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A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 228-245页

作者： Prita Daliya Elizabeth H.Gemmill Dileep N.lobo simon l.Parsons Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute for Health Research(NIHR)Nottingham Biomedical Research CentreNottingham University Hospitals NHS Trust and University of NottinghamQueen’s Medical CentreNottingham NG72UHUK Department of General Surgery Sherwood Forest Hospitals NHS TrustKing’s Mill HospitalSutton-in-Ashfield NG174JLUK MRC/ARUK Centre for Musculoskeletal Ageing Research School of Life SciencesUniversity of NottinghamQueen’s Medical CentreNottingham NG72UKUK Trent Oesophago-Gastric Unit City Hospital CampusNottingham University Hospitals NHS TrustNottingham NG51PBUK

Patient reported outcome measures(PROMs)provide a valuable means of measuring outcomes subjectively from a patient's perspective,facilitating the assessment of service quality across healthcare providers,and assisting patients and clinicians in shared decision *** primary aim of this systematic review was to critically appraise all historic studies evaluating patient reported quality of life,in adult patients undergoing laparoscopic cholecystectomy for symptomatic *** secondary aim was to perform a quality assessment of cholecystectomy-specific PROM-validation studies.A literature review was performed in PubMed,Google ScholarTM,the Cochrane library,Medline,CINAHl,EMBASE and PsychINFO databases up to September *** characteristics,PROM-specific details and a bias assessment were summarised for non-validation studies.A COnsensus-based Standards for the selection of health Measurement INstruments(COSMIN)analysis was performed to assess the methodological quality of identified PROM-validation *** one studies were found to evaluate health-related quality of life(HRQol)after laparoscopic *** 94.1%of these studies included PROMs as a primary outcome measure,level 1 evidence through randomised controlled trials(RCTs).There was significant variation in the selection and reporting of PROMs,with no studies declaring patient involvement in PROM selection,and 88.2%of studies failing to document the management of missing data points,or non-returned surveys(33.3%).In the 6 PROM-validation studies identified,only 5 psychometric properties were evaluated,the findings of which were limited due to the small number of *** systematic review identifies a lack in consistency of study design and PRO reporting in clinical *** an increasing number of studies are being performed to evaluate PROs,a lack of adherence to existing PRO administration and reporting guidelines is continuing to negatively affect st

关键词： Cholecystectomy patient reported outcomes(PROs) patient reported outcome measures(PROMs) quality of life(Qol) COnsensus-based Standards for the selection of health Measurement INstruments(COSMIN)

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Inheritance patterns of secondary symbionts during sexual reproduction of pea aphid biotypes

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Insect Science 2014年第3期21卷 291-300页

作者： jean Peccoud joêl Bonhomme Frédérique Mahéo Manon de la Huerta Olivier Cosson jean-Christophe simon INRA Institut de Génétique Environnement et Protection des Plantes (UMR IGEPP) Domaine de La Motte 35653 le Rheu cedex France

Herbivorous insects frequently harbor bacterial symbionts that affect their ecol- ogy and evolution. Aphids host the obligatory endosymbiont Buchnera, which is requiredfor reproduction, together with facultative symbionts whose frequencies vary across aphid populations. These maternally transmitted secondary symbionts have been particularlystudied in the pea aphid, Acyrthosiphon pisum, which harbors at least 8 distinct bacterial species （not counting Buchnera） having environmentally dependent effects on host *** particular, these symbiont species are associated with pea aphid populations feeding on specific plants. Although they are maternally inherited, these bacteria are occasionallytransferred across insect lineages. One mechanism of such nonmaternal transfer is paternal transmission to the progeny during sexual reproduction. To date, transmission of secondarysymbionts during sexual reproduction of aphids has been investigated in only a handful of aphid lineages and 3 symbiont species. To better characterize this process, we investigatedinheritance patterns of 7 symbiont species during sexual reproduction of pea aphids through a crossing experiment involving 49 clones belonging to 9 host-specialized biotypes, and117 crosses. Symbiont species in the progeny were detected with diagnostic qualitative PCR at the fundatrix stage hatching from eggs and in later parthenogenetic *** found no confirmed case of paternal transmission of symbionts to the progeny, and we observed that maternal transmission of a particular symbiont species （Serratia symbiotica）was quite inefficient. We discuss these observations in respect to the ecology of the pea aphid.

