检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A型肉毒杆菌毒素联合眼睑手术治疗面肌痉挛

国际眼科杂志 2020年第5期20卷 754-758页

作者： Kenneth K.h.Lai Andrew K.T.Kuk Edwin Chan simon T.C.Ko 中国香港东华东院眼科

目的:A型肉毒杆菌毒素(Botox)联合眼睑手术治疗面肌痉挛(hFS)疗效观察。方法:回顾性分析患者的影像和医疗记录,并对注射Botox的患者治疗效果和并发症进行分析。结果:共纳入76例(女性58例)hFS患者至少接受4次Botox注射。平均随访时间为83... 详细信息

目的:A型肉毒杆菌毒素(Botox)联合眼睑手术治疗面肌痉挛(hFS)疗效观察。方法:回顾性分析患者的影像和医疗记录,并对注射Botox的患者治疗效果和并发症进行分析。结果:共纳入76例(女性58例)hFS患者至少接受4次Botox注射。平均随访时间为83±50(20~112)mo,平均注射16±10(4~34)次。发病高峰年龄为55~64a,平均发病年龄为66±11(32~85)a。多达23%的面肌痉挛患者存在与面神经关系密切的异常血管结构(右侧8例,左侧7例)(MRI=14,CT=1),其中以椎动脉累及最多(n=6),其次是小脑前下动脉(n=5)。原发性hFS患者的有效期间较继发性hFS患者短(2.5 vs 3.1mo,PhFS患者长(4.1 vs 3.8d,P=0.739),SSAs较继发性hFS患者低(1.7 vs 1.9,P=0.179)。19例先前存在眼睑疾病的患者中有12例接受了手术矫正,包括上睑成形术(n=12)、肌肉切除(7例)、眉成形术(7例)和提上睑肌腱膜修复术(5例)。5例(41.7%)接受手术矫正和对肉毒杆菌素反应不佳的患者术后6mo症状改善(发病时间:P=0.0256,有效期间:P=0.374,SSAs:P=0.0161)。12例行眼睑手术患者术后并发症发生率低于未行眼睑手术患者(23%vs 42%,P≤0.05)。结论:Botox对于治疗hFS是一种安全有效的方法。继发性hFS患者使用肉毒杆菌毒素的治疗效果优于原发性hFS患者。对于并发眼睑疾病的患者而言,眼睑手术可提高患者满意度,降低并发症发生率,从而提高后续Botox注射的效果。

关键词：面肌痉挛肉毒杆菌毒素眼睑手术 MRI

Surgical management of hepato-pancreatic metastasis from renal cell carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2017年第2期9卷 70-77页

作者： Nikolaos A Chatzizacharias Anais Rosich-Medina Khaled Dajani simon harper Emmanuel huguet Siong S Liau Raaj K Praseedom Asif Jah Department of hPB and Transplant Surgery Addenbrooke’s HospitalCambridge University Hospitals NHS Foundation TrustCambridgeshire CB2 0QQUnited Kingdom

AIM To investigate the outcomes of liver and pancreatic resections for renal cell carcinoma(RCC) metastatic disease. METhODS This is a retrospective, single centre review of liver and/or pancreatic resections for RCC metastases between January 2003 and December 2015. Descriptive statistical analysis and survival analysis using the Kaplan-Meier estimation were *** Thirteen patients h ad 7 pancreatic and 7 liver resections, with median follow-up 33 mo(range: 3-98). Postoperative complications were recorded in 5 cases, with no postoperative mortality. Three patients after hepatic and 5 after pancreatic resection developed recurrent disease. Median overall survival was 94 mo(range: 23-94) after liver and 98 mo(range: 3-98) after pancreatic resection. Disease-free survival was 10 mo(range 3-55) after liver and 28 mo(range 3-53) after pancreatic resection. CONCLUSION Our study shows that despite the high incidence of recurrence, long term survival can be achieved with resection of hepatic and pancreatic RCC metastases in selected cases and should be considered as a management option in patients with oligometastatic disease.

关键词： Renal cell carcinoma Metastasis Pancreas Liver Surgery

A potential role of karyopherin a2 in the impaired maturation of dendritic cells observed in glioblastoma patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroimmunology and Neuroinflammation 2015年第1期2卷 8-14页

作者： Konstantinos Gousias Alexander von Ruecker Gerrit h.Gielen Pitt Niehusmann Andreas Waha hartmut Vatter Matthias simon Department of Neurosurgery University Hospital of BonnSigmund-Freud-Strasse 2553105 BonnGermany Department of Neurosurgery University Hospital of BochumBergmannsheilBürkle-de-la-Camp-Platz 144789 BochumGermany Department of Pathology University Hospital of BonnSigmund-Freud-Strasse 2553105 BonnGermany Department of Neuropathology University Hospital of BonnSigmund-Freud-Strasse 2553105 BonnGermany

