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The Innovation 2024年第4期5卷 34-40,33页

作者： Chuanliang Cui Juan li Yue Yang Lu Si Zhihong Chi lili Mao Xuan Wang Bixia Tang Xieqiao Yan siming li li Zhou Xiaoting Wei Yuping Shen Qun Guo Shirui Zheng Jun Guo Bin lian Department of Renal Cancer and Melanoma Peking University Cancer Hospital&InstituteKey laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Beijing 100142China Innovent Biologics Inc.Suzhou 215123China

IBI310 is a recombinant fully human IgG1 antibody against cytotoxic T lymphocyte antigen *** study was conducted to evaluate IBI310 monotherapy or combination therapy with sintilimab in the patients with advanced melanoma or urothelial carcinoma(UC).Patients in phase 1a received IBI310 at 0.3/1/2/3 mg/kg intravenously(IV)every 3 weeks(Q3W)following the accelerated titration and 3+3 escalation *** in phase 1b received IBI310(1/2/3 mg/kg IV,Q3W)plus sintilimab(200 mg IV,Q3W)for four cycles,followed by sintilimab maintenance *** phase 1b expansion of IBI310 plus sintilimab was performed in patients with advanced melanoma or ***,53 patients were enrolled,including 10 patients with melanoma in phase 1a,34 with melanoma,and 9 with UC in phase ***,94.3%of patients(50/53)experienced at least one treatment-related adverse event(TRAE)with most being grade 1–2;26.4%of patients(14/53)experienced grade 3 or higher *** phase 1a,the disease control rate(DCR)was 50.0%(95%confidence interval[CI],18.7%–81.3%).In phase 1b,the objective response rate(ORR)and DCR were 17.6%(95%CI,6.8%–34.5%)and 44.1%(95%CI,27.2%–62.1%),respectively,for melanoma,and were 22.2%(95%CI,2.8%–60.0%)and 66.7%(95%CI,29.9%–92.5%),respectively,for ***310 monotherapy or combination therapy with sintilimab was well tolerated with favorable antitumor activity across patients with advanced melanoma and UC.

关键词： melanoma mono experienced

重建起源和有效性的关联——论哈贝马斯《也是一部哲学史》的谱系学方法

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哲学分析 2024年第2期15卷 178-195,199页

作者：李思铭复旦大学哲学学院法兰克福大学规范性秩序研究中心

谱系学是哈贝马斯2019年发表的巨著《也是一部哲学史》的核心方法,也是其合理重构方法的延续。从理论对象去讲,谱系学不再直接关注参与者行动过程中的有效性要求,而是重新追溯这种有效性要求的理论起源。为此,哈贝马斯一方面转向了全新... 详细信息

谱系学是哈贝马斯2019年发表的巨著《也是一部哲学史》的核心方法,也是其合理重构方法的延续。从理论对象去讲,谱系学不再直接关注参与者行动过程中的有效性要求,而是重新追溯这种有效性要求的理论起源。为此,哈贝马斯一方面转向了全新的反思性观察者,把起源看作与有效性相同的学习过程;另一方面,他强调发挥谱系学的辩护性功能,并且认为学习过程的唯物辩证性特征维持了起源和有效性之间的逻辑独立性。从理论内涵来看,哈贝马斯主张将信仰和知识的关系作为理解西方哲学史的核心线索。他提出通过翻译克服宗教对于哲学的异质性,凭借可错性约束欧洲视角的普遍性,最终激励当代人重拾对政治实践的信心。

关键词：《也是一部哲学史》合理重构反思性观察者辩护性谱系学学习过程

关节腔注射治疗骨关节炎药物载体系统中的软骨靶向功能

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中国组织工程研究 2024年第3期28卷 458-463页

作者：陈俊炎孟庆奇李斯明贵州医科大学贵州省贵阳市550025 暨南大学附属广州市红十字会医院广东省广州市510220

背景:关节腔注射给药已经在骨关节炎治疗中占有重要地位,新型的药物递送系统的开发给予了更多选择。软骨靶向功能是针对治疗骨关节炎时药物附着或留置在软骨层中形成药库,达到缓释和精准药物递送。目的:综述关节腔注射治疗骨关节炎中各... 详细信息

背景:关节腔注射给药已经在骨关节炎治疗中占有重要地位,新型的药物递送系统的开发给予了更多选择。软骨靶向功能是针对治疗骨关节炎时药物附着或留置在软骨层中形成药库,达到缓释和精准药物递送。目的:综述关节腔注射治疗骨关节炎中各种软骨靶向生物材料和其特点。

