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Transanal eco-Doppler evaluation after hemorrhoidal artery embolization

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World Journal of Gastroenterology 2024年第17期30卷 2332-2342页

作者： Roberta Tutino Tommaso Stecca Fabrizio Farneti Marco Massani Giulio Aniello santoro Dipartimento Chirurgia Generale e Specialistica AOU Cittàdella Salute e della Scienza di TorinoTorino 10126Italy Division of General Surgery 1 Treviso Regional HospitalAULSS 2 Marca TrevigianaTreviso 31100Italy Division of Radiology Treviso Regional HospitalAULSS 2 Marca TrevigianaTreviso 31100Italy Tertiary Referral Pelvic Floor Center Division of General Surgery 2AULSS 2 Marca TrevigianaTreviso 31100Italy

BACKGROUND Hemorrhoidal artery embolization(Emborrhoid)is a novel method for the treatment of severe hemorrhoidal *** having a technical success rate of 93%-100%,the clinical success ranges between 63%and 94%,with a rebleeding rate of 13.6%.AIM To evaluate the effectiveness of this procedure in reducing hemorrhoidal flow and hemorrhoidal *** This prospective observational pilot study was conducted at Division of General Surgery 1 and Tertiary Referral Pelvic Floor Center,Treviso Regional Hospital,*** a 2 months period(February-March 2022),consecutive patients with hemorrhoidal bleeding scores(HBSs)≥4,Goligher scores of II or III,failure of non-operative management,and a candidate for Emborrhoid were *** ultrasound with eco-Doppler was performed preoperatively and 1 month after the *** primary endpoint was to quantify the changes in arterial hemorrhoidal flow after *** secondary endpoint was to evaluate the correlation between the flow changes and the *** Eleven patients underwent *** overall pretreatment mean systolic peak(MSP)was 14.66 cm/*** highest MSP values were found in the anterior left lateral(17.82 cm/s at 1 o’clock and 15.88 cm/s at 3 o’clock)and in the posterior right lateral(14.62 cm/s at 7 o’clock and 16.71 cm/s at 9 o’clock)quadrants of the anal *** treatment,the overall MSP values were significantly reduced(P=0.008)although the correlation between MSP and HBS changes was weak(P=0.570).A statistical difference was found between distal embolization compared with proximal embolization(P=0.047).However,the coil landing zone was not related to symptoms improvement(P=1.000).A significant difference in MSP changes was also reported between patients with type 1 and type 2 superior rectal artery(SRA)anatomy(P=0.040).No relationship between hemorrhoidal grades(P=1.000),SRA anatomy(P=1.000)and treatment outcomes was *** The preliminary findings of this pilo

关键词： Hemorrhoidal artery embolization Hemorrhoidal embolization Hemorrhoidal vascularization Transanal eco-Doppler Transanal ultrasound

Structured magnetic resonance imaging and endoanal ultrasound anal fistulas reporting template(SMART):An interdisciplinary Delphi consensus

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3288-3300页

作者： Iwona Sudoł-Szopińska Pankaj Garg Anders Mellgren Antonino Spinelli Stephanie Breukink Francesca Iacobellis Małgorzata Kołodziejczak Przemysław Ciesielski Christian Jenssen SMART Collaborative Group Giulio Aniello santoro Department of Radiology National Institute of GeriatricsRheumatology and RehabilitationWarsaw 02-637Poland Department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia Department of Surgical Oncology King Faisal Specialist Hospital&Research CenterRiyadh 11211Saudi Arabia Department of Biomedical Sciences Humanitas UniversityPieve Emanuele-MilanItaly IRCCS Humanitas Research Hospital Rozzano-MilanItaly Department of Surgery Maastricht and NUTRIM Institute of Nutrition and Translational Research in Metabolism GROW-Research Institute for Oncology and Reproductionthe Netherlands Department of General and Emergency Radiology A.Cardarelli HospitalNaples 80131CampaniaItaly Warsaw Proctology Center St.Elizabeth HospitalWarsaw 02-616Poland Department of Internal Medicine Hospital Märkisch OderlandStrausberg 15344BrandenburgGermany Brandenburg Institute for Clinical Ultrasound Neuruppin 16186BrandenburgGermany Third Referral Pelvic Floor Center Division of Surgery 2AULSS n.2 Marca TrevigianaDISCOG University of PaduaTrevisoItaly 不详

