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Aging effects on QT interval： Implications for cardiac safety of antipsychotic drugs

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Journal of Geriatric Cardiology 2014年第1期11卷 20-25页

作者： simon W. Rabkin Department of medicine (Cardiology) University of British Columbia 9th Floor 2775 Laurel St. Vancouver B.C. V5Z 1M9 Canada

ObjectivesTo 明确地在心脏的毒性上探索老化的效果年龄和抑制精神的药的相互作用与搜索策略用 OvidSP 平台被寻找改变 QT *** medline 数据库：“； QT interval”；或 “； QT”；并且 “； ageȁ... 详细信息

ObjectivesTo 明确地在心脏的毒性上探索老化的效果年龄和抑制精神的药的相互作用与搜索策略用 OvidSP 平台被寻找改变 QT *** medline 数据库：“； QT interval”；或 “； QT”；并且 “； age”；或 “； aging”；。入口标准是：有两性上的数据的超过 10,000 个显然健康的个人；为心率(QTc ) 和它的变化的表情改正延续到更旧的 *** 的多重年龄十年的 QT 间隔与增加年龄在持续时间增加了。在正常人口在 QTc 认为谦虚的是 SD 增长，氯普马嗪的增加生产了比好久 70 岁以上的 450 ms 平均大的 QTc。Risperidone，那平均没改变 QTc，将被期望在一些情形下面在他们的 70 年中年里在人生产 450 ms 的 QTc。QTc 延伸 >；有抑制精神的药的 500 ms 在 99 th 百分位数。当与抑制精神的药导致的期望的 QT 间隔变化的范围结合了时，它可以与平均不在显然正常的老人或女人为 QT 间隔改变价值的 *** 范围的 Haloperidol 发生，能乐意地与延长 QTc 被联系。有在 99 th 百分位数可以与甚至不是的那些通常与 QTc 延伸联系了的抑制精神的药有严肃的 QTc 延伸。

关键词：抗精神病药 QT 心脏药物 mEDLINE数据库安全性对抗搜索策略

Study of a Toposequence of West mayo-Kani Soils (Far North Cameroon)

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Open Journal of Soil Science 2022年第10期12卷 523-539页

作者： Souoré Irène Basga simon Doumnang mbaigane Jean-Claude Ngaro m’baïti management of Water Resources Soils and Environment Department of Earth Sciences Faculty of Sciences University of Ngaoundéré Ngaoundéré Cameroon Institute of Agronomic Research for Development (IRAD) of Garoua Garoua Cameroon Laboratory of Geology Geomorphology and Remote Sensing University of N’Djamena N’Djamena Chad

The soils of Gadas, object of the present study, are identified on the macromorphological, physico-chemical level and the indices of erodibility are related to their physico-chemical properties. The physico-chemical analyzes were carried out by standard methods. The macromorphological analysis of a toposequence made it possible to identify five types of soils: the lithosols which occupy the high zones of the landscape, the colluvial soils (arenosols, regosols) which are located high on the piedmont, alluvial soils (fluvisols) which are located at the bottom of the slope in the alluvial plain and are the most extensive, topomorphic vertisols, and brown soils formed on granite are located either between a colluvial soil and alluvial soil. Physico-chemical analyzes of the soils of Gadas show that these soils are weakly acidic to neutral, sandy to sandy-clayey, saturated, low in nitrogen and organic matter and characterized by average proportions of exchangeable bases. The study of soil erodibility, based on the use of erodibility indices, showed that alluvial soils and brown soils formed on granites are the most susceptible to erosion, whereas vertisols and colluvial soils are the least vulnerable to erosion.

关键词： Far North Cameroon West mayo-Kani Gadas Soils Erodibility

Chronic disease care integration into primary care services in sub-Saharan Africa:a‘best fit’framework synthesis and new conceptual model

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Family medicine and Community Health 2022年第3期10卷 43-59页

作者： simon R Harrison Aileen m Jordan Biomedical Sciences The University of Edinburgh College of Medicine and Veterinary MedicineEdinburghUK

Objective To examine the relevance of existing chronic care models to the integration of chronic disease care into primary care services in sub-Saharan Africa and determine whether additional context-specific model elements should be ***‘Best fit’framework synthesis comprising two systematic *** systematic review of existing chronic care conceptual models with construction of a priori *** systematic review of literature on integrated HIV and diabetes care at a primary care level in sub-Saharan Africa,with thematic analysis carried out against the a priori *** conceptual model constructed from a priori themes and new *** of bias of included studies was assessed using CASP and *** criteria Conceptual models eligible for inclusion in construction of a priori framework if developed for a primary care context and described a framework for long-term management of chronic disease *** eligible for inclusion in second systematic review described implementation and evaluation of an intervention or programme to integrate HIV and diabetes care into primary care services in *** sources Pubmed,Embase,CINAHL Plus,Global Health and Global Index medicus databases searched in April 2020 and September *** Two conceptual models of chronic disease care,comprising six themes,were used to develop the a priori *** systematic review of primary research identified 16 articles,within which all 6 of the a priori framework themes,along with 5 new themes:Improving patient access,stigma and confidentiality,patient-provider partnerships,task-shifting,and clinical mentoring.A new conceptual model was constructed from the a priori and new *** The a priori framework themes confirm a need for co-ordinated,longitudinal chronic disease care integration into primary care services in sub-Saharan *** of the primary research suggests integrated care for HIV and diabetes at a