关键词：软骨靶向关节腔注射骨关节炎软骨穿透药物载体生物材料

对完善境内债券市场基础制度的几点思考——基于中资美元债与境内债市场比较

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债券 2024年第2期 22-26页

作者：李思明中证金融研究院

中资美元债在评级、发行、交易、存续期管理及违约处置等方面,主要借鉴了美国债券市场基础制度,相关实践对完善境内债券市场基础制度有可借鉴之处。本文基于中资美元债与境内债市场比较研究,对完善境内债券市场基础制度提出了加强信用... 详细信息

中资美元债在评级、发行、交易、存续期管理及违约处置等方面,主要借鉴了美国债券市场基础制度,相关实践对完善境内债券市场基础制度有可借鉴之处。本文基于中资美元债与境内债市场比较研究,对完善境内债券市场基础制度提出了加强信用评级体系建设、丰富投资者类型、加强投资者保护、优化完善债券风险处置机制等政策建议。

关键词：中资美元债基础制度信用评级市场流动性

ADAPTIVE TRIMMED MEAN AS A LOCATION ESTIMATE

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Journal of Systems Science & Complexity 2012年第5期25卷 973-986页

作者： siming li Yong li Jiao JIN Department of Statistics and Financial Mathematics School of Mathematical SciencesKey Laboratory of Mathematics and Complex SystemsMinistry of EducationBeijing Normal University

The trimmed mean is one of the most common estimators of location for symmetrical distributions, whose effect depends on whether the trim rate matches the proportion of contaminated data. Based on the geometric characteristics of the curve of the trimmed variance function, the authors propose two kinds of adaptive trimmed mean algorithms. The accuracy of the estimators is compared with that of other often-used estimates, such as sample mean, trimmed mean, trimean, and median, by means of simulation method. The results show that the accuracy of the adaptive derivative optimization trimmed mean method is close to the optimum performance in case of medium contamination （the contamination rate is less than 50%）. Under high contamination situation （the contamination rate equals 8070）, the performance of the estimates is comparable to that of the median and is superior to other counterparts.

关键词： Adaptive location parameter robust trimmed mean.

Data Assimilation Method Based on the Constraints of Confidence Region

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Advances in Atmospheric Sciences 2018年第3期35卷 334-345页

作者： Yong li siming li Yao SHENG Luheng WANG School of Statistics Beijing Normal University School of Mathematical Sciences Beijing Normal University

The ensemble Kalman filter （EnKF） is a distinguished data assimilation method that is widely used and studied in various fields including methodology and oceanography. However, due to the limited sample size or imprecise dynamics model, it is usually easy for the forecast error variance to be underestimated, which further leads to the phenomenon of filter divergence. Additionally, the assimilation results of the initial stage are poor if the initial condition settings differ greatly from the true initial state. To address these problems, the variance inflation procedure is usually adopted. In this paper, we propose a new method based on the constraints of a confidence region constructed by the observations, called EnCR, to estimate the inflation parameter of the forecast error variance of the EnKF method. In the new method, the state estimate is more robust to both the inaccurate forecast models and initial condition settings. The new method is compared with other adaptive data assimilation methods in the Lorenz-63 and Lorenz-96 models under various model parameter settings. The simulation results show that the new method performs better than the competing methods.

关键词： data assimilation ensemble Kalman filter error variance inflation confidence region Lorenz model

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“长新冠”患者疲劳的机制研究进展

实用医学杂志 2024年第9期40卷 1186-1190页

作者：关巧妍包宋羽崔源源李思铭山西中医药大学太原030024 中国中医科学院西苑医院心血管科北京100091

自新型冠状病毒感染(COVID-19)以来,许多感染患者出现多个系统症状,而这些症状在感染3个月后仍会存在较长时间,被称为“长新冠(Long COVID)”。大量研究表明疲劳是“长新冠”诸多症状中最常见的症状,已严重影响患者生活质量。因此,了解... 详细信息

自新型冠状病毒感染(COVID-19)以来,许多感染患者出现多个系统症状,而这些症状在感染3个月后仍会存在较长时间,被称为“长新冠(Long COVID)”。大量研究表明疲劳是“长新冠”诸多症状中最常见的症状,已严重影响患者生活质量。因此,了解“长新冠”引起疲劳症状的机制尤为重要。本文通过梳理相关文献,总结“长新冠”疲劳的可能机制,包括免疫反应、氧化应激、影响中枢神经系统等,旨在提高临床对“长新冠”引起疲劳的认识,并为其治疗提供一定的思路。

关键词：长新冠疲劳机制

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基于阴离子交换膜电解水的离聚物研究进展

材料导报 2024年第8期38卷 24-34页

作者：赵涔凯邹杰鑫王旻李思明赵微张时林滕珏瑾王艳皎吴明铂胡涵李亚伟中国石油大学(华东)化学化工学院重质油国家重点实验室山东青岛266580 青岛海尔智能技术研发有限公司山东青岛266101 山西大学化学化工学院太原030006 能量转换与储存材料山西省重点实验室太原030006