BACKGROUND There is still considerable heterogeneity regarding which features of cryptoglandular anal fistula on magnetic resonance imaging(MRI)and endoanal ultrasound(EAUS)are relevant to surgical *** a con-sequence,the quality and completeness of the report are highly dependent on the training and experience of the *** To develop a structured MRI and EAUS template(SMART)reporting the minimum dataset of information for the treatment of anal *** This modified Delphi survey based on the RAND-UCLA appropriateness for consensus-building was conducted between May and August *** hundred and fifty-one articles selected from a systematic review of the lite-rature formed the database to generate the evidence-based statements for the Delphi *** questions were anonymously voted by an interdisciplinary multidisciplinary group for a maximum of three iterative *** degree of agreement was scored on a numeric 0–10 *** consensus was defined as a score≥8 for≥80%of the *** Eleven scientific societies(3 radiological and 8 surgical)endorsed the *** three rounds of voting,the experts(69 colorectal surgeons,23 radiologists,2 anatomists,and 1 gastroenterologist)achieved consensus for 12 of 14 statements(85.7%).Based on the results of the Delphi process,the six following features of anal fistulas were included in the SMART:Primary tract,secondary extension,internal opening,presence of collection,coexisting le-sions,and sphincters *** A structured template,SMART,was developed to standardize imaging reporting of fistula-in-ano in a simple,systematic,time-efficient way,providing the minimum dataset of information and visual diagram useful to refer-ring physicians.

关键词： Anal fistulas Fistula-in-ano Template Reporting Magnetic resonance imaging Endoanal ultrasound

What do we know about the role of lncRNAs in multiple sclerosis?

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neural Regeneration Research 2021年第9期16卷 1715-1722页

作者： Viviana Nociti Massimo santoro Institute of neurology Fondazione Policlinico Universitario‘A.Gemelli’IRCCSUniversitàCattolica del Sacro CuoreRomeItaly IRCCS Fondazione Don Carlo Gnocchi FlorenceItaly

Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanisms leading to autoimmune diseases are still only partially understood. We know that genetic, epigenetic, molecular, and cellular factors resulting in pathogenic inflammatory responses are certainly involved. Long non-coding RNAs(lncRNAs) are non-protein coding transcripts longer than 200 nucleotides that play an important role in both innate and acquired immunity, so there is great interest in lncRNAs involved in autoimmune diseases. The research on multiple sclerosis has been enriched with many studies on the molecular role of lncRNAs in the pathogenesis of the disease and their potential application as diagnostic and prognostic biomarkers. In particular, many multiple sclerosis fields of research are based on the identification of lncRNAs as possible biomarkers able to predict the onset of the disease, its activity degree, its progression phase and the response to disease-modifying drugs. Last but not least, studies on lncRNAs can provide a new molecular target for new therapies, missing, so far, a cure for multiple sclerosis. While our knowledge on the role of lncRNA in multiple sclerosis has recently improved, further studies are required to better understand the specific role of lncRNAs in this neurological disease. In this review, we present the most recent studies on molecular characterization of lncRNAs in multiple sclerosis disorder discussing their clinical relevance as biomarkers for diagnosis and treatments.