关键词： bacteria Homoptera paternal inheritance phytophagous insects symbiosis transmission failure

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High Q and sub-wavelength THz electric field confinement in ultrastrongly coupled THz resonators

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Photonics Research 2023年第7期11卷 1203-1216页

作者： simon MESSElOT SOlEN COEYMANS jEROME TIGNON SUKHDEEP DHIllON jUlIETTE MANGENEY laboratoire de Physique de l’Ecole Normale Supérieure Ecole normale supérieurePSL UniversitySorbonne UniversitéUniversitéParis DiderotSorbonne Paris CitéCNRS24 rue Lhomond75005 ParisFrance

The control of light–matter coupling at the single electron level is currently a subject of growing interest for the development of novel quantum devices and for studies and applications of quantum *** the terahertz(THz)spectral range,this raises the particular and difficult challenge of building electromagnetic resonators that can conciliate low mode volume and high quality ***,we report on hybrid THz cavities based on ultrastrong coupling between a Tamm cavity and an lC circuit metamaterial and show that they can combine high quality factors of up to Q=37 with a deep-subwavelength mode volume of V=3.2×10^(-4)λ^(3).Our theoretical and experimental analysis of the coupled mode properties reveals that,in general,the ultrastrong coupling between a metamaterial and a Fabry–Perot cavity is an effective tool to almost completely suppress radiative losses and,thus,ultimately limit the total losses to the losses in the metallic *** Tamm cavity-lC metamaterial coupled resonators open a route toward the development of single photon THz emitters and detectors and to the exploration of ultrastrong THz light–matter coupling with a high degree of coherence in the few to single electron limit.

关键词： coupling cavity coupled

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Iris microhaemangioma: a management strategy

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International journal of Ophthalmology(English edition) 2013年第2期6卷 246-250页

作者： Aruna Dharmasena simon Wallis Department of Ophthalmology Royal Bolton Hospital Foundation Trust

AIM: To analyse previous literature and to formulate a management strategy for iris microhaemangiomas (IMH).METHODS:Areview of the literature in English language articles on ***: Thirty five English language articles fulfilled the criteria for inclusion to the study and based on the contents on these articles a management strategy was formulated. Age at presentation ranged from 42 to 80 years with no sex or racial predisposition. Most patients with IMH have no systemic disease but a higher incidence had been reported in patients with diabetes mellitus, myotonic dystrophy, chronic obstructive pulmonary disease (COPD) and several other systemic and ophthalmic co-morbidities. Most patients remained asymptomatic until they experienced a sudden blurring of vision due to a hyphaema. Some patients only develop a self-limiting single episode of hyphaema and therefore the laser or surgical photocoagulation of iris should be reserved for the cases complicated with recurrent hyphaema. In some patients, several laser photoco-agulation sessions may be needed and the recurrent iris vascular tufts may require more aggressive treatment. Iris fluorescein angiography (IFA) is useful in identifying the true extent of the disease and helps to improve the precision of the laser treatment. Surgical excision (iridectomy) should only be considered in patients who fail to respond to repeated laser treatment. In some cases IMHs has been initially misdiagnosed as amaurosis fugax, iritis and Posner-Schlossman ***: Owing to its scarcity, there is no good quality scientific evidence to support the management of IMH. The authors discuss the various treatment options and present a management strategy based on the previous literature for the management for this rare condition and its complications.

关键词： iris microhaemangioma iris vascular tufts capillary haemangioma of iris Cobb's tufts Argon laser photocoagulation

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Health and nursing policies,laws and in-service,governance and management,nursing leadership

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International journal of Nursing Sciences 2017年第4期4卷 339-340页

作者： simon Hlungwani Democratic Nursing Organisation of South Africa South Africa

***·South Africa is situated at the Apex of the African Continent·The last country to be liberated in Africa,in 1994·Population of 51 million·4.2 million foreign nationals from around SADC·Dominated by rural Areas *** policies *** of parliament·The Constitutional of the Republic of South Africa·Bill of Rights·National Health Act,2003(Act No.61 of 20013)·Nursing Act,2005(Act No 33 of 2005)·Mental Health Act·Pharmacy Act *** health policies·Policy on Primary Health Care·Policy on Maternal and Child Health·Policy guideline of School Health Services·Policy on Nurse Initiated and Managed Anti-Retroviral Treat-ment(NIMART)·Nursing Strategy *** strategy Objectives to:·Promote and maintain a high standard and quality of nursing and midwifery education and training;·Enhance and maintain professionalism and professional ethos amongst members of the nursing and midwifery professions;·Promote and maintain an enabling,well-resourced and positive practice environment for nursing,midwifery and patients/cli-ents throughout the lifespan;·Enable strong leadership at all levels of nursing and midwifery practice;·Guide the production of sufficient numbers and the appropriate categories of nurses required to deliver healthcare services within the policy framework for the healthcare system.

