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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang Wong Hoi She simon Hing-Yin Tsang Chung Mau Lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

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The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens

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Infectious Microbes & Diseases 2024年第2期6卷 65-73页

作者： Alexandra Stream Ross Corriden simon Döhrmann Richard L.Gallo Victor Nizet Ericka L.Anderson Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San Diego School of MedicineLa JollaCaliforniaUSA Department of Dermatology University of California San Diego School of MedicineLa JollaCaliforniaUSA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCaliforniaUSA

Vitamin A and its biologically active derivative,retinoic acid(RA),are important for many immune ***,in particular,is essential for the development of immune cells,including neutrophils,which serve as a front-line defense against *** vitamin A deficiency has been linked to higher susceptibility to infections,the precise role of vitamin A/RA in host-pathogen interactions remains poorly ***,we provided evidence that RA boosts neutrophil killing of methicillin-resistant Staphylococcus aureus(MRSA).RA treatment stimulated primary human neutrophils to produce reactive oxygen species,neutrophil extracellular traps and the antimicrobial peptide cathelicidin(LL-37).Because RA treatment was insufficient to reduce MRSA burden in an in vivo murine model of skin infection,we expanded our analysis to other infectious *** did not affect the growth of a number of common bacterial pathogens,including MRSA,Escherichia coli K1 and Pseudomonas aeruginosa;however,RA directly inhibited the growth of group A Streptococcus(GAS).This antimicrobial effect,likely in combination with RA-mediated neutrophil boosting,resulted in substantial GAS killing in neutrophil killing assays conducted in the presence of ***,in a murine model of GAS skin infection,topical RA treatment showed therapeutic potential by reducing both skin lesion size and bacterial *** findings suggest that RA may hold promise as a therapeutic agent against GAS and perhaps other clinically significant human pathogens.

关键词： retinoic acid neutrophil bacterial infection Staphylococcus aureus group A Streptococcus neutrophil extracellular traps antimicrobial peptide cathelicidin

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Effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

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Journal of Sport and Health Science 2024年第1期13卷 90-98页

作者： Tania Pinto-Escalona Erica Gobbi Pedro L.Valenzuela simon J.Bennett Pierluigi Aschieri Manuel Martin-Loeches Antonio Paoli Oscar Martinez-de-Quel Faculty of Education Complutense University of MadridMadrid 28040Spain Department of Biomolecular Sciences University of Urbino“Carlo Bo”Urbino 61029Italy Department of Systems Biology University of AlcaláMadrid 28805Spain Research Institute for Sport and Exercise Sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian Judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for the Behavioural Sciences Department Complutense University of MadridMadrid 28040Spain Department of Biomedical Sciences University of PaduaPadua 35122Italy

Purpose:To examine the effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness in children aged 7-8 ***:Twenty schools in 5 different European countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(Sport at School trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an intervention group,which replaced these lessons with a 1-year karate intervention(Karate Mind and Movement program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±SD)completed the study,of which 333 and 388 were assigned to the control group and intervention group,*** included academic performance(average grade),psychosocial functioning(Strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The intervention provided small but significant benefits compared to the control group for academic achievement(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;p0.05).Conclusion:A 1-year school-based karate intervention was effective in improving academic achievement,conduct problems,and physical fitness in primary school *** results support the inclusion of karate during physical education lessons.

关键词： Academic performance Cardiorespiratory fitness Conduct problems Karate Physical fitness

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Interdecadal variability of summer precipitation in the Three River Source Region: Influences of SST and zonal shifts of the East Asian subtropical westerly jet

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Atmospheric and Oceanic Science Letters 2024年第5期17卷 47-53页

作者： Yumeng Liu Xianhong Meng Lin Zhao S-Y.simon Wang Lixia Zhang Zhaoguo Li Chan Wang Yingying An Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina Zoige Plateau Wetlands Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina University of Chinese Academy of Sciences BeijingChina Utah Climate Center Utah State UniversityLoganUSA The State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

Summer precipitation in the Three Rivers Source Region(TRSR)of China is vital for the headwaters of the Yellow,Yangtze,and Lancang rivers and exhibits significant interdecadal *** study investigates the influence of the East Asian westerly jet(EAWJ)on TRSR rainfall.A strong correlation is found between TRSR summer precipitation and the Jet Zonal Position Index(JZPI)of the EAWJ from 1961 to 2019(R=0.619,p<0.01).During periods when a positive JZPI indicates a westward shift in the EAWJ,enhanced water vapor anomalies,warmer air,and low-level convergence anomalies contribute to increased TRSR summer *** empirical orthogonal function and regression analyses,this research identifies the influence of large-scale circulation anomalies associated with the Atlantic–Eurasian teleconnection(AEA)from the North Atlantic(NA).The interdecadal variability between the NA and central tropical Pacific(CTP)significantly affects TRSR *** influence is mediated through the AEA via a Rossby wave train extending eastward along the EAWJ,and another south of 45°***,the NA–CTP Opposite Phase Index(OPI),which quantifies the difference between the summer mean sea surface temperatures of the NA and the CTP,is identified as a critical factor in modulating the strength of this teleconnection and influencing the zonal position of the EAWJ.

