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“双碳”战略下上党区铁路专用线煤炭运量研究

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铁道货运 2024年第6期42卷 68-74页

作者：王慧勇赵思萌吴迪中铁第六勘察设计院集团有限公司铁道工程设计研究院天津300308

随着“双碳”战略的实施,运输结构加速调整。长治市上党区新建煤炭铁路专用线,推进区域煤炭运输“公转铁”,实现运输领域低碳发展。为合理确定铁路专用线承担的煤炭运量,以产销平衡法为基础,分析上党区煤炭资源储量、分布和规划情况,重... 详细信息

随着“双碳”战略的实施,运输结构加速调整。长治市上党区新建煤炭铁路专用线,推进区域煤炭运输“公转铁”,实现运输领域低碳发展。为合理确定铁路专用线承担的煤炭运量,以产销平衡法为基础,分析上党区煤炭资源储量、分布和规划情况,重点研究煤炭运输市场、外运通道径路比选、运费运价、线路能力利用率,结合运输结构调整政策、煤炭外运通路功能和铁路专用线合理吸引范围,选择最优运输径路,综合分析确定了铁路专用线承担的煤炭运量,为铁路专用线可行性研究提供依据。

关键词： “双碳”战略公转铁铁路专用线煤炭运输运量预测

A protective AAV vaccine for SARS-CoV-2

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3641-3644页

作者： simeng zhao Junzi Ke Boyu Yang Fangzhi Tan Jie Yang Chao-Po Lin Haopeng Wang Guisheng Zhong iHuman Institute ShanghaiTech University201210 ShanghaiChina School of Life Science and Technology ShanghaiTech University201210 ShanghaiChina Shanghai Clinical Research and Trial Center ShanghaiChina

Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has caused the COVID-19 pandemic,with more than 528 million infections and 6.2 million *** fight against this rapidly spreading pandemic,prophylactic vaccines have been developed using different techniques,such as inactivated virus,messenger RNAs,recombinant proteins,and viral-vectored ***,rapidly spreading variants of SARS-CoV-2,such as alpha,beta,delta,and omicron variants,have been emerging.

关键词： protective acute respiratory

A core epitope targeting antibody of SARS-CoV-2

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Protein & Cell 2023年第1期14卷 74-78页

作者： simeng zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang Suwen zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong iHuman Institute ShanghaiTech UniversityShanghai 201210China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Innovative Center for Pathogen Research Guangzhou LaboratoryGuangzhou 510005China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical Sciences and Biosafety Level 3 LaboratoryFudan UniversityShanghai 200032China Department of Hepatobiliary Surgery Anhui Province Key Laboratory of Hepatopancreatobiliary SurgeryThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineThe University of Science and Technology of ChinaHefei 230001China Department of Pulmonary and Critical Care Medicine Division of Life Sciences and MedicineThe First Affiliated Hospital of USTCThe University of Science and Technology of ChinaHefei 230026China Division of Life Sciences and Medicine The First Affiliated Hospital of USTCThe University of Sciences and Technology of ChinaHefei 230001China

Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections and deaths worldwide.A series of potent neutralizing antibodies with defined epitopes targeting RBD have been recently identified with different ***,being an RNA virus,the instability of the SARS-CoV-2 genome results in numerous S-protein variants with altered viral phenotypes.

关键词： acute respiratory globally

Study on Anti-tumor Cyclopeptide RAs

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Study on Anti-tumor Cyclopeptide RAs

中国化学会第29届学术年会

作者： simeng zhao Zhe Wang Junting Fan Guangzhi Zeng Ninghua Tan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Cyclopeptide RAs, belonging to Rubiaceae-type cyclopeptides isolated from plants, are homodicyclohexapeptides formed with one a-D-alanine, one N-methyl a-L-alanine, three modified N-methyl a-L-tyrosines and one other protein a-L-amino acid[1]. For RAs’ unique structure, potential anti-tumor in vitro and in vivo, unclear mechanism and cancer clinic use in Chinese herbs, more efforts have been done in the lab during past years. Herein we report RAs’ isolation from 8 Rubia medicinal plants, synthesis and QSAR, anti-tumor activity in vitro and in vivo, mechanisms involving into autophagy, apoptosis, anti-angiogenesis, NF-kB pathway, Hedgehog pathway, Hippo pathway, and gene chip. Now RAs have been listed and patented as one candidate for new drug R ＆ D[2-3].

