US$207,714 per ***+abiraterone+docetaxel exhibited the most favorable ICER among strategies without sipuleucel-T at US$165,460 per ***:Based on the available survival data and current costs of treatment,all treatment strategies greatly exceed a commonly assumed societal willingness-to-pay threshold of US$100,000 per *** in this regard can only comewith a reduction in pricing,better tailoring of treatment or significant enhancements in survival with clinical use of treatment combinations or sequences.

关键词： Metastatic prostate cancer Costs and cost analysis Health expenditures Economics Pharmaceutical

Decoding earth’s plate tectonic history using sparse geochemical data

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Geoscience Frontiers 2020年第1期11卷 265-276页

作者： Michael G.Tetley Zheng-Xiang Li Kara j.Matthews simon E.Williams R.Dietmar Müller EarthByte Group School of GeosciencesUniversity of SydneyNSWAustralia Seismological Laboratory California Institute of TechnologyPasadenaCAUSA Data61 CSIROAustralian Technology ParkNSWAustralia Earth Dynamics Research Group The Institute for Geoscience Research(TIGeR)School of Earth and Planetary SciencesCurtin University of TechnologyGPO Box U1987PerthWA 6845Australia

Accurately mapping plate boundary types and locations through time is essential for understanding the evolution of the plate-mantle system and the exchange of material between the solid Earth and surface ***,the complexity of the Earth system and the cryptic nature of the geological record make it difficult to discriminate tectonic environments through deep *** we present a new method for identifying tectonic paleo-environments on Earth through a data mining approach using global geochemical *** first fingerprint a variety of present-day tectonic environments utilising up to 136 geochemical data attributes in any available combination.A total of 38301 geochemical analyses from basalts aged from 5-0 Ma together with a well-established plate reconstruction model are used to construct a suite of discriminatory models for the first order tectonic environments of subduction and mid-ocean ridge as distinct from intraplate hotspot oceanic environments,identifying 41,35,and 39 key discriminatory geochemical attributes,*** training and validation,our model is applied to a global geochemical database of 1547 basalt samples of unknown tectonic origin aged between 1000-410 Ma,a relatively ill-constrained period of Earth’s evolution following the breakup of the Rodinia supercontinent,producing 56 unique global tectonic environment predictions throughout the Neoproterozoic and Early *** are used to discriminate between three alternative published Rodinia configuration models,identifying the model demonstrating the closest spatio-temporal consistency with the basalt record,and emphasizing the importance of integrating geochemical data into plate *** approach offers an extensible framework for constructing full-plate,deeptime reconstructions capable of assimilating a broad range of geochemical and geological observations,enabling next generation Earth system models.

关键词： Plate tectonics Geochemistry Geodynamics Supercontinents Rodinia Big data

语言测评中的统计分析当代国外语言学与应用语言学文库第3辑

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Understanding the effects of the core on the nutation of the Earth

丛书名：当代国外语言学与应用语言学文库

2014年

作者： Lyle F. Bachman antony j. Kunnan

本书共分为三部分，第一部分由第1章至第3章组成，介绍了语言测评的基本概念及统计方法，第二部分由第4章至第6章组成，介绍了分析和改进测试的统计方法，第三部分由第7章至第10章组成，介绍了使用测评的统计方法。

ISBN: (纸本)9787513539630

关键词：语言

来源：畅想之星图书光盘版（南... 评论

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Geodesy and Geodynamics 2017年第6期8卷 389-395页

作者： Véronique Dehant Raphael Laguerre jérémy Rekier Attilio Rivoldini Santiago Andres Triana antony Trinh Tim Van Hoolst Ping Zhu Royal Observatory of Belgium 3 Avenue Circulaire B-1180 Brussels Belgium

In this review paper, we examine the changes in the Earth orientation in space and focus on the nutation（shorter-term periodic variations）, which is superimposed on precession（long-term trend on a timescale of years）. We review the nutation modelling involving several coupling mechanisms at the core-mantle boundary using the Liouville angular momentum equations for a two-layered Earth with a liquid flattened core. The classical approach considers a Poincare fluid for the core with an inertial pressure coupling mechanism at the core-mantle boundary. We examine possible additional coupling mechanisms to explain the observations. In particular, we examine how we can determine the flattening of the core as well as information on the magnetic field and the core flow from the nutation observations. The precision of the observations is shown to be high enough to increase our understanding on the coupling mechanisms at the core-mantle boundary.