Aim:Patients with glioblastomas demonstrate well‑documented immunological impairments including decreased numbers of mature dendritic cells(DCs).Recent data identified karyopherin a2(KPNA2),a nucleocytoplasmic shuttling receptor,as diagnostic and prognostic biomarker for *** aim of this ongoing study is to correlate parameters of immunity and nucleocytoplasmic transport in glioblastoma ***:We preoperatively collected serum from 17 patients with glioblastomas and determined DC subsets(hLA DR+Lin-,CD34-,CD45+,CD123+,CD11+were analyzed)using a 6‑color flow cytometry *** levels of KPNA2 and nuclear accumulation of p53 were evaluated semi‑quantitatively by immunohistochemistry.O6‑methylguanine DNA methyltransferase(MGMT)and isocitrate dehydrogenase‑1(IDh‑1)status were assessed by pyrosequencing and immunohistochemistry,***:Median expression levels for both KPNA2 and p53 were 5-10%.IDh‑1‑R132h mutation and MGMT promoter hypermethylation was detected in 3/16 and 1/9 patients,*** counts of total mature DCs,myeloid DCs and plasmacytoid DCs were 9.6,2.1,3.4 cells/μL.A preliminary analysis suggests an association between low KPNA2 nuclear expression and increased numbers of mature ***,this correlation did not reach statistical significance so far(P=0.077).Conclusion:Our preliminary data may indicate a role of KPNA2 in the impaired maturation of DCs observed in glioblastoma patients.

关键词： Glioblastomas isocitrate dehydrogenase‑1 karyopherin a2 mature dendritic cells O6‑methylguanine DNA methyltransferase p53

Water and sediment quality parameters in the Chalan Beel, the largest wetland of Bangladesh

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Oceanology and Limnology 2015年第4期33卷 895-904页

作者： SAYEED Md.Abu hOSSAIN Mostafa Ali Reza WAhAB Md.Abdul hASAN Md.Tawheed simon Kumar Das MAZUMDER Sabuj Kanti Faculty of Fisheries Sylhet Agricultural University Faculty of Fisheries Bangladesh Agricultural University School of Environmental and Natural Resource Sciences Faculty of Science and Technology Universiti Kebangsaan Malaysia Marine Ecosystem Research Center Faculty of Science and Technology Universiti Kebangsaan Malaysia

A study was conducted to investigate the status of the water and sediment quality in the Chalan Beel——a major fresh water fish reservoir of the country for a period of one year from July 2007 to June 2008. The mean values of water quality parameters(depth: 214.73±152.22 cm, temperature 27.68±4.26℃, transparency 123±82 cm, p h 9.7±0.47, total alkalinity 137±42 mg/L, conductivity 307±147 μs/cm, total dissolved solids 183±89 mg/L, ammonia-N 0.27±0.39 mg/L, nitrate-N 0.09±0.07 mg/L, phosphate-P 2.01±2.53 mg/L) and sediment quality parameters(p h 7.21±0.35, organic matter 2.59±0.52%, total nitrogen 0.09±0.04%, available phosphorus 5.4±3.6 Meq./100 g and exchangeable potassium 0.43±0.14 Meq./100 g) were within the range recommended for most of the inland fishes of Bangladesh. Although the water and sediment quality parameters except ammonia and phosphate are in the suitable range, the overall results suggest that better management techniques should be practiced in order to overcome the declining trend of associated aquatic life(fauna and flora) of this important fresh water body of Bangladesh.

关键词： Chalan Beel total dissolve solids transparency residual effect organic matter sustainable management

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

关于人为事物的科学 1版

关于人为事物的科学

Evaluating the phyto-complexity and poly-pharmacology of spices: The case of Aframomum melegueta K. Schum (Zingiberaceae)

丛书名：根据麻省理工学院出版社1981年第2版译出

1985年

作者：（美）西蒙（simon h.A.）杨砾译

根据麻省理工学院出版社1981年第2版译出。书名原文: The sciences of the artificial.

ISBN: (纸本)17185·3

根据麻省理工学院出版社1981年第2版译出。书名原文: The sciences of the artificial.

关键词：社会科学总论社会科学理论与方法论

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Food Bioscience 2022年第5期49卷 1230-1245页

作者： simon Vlad Luca Adriana Trifan Gokhan Zengin Kouadio Ibrahim Sinan Abdullahi Ibrahim Uba Izabela Korona-Glowniak Krystyna Skalicka-Wo´zniak Biothermodynamics TUM School of Life SciencesTechnical University of Munich85354FreisingGermany Department of Pharmacognosy Grigore T.Popa University of Medicine and Pharmacy Iasi700115IasiRomania Physiology and Biochemistry Research Laboratory Department of BiologyScience FacultySelcuk UniversityUniversity Campus42130KonyaTurkey Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Pharmaceutical Microbiology Faculty of PharmacyMedical University of Lublin20-093LublinPoland Department of Natural Products Chemistry Medical University of Lublin20-093LublinPoland