关键词： Cyclopeptides RAs Anti-tumor

来源： cnki会议评论

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中国技术创新的大规模空间集聚与趋势

经济地理 2023年第11期43卷 126-134页

作者：赵思萌赵作权赵紫威中国科学院科技战略咨询研究院中国北京100190 中国科学院大学公共政策与管理学院中国北京100049

文章根据“企知道”专利微观数据,使用标准差椭圆、相对集聚系数、正六边形格网方法,以国土空间与专利区位空间为参照基准,分析了2009—2020年中国战略性新兴产业专利的大规模空间集聚的水平、形态、模式及变化趋势。结果表明:①中国发... 详细信息

文章根据“企知道”专利微观数据,使用标准差椭圆、相对集聚系数、正六边形格网方法,以国土空间与专利区位空间为参照基准,分析了2009—2020年中国战略性新兴产业专利的大规模空间集聚的水平、形态、模式及变化趋势。结果表明:①中国发明专利总体呈现出向东南移动、集中化与集聚化的趋势,其标准差椭圆面积收缩了14.37%,相对集聚系数增长了8.94%。②中国发明专利总体呈现集中式大规模集聚模式,核心集聚区位于长三角地区——北至江苏盐城、南至浙江温州、西至安徽池州、东至上海。③在8个战略性新兴细分产业中,6个产业的创新呈现集中式集聚模式,其中集聚程度最高的产业为新一代信息技术、数字创意和新能源,集聚程度最低的产业为节能环保,集聚程度由高转低的产业为生物产业。

关键词：创新集聚相对集聚集聚模式标准差椭圆发明专利

Numerical Investigations on Dynamic Stall Characteristics of a Finite Wing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 444-457页

作者： JING simeng CAO Chenkai GAO Yuan zhao Qijun zhao Guoqing National Key Laboratory of Helicopter Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

The paper examines the dynamic stall characteristics of a finite wing with an aspect ratio of eight in order to explore the 3D effects on flow topology,aerodynamic characteristics,and pitching ***,CFD methods are developed to calculate the aerodynamic characteristics of *** URANS equations are solved using a finite volume method,and the two-equation k-ωshear stress transport(SST)turbulence model is employed to account for viscosity ***,the CFD methods are used to simulate the aerodynamic characteristics of both a static,rectangular wing and a pitching,tapered wing to verify their effectiveness and *** numerical results show good agreement with experimental ***,the static and dynamic characteristics of the finite wing are computed and *** results reveal significant 3D flow structures during both static and dynamic stalls,including wing tip vortices,arch vortices,Ω-type vortices,and ring *** phenomena lead to differences in the aerodynamic characteristics of the finite wing compared with a 2D ***,the finite wing has a smaller lift slope during attached-flow stages,higher stall angles,and more gradual stall *** separation initially occurs in the middle spanwise section and gradually spreads to both *** aerodynamic damping,the inboard sections mainly generate unstable ***,sections experiencing light stall have a higher tendency to produce negative damping compared with sections experiencing deep dynamic stall.

关键词： finite wing dynamic stall aerodynamic damping 3D effects

煤炭开采对“矿-农”复合区农田质量影响评价

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农业工程学报 2020年第9期36卷 273-282,F0003页

作者：徐占军赵思萌王培周毕如田山西农业大学资源环境学院太谷030801

农田质量的内涵应包括本底质量、经济质量和生态环境质量3部分。煤炭开采导致农田严重受损,科学合理评价煤炭开采对矿-农复合区农田质量的影响,对制定区域土地复垦规划和综合整治有着重要的意义。以山西省泽州县长河流域为研究区,该研... 详细信息

