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Long-Term Outcomes Comparing Minimally Invasive Mitral Valve Repair versus Conventional Mitral Valve Surgery

World Journal of Cardiovascular Surgery 2018年第8期8卷 127-139页

作者： Matthew Jackson Manraj S. Sandhu Chao Dong Bilal Bawamia Muhammad Qureshi Khalid Khan Andrew Goodwin simon kendall Steven Hunter Richard Graham Jeetendra Thambyrajah Enoch F. Akowuah Cardiothoracic Surgery The James Cook University Hospital Middlesbrough UK Cardiology The Freeman Hospital Newcastle UK

Objectives: To compare the long term outcomes between minimally invasive mitral valve repair (MiMVR) and conventional surgery. Current retrospective comparisons between the techniques frequently report echocardiographical (echo) outcomes early after surgery and rarely report them later. Methods: Patients were selected for MiMVR by the surgical multi-disciplinary meeting from June 2008-March 2013. Patients included had at least two transthoracic post-operative echocardiograms. Echocardiographic parameters including left ventricular size and systolic function, degree of mitral regurgitation (MR) and mean mitral valve gradient were recorded. Clinical outcomes including all-cause mortality, re-operation, recurrence of at least moderate MR and elevated mean mitral valve gradients > 5 mmHg were recorded and compared using Kaplan-Meier survival analysis. Results: 223 patients were screened, 96 (43%) met the criteria and were included. Thirty-seven patients underwent conventional surgery and 59 underwent MiMVR. Mean clinical follow-up was 6.3 years and echo follow up was 3.2 years. There was a significantly higher recurrence of moderate MR in the conventional group (38% (n = 19) versus 17% (n = 10)). The mean LV end-diastolic diameter was 4.8 cm (conventional) versus 5.0 cm (MiMVR). The incidence of elevated PG was 26% (n = 13, conventional) and 23% (n = 14, MiMVR). There was no significant difference in incidence in re-operation (conventional 12% (n = 6), MiMVR 8.3% (n = 5)). Long-term mortality was higher in the conventional group (1.7% vs. 18% p = 0.004) although the logistic Euroscore was significantly higher 6.8% ± 5.4 vs. 3.6% ± 1.6. Conclusions: Minimally invasive mitral valve surgery is safe and feasible in selected patients with good medium and long-term echocardiographic follow-up.

关键词： Mitral Valve Surgery Minimally Invasive Surgery Echocardiogram Clinical Outcomes

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Factors That Influence Healthcare Professionals’ Online Interaction in a Virtual Community of Practice

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Social Networking 2013年第4期2卷 174-184页

作者： Faith Ikioda Sally kendall Fiona Brooks Anna De Liddo simon Buckingham Shum Centre for Research in Primary and Community Care University of Hertfordshire Hatfield UK Knowledge Media Institute Open University Milton Keynes UK

Online technologies have facilitated the development of Virtual Communities of Practice (virtual CoPs) to support health professionals collaborate online to share knowledge, improve performance and support the spread of innovation and best practices. Research, however,shows that many virtual CoPs do not achieve their expected potential because online interaction among healthcare professionals is generally low. Focusing on health visitors, who are UK qualified midwives or nurses who have undertaken additional qualifications as specialist public health workers in the community, the paper examines the factors that influence online interaction among health visitors collaborating to share knowledge and experience in a virtual CoP. The paper makes suggestions for how to improve online interaction among health professionals in virtual CoPs by increasing the size of membership in order to take advantage of both posting and viewing contributions, facilitating moderation to improve networking among geographically dispersed members groups and im-proving the topic relevance in order to stimulate contributions.

关键词： Virtual Community of Practice Health Visitors Online Interaction Collaboration

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Influence of interparticle interactions on the kinetics of self-assembly and mechanical strength of nanoparticulate aggregates

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Particuology 2009年第2期7卷 106-113页

作者： Roberto Moreno-Atanasio simon J.Antony Richard A.Williams Institute of Particle Science and Engineering University of LeedsLeedsLS2 9JTUnited Kingdom

Computer simulations based on Discrete Element Method have been performed in order to investigate the influence of interparticle interactions on the kinetics of self-assembly and the mechanical strength of nanoparticle aggregates. Three different systems have been considered. In the first system the interaction between particles has been simulated using the JKR （Johnson, kendall and Roberts） contact theory, while in the second and third systems the interaction between particles has been simulated using van der Waals and electrostatic forces respectively. In order to compare the mechanical behaviour of the three systems, the magnitude of the maximum attractive force between particles has been kept the same in all cases. However, the relationship between force and separation distance differs from case to case and thus, the range of the interparticle force. The results clearly indicate that as the range of the interparticle force increases, the self-assembly process is faster and the work required to produce the mechanical failure of the assemblies increases by more than one order of magnitude.

