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利用低能质子束产生高强度放射性束流

高能物理与核物理 2006年第7期30卷 675-679页

作者：郭冰柳卫平 Trinczek M Lapi S Ames F Buckley K R d’Auria J M Jayamanna K Ruiz C Ruth T J 中国原子能科学研究院核物理研究所北京102413 TRIUMF Vancouver B.C.CANADAV6T 2A3 simon Fraser University Burnaby B.C.CANADAV5A 1S6 TRIUMF Vancouver B.C.CANADAV6T 2A3 Simon Fraser UniversityBurnabyB.C.CANADAV5A 1S6

加拿大TRIUMF实验室利用11C成功验证了一种产生高强度(-108ions／s)放射性束流的方法．该方法不同于普通在线同位素分离方法,它利用了13MeV的低能强流质子束,可以产生一系列核天体物理实验感兴趣的高强度放射性束流．

关键词：放射性束流在线同位素分离炮弹碎裂束流强度

Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4

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Bone Research 2021年第3期9卷 313-322页

作者： Yao Fan Rongrong Zha Tomohiko Sano Xinyu Zhao Shengzhi Liu Mark d.Woollam di Wu Xun Sun Kexin Li Motoki Egi Fangjia Li Kazumasa Minami Amanda P.Siegel Takashi Horiuchi Jing Liu Mangilal Agarwal Akihiro Sudo Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota department of Phamacology School of PharmacyHarbin Medical UniversityHarbinChina department of Biomedical Engineering Indiana University Purdue University IndianapolisIndianapolisIndianaUSA department of Orthopedic Surgery Mie UniversityMieJapan Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijingChina department of Chemistry and Chemical Biology Indiana University Purdue University IndianapolisIndianapolisINUSA Integrative Nanosystems development Institute Indiana University Purdue University IndianapolisIndianapolisINUSA Graduate School of Engineering Mie UniversityMieJapan department of Physics Indiana University Purdue University IndianapolisIndianapolisINUSA department of Radiation Oncology Osaka University Graduate School of MedicineSuitaOsakaJapan simon Cancer Center Indiana University School of MedicineIndianapolisINUSA department of Surgery Simon Cancer Research CenterIndiana University School of MedicineIndianapolisINUSA

Mechanical loading to the bone is known to be beneficial for bone homeostasis and for suppressing tumor-induced osteolysis in the loaded ***,whether loading to a weight-bearing hind limb can inhibit distant tumor growth in the brain is *** examined the possibility of bone-to-brain mechanotransduction using a mouse model of a brain tumor by focusing on the response to Lrp5-mediated Wnt signaling and dopamine in tumor *** results revealed that loading the tibia with elevated levels of tyrosine hydroxylase,a rate-limiting enzyme in dopamine synthesis,markedly reduced the progression of the brain *** simultaneous application of fluphenazine(FP),an antipsychotic dopamine modulator,enhanced tumor *** and FP exerted antitumor effects through the dopamine receptors dRd1 and dRd2,***,dopamine downregulated Lrp5 via dRd1 in tumor cells.A cytokine array analysis revealed that the reduction in CCN4 was critical for loading-driven,dopamine-mediated tumor *** silencing of Lrp5 reduced CCN4,and the administration of CCN4 elevated oncogenic genes such as MMP9,Runx2,and *** summary,this study demonstrates that mechanical loading regulates dopaminergic signaling and remotely suppresses brain tumors by inhibiting the Lrp5-CCN4 axis via dRd1,indicating the possibility of developing an adjuvant bone-mediated loading therapy.

关键词： dopamine mediated elevated

使用数据挖掘方法将功能独立性评定量表运动分数转换至改良巴氏指数分数

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康复学报 2021年第5期31卷 365-371页

作者：黄力恒黄锦文吴显波香港东华学院中国香港香港大埔医院中国香港香港九龙医院中国香港

目的:为了适应临床和科研的需要,建立和评估一种功能独立性评定量表(FIM)运动分数转换至改良巴氏指数(MBI)分数的方法。方法:回顾性分析2005—2016年香港某康复医院的卒中患者在刚接受作业治疗时FIM运动分数和MBI分数。采取数据挖掘方法... 详细信息