关键词： Precession Nutation Core

Weave geometry generation avoiding interferences for mesoscale RVEs

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journal of Materials Science & Technology 2019年第12期35卷 2869-2882页

作者： Daniel Höwer Shengkai Yu Trenton M.Ricks Brett A.Bednarcyk Evan j.Pineda Bertram Stier Stefanie Reese jaan-Willem simon Institute of Applied Mechanics RWTH Aachen University52074 AachenGermany NASA Glenn Research Center ClevelandOH 44135USA Collier Research and Development Corporation Newport NewsVA 23606USA

An algorithm which allows the generation of representative volume elements(RVEs) for complex woven and warp-interlaced fiber-reinforced composite topologies while avoiding unphysical tow intersections is presented. This is achieved by extending an existing RVE generation strategy in two significant ways:(1) the local cross section shape of the tow is adjusted depending on the local tow curvature in a way that preserves the cross sectional area of the tow, and(2) the elementary crimp interval is separated into a planar and a transition region. The modifications facilitate the generation of a wide range of elaborate textile topologies without tow intersections, which are present without the proposed modifications unless complex tow to tow contact models are introduced. The mechanical properties of plain weaves were predicted based on the topology generated with the proposed algorithm as well as based on RVEs which were constructed based on actual micrographs, i.e. a "digital twin" of the actual microstructure. A comparison of the predicted mechanical properties based on finite element and Multiscale Generalized Method of Cells techniques shows close agreement. However, some differences exist with respect to experimentally determined material parameters due to the finite dimensions of the specimens. Lastly,mechanical properties of multilayered weaves are predicted with the finite element method. The considered material systems are carbon fiber in epoxy matrix as well as C/C-SiC. However, the procedure is applicable to a wide range of material systems.

关键词： RVE generation Multiscale analysis Composites

Rapid Validated Stability Indicating Method for Nizatidine and Its Impurities Quantification

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American journal of Analytical Chemistry 2011年第3期2卷 314-323页

作者： antony Raj Gomes Pannala Raghuram j. Sriramulu Nimmakalaya Srinivas 不详

This research article describes stability indicating fast liquid chromatographic method for determination of chromatographic purity and assay of Nizatidine as a alternate for two different methods for chromatographic purity and assay as given in USP Monograph and *** Monograph. Proposed method is developed on Waters symmetry RP18 (50 × 4.6 mm), 3.5 μm stationary phase using gradient elution with combination of Ammonium acetate Diethyl amine buffer, Methanol and Tetrahydrofuran as mobile phase. Favorable results are obtained under developed conditions, which guarantee good separation of studied components. Whereas, data obtained from method validation confirm specificity, high sensitivity, linearity in a range of studied concentrations, repeatability and good accuracy of this method. Considerable degradation observed in oxidation stress condition was detected by this method. Eight impurities are studied among which impurity-5 is found major degradant. The stress samples are assayed against a qualified standard and the mass balance is found close to 99.2%. The developed method can be used for routine samples as well as stability studies.

关键词： Column Liquid Chromatography Nizatidine Forced Degradation Validation Stability Indicating

Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial

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四川生理科学杂志 2021年第10期43卷 1799-1799页

作者： simon j Bowman Rheumatology Department University Hospitals Birmingham NHS Foundation Trust Birmingham UK Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham UK National Institute for Health Research Birmingham Biomedical Research Centre University of Birmingham Birmingham UK Rheumatology Department Milton Keynes University Hospital Milton Keynes UK Rheumatology Clinic Scripps Memorial Hospital and Research Institute La Jolla CA USA Department of Medicine Rheumatology and Clinical Immunology Charité Universitätsmedizin and Deutsches Rheumaforschungszentrum Berlin Germany Université Paris Saclay Assistance Publique-Hôpitaux de Paris Hôpital Bicêtre INSERM U1184 Le Kremlin Bicêtre France Division of Oral Medicine Tufts School of Dental Medicine Boston MA USA Division of Rheumatology Johns Hopkins School of Medicine Baltimore MD USA Rheumatology Department University Hospitals Birmingham NHS Foundation Trust Birmingham UK Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham UK National Institute for Health Research Birmingham Biomedical Research Centre University of Birmingham Birmingham UK Chronic Diseases Research Center Nova Medical School Lisbon Portugal Instituto Português de Reumatologia Lisbon Portugal Rheumatology Department Hospital Cuf Descobertas Lisbon Portugal Clinic of Rheumatology University Hospital Santa Maria della Misericordia Department of Medical Area University of Udine Udine Italy Division of Rheumatology and Clinical Immunology Department of Internal Medicine IV Ludwig-Maximilians-University of Munich Munich Germany Department of Rheumatology Liverpool University Hospitals NHS Foundation Trust and Edge Hill University Liverpool UK Novartis Pharma Basel Switzerland Novartis Pharmaceuticals East Hanover NJ USA