The seeds of Aframomum melegueta K. Schum (grains of paradise, Zingiberaceae) are used as a common spice in African countries and a fine condiment in the European cuisine. In this study, we evaluated the phytochemical profile of various seed extracts of A. melegueta as well as their antimicrobial, antioxidant and enzyme inhibitory effects. In total, 25 diarylheptanoids, five gingerol derivatives and nine phenolic/organic acids were tentatively annotated in A. melegueta by liquid chromatography hyphenated with high resolution tandem mass spectrometry (LC-hRMS/MS). A. melegueta showed a moderate inhibitory activity against different human pathogenic microbial strains, with h. pylori the most sensitive microorganism. A strong antioxidant and enzyme inhibitory potential was shown in various radical scavenging, reducing and chelating assays as well as in cholinesterase, tyrosinase and glucosidase assays. Several specialized metabolites from A. melegueta (diarylheptanoids, gingerols) were shown to be directly linked with the investigated antioxidant and enzyme inhibitory activities, as evaluated through the correlation analysis. In addition, two diarylheptanoids (one heptan-3-ol and one heptan- 3,5-diol) displayed the strongest binding to acetylcholinesterase (AChE) via multiple h-bonds, a couple of π-π interactions and van der Waals interactions all over the catalytic channel of the enzyme, as evidenced by the molecular docking study. Overall, our work brings new contributions to the phyto-complexity and poly-pharmacology of spices from genus Aframomum than can find future applications in pharmaceutical, nutraceutical or cosmeceutical industry.

关键词： Aframomum melegueta Zingiberaceae Spices Gingerols helicobacter

Unifying concepts in methanogenic,aerobic,and anammox sludge granulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第1期17卷 17-30页

作者： simon Mills Anna Christine Trego Marco Prevedello Jo De Vrieze Vincent O’Flaherty Piet N.L.Lens Gavin Collins Microbial Communities Laboratory School of Biological and Chemical SciencesNational University of Ireland GalwayUniversity RoadGalwayH91 TK33Ireland Microbial Ecology Laboratory School of Biological and Chemical Sciences University of GalwayUniversity RoadGalwayH91 TK33Ireland Center for Microbial Ecology and Technology(CMET) Ghent UniversityCoupure Links 653B-9000GentBelgium University of Galway University RoadGalwayH91 TK33Ireland

The retention of dense and well-functioning microbial biomass is crucial for effective pollutant removal in several biological wastewater treatment *** solids retention is often achieved through aggregation of microbial communities into dense,spherical aggregates known as granules,which were initially discovered in the *** granules have since been widely applied in upflow anaerobic digesters for waste-to-energy ***,granular biomass has been applied in aerobic wastewater treatment and anaerobic ammonium oxidation(anammox)*** mechanisms underpinning the formation of methanogenic,aerobic,and anammox granules are the subject of ongoing *** each granule type has been extensively studied in isolation,there has been a lack of comparative studies among these granulation *** is likely that there are some unifying concepts that are shared by all three sludge *** these unifying concepts could allow a unified theory of granulation to be ***,we review the granulation mechanisms of methanogenic,aerobic,and anammox granular sludge,highlighting several common concepts,such as the role of extracellular polymeric substances,cations,and operational parameters like upflow velocity and shear *** have then identified some unique features of each granule type,such as different internal structures,microbial compositions,and quorum sensing ***,we propose that future research should prioritize aspects of microbial ecology,such as community assembly or interspecies interactions in individual granules during their formation and growth.

关键词： Granule Granulation Anaerobic digestion Anammox Aerobic granule

New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p h metry in extraesophageal gastroesophageal reflux disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第3期21卷 982-987页

作者： Valentin Becker Romina Drabner simone Graf Christoph Schlag simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj Ⅱ.Medizinische Klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany hals-Nasen Ohren Klinik Klinikum rechts der IsarTechnische Universit?t München81675 MünchenGermany

AIM:To determine the laryngeal h+K+-ATPase and pharyngeal p h in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI ***:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human h+K+-*** real-time RT-PCR for each of the h+K+-ATPase subunits was *** p h values were assessed in the aerosolized environment of the oropharynx(Dxp h Catheter) and compared to a subsequently applied combined p h/MII ***:Twenty patients with LPR symptoms were *** only one patient,the laryngeal h+K+-ATPase was verified by immunohistochemical *** another patient,real-time RT-PCR for each h+K+-ATPase subunit was *** out of twenty patients had pathological results in Dxp h,and 6/20 patients had pathological results in p h/*** patients had pathological results in both functional *** out of twenty patients responded to ***:The laryngeal h+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR *** hypotheses for the pathomechanism are *** role of pharyngeal p h-metry remains unclearand its use can only be recommended for patients in a research study setting.

关键词： Laryngopharyngeal reflux Proton pump inhibitor Gas