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Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun Hon Yan Min Bao Kate C.Chan Kin Wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung Chiu Li Deng Chun-Hui He Kin Mui Ieong Jeng Sum C.Kung Ping Lam Shu Yan David Lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei Shi Ka Ka siu Wei-Ping Tan Maggie Haitian Wang Tak Wai Wong Bao-Jing Wu Ada Y.F.Yip Yue-Jie Zheng Daniel K.ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, Png', and 'smoker in family' were prevalent among the four cities. Logistic regres-sion showed better control of asthma was associated with better PADQLQ (B=?0.029, P ng at home (B=3.9, P ng the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine

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香港中小学公民教育的发展与对策

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基础教育 2011年第2期8卷 120-128页

作者：胡少伟香港教育学院国际教育与终身学习学系

本文剖析了香港于回归前后公民教育的发展。因受前殖民地教育的影响,回归初期,香港中小学生的建构新国民身份教育进展不大;近年特区政府逐步加强推行公民教育。作为一个国际城市,在全球化的情境中,香港学校要以全球、国家和本土等三个... 详细信息

本文剖析了香港于回归前后公民教育的发展。因受前殖民地教育的影响,回归初期,香港中小学生的建构新国民身份教育进展不大;近年特区政府逐步加强推行公民教育。作为一个国际城市,在全球化的情境中,香港学校要以全球、国家和本土等三个层次向学生推行公民教育,以应对学生的需要。

关键词：公民教育香港教育国民身份

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对话王子:李明的梦境启示

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艺术界 2018年第1期 126-131页

作者： ng Wing Sze

天线空间一直是驻扎在上海M50艺术区的中坚力量。在将中国年轻一代的艺术家推向国际舞台，以及将国外的当代艺术实践引入中国这两方面，它都扮演着关键的角色。创办人王子自画廊成立之初便代理了艺术家李明的作品。

关键词：李明艺术欣赏艺术作品艺术创作

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比较复方丹参滴丸与地奥心血康胶囊治疗心绞痛随机对照临床试验的系统评价和meta分析

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中西医结合学报 2012年第1期10卷 25-34页

作者：吴翠珊王善萍张君隆吴玉丹贾永亮梁少伟澳门大学中药质量研究国家重点实验室澳门999078 澳门大学中华医药研究院澳门999078 Joint Edinburgh-Macao Laboratory for Biomedical Informatics and Global Health Technologies School of InformaticsUniversity of Edinburgh

背景:复方丹参滴丸与地奥心血康胶囊是治疗冠心病心绞痛的常用中成药,已有临床试验比较它们的疗效,但尚未发现比较两者治疗心绞痛疗效的系统评价报告。目的:基于复方丹参滴丸和地奥心血康胶囊治疗心绞痛的临床随机对照试验(radominzed c... 详细信息

背景:复方丹参滴丸与地奥心血康胶囊是治疗冠心病心绞痛的常用中成药,已有临床试验比较它们的疗效,但尚未发现比较两者治疗心绞痛疗效的系统评价报告。目的:基于复方丹参滴丸和地奥心血康胶囊治疗心绞痛的临床随机对照试验(radominzed controlled trial,RCT),通过meta分析系统评价两者治疗心绞痛的疗效。检索策略:检索发表于1994年至2011年的复方丹参滴丸和地奥心血康胶囊治疗心绞痛的RCT报告。检索的中文数据库包括中国博士学位论文全文数据库、中国期刊全文数据库、中国优秀硕士学位论文全文数据库和万方数据库;检索的外文数据库为Cochrane图书馆、荷兰医学文摘、ScienceDirect、MEDLINE(EBSCOhost)和PubMed。最后检索日期为2011年4月7日。纳入标准:报告描述为RCT,不限定发表语言;干预措施为使用药物治疗心绞痛;治疗组和对照组分别采用复方丹参滴丸和地奥心血康胶囊;治疗结局指标包括总体疗效和心电图改善;试验参与者需为冠心病心绞痛患者;疗程至少为28d。资料提取与分析:提取的数据项如下:发表年份;作者姓名;试验日期;试验组与对照组参与者的基线可比性;总样本量;疗效指标,包括总体疗效和心电图改善;疗程;每天给药剂量;复方丹参滴丸和地奥心血康胶囊的不良反应;总体疗效和心电图改善的有关数据。通过纳入和排除标准筛选检索到的RCT,利用Jadad评分量表和Cochrane偏倚风险评估量表进行质量评分。采用优势比(odds ratio,OR)和95%可信区间(confidence interval,CI)衡量总体疗效和心电图改善的效应值。根据纳入RCT的基本特征,进行亚组分析和敏感性分析。结果:最终纳入9篇RCT报告,包括926名试验参与者。9篇RCT中8篇的Jadad得分为2,另外1篇得分为4。复方丹参滴丸对地奥心血康胶囊的总体疗效的优势比为2.06(95%CI:1.03～4.12;P总效应=0.04)。6篇报告心电图疗效的RCT中复方丹参滴丸对地奥心血康胶囊的优势比为1.92(95%CI:1.23～3.00;P心电图疗效=0.004)。亚组分析及敏感性分析未发现可以显著影响结果稳定性的因素。结论:研究结果表明复方丹参滴丸治疗冠心病心绞痛的疗效优于地奥心血康,但尚需要更多高质量的RCT以确定疗效的差异程度。