关键词： nursing nurse Pharmacy

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Ileal pouch surgery for ulcerative colitis

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World journal of Gastroenterology 2007年第24期13卷 3288-3300页

作者： simon P Bach Neil j Mortensen Department of Colorectal Surgery John Radcliffe Hospital Oxford OX3 9DU United Kingdom

Ulcerative colitis (UC) is a relapsing and remitting disease characterised by chronic mucosal and submucosal inflammation of the colon and rectum. Treatment may vary depending upon the extent and severity of inflammation. Broadly speaking medical treatments aim to induce and then maintain remission. Surgery is indicated for inflammatory disease that is refractory to medical treatment or in cases of neoplastic transformation. Approximately 25% of patients with UC ultimately require colectomy. Ileal pouch-anal anastomosis (IPAA) has become the standard of care for patients with ulcerative colitis who ultimately require colectomy. This review will examine indications for IPAA, patient selection, technical aspects of surgery, management of complications and long term outcome following this procedure.

关键词： Ulcerative colitis Ileal Pouch Ileal pouch anal anastomosis

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Nonlinear shear behavior of rock joints using a linearized implementation of the Barton-Bandis model

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journal of Rock Mechanics and Geotechnical Engineering 2017年第4期9卷 671-682页

作者： simon Heru Prassetyo Marte Gutierrez Nick Barton Department of Civil and Environmental Engineering Colorado School of Mines Golden CO 80401 USA Nick Barton and Associates Oslo Norway

Experiments on rock joint behaviors have shown that joint surface roughness is mobilized under shearing,inducing dilation and resulting in nonlinear joint shear strength and shear stress *** displacement *** Barton-Bandis(B-B) joint model provides the most realistic prediction for the nonlinear shear behavior of rock *** B-B model accounts for asperity roughness and strength through the joint roughness coefficient(jRC) and joint wall compressive strength(jCS) ***,many computer codes for rock engineering analysis still use the constant shear strength parameters from the linear Mohr-Coulomb(M-C) model,which is only appropriate for smooth and non-dilatant *** limitation prevents fractured rock models from capturing the nonlinearity of joint shear *** bridge the B-B and the M C models,this paper aims to provide a linearized implementation of the B-B model using a tangential technique to obtain the equivalent M-C parameters that can satisfy the nonlinear shear behavior of rock *** equivalent parameters,namely the equivalent peak cohesion,friction angle,and dilation angle,are then converted into their mobilized forms to account for the mobilization and degradation of jRC under *** conversion is done by expressing jRC in the equivalent peak parameters as functions of joint shear displacement using proposed hyperbolic and logarithmic functions at the pre-and post-peak regions of shear displacement,***,the pre-and post-peak joint shear stiffnesses are derived so that a complete shear stress-shear displacement relationship can be *** of the linearized implementation of the B-B model show that the shear stress-shear displacement curves,the dilation behavior,and the shear strength envelopes of rock joints are consistent with available experimental and numerical results.

关键词： Rock joints joint shear behavior Friction and dilation Barton-Bandis(B-B) model Equivalent Mohr-Coulomb(M-C) parameters

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Management of occluded self-expanding biliary metal stents in malignant biliary disease

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 49-54页

作者： simon Nennstiel Isolde Tschurtschenthaler Bruno Neu Hana Algül Monther Bajbouj Roland M. Schmid Stefan von Delius Andreas Weber Klinik und Poliklinik fur Innere Medizin Ⅱ Klinikum rechts der Isar der Technischen Universitar Manchen Ismaninger Straβe 22 Munich 81675 Germany Medizinische Klinik II Krankenhaus Landshut-Achdorf Academic Teaching Hospital Technische Universitar Munchen Achdorferweg 3 Landshut 84036Germany