农田质量的内涵应包括本底质量、经济质量和生态环境质量3部分。煤炭开采导致农田严重受损,科学合理评价煤炭开采对矿-农复合区农田质量的影响,对制定区域土地复垦规划和综合整治有着重要的意义。以山西省泽州县长河流域为研究区,该研究首先建立了煤炭开采沉陷区农田质量评价的指标体系,选取农田自然质量、农业生产条件、区位条件、农田环境条件来表征农田质量,对并依据这些指标进行空间可视化,利用多因素加权求和的方法对农田质量进行综合评价。研究结果表明:与煤炭开采非扰动区相比,位于煤矿区井田边界内的农田自然质量、农业生产条件、区位条件、农田生态环境条件评价分值均较低;煤矿井田边界范围内的农田质量(平均值为0.37)低于非矿区农田(平均值为0.55)。应结合煤炭开采扰动影响区农田质量区域分布特点,制定科学合理的矿-农复合区土地复垦规划和土地综合整治方案。

关键词：开采复垦农田质量矿-农复合区

参与标准研制对企业绩效有影响吗?--战略性新兴产业的研究

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管理工程学报 2022年第2期36卷 37-48页

作者：熊文赵思萌王旭孙翊北京工商大学经济学院北京100048 中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100039

企业是标准研制的主体,能否获得及获得多少收益是企业决定是否参与标准研制的关键变量。本文以战略性新兴产业为例,将企业是否参与标准研制作为类别变量,企业的经营收益作为目标变量,企业的资本投入、劳动投入、政府、创新和控股股东这... 详细信息

企业是标准研制的主体,能否获得及获得多少收益是企业决定是否参与标准研制的关键变量。本文以战略性新兴产业为例,将企业是否参与标准研制作为类别变量,企业的经营收益作为目标变量,企业的资本投入、劳动投入、政府、创新和控股股东这几个因素作为控制变量,并将企业按照规模、组织形式、地区和企业参与研制的标准分类,分别进行了全样本和分类别的PSM匹配分析。结论显示:从整体角度看,战略新兴产业企业参与标准研制能从利润水平方面提升绩效,但稳健性不够,主要源于其强烈的异质性特点;参与研制的大企业能从企业规模和利润水平两方面提升企业绩效,而小企业只能从企业规模方面提升绩效;非国有企业参与标准研制对企业规模和利润水平两方面绩效都有正向促进作用,且作用较为稳健;东部和中部地区的企业参与标准研制分别能够增加其利润水平和企业规模;另外,参与地方标准的研制有利于从利润水平方面提升企业绩效。在此基础上,提出若干推动企业积极参与标准研制的政策建议。

关键词：战略性新兴产业标准研制 PSM匹配

Identification of natural products as novel ligands for the human 5-HT2C receptor

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Biophysics Reports 2018年第1期4卷 50-61页

作者： Yao Peng simeng zhao Yiran Wu Haijie Cao Yueming Xu Xiaoyan Liu Wenqing Shui Jianjun Cheng Suwen zhao Ling Shen Jun Ma Ronald J.Quinn Raymond C.Stevens Guisheng Zhong Zhi-Jie Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of Sciences Institute of Molecular and Clinical Medicine Kunming Medical University iHuman Institute Shanghai Tech University University of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University College of Pharmacy Nankai University High-throughput Molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and Medicine Eskitis Institute for Drug Discovery Griffith University

G protein-coupled receptors(GPCRs) constitute the largest human protein family with over 800 members,which are implicated in many important medical conditions. Serotonin receptors belong to the aminergic GPCR subfamily and play important roles in physiological and psychological activities. Structural biology studies have revealed the structures of many GPCRs in atomic details and provide the basis for the identification and investigation of the potential ligands, which interact with and modulate the ***, an integrative approach combining a focused target-specific natural compound library, a thermalshift-based screening method, affinity mass spectrometry, molecular docking, and in vitro as well as in vivo functional assay, was applied to identify(–)-crebanine and several other aporphine alkaloids as initial hits for a human serotonin receptor subtype, the 5-HT2Creceptor. Further studies illuminated key features of their binding affinity, downstream signaling and tissue reaction, providing a molecular explanation for the interaction between(–)-crebanine and human 5-HT2Creceptor.

关键词： GPCR 5-HT 2C receptor Natural product Alkaloids