关键词： Summer precipitation East Asian subtropical westerly jet Three River Source Region Atlantic-Eurasian teleconnection

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Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1607-1622页

作者： Giulia Foggi Melissa Terranova Matteo Daghio Sergej L.Amelchanka Giuseppe Conte simon Ineichen Monica Agnolucci Carlo Viti Alberto Mantino Arianna Buccioni Michael Kreuzer Marcello Mele Department of Agriculture Food and Environment(DAFE)University of Pisa56124 PisaItaly AgroVet‑Strickhof ETH ZurichLindauSwitzerland Department of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorence 50144Italy Centro Di Ricerche Agro‑Ambientali“E.Avanzi” University of PisaPisa 56122Italy School of Agricultural Forest and Food Sciences HAFLBern University of Applied SciencesZollikofenSwitzerland Institute of Agricultural Sciences ETH ZurichLindauSwitzerland

Background Dietary supplements based on tannin extracts or essential oil compounds(EOC)have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry.A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia *** these,Q-2(named after quebracho extract and EOC blend 2,composed of carvacrol,thymol,and eugenol)and C-10(chestnut extract and EOC blend 10,consisting of oregano and thyme essential oils and limonene)have been investigated in detail in the present study with the semi-continuous rumen simulation technique(Rusitec)in three independent *** this purpose,Q-2 and C-10,dosed according to the previous study,were compared with a non-supplemented diet(negative control,NC)and with one supplemented with the commercial EOC-based Agolin^(R) Ruminant(positive control,PC).Results From d 5 to 10 of fermentation incubation liquid was collected and analysed for pH,ammonia,protozoa count,and gas *** residues were collected for the determination of ruminal *** d 10,samples of incubation liquid were also characterised for bacterial,archaeal and fungal communities by high-throughput sequencing of 16S rRNA and 26S ribosomal large subunit gene *** of the duration of the fermentation period,Q-2 and C-10 were similarly efficient as PC in mitigating either ammonia(-37%by Q-2,-34%by PC)or methane formation(-12%by C-10,-12%by PC).The PC was also responsible for lower feed degradability and bacterial and fungal richness,whereas Q-2 and C-10 effects,particularly on microbiome diversities,were limited compared to *** All additives showed the potential to mitigate methane or ammonia formation,or both,in vitro over a period of 10 ***,several differences occurred between PC and Q-2/C-10,indicating different mechanisms of *** pronounced defaunation caused by PC a

关键词： Additive Bacteria Continuous culture Degradability Fermentation Fungi Greenhouse gas In vitro Microbiome Rumen

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基于系统动力学的北京自动驾驶汽车市场发展研究

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系统科学与数学 2024年

作者：徐猛毛玮 SHEPHERD simon HARRISON Gillian 北京交通大学系统科学学院利兹大学交通研究所

本文从自动驾驶汽车市场发展角度,围绕私人汽车与共享自动驾驶汽车的市场发展特征进行动力学分析.结合自动驾驶技术发展现状,通过选取居民对自动驾驶技术信任度、购买意愿、使用意愿以及共享自动驾驶汽车服务可达性等指标衡量自动驾驶... 详细信息

本文从自动驾驶汽车市场发展角度,围绕私人汽车与共享自动驾驶汽车的市场发展特征进行动力学分析.结合自动驾驶技术发展现状,通过选取居民对自动驾驶技术信任度、购买意愿、使用意愿以及共享自动驾驶汽车服务可达性等指标衡量自动驾驶汽车市场发展,提出自动驾驶汽车市场发展系统动力学模型.以北京为例,分析其从2014年至2050年的汽车市场发展情况,以及在2024年至2050年自动驾驶汽车的数量变化情况,并估计自动驾驶汽车的市场份额.结果表明:自动驾驶汽车数量将在2040年超过传统汽车;预计到2050年,自动驾驶汽车市场份额将超过90%.进一步地,构建自动化驾驶技术发展、共享自动驾驶汽车推广等发展方案,对自动驾驶汽车应用场景进行拓展建模分析.结果显示:自动驾驶技术快速发展,将会吸引更多居民使用私人自动驾驶汽车;推广共享自动驾驶汽车,能够有效减少未来私人自动驾驶汽车的购买量.本研究为未来城市自动驾驶汽车发展提供了参考.