Background:Sjögren's syndrome is an autoimmune disease characterised by dry eyes and mouth,systemic features,and reduced quality of *** are no disease-modifying treatments.A new biologic,ianalumab(VAY736),with two modes of suppressing B cells,has previously shown preliminary *** dose-finding trial aimed to assess the safety and efficacy of different subcutaneous doses of ianalumab in patients with moderate to severe primary Sjögren's syndrome.

关键词： subcutaneous patients doses

The GATK joint genotyping workflow is appropriate for calling variants in RNA-seq experiments

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journal of Animal Science and Biotechnology 2019年第3期10卷 811-816页

作者： jean-simon Brouard Flavio Schenkel Andrew Marete Nathalie Bissonnette Sherbrooke Research and Development Centre Agriculture and Agri-Food CanadaSherbrookeQC J1M 0C8Canada Center of Genetic Improvement of Livestock University of GuelphGuelphON N1G 2W1Canada

The Genome Analysis Toolkit(GATK) is a popular set of programs for discovering and genotyping variants from next-generation sequencing *** current GATK recommendation for RNA sequencing(RNA-seq) is to perform variant calling from individual samples,with the drawback that only variable positions are *** 3.0 and above of GATK offer the possibility of calling DNA variants on cohorts of samples using the HaplotypeCaller algorithm in Genomic Variant Call Format(GVCF) *** this approach,variants are called individually on each sample,generating one GVCF file per sample that lists genotype likelihoods and their genome *** a second step,variants are called from the GVCF files through a joint genotyping *** strategy is more flexible and reduces computational challenges in comparison to the traditional joint discovery *** a GVCF workflow for mining SNP in RNA-seq data provides substantial advantages,including reporting homozygous genotypes for the reference allele as well as missing *** advantage of RNA-seq data derived from primary macrophages isolated from 50 cows,the GATK joint genotyping method for calling variants on RNA-seq data was validated by comparing this approach to a so-called "per-sample" *** addition,pair-wise comparisons of the two methods were performed to evaluate their respective sensitivity,precision and accuracy using DNA genotypes from a companion study including the same 50 cows genotyped using either genotyping-by-sequencing or with the Bovine SNP50 Beadchip(imputed to the Bovine high density).Results indicate that both approaches are very close in their capacity of detecting reference variants and that the joint genotyping method is more sensitive than the per-sample *** that the joint genotyping method is more flexible and technically easier,we recommend this approach for variant calling in RNA-seq experiments.

关键词： GATK GVCF joint genotyping RNA-seq SNP

Regulation of Plant Vitamin Metabolism:Backbone of Biofortification for the Alleviation of Hidden Hunger

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Molecular Plant 2021年第3期14卷 40-60页

作者： Ling jiang simon Strobbe Dominique Van Der Straeten Chunyi Zhang Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Laboratory of Functional Plant Biology Ghent UniversityK.L.Ledeganckstraat 359000 GhentBelgium These authors contributed equally to this work

Micronutrient deficiencies include shortages of vitamins and *** affect billions of people and are associated with long-range effects on health,learning ability,and huge economic *** of multiple micronutrients can play an important role in combating *** challenge,however,is to balance plant growth with nutrient requirements for ***,we summarize the major progress about vitamin biosynthesis and its response to the changing *** discuss the interactions among vitamins as well as possible strategies for vitamin ***,we propose to integrate new breeding technologies with metabolic pathway modification to facilitate the biofortification of crops,thereby alleviating the hidden hunger of target populations.

关键词： vitamins biosynthesis regulatory mechanisms biofortification hidden hunger