关键词： services integration synthesis

East African topography and volcanism explained by a single,migrating plume

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Geoscience Frontiers 2020年第5期11卷 1669-1680页

作者： Rakib Hassan simon E.Williams michael Gurnis Dietmar muller School of Geosciences Room 412Madsen Building F09 Eastern AvenueThe University of SydneyNSW2006Australia Seismological Laboratory California Institute of TechnologyPasadenaCA91125USA Now at Geoscience Australia GPO Box 378CanberraACT2601Australia State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China

Anomalous topographic swells and Cenozoic volcanism in east Africa have been associated with mantle *** models involving one or more fixed plumes beneath the northeastward migrating African plate have been suggested to explain the space-time distribution of magmatism in east *** devise paleogeographically constrained global models of mantle convection and,based on the evolution of flow in the deepest lower mantle,show that the Afar plume migrated southward throughout its *** models suggest that the mobile Afar plume provides a dynamically consistent explanation for the spatial extent of the southward propagation of the east African rift system(EARS),which is difficult to explain by the northeastward migration of Africa over one or more fixed plumes alone,over the last≈45 *** further show that the age-progression of volcanism associated with the southward propagation of EARS is consistent with the apparent surface hotspot motion that results from southward motion of the modelled Afar plume beneath the northeastward migrating African *** models suggest that the Afar plume became weaker as it migrated southwards,consistent with trends observed in the geochemical record.

关键词： Numerical mantle flow models Deep mantle flow LLSVP morphology Plume dynamics Plume motion Dynamic topography

Selected gas response measurements using reduced graphene oxide decorated with nickel nanoparticles

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Nano materials Science 2021年第4期3卷 412-419页

作者： Ilka simon Yulyan Haiduk Rolf mtilhaupt Vladimir Pankov Christoph Janiak Institut für Anoganische Chemie und Strukturchemie Heinrich-Heine Universität Düsseldorf 40204DüsseldorfGermany Chemical Faculty Belarusian State UniversityLenningradskaya Str.14220050 MinskBelarus Freiburg materials Research Center and Institute for macromolecular Chemistry Albert-Ludwigs-UniversityFreiburg79104FreiburgGermany

The work reports the synthesis of nickel nanoparticles supported on thermally reduced graphene oxides(rGO)in the ionic liquid[BmIm][NTf_(2)]through microwave decomposition ***@rGO with the polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)as binder was positively tested for its response towards the oxidizing gas nitrogen dioxide(10 ppm in air),the reducing gas carbon monoxide(3000 ppm in N_(2))and the volatile organic compound(VOC)acetone(35,000 ppm in air).The results from different gases were compared at different temperatures with the best results for NO_(2) at 200℃.Additionally,it is shown for NO_(2) gas that the Ni@rGO-PEDOT:PSS polymer composite gives better results than the rGO-PEDOT:PSS polymer *** the heat treatment the oxidation state of pure nickel nanoparticles were confirmed by powder diffraction.

关键词： Nickel nanoparticles Reduced graphene oxide Gas sensing Nanocomposite

EPR and magnetic Susceptibility Studies of Cr^(3+) Ions in the 70TeO_2·25B_2O_3·5PbO Glass matrix

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Journal of materials Science & Technology 1997年第5期13卷 374-378页

作者： Peteanu m. simon V. muresan N. Ardelean I. Filip S. Faculty of Physics Babes-Bolyai University 3400 Cluj-Napoca Romania Dept. of Physics University of Oradea 3700 Oradea Romania

By using EPR and magnetic susceptibility measurements, the Cr ion distribution in the xCr2O3.(1-x)[70TeO2·25B2O3·5PbO] glasses with 0＜x≤20 mol% was studied. EPR investigation evidencedthe presence of Cr3+ ions in agreement with the experimentally obtained atomic magnetic moment values. For concentrations x≤3 mol%, the isolated Cr3+ ions coexist with those coupledby dipole-dipole interactions. For x＞3 mol%, the Cr3+ ions participate in superexchange interactions and are predominantly antiferromagnetically coupled.

