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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher michael J.Lamonte Andrea Z.LaCroix Eleanor m.simonsick Steven P.hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(mL),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several mL VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVm)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:measured VO_(2max)is a strong predictor of *** mL can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology mortality

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Aging impairs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja m.maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling simon melov simon Tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

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modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg michael B.morris marcela m.m.Bilek Anyu Zhang Behnam Akhavan simon Fleming maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter medical Research Institute(HmRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

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Photoelectrochemical Iron-Catalyzed C(sp^(3))-H Borylation of Alkanes in a Position-Selective manner

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CCS Chemistry 2024年第6期6卷 1430-1438页

作者： Wen Wei Bin Wang simon L.Homölle Jinbin Zhu Yanjun Li Tristan von münchow Isaac maksso Lutz Ackermann Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen37077 Göttingen

Catalytic C-H borylation is of prime topical importance,since easily available feedstock chemicals can thereby be transformed into valuable transient functional groups in the absence of directing ***,we disclose an iron-catalyzed C(sp^(3))-H borylation of simple,non-prefunctionalized alkanes,providing access to value-added products in a single step by means of *** power of merging photo-and electrochemistry was mirrored by ample scope and exceedingly mild reaction ***,an outstanding position-selectivity in favor of primary C(sp^(3))-H proved viable within the photoelectrochemical borylation through a chemo-selective anodic overoxidation *** ferro-photoelectrochemistry strategy avoids toxic precious transition metals,enabling C(sp^(3))-H borylations in a site-selective fashion.

关键词： photoelectrocatalysis C(sp^(3))-H borylation iron catalysis position-selectivity chlorine radical

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A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson malcolm White John R.m.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John m.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.hooker simon m.hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter maggs Graeme P.A.malcolm OBE Stuart P.D.mangles William martin Paul mcKenna Richard O.moore Clive morrison Zulfikar Najmudin David Neely Geoff H.C.New michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon mBE Zheng-ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK mirli Books ChelmsfordUK m Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser micromachining Ltd St AsaphUK mBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy miriam E.A.Tschaffon-müller Shan Jiang Tobias malte Ballhause Anke Baranowsky simon von Kroge Julian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa melanie Haffner-Luntzer David J.Beech Frank Timo Beil michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and metabolic medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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气候紧急状况与高等教育

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清华大学教育研究 2024年第1期45卷 6-16,49页

作者：西蒙·马金森赵琳(译) 牛津大学教育系美国清华大学教育研究院北京100084

气候紧急状况是一场生存危机,迫切需要人们从根本上改变社会经济发展的主导模式。在竞争性积累和过度消费造成的破坏中,当务之急是建立一种可持续的道德秩序,体现建设性的人与自然的关系以及人与人的关系。按照涂尔干的观点,道德秩序的... 详细信息

气候紧急状况是一场生存危机,迫切需要人们从根本上改变社会经济发展的主导模式。在竞争性积累和过度消费造成的破坏中,当务之急是建立一种可持续的道德秩序,体现建设性的人与自然的关系以及人与人的关系。按照涂尔干的观点,道德秩序的主要组成部分是国家和个人:国家是集体利益的重要保障,个人则负责自我完善和实现社会价值。气候紧急状况突显了世界各国的能力,既要在中央层面有效组织,又要对地方机构下放权力,使其能够有效解决地区问题和灾害。高等教育机构与政府合作,在以下方面发挥着核心作用:推进和捍卫科学,提升治理的知识和技能,培养在地方、社区、国家、区域和全球范围内有效开展社会行动的反思性主体。气候紧急状况还呼唤对课程进行全面改革,使其符合生态生存的要求。高等教育具有先进的跨国合作能力,可以助力民族国家推进稳定的全球合作进程,这一合作进程充满困难却至关重要。在解决这些问题方面,中国和中国的高等教育具有强大的内生传统,包括古代传统和近代传统。这些传统包括中华民族的共识作用,其在有效运用时可以获得广泛的公众支持;在中央政策框架内进行深度权力下放的治理方式;儒家文化所倡导的修身,能够培养出具有自我反思能力的终身学习者;以及“天下”的观念——一种基于道德价值观和行为规范而非强制的全球合作方法。如果再结合西方所尊崇的个人自由和主动性,上述特质在中国乃至全世界应对气候紧急状况方面都将大有可为。

关键词：气候紧急状况生态过度消费政府权力下放高等教育儒家思想科学

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Comparative Study of the Physicochemical Quality of the Waters of the méné River (Sassandra Watershed, Ivory Coast) in the Dry Season and in the Rainy Season

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Journal of Environmental Protection 2024年第6期15卷 738-746页