关键词： Nanoparticles Discrete Element Method (DEM) Self-assembly JKR model van der Waals force

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Assessment of faunal communities and habitat use within a shallow water system using non-invasive BRUVs methodology

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Aquaculture and Fisheries 2020年第5期5卷 224-233页

作者： Henriette M.V.Grimmel Robert W.Bullock simon L.Dedman Tristan L.Guttridge Mark E.Bond Bimini Biological Field Station Foundation South BiminiBahamas Hull International Fisheries Institute University of HullHullHU67RXUnited Kingdom Independent Researcher San CarlosCAUSA Department of Biological Sciences Florida International University3000 NE 151th StreetNorthMiamiFL33181USA Saving the Blue KendallMiami33186USA

Seagrass and mangrove habitats have long been established as critical for diverse species at various life-stages,particularly as nursery ***,despite their intrinsic and environmental value,these ecosystems are increasingly threatened by anthropogenic *** Bimini,Bahamas,where ongoing development threatens ecosystem integrity,baited remote underwater video surveys(BRUVs)were used to examine faunal communities in both nearshore habitat and a shallow water central lagoon(average depth 1 m).The study assessed species abundances and spatial distribution in a currently unperturbed of the North Bimini Marine Reserve(NBMR).A total of 140 BRUVs,conducted over a 13-month period,recorded 62 species from 27 different *** was used to assess relative abundances and multivariate analyses(***,PCA,PERMANOVA)investigated differences in community composition across discrete factors and environmental *** Regression Trees(BRTs)were used to explore environmental variables for their uncorrelated influences on recorded species *** evidenced the importance of habitat diversity and particularly mangroveadjacent habitat for teleost fishes in Bimini with species diversity and abundance being significantly greater in the mangrove-adjacentdge ***,the study highlighted differences in environmental conditions between habitat types and the association this had with species diversity,abundance and *** the shallow water environment,BRUVs served as a scalable,non-invasive technique to assess community structures within the study *** from this study should inform ongoing decision-making processes regarding the protection of the Bimini Islands ecosystem.

关键词： Baited remote underwater video MaxN Mangrove edge habitat Bahamas Bimini

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Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides,and factors associated with residual infection among Kenyan school children

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Infectious Diseases of Poverty 2017年第1期6卷 249-260页

作者： Stella Kepha Charles S.Mwandawiro Roy M.Anderson Rachel L.Pullan Fred Nuwaha Jorge Cano Sammy M.Njenga Maurice R.Odiere Elizabeth Allen simon J.Brooker Birgit Nikolay School of Public Health Makerere University College of Health SciencesKampalaUganda Eastern and Southern Africa Centre of International Parasite Control Kenya Medical Research Institute(KEMRI)NairobiKenya London Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK London School of Hygiene and Tropical Medicine LondonUK Centre for Global Health Research KEMRIKisumuKenya KEMRI-Wellcome Trust Research Programme NairobiKenya

Background:School-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths(STHs),however,the frequency of drug administration varies in different *** this study,we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children,and investigated the factors associated with residual ***:We performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring *** received either a single treatment or 4-monthly albendazole treatments were followed longitudinally from February 2014 to October *** relative impact of treatment and factors associated with residual infections were investigated using mixed-effects regression *** to infection was assessed based on Spearman’s rank and kendall’s Tau correlation ***:In the 4-monthly treatment group,the proportion of children infected with hookworm decreased from 59.9 to 5.7%,while Ascaris lumbricoides infections dropped from 55.7 to 6.2%.In the single treatment group,hookworm infections decreased over the same time period from 58.7 to 18.3%(12.6%absolute difference in reduction,95%CI:8.9-16.3%),and *** from 56.7 to 23.3%(17.1%absolute difference in reduction,95%CI:13.1-21.1%).There was strong evidence for predisposition to both STH *** hookworm infection among children on 4-monthly treatment were associated with male sex and baseline nutritional status,whereas *** infection was associated with individual and school-level infection at baseline,latrine cleanliness at ***:This study found that 4-monthly treatment w more effective than single annual *** treatments led to dramatic reductions in the intensities of STHs,but did not completely clear infections among school children in Kenya,a presumed reflection of reinfection in a setti

关键词： School-based deworming Soil-transmitted helminths Albendazole School children Kenya

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使用数据挖掘方法将功能独立性评定量表运动分数转换至改良巴氏指数分数

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康复学报 2021年第5期31卷 365-371页

作者：黄力恒黄锦文吴显波香港东华学院中国香港香港大埔医院中国香港香港九龙医院中国香港

目的:为了适应临床和科研的需要,建立和评估一种功能独立性评定量表(FIM)运动分数转换至改良巴氏指数(MBI)分数的方法。方法:回顾性分析2005—2016年香港某康复医院的卒中患者在刚接受作业治疗时FIM运动分数和MBI分数。采取数据挖掘方法... 详细信息

目的:为了适应临床和科研的需要,建立和评估一种功能独立性评定量表(FIM)运动分数转换至改良巴氏指数(MBI)分数的方法。方法:回顾性分析2005—2016年香港某康复医院的卒中患者在刚接受作业治疗时FIM运动分数和MBI分数。采取数据挖掘方法,包括(1)订立数据规格条件;(2)检查和选取符合规定的数据;(3)将数据随机分组;(4)制订这2个量表的项目配对;(5)使用"秩不变量"方法对换数据;(6)校验数据对换方法。结果:将符合规定的6574例患者随机分成背景相仿的A、B 2组,A组的各项MBI分数与FIM运动分数显示两者有高度关联性(kendall’s tau-b值0.796~0.987,P<0.01)。再依据"秩不变量"方法制定这2个量表项目的对换表。最后使用对换表将B组数据转换后再检查其关联性,其"单对单项"和"单对多项"的Co-hen’s Kappa系数(k)为0.770~0.913。校验结果提示MBI分数与对换的MBI分数有高度的关联性。结论:该数据挖掘方法制订出的对换方法通过统计学的校验,且易于使用,适合处理或比较有关卒中康复的相关数据。

关键词：独立性评定量表改良巴氏指数功能评估卒中康复

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