在能源日益匮乏的今天,氢能作为一种可再生、绿色环保的新型能源成为全球节能降碳的重要载体。传统的碱水电解(Alkaline water electrolysis,AWE)制氢要求较高pH的碱液作为电解液,而且只能在低电流密度下工作;质子交换膜电解水(Proton e... 详细信息

在能源日益匮乏的今天,氢能作为一种可再生、绿色环保的新型能源成为全球节能降碳的重要载体。传统的碱水电解(Alkaline water electrolysis,AWE)制氢要求较高pH的碱液作为电解液,而且只能在低电流密度下工作;质子交换膜电解水(Proton exchange membrane water electrolysis,PEMWE)制氢技术具有电流密度大、效率高的特点,被人们视为最有前景的电解水制氢技术,但是其昂贵的催化剂以及所需的高耐酸性部件成为制约PEMWE发展的重要因素。阴离子交换膜电解水(Anion exchange membrane water electrolysis,AEMWE)作为一种新兴的技术,可以实现低成本“绿氢”制备。相较于AWE,AEMWE避免了高浓度碱液的循环;相较于PEMWE,AEMWE则具有成本低、腐蚀性低等优势。离聚物作为关键部件膜电极(Membrane electrode assembly,MEA)中三相界面(Triple phase boundary,TPB)的重要组成部分,对AEMWE内部催化作用和水管理能力起着重要作用。本文首先围绕AEMWE技术原理和离聚物在AEMWE中的作用进行了概述,随后对常见的不同种类的阴离子离聚物结构及特点进行了总结,最后从结构、含量以及添加剂调控三种调控策略入手,针对如何调控离聚物以达到更加优异的电解性能进行了具体的分析总结。

关键词：阴离子交换膜电解水离聚物三相界面调控策略

Ground motion amplification pattern with TBM tunnels crossing soil-rock interface:Shaking table test

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Underground Space 2023年第5期12卷 202-217页

作者： siming li Roberto Cudmani Mingqing Xiao Zhiming Guo Yong Yuan College of Civil Engineering Tongji UniversityShanghai 200092China Department of Civil and Environmental Engineering Technical University of MunichMu¨nchen 81245Germany China Railway Siyuan Survey and Design Group Co. Ltd.Wuhan 430063China Public Works Construction Center Nanjing 210019China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China

The current aseismic design has seldom considered the effect caused by underlain *** studies focused on the scenarios of tunnels embedded in homogeneous soil under transverse seismic *** paper aims to investigate the tunnel effect on the surface acceleration response in soil-rock strata by shaking table *** sets of excitations are employed and input along the shaking table in both transverse and longitudinal *** soil-rock site is classified as four micro-zones with varying conditions,to mount observation stations of acceleration *** characteristics of the four zones are identified by the transfer function(TF)method,and the tunnel effect on the ground acceleration response is obtained by comparing the spectral acceleration results between the free-field and ground-tunnel *** test results indicate that the tunnel effect varies with the site ***,a significant amplification effect is observed at the A4 zone,located on the soil deposit near the soil-rock ***,it is proved that the scattering waves generated at the interface and the standing waves trapped between the tunnel and upper ground surface account for the amplification,revealed by the discrepancies of the TF results and acceleration details between the free-field and ground-tunnel models.

关键词： Tunnel Soil-rock interface Seismic excitation Ground response Site characteristics

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生物增效技术处理制革废水的试验研究

皮革制作与环保科技 2024年第2期5卷 19-21页

作者：姚阳刘思帆李思明武汉森泰环保股份有限公司湖北武汉430070

生物增效技术可以显著提高废水处理效果。在处理前,废水中的有机物质和重金属离子含量较高,COD和BOD_(5)浓度都超过了国家排放标准。经过生物增效技术处理后,废水中的COD和BOD_(5)浓度明显降低,并符合国家排放标准要求。本试验结果表明... 详细信息

生物增效技术可以显著提高废水处理效果。在处理前,废水中的有机物质和重金属离子含量较高,COD和BOD_(5)浓度都超过了国家排放标准。经过生物增效技术处理后,废水中的COD和BOD_(5)浓度明显降低,并符合国家排放标准要求。本试验结果表明,生物增效技术是一种高效、经济、环保的制革废水处理方法,可以降低废水中有机物质的含量,并达到国家排放标准要求。同时,生物增效技术还能促进废水中有益菌群的生长,改善废水的微生物环境。因此,生物增效技术在制革废水处理中具有广阔的应用前景。

关键词：生物增效技术处理制革废水试验