作者： Konan Lopez Kouamé Gansso Valentin Akilinon Olivier simon mananga Kombo Gneneyougo Emile Soro Bi Tié Albert Goula Science and Technology Department Alassane Ouattara University Bouak Ivory Coast Environmental Sciences Laboratory Nangui Abrogoua University Abidjan Ivory Coast

The study carried out on the waters of the méné River led to an overall assessment of its water quality during the dry season and the rainy season. The analysis focused on eight (8) water samples taken from the river during a period of dry season (January-February) and a period of rainy season (June and September). The various physicochemical parameters were measured according to Afnor standardized methods. The readings of temperature, turbidity, pH and conductivity made it possible to account for the disturbances occurring in water quality. A temporal variation correlated with the seasons (dry or rainy) is noted. Turbidity depends on the concentration of suspended solids (SS) in the water and drained particles and therefore on the seasons. Just like the temperature, the conductivity changes with the season. The waters of the méné River are generally acidic. The results obtained show that there is a low level of pollution by chlorides, phosphates, nitrites and nitrates. A slight pollution of the waters of méné in organic matter (chemical oxygen demand values are less than 25 mg∙L−1 during dry season and 32.33 ± 4.73 mg∙L−1 during rainy season) was observed. The concentrations of metallic trace elements such as iron, manganese and aluminum indicate significant pollution of these waters by these elements. Overall, the waters of the méné River are of satisfactory quality because all the physicochemical parameters analyzed have values below standards during the dry season as well as during the rainy season with the exception of COD and a few metallic trace elements.

关键词： méné Physicochemical Parameters River Season Water Quality

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Floristic Composition, Population Structure, and Recruitment Status of Plant Species: A Case Study of Farmer-managed Natural Regeneration Practices in Arid and Semi-Arid Lands in Kenya

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Open Journal of Forestry 2024年第2期14卷 141-154页

作者： simon Kosgei Choge Samson Okoth Ojunga Dub Isacko Dokata William Kimen Chepkirui Justus musau Faith milkah muniale Ivan Kiplagat Kiptui Kenya Forestry Research Institute-Rift Valley Eco-Region Research Program Marigat Kenya Kenya Forestry Research Institute-Lake Victoria Eco-Region Research Program Kisumu Kenya Kenya Forestry Research Institute-Rift Valley Eco-Region Research Program Londiani Kenya CRIFSUP Project World Vision Kenya Nairobi Kenya

The technique of Farmer managed Natural Regeneration (FmNR) is being promoted as a cost-effective approach for restoring degraded arable dry lands. Its effectiveness has been observed in many countries across the globe, where it is a traditional practice, and is now being encouraged across the African continent. This study aimed to evaluate the impact of FmNR on floristic Composition, Vegetation Structure, and Regeneration Status of woody Plant Species in the severely degraded Central Rift, Kenya. The study systematically assessed how FmNR influenced species composition, vegetation structure and regeneration status from two sample plots involved in FmNR practices. Transect lines and quadrats methods were utilized to collect data, specifically regarding the floristic composition, vegetation structure, and regeneration status of woody plant species. Quadrats and sub-quadrats of varying sizes (10 m by 10 m, 5 m by 5 m, and 1 m by 1 m) were nested along the transect lines for data collection. Furthermore, measurements of tree growth and development, including root collar diameter, diameter at breast height (D130) and heights within the study blocks, were taken. The data was then analyzed using R-software. Results showed a marked progressive increase in numbers of trees, saplings, seedlings, shrubs and herbs in all FmNR sites and reductions in all non-FmNR sites. The study advocates for widespread promotion of the FmNR practice both as an environmental conservation and restoration strategy.

关键词： Farmer managed Natural Regeneration FmNR Floristic Composition Vegetation Structure Regeneration Biodiversity

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m+博物馆

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世界建筑导报 2024年第3期39卷 96-99页

作者： Virgile simon Bertrand(摄) Kevin mak(摄) 不详

m+博物馆是西九文化区的一大文化中心,为20世纪和21世纪的艺术、设计、建筑和动态影像的展示场所。仅仅20年前,西九文化区所处之地还是海港的一部分。一块接一块地填海造地,将天然港湾改造成为陆地。现在,这片人工填海的土地是西九文化... 详细信息

m+博物馆是西九文化区的一大文化中心,为20世纪和21世纪的艺术、设计、建筑和动态影像的展示场所。仅仅20年前,西九文化区所处之地还是海港的一部分。一块接一块地填海造地,将天然港湾改造成为陆地。现在,这片人工填海的土地是西九文化区新建筑的建设场地。有意思的是,恰好是另一项曾被视为场地规划的阻碍工程,即机场快线的地下隧道,定义了这片区域的特殊性,成为m+博物馆项目设计的起点。

关键词：文化区场地规划建设场地填海造地动态影像博物馆地下隧道 21世纪

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