关键词：城市交通市场份额系统动力学自动驾驶汽车共享自动驾驶汽车汽车市场发展

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Leadership and Top Management Influence on Total Quality Management Implementation in the Ghanaian Construction Industry

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Journal of Building Construction and Planning Research 2024年第2期12卷 37-51页

作者： Ansah Samuel Kwame Tekpe Emmanuel Ametepey simon Ofori Department of Construction Technology and Management Cape Coast Technical University Cape Coast Ghana Department of Building Technology Koforidua Technical University Koforidua Ghana

This study aims to determine the key and underlying Leadership and Top Management (LTM) factors that have a significant impact on sustaining the implementation of Total Quality Management (TQM) within the construction industry in Ghana. The research methodology employed in this study was a quantitative technique. Questionnaires were distributed to 641 participants within construction industry in Ghana. Questionnaires retrieved for the analysis were 536. Three steps approached were used for the data analysis. These include Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Modeling (SEM) analysis. After conducting the EFA and CFA, SEM was also used to analyze the construct validity. The SEM analysis helps to determine four key indicator variables for the leadership and top management construct. These include Leadership/Top Management approach to employees’ management, Leadership/Top Management understanding of TQM, Leadership/Top Management empowerment of employees to resolve quality issues, and Leadership/Top Management endorsement of TQM. All the four indicator variables were found to be good of fit and closely associated with the dependent variable. The study adds to the body of knowledge by using EFA, CFA and SEM techniques to establish key leadership and top management factors affecting TQM implementation in Ghana’s construction industry. The findings in general suggested that leadership and top Management factors identified have a direct positive impact on sustaining TQM implementation in the Ghanaian construction industry. Consequently, the leadership and top management factors identified in this study can help improve TQM in the Ghanaian construction industry.

关键词： Construction Industry Leadership Top management Total Quality Management

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关于全球高等教育研究未来的若干思考

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中国高教研究 2024年第8期 9-13页

作者： simon Marginson 沈文钦(译) 王嘉璐(译) 牛津大学教育系牛津OX12JD 全球高等教育研究中心北京大学教育学院

制度化的高等教育研究起源于20世纪60年代的美国,其中马丁·特罗和伯顿·克拉克作为开创者作出了独特的贡献。20世纪80年代以来,新自由主义的崛起、全球化的发展、技术的膨胀成为高等教育系统的突出特征,高等教育研究需要对这些发展及... 详细信息

制度化的高等教育研究起源于20世纪60年代的美国,其中马丁·特罗和伯顿·克拉克作为开创者作出了独特的贡献。20世纪80年代以来,新自由主义的崛起、全球化的发展、技术的膨胀成为高等教育系统的突出特征,高等教育研究需要对这些发展及其效应进行深入分析。在新的时代背景下,高等教育系统自身面临新的挑战,这主要包括毕业生的结果与机会公平、大学生就业、高等教育的社会价值以及如何促进更加多元的声音和主题等方面。随着东亚高等教育体系的崛起,世界高等教育格局正在发生重大变迁,世界各国需要增进彼此的理解,通过他者思考以理解自身的高等教育体系和世界高等教育体系是必不可少的。

关键词：高等教育研究多样性人力资本

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Photoelectrochemical Iron-Catalyzed C(sp^(3))-H Borylation of Alkanes in a Position-Selective Manner

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CCS Chemistry 2024年第6期6卷 1430-1438页

作者： Wen Wei Bin Wang simon L.Homölle Jinbin Zhu Yanjun Li Tristan von Münchow Isaac Maksso Lutz Ackermann Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen37077 Göttingen

Catalytic C-H borylation is of prime topical importance,since easily available feedstock chemicals can thereby be transformed into valuable transient functional groups in the absence of directing ***,we disclose an iron-catalyzed C(sp^(3))-H borylation of simple,non-prefunctionalized alkanes,providing access to value-added products in a single step by means of *** power of merging photo-and electrochemistry was mirrored by ample scope and exceedingly mild reaction ***,an outstanding position-selectivity in favor of primary C(sp^(3))-H proved viable within the photoelectrochemical borylation through a chemo-selective anodic overoxidation *** ferro-photoelectrochemistry strategy avoids toxic precious transition metals,enabling C(sp^(3))-H borylations in a site-selective fashion.

关键词： photoelectrocatalysis C(sp^(3))-H borylation iron catalysis position-selectivity chlorine radical

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Proterozoic to Phanerozoic case studies of laser ablation microanalysis for microbial carbonate U–Pb geochronology

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Geoscience Frontiers 2024年第2期15卷 30-40页

作者： Yuxiang Jiang simon V.Hohl Xiangtong Huang Shouye Yang State Key Laboratory of Marine Geology School of Ocean and Earth SciencesTongji UniversityShanghai 200092China

Some of the earliest bio-sedimentary records of life on Earth are represented by microbial carbonates,which are also critical geochemical archives of ancient seawater chemistry and the environmental circumstances in which they *** paleo-microbial environments on Earth and potentially other planets requires precise determination of the depositional ages of these ***(abiogenic)carbonate geochemistry communities can now use developments in in-situ laser ablation U-Pb dating using inductively coupled plasma mass spectrometry(LA-ICP-MS).Due to the effects of impurity mixing and diagenesis,microbial carbonates have received little geochronological study despite their broad relevance for understanding ancient seawater’s environmental conditions and geochemical *** study demonstrates using time-of-flight mass spectrometry(TOF-MS)to perform quick,quantitative elemental mapping before U-Pb spot dating to improve experiment success rates and data reliability and offers four practical application examples.

关键词： Stromatolite Microbial carbonate Carbonate geochronology In-situ LA-ICP-MS ICP-Time Of Flight-MS Trace element mapping

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