Background: Occlusion of self-expanding metal stents(SEMS) in malignant biliary obstruction occurs in up to 40% of patients. This study aimed to compare the different techniques to resolve stent occlusion in our collective of ***: Patients with malignant biliary obstruction and occlusion of biliary metal stent at a tertiary referral endoscopic center were retrospectively identified between April 1, 1994 and May 31, 2014. The clinical records were further analyzed regarding the characteristics of patients, malignant strictures, SEMS,management strategies, stent patency, subsequent interventions, survival time and case ***: A total of 108 patients with biliary metal stent occlusion were identified. Seventy-nine of these patients were eligible for further analysis. Favored management was plastic stent insertion in 73.4% patients. Second SEMS were inserted in 12.7% patients. Percutaneous transhepatic biliary drainage and mechanical cleansing were conducted in a minority of patients. Further analysis showed no statistically significant difference in median overall secondary stent patency(88 vs. 143 days, P = 0.069), median survival time(95 vs. 192 days, P = 0.116), median subsequent intervention rate(53.4% vs. 40.0%, P = 0.501)and median case charge(€5145 vs. €3473, P = 0.803) for the treatment with a second metal stent insertion compared to plastic stent insertion. In patients with survival time of more than three months,significantly more patients treated with plastic stents needed re-interventions than patients treated with second SEMS(93.3% vs. 57.1%, P = 0.037).Conclusions: In malignant biliary strictures, both plastic and metal stent insertions are feasible strategies for the treatment of occluded SEMS. Our data suggest that in palliative biliary stenting, patients especially those with longer expected survival might benefit from second SEMS insertion. Careful patient selection is important to ensure a proper decision for either management

关键词： Self-expanding metal stents Biliary tract neoplasms Endoscopic retrograde cholangiopancreatography Biliary tract diseases Complications

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A simultaneous approach for integration of thermal energy storages in industrial processes using multiperiod heat integration

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Energy Storage and Saving 2022年第2期1卷 117-128页

作者： simon Möhren Christian Schäfer jörg Meyer Hartmut Krause SWK E2 Institute for Energy Technology and Energy Management Hochschule Niederrhein University of Applied ScienceKrefeld47805Germany Institute of Thermal Engineering TU Bergakademie FreibergFreiberg09599Germany

In times of increasing global warming,enormous efforts are required to rapidly reduce greenhouse gas(GHG)*** to the EU’s target of climate neutrality by 2050 and the even more ambitious goal of becoming climate-neutral in Germany by 2045,it is necessary to systematically increase energy efficiency and decarbonize the industrial heat *** methods of heat integration can be used to exploit existing potentials for waste heat utilization and to integrate renewable technologies for heating and *** using a non-stationary,multiperiod approach,additional energy savings can be achieved by integrating a thermal energy storage(TES)that enables heat transportation over *** paper presents a simultaneous approach for thermal energy storage integration into multiperiod heat integration *** approach can be used to minimize energy demand,costs and CO 2 emissions and is demonstrated in two case *** case study 1,it is shown that the presented approach is capable of integrating a TES properly into a simple multiperiod heat integration problem with two *** case study 2,a simplified example from a cosmetics manufactory is *** total utility demand can be reduced by up to 44.3%due to TES integration and the energetic optimal storage size can be determined as 125 m *** savings are strongly dependent on the constellation of heat flows between the periods,on the temperature levels and on the storage *** reductions of energy demand,costs and CO 2 emissions can be achieved with TES being properly integrated into a suitable operating environment.

关键词： Multiperiod heat integration Thermal energy storage Waste heat utilization Heat exchanger network Energy efficiency

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Effect of Small Addition of Sc on the Microstructural Evolution in Al-15Ag Alloy

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journal of Materials Science & Technology 2005年第5期21卷 630-634页

作者： Zhiguo CHEN Ziqiao ZHENG simon P.Ringer School of Materials Science and Engineering Central South University Changsha 410083 China Australian Key Centre for Microscopy & Microanalysis The University of Sydney 2006 NSW Australia

The effect of small addition of Sc on the microstructural evolution in Al-15Ag alloy was investigated by Monte Carlo simulation and transmission electron microscopy （TEM）. Monte Carlo simulation results indicate that Ag clustering is suppressed by the addition of Sc during the initial ageing stage, and there is a little chemical repulsion between Ag atoms and Sc atoms. TEM observations show that the morphology of γ′ precipitation can be modified by the small addition of Sc, which does result in a refinement of γ′ precipitates in Al-15Ag-0.2Sc. The mechanism by which trace Sc affect the microstructure is to reduce the ledge density of γ′precipitates.

关键词： Aluminium alloys Ageing Microstructure Scandium

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