关键词：中药复方心绞痛 meta分析随机对照试验

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针刺治疗香港地区慢性疲劳综合征的临床研究

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中西医结合学报 2007年第6期5卷 630-633页

作者：姚韧敏吴兆文徐燕龄陈日龙香港大学中医药学院香港大学行为健康教研中心

目的:评价传统针剌治疗香港地区慢性疲劳综台征(chronic fatigue syndrome,CFS)的临床疗效。方法:采用单盲、随机、对照研究方法,将99例合恪受试者按1:1比例随机分成治疗组50例和对照组49例。治疗组以传统针刺法,选取百会、足三里、三... 详细信息

目的:评价传统针剌治疗香港地区慢性疲劳综台征(chronic fatigue syndrome,CFS)的临床疗效。方法:采用单盲、随机、对照研究方法,将99例合恪受试者按1:1比例随机分成治疗组50例和对照组49例。治疗组以传统针刺法,选取百会、足三里、三阴交穴治疗;对照组以平针按穴法(针不刺入皮肤),选穴同治疗组。疗程共4周。每周治疗2次。按照英国Trudie Chalder等制定的疲劳量表和美国疾病控制中心1994年制定的CFS诊断标准及SF-12生活质量量表,建立效应评价表,评价疗效及安全性。结果:治疗后两组临床症状得到改善,在身体疲劳、精神疲劳及SF-12生活质量方面,治疗组优于对照组(P<0.01或P<0.05);受试者未发现不良反应。结论:针剌治疗CFS安全有效。

关键词：慢性疲劳综合征针刺临床试验

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Analysis of the GTPase Activity and Active Sites of the ng Domains of FtsY and Ffh from Streptomyces coelicolor

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Acta Biochimica et Biophysica Sinica 2006年第7期38卷 467-476页

作者： Hui-Jun DOng~1 Sheng-Mao TAO~1 Yong-Quan LI~(1*)siu-Hong CHAN~2 Xue-Ling SHEN~1 Chun-Xia WAng~1 Wen-Jun GUAN~1 1 Institute of Biochemistry,College of Life Science,Zhejiang University,Hangzhou 310027,China 2 New England Biolabs,Ipswich,MA 01938,USA Institute of Biochemistry College of Life Science Zhejiang UniversityHangzhou 310027 China New England BiolabsIpswich MA 01938 USA

Fifty-four homolog(Ffh)and FtsY are the central components of the signal recognitionparticle secretory pathway of *** this study,the core domain and active sites of FtsY and Ffh fromStreptomyces coelicolor,which are responsible for guanosine triphosphate(GTP)hydrolysis,were identi-fied using site-directed *** were introduced to the conserved GXXGXGK loop of theputative GTP binding *** of the Lys residue to Gly in both FtsY and Ffh ng domains significantlydecreased the GTPase activity and GTP binding ***,a structural model of the ternarycomplex of FtsY/Ffh ng domains and the non-hydrolyzable GTP analog guanylyl 5′-(β,γ-methylenediphosphonate)also revealed that each Lys residue in GXXGXGK of FtsY and Ffh provides thepredicted hydrogen bond required for GTP ***,in Fts Y not in Ffh,mutation of the first Glyresidue in the GXXGXGK loop disrupted the GTPase *** addition,protease-digesting test demon-strated that ng protein with the mutation of Lys residue was decomposed more *** blot analysissuggested that in Streptomyces coelicolor,Fts Y is present in the membrane fraction and Ffh in the cytosolfraction during the mid-log phase of *** results indicated that Lys residue in the putative GTPbinding loop was the crucial residue for the GTPase activity of ng domain.

关键词： Streptomyces coelicolor signal recognition particle ng domain GTPase FtsY Ffh

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In situ observation of synthesized nanoparticles in ultra-dilute aerosols via X-ray scattering

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Nano Research 2019年第1期12卷 25-31页

作者： Sarah R.McKibbin Sofie Yngman Olivier Balmes Bengt O.Meuller simon Tagerud Maria E.Messing Giuseppe Portale Michael Sztucki Knut Deppert Lars Samuelson Martin H.Magnusson Edvin Lundgren Anders Mikkelsen Department of Physics and Nanolund Lund UniversityBox 11822100 LundSweden MaxIV Laboratory Lund UniversityBox 11822100 LundSweden University of Groningen Zemike Institute for Advanced MaterialsNijenborgh 4NL-9747 AG GroningenThe Netherlands ESRF-The European Synchrotron CS 4022038043 Grenoble Cedex 9France

In-air epitaxy of nanostructures(Aerotaxy)has recently emerged as a viable route for fast,large-scale *** this study,we use small-a ngle X-ray scatteri ng to perform direct in-flight characterizati ons of the first step of this process,i.e.,the en gineered formatio n of Au and Pt aerosol nan oparticles by spark gen erati on in a flow of N2 *** represe nts a particular challe nge for characterizati on because the particle density can be extremely low in con trolled *** particles produced are exami ned duri ng producti on at operatio nal pressures close to atmospheric conditions and exhibit a log no rmal size distributi on ranging from *** Au and Pt particle productio n and detection are *** observe and characterize the nanoparticles at different stages of synthesis and extract the corresponding domi nant physical properties,in cludi ng the average particle diameter and sphericity,as in flue need by particle sintering and the prese nee of *** observe highly sorted and sin tered spherical Au nano particles at ultra-dilute concen tratio ns(ng to a volume fraction below 3×10^-10,which is orders of magnitude below that of previously measured *** independently confirm an average particle radius of 25 nm via Guinier and Kratky plot *** study indicates that with high-intensity synchrotron beams and careful con sideratio n of backgro und removal,size and shape info rmati on can be obtai ned for extremely low particle concentrations with industrially relevant narrow size distributions.

关键词： aerosol nanoparticle synthesis in situ analysis small-angle X-ray scattering Aerotaxy

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海南鹦哥岭的种子植物区系

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生物多样性 2007年第4期15卷 382-392页

作者：张荣京邢福武萧丽萍刘演叶育石吴世捷陈红锋王发国中国科学院华南植物园中国科学院研究生院北京100049 香港嘉道理农场暨植物园广西植物研究所

海南鹦哥岭保存了我国华南地区面积最大和最原始的热带雨林。2003-2006年间,作者通过近4个月的野外调查,对该地区植物物种多样性进行了研究,以期阐明其种子植物区系组成及其在中国植物物种多样性研究及保育中的重要性。结果如下:该地区... 详细信息

海南鹦哥岭保存了我国华南地区面积最大和最原始的热带雨林。2003-2006年间,作者通过近4个月的野外调查,对该地区植物物种多样性进行了研究,以期阐明其种子植物区系组成及其在中国植物物种多样性研究及保育中的重要性。结果如下:该地区共有野生种子植物173科825属1,706种(含变种)。该地植物区系成分热带性质较强,在属的水平上,泛热带和热带亚洲成分占优势,各占非世界属总数的25.28%和32.36%;中国特有属8个,占非世界属总数的1.01%,其中海南特有属2个,分别为多核果属(Pyrenocarpa)、盾叶苣苔属(Metapetrocosmea)。在种的水平上,热带成分占非世界种总数的70.50%,处于明显优势地位;中国特有种474种,占非世界种总数的28.42%,其中海南特有种149种,占中国特有种的31.44%。鹦哥岭的植物区系在组成上具有较强的特殊性,主要表现在不但具有较多的特殊类群,而且是亚热带植物种类与典型热带植物种类、干热性植物种类与湿热性植物种类相互渗透的交汇地带,在植物区系地理研究方面具有重要意义。最后作者还讨论了该地区与邻近4个地区植物区系的联系,认为鹦哥岭与吊罗山的种子植物区系相似性最大,而与鼎湖山、西双版纳的种子植物区系相比,鹦哥岭表现出更强的热带性。