目的:为了适应临床和科研的需要,建立和评估一种功能独立性评定量表(FIM)运动分数转换至改良巴氏指数(MBI)分数的方法。方法:回顾性分析2005—2016年香港某康复医院的卒中患者在刚接受作业治疗时FIM运动分数和MBI分数。采取数据挖掘方法,包括(1)订立数据规格条件;(2)检查和选取符合规定的数据;(3)将数据随机分组;(4)制订这2个量表的项目配对;(5)使用"秩不变量"方法对换数据;(6)校验数据对换方法。结果:将符合规定的6574例患者随机分成背景相仿的A、B 2组,A组的各项MBI分数与FIM运动分数显示两者有高度关联性(Kendall’s tau-b值0.796~0.987,P<0.01)。再依据"秩不变量"方法制定这2个量表项目的对换表。最后使用对换表将B组数据转换后再检查其关联性,其"单对单项"和"单对多项"的Co-hen’s Kappa系数(k)为0.770~0.913。校验结果提示MBI分数与对换的MBI分数有高度的关联性。结论:该数据挖掘方法制订出的对换方法通过统计学的校验,且易于使用,适合处理或比较有关卒中康复的相关数据。

关键词：独立性评定量表改良巴氏指数功能评估卒中康复

Three-dimensional imaging of the uterus:The value of the coronal plane

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World Journal of Radiology 2015年第12期7卷 484-493页

作者： Lufee Wong Nikki White Jayshree Ramkrishna Edward Araujo Júnior simon Meagher Fabricio da Silva Costa Monash Ultrasound for Women department of Obstetrics and Gynaecology Monash Medical CentreSouthern Health department of Obstetrics Paulista School of Medicine-Federal University of Sao Paulo(EPM-UNIFESP)

Advent in three-dimensional(3d) imaging technology has seen 3d ultrasound establish itself as a useful adjunct complementary to traditional two-dimensional imaging of the female pelvis. This advantage largely arises from its ability to reconstruct the coronal plane of the uterus, which allows further delineation of many gynecological disorders. 3d imaging of the uterus is now the preferred imaging modality for assessing congenital uterine anomalies and intrauterine device localization. Newer indications include the diagnosis of adenomyosis. It can also add invaluable information to delineate other endometrial and myometrial pathology such as fibroids and endometrial polyps.

关键词： Three-dimensional ultrasound Coronal view Pelvis Uterus Uterine anomalies

帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析

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中华肿瘤防治杂志 2021年第24期28卷 1841-1850页

作者：陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh 山东省肿瘤防治研究院(山东省肿瘤医院) 山东第一医科大学(山东省医学科学院)山东济南250117 不详 department of Radiation Oncology The University of Texas M D Anderson Cancer CenterHoustonTX 77030USA

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MdACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,... 详细信息

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MdACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MdACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MdACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为dACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MdACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MdACC研究(NCT02444741)均在***上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括Pd-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。

关键词：帕博利珠单抗非小细胞肺癌放疗汇总分析

血浆游离dNA水平增高可作为预测重型颅脑损伤患者死亡率的独立指标(英文)

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中华神经外科疾病研究杂志 2014年第3期13卷 258-258页

作者： Rodrigues Filho EM1 simon d Ikuta N Klovan C dannebrock F de Oliveira CO Regner A 1ULBRA Laboratório de Biomarcadores do TraumaCanoasRSBrazil

Trauma is the leading cause of death under 45 years worldwide and up to 50% of trauma fatalities are due to brain *** of outcome is one of the major problems associated with severe TBI and research efforts have focused on the investigation of biomarkers with prognostic value following TBI. Therefore,our aim was to investigate whether cell-free dNA concentrations correlated to short-term primary outcome( survivor or death) and GCS scores following severe TBI. A total of 188 victims of severe TBI were enrolled in this prospective study,outcome variables comprised: survival and neurological assessment using the GCS at ICU discharge. Control blood samples were obtained from 25 healthy volunteers. Peripheral venous blood was collected at admission in the ICU. Plasma dNA was measured using a real-time quantitative PCR assay for the β-globin gene. There was correlation between higher dNA levels and both fatal outcome and lower hospital admission GCS scores. Plasma dNA concentrations at the chosen cut- off point( ≥171,381 kilogenomesequivalents /L) predicted mortality with a specificity of 90% and a sensitivity of 43%. Logistic regression analysis showed that elevated plasma dNA levels were independently associated with death( P dNA concentration was a predictor of short-term mortality following severe TBI.