关键词： antisense lncRNAs enhancer lncRNAs epigenetics immune system intergenic lncRNA intronic lncRNA multiple sclerosis sense lncRNAs single nucleotide polymorphisms

Subtotal gastrectomy for gastric cancer

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World Journal of Gastroenterology 2014年第38期20卷 13667-13680页

作者： Roberto santoro Giuseppe M Ettorre Eugenio santoro Department of General Surgery and Transplantation San CamilloForlanini General Hospital

Although a steady decline in the incidence and mortality rates of gastric carcinoma has been observed in the last century worldwide, the absolute number of new cases/year is increasing because of the aging of the population. So far, surgical resection with curative intent has been the only treatment providing hope for cure; therefore, gastric cancer surgery has become a specialized field in digestive surgery. Gastrectomy with lymph node (LN) dissection for cancer patients remains a challenging procedure which requires skilled, well-trained surgeons who are very familiar with the fast-evolving oncological principles of gastric cancer surgery. As a matter of fact, the extent of gastric resection and LN dissection depends on the size of the disease and gastric cancer surgery has become a patient and “disease-tailored” surgery, ranging from endoscopic resection to laparoscopic assisted gastrectomy and conventional extended multivisceral resections. LN metastases are the most important prognostic factor in patients that undergo curative resection. LN dissection remains the most challenging part of the operation due to the location of LN stations around major retroperitoneal vessels and adjacent organs, which are not routinely included in the resected specimen and need to be preserved in order to avoid dangerous intra- and postoperative complications. Hence, the surgeon is the most important non-TMN prognostic factor in gastric cancer. Subtotal gastrectomy is the treatment of choice for middle and distal-third gastric cancer as it provides similar survival rates and better functional outcome compared to total gastrectomy, especially in early-stage disease with favorable prognosis. Nonetheless, the resection range for middle-third gastric cancer cases and the extent of LN dissection at early stages remains controversial. Due to the necessity of a more extended procedure at advanced stages and the trend for more conservative treatments in early gastric cance

关键词： Gastric cancer Gastrectomy Lymphadenectomy Laparoscopy Endoscopy Quality of life Gastric stump cancer

Virtual earth cloud: a multi-cloud framework for enabling geosciences digital ecosystems

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International Journal of Digital Earth 2023年第1期16卷 43-65页

作者： Mattia santoro Paolo Mazzetti Stefano Nativi National Research Council of Italy Institute of Atmospheric Pollution Research-Unit of FlorenceRomaItaly Joint Research Centre of the European Commission B6 UnitIspraltaly

Humankind is facing unprecedented global environmental and social challenges in terms of food,water and energy security,resilience to natural hazards,*** address these challenges,international organizations have defined a list of policy actions to be achieved in a relatively short and medium-term *** development and use of knowledge platforms is key in helping the decision-making process to take significant decisions(providing the best available knowledge)and avoid potentially negative impacts on society and the *** knowledge platforms must build on the recent and next coming digital technologies that have transformed society–including the science and engineering *** Earth Data(BED)science aims to provide the methodologies and instruments to generate knowledge from numerous,complex,and diverse data *** science requires the development of Geoscience Digital Ecosystems(GEDs),which bank on the combined use of fundamental technology units(*** data,learning-driven artificial intelligence,and network-based computing platform)to enable the development of more detailed knowledge to observe and test planet Earth as a *** manuscript contributes to the BED science research domain,by presenting the Virtual Earth Cloud:a multi-cloud framework to support GDE implementation and generate knowledge on environmental and social sustainability.

关键词： Earth observation geosciences digital ecosystem virtual cloud big earth data multi-cloud interoperability science

Synthesis and characterization of lanthanum bonded agar-carbomer hydrogel:a promising tool for biomedical research

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Journal of Rare Earths 2011年第3期29卷 259-264页

作者： Filippo Rossi Marco santoro Tommaso Casalini Giuseppe Perale Dipartimento di Chimica Materialied Ingegneria Chimica"G.Natta"Politecnico di MilanoVia Mancinelli7

Agar-Carbomer（branched poly（acrylic acid）） hydrogel,an injectable bio-resorbable scaffold with a controlled nanostructure specifically designed for neural cell housing,was developed together with a new protocol for building three dimensional biohybrid cell/hydrogel *** order to overcome classic structural analysis inconveniences due to the high water amount,which affects instruments results and reliability,agar-Carbomer hydrogels were synthesized by microwave-assisted block copolymerization together with La3＋ *** glycol,glycerol and buffered saline solution were used as cross-linking agents and solvent,*** properties were not affected by the presence of lanthanum,and were checked via