关键词：物种多样性植物地理成分特有性保育

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Thoracic surgery in 2030

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中华胸部外科电子杂志 2021年第3期8卷 145-152页

作者： Joyce W.Y.Chan Rainbow W.H.Lau Aliss T.C.Chang Ivan C.H.siu Teddy H.Y.Wong Zheng Li Calvin S.H.ng Department of Surgery Prince of Wales Hospitalthe Chinese University of Hong KongHong Kong SARChina

Introduction Thoracic surgery has evolved at an exponential pace since the first clinical lung resection in *** first pneumonectomy was performed in 1895,the first lobectomy in 1901,while double lumen endotracheal intubation for pulmonary resection did not occur until *** 1990s saw the development of game-changer video-assisted thoracoscopic surgeries(VATS),while the 2000s gave witness to the explosive boom of robotic *** Abraham Lincoln once said,“The best way to predict the future is to create it”,in this article we discuss the current cutting-edge technologies and attempt to predict the future of thoracic surgery in 10 years’time.

关键词： surgery lung clinical

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Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-ng

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Molecular Plant 2019年第7期12卷 1027-1036页

作者： Zhaohui Zhong simon Sretenovic Qiurong Ren Lijia Yang Yu Bao Caiyan Qi Mingzhu Yuan Yao He Shishi Liu Xiaopei Liu Jiaheng Wang Lan Huang Yan Wang Dibin Baby David Wang Tao Zhang Yiping Qi Yong Zhang Department of Biotechnology School of Life Sciences and Technology Center for Informational Biology University of 曰ectronic Science and Technology of China Room 216 Main Building No. 4 Section 2 North Jianshe Road Chengdu 610054 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA Jiangsu Key Laboratory of Crop Genetics and Physiology Co-Innovation Center for Modern Production Technology of Grain Crops Key Laboratory of Plant Functional Genomics of the Ministry of Education Yangzhou University Yangzhou 225009 China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou University Yangzhou 225009 China Indian Institute of Science Education and Research Timpati Andhra Pradesh 517507 India Seven Lakes High School Katy TX 77494 USA Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA

Two recently engineered SpCas9 variants, namely xCas9 and Cas9-ng, show promising potential in improving targeting specificity and broadening the targeting range. In this study, we evaluated these Cas9 variants in the model and crop plant, rice. We first tested xCas9-3.7, the most effective xCas9 variant in mammalian cells, for targeted mutagenesis at 16 possible ngN PAM (protospacer adjacent motif) combinations in duplicates. xCas9 exhibited nearly equivalent editing efficiency to wild-type Cas9 (Cas9-WT) at most canonical ngG PAM sites tested, whereas it showed limited activity at non-canonical ngH (H = A, C, T) PAM sites. High editing efficiency of xCas9 at ngG PAMs was further demonstrated with C to T base editing by both rAPOBECI and PmCDAI cytidine deaminases. With mismatched sgRNAs, we found that xCas9 had improved targeting specificity over the Cas9-WT. Furthermore, we tested two Cas9-ng variants, Cas9-ngv1 and Cas9-ng, for targeting ngN PAMs. Both Cas9-ng variants showed higher editing efficiency at most non-canonical ng PAM sites tested, and enabled much more efficient editing than xCas9 at AT-rich PAM sites such as GAT, GAA, and CAA. Nevertheless, we found that Cas9-ng variants showed significant reduced activity at the canonical ngG PAM sites. In stable transgenic rice lines, we demonstrated that Cas9-ng had much higher editing efficiency than Cas9-ngv1 and xCas9 at ng PAM sites. To expand the base-editing scope, we developed an efficient C to T base-editing system by making fusion of Cas9-ng nickase (D10A version), PmCDAI, and UGI. Taken together, our work benchmarked xCas9 as a high-fidelity nuclease for targeting canonical ngG PAMs and Cas9-ng as a preferred variant for targeting relaxed PAMs for plant genome editing.

关键词： xCas9 Cas9-ng high fidelity non-canonical PAM base editing

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