关键词：神经外科学疾病临床研究症状

基于体波有限频层析成像的青藏高原南部和中部下方印度大陆岩石层俯冲和撕裂的三维图像

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世界地震译丛 2016年第6期47卷 521-542页

作者： Xiaofeng Liang Yun Chen Xiaobo Tian Yongshun John Chen James Ni Andrea Gallegos simon L.Klemperer Minling Wang Tao Xu Changqing Sun Shaokun Si Haiqiang Lan Jiwen Teng 左思成中国科学院地质与地球物理研究所

使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印... 详细信息

使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印度大陆岩石层(ICL)。印度大陆岩石层似乎在青藏高原中部比东部向北延伸更多——沿85°E在31°N到达350km深处,而沿91°E则是在30°N到达350km深度。P波和S波低速异常区在当惹雍错裂谷、亚东—谷露裂谷和错那裂谷下方从下地壳延伸至≥180km深度,这表明青藏高原南部的裂谷可能包含了整个岩石层的变形。当惹雍错裂谷下方的异常区向下延伸到约180km,而亚东—谷露裂谷西部和错那裂谷东部的异常延伸到了超过300km的深度。亚东—谷露裂谷西部的低速区上地幔延伸至最北,并且似乎与青藏高原中部下方广阔的上地幔低速区相连。于是,北向俯冲的印度板块沿着南北走向的裂缝撕裂。这些裂缝允许或者导致的软流层上涌同青藏高原北部上地幔相类似。

关键词：印度大陆岩石层青藏高原体波走时层析成像俯冲撕裂上地幔

A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth david Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker dangor Laurence devereux Peter E.dyer Anthony dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin denis R.Hall david C.Hanna Wayne Harris david I.Hillier Christopher J.Hooker simon M.Hooker Nicholas Hopps Janet Hull david Hunt dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.d.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin david Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng david Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK deBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBdA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

Revisit to Two-Proton Radioactivity of 19Mg and Observation of Two-Proton decay of 30Ar

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原子核物理评论 2016年第2期33卷 197-202页

作者：徐晓栋 I.Mukha L.Acosta E.Casarejos A.A.Ciemny W.dominik J.duénas-díaz V.dunin J.M.Espino A.Estradé F.Farinon H.Geissel A.Fomichev T.A.Golubkova A.Gorshkov L.V.Grigorenko Z.Janas G.Kamiński O.Kiselev R.Knbel S.Krupko M.Kuich Yu.A.Litvinov G.Marquinez-dur'an I.Martel C.Mazzocchi C.Nociforo A.K.Ord'uz M.Pfützner S.Pietri M.Pomorski A.Prochazka S.Rymzhanova A.M.S'anchez-Benítez C.Scheidenberger P.Sharov H.simon B.Sitar R.Slepnev M.Stanoiu P.Strmen I.Szarka M.Takechi Y.K.Tanaka H.Weick M.Winkler J.S.Winfield Ⅱ.Physikalisches Institut Justus-Liebig-Universitt Gie?en GSI Helmholtzzentrum für Schwerionenforschung Gmb H School of Physics and Nuclear Energy Engineering Beihang University National Research Centre "Kurchatov Institute" INFN Laboratori Nazionali del Sud Instituto de Física Universidad Nacional Autónoma de México University of Vigo Faculty of Physics University of Warsaw department of Applied Physics University of Huelva Veksler and Baldin Laboratory of High Energy Physics department of Atomic Molecular and Nuclear PhysicsUniversity of Seville University of Edinburgh Flerov Laboratory of Nuclear Reactions Advanced Educational and Scientific Center Moscow State University FSBI "SSC RF ITEP"of NRC "Kurchatov Institute" National Research Nuclear University "MEPh I" Institute of Nuclear Physics PAN Faculty of Physics Warsaw University of Technology Faculty of Mathematics and Physics Comenius University IFIN-HH University of Tokyo

An experiment aimed to investigate the two-proton(2p) decay of the previously unknown nucleus ^(30)Ar was performed at GSI. By tracking the decay products in-flight with silicon micro-strip detectors, the 2p decays of ^(30)Ar were observed for the first time. For the calibration purpose, 2p decays of ^(19)Mg were also remeasured by tracking the coincident ^(17)Ne+p+p trajectories. By comparing the measured angular p-17 Ne correlations with those obtained from the corresponding Monte Carlo simulations,the simultaneous 2p decay of ^(19)Mg ground state and the sequential 2p emission of several known excited states of ^(19)Mg were confirmed. One new excited state in ^(19)Mg and two new excited states in ^(18)Na were observed.

关键词： proton drip line decay by proton emission nuclear energy level