关键词： PbO Ions in the 70TeO2 Glass matrix EPR and magnetic Susceptibility Studies of Cr Cr

Extracting structural motifs from pair distribution function data of nanostructures using explainable machine learning

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npj Computational materials 2022年第1期8卷 2053-2063页

作者： Andy S.Anker Emil T.S.Kjær mikkel Juelsholt Troels Lindahl Christiansen Susanne Linn Skjærvø mads Ry Vogel Jørgensen Innokenty Kantor Daniel Risskov Sørensen simon J.L.Billinge Raghavendra Selvan Kirsten m.Ø.Jensen Department of Chemistry and Nano-Science Center University of Copenhagen2100CopenhagenDenmark Department of materials University of OxfordParks RoadOxfordUK Department of Chemistry&iNANO Aarhus University8000AarhusDenmark mAX IV Laboratory Lund University22484LundSweden Department of Physics Technical University of Denmark2880LyngbyDenmark Department of Applied Physics and Applied mathematics Columbia UniversityNew YorkNY10027USA Condensed matter Physics and materials Science Department Brookhaven National LaboratoryUptonNY11973USA Department of Computer Science University of Copenhagen2100CopenhagenDenmark Department of Neuroscience University of Copenhagen2200CopenhagenDenmark

Characterization of material structure with X-ray or neutron scattering using *** Distribution Function(PDF)analysis most often rely on refining a structure model against an experimental ***,identifying a suitable model is often a ***,automated approaches have made it possible to test thousands of models for each dataset,but these methods are computationally expensive and analysing the output,*** structural information from the resulting fits in a meaningful way,is *** machine Learning based motif Extractor(mL-motEx)trains an mL algorithm on thousands of fits,and uses SHAP(SHapley Additive exPlanation)values to identify which model features are important for the fit *** use the method for 4 different chemical systems,including disordered nanomaterials and ***-motEx opens for a type of modelling where each feature in a model is assigned an importance value for the fit quality based on explainable mL.

关键词： explain structural meaningful

Intensity of parasitic infestation in silver carp,Hypophthalmichthys molitrix

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 1024-1028页

作者： m.m.ALAm m.A.KHAN m.A.HUSSAIN D.mOUmITA A.G.mAZLAN K.D.simon Department of Fisheries University of RajshahiRajshahi 6205Bangladesh School of Environmental and Natural Resource Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorD.E.Malaysia

Silver carp,Hypopthalmichthys molitrix is one of the most economically valuable fish species in ***,its production is often hindered by parasite-induced *** present study reports the intensity of parasitic infestation in 216 specimens of *** collected from different fish markets in Rajshahi City,*** different parasite species (Trichodina pediculatus,Dactylogyrus vastator,Ichthyophthirius multifilis,Gyrodactylus elegans,Lernaea sp.,Apiosoma sp.,myxobolus rohitae,Camallanus ophiocephali,and Pallisentis ophiocephali) were recovered from the gill,skin,stomach,and intestine of host *** highest level of infection was observed for host skin,while lower levels were observed for host gill,stomach,and *** results also revealed that the intensity of parasite infection in different organs of *** varied with the *** particular,the highest levels of infection were recorded during the winter period (November-February),when fish are most susceptible to *** findings of the study will help in the management and conservation of ***.

关键词：寄生虫学研究实验原虫病

Axisymmetric alternating direction explicit scheme for efficient coupled simulation of hydro-mechanical interaction in geotechnical engineering-Application to circular footing and deep tunnel in saturated ground

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Journal of Rock mechanics and Geotechnical Engineering 2018年第2期10卷 259-279页

作者： simon Heru Prassetyo marte Gutierrez Department of Civil and Environmental Engineering Colorado School of MinesGoldenUSA mining Engineering Program Institut Teknologi BandungBandungIndonesia

Explicit solution techniques have been widely used in geotechnical engineering for simulating the coupled hydro-mechanical(H-m) interaction of fluid flow and deformation induced by structures built above and under saturated ground, i.e. circular footing and deep tunnel. However, the technique is only conditionally stable and requires small time steps, portending its inefficiency for simulating large-scale H-m problems. To improve its efficiency, the unconditionally stable alternating direction explicit(ADE)scheme could be used to solve the flow problem. The standard ADE scheme, however, is only moderately accurate and is restricted to uniform grids and plane strain flow conditions. This paper aims to remove these drawbacks by developing a novel high-order ADE scheme capable of solving flow problems in nonuniform grids and under axisymmetric conditions. The new scheme is derived by performing a fourthorder finite difference(FD) approximation to the spatial derivatives of the axisymmetric fluid-diffusion equation in a non-uniform grid configuration. The implicit Crank-Nicolson technique is then applied to the resulting approximation, and the subsequent equation is split into two alternating direction sweeps,giving rise to a new axisymmetric ADE scheme. The pore pressure solutions from the new scheme are then sequentially coupled with an existing geomechanical simulator in the computer code fast Lagrangian analysis of continua(FLAC). This coupling procedure is called the sequentially-explicit coupling technique based on the fourth-order axisymmetric ADE scheme or SEA-4-AXI. Application of SEA-4-AXI for solving axisymmetric consolidation of a circular footing and of advancing tunnel in deep saturated ground shows that SEA-4-AXI reduces computer runtime up to 42%-50% that of FLAC’s basic scheme without numerical instability. In addition, it produces high numerical accuracy of the H-m solutions with average percentage difference of only 0.5%-1.8%.

关键词： Hydro-mechanical(H-m) interaction Explicit coupling technique Alternating direction explicit(ADE) scheme High-order finite difference(FD) Non-uniform grid Axisymmetric consolidation Circular footing Deep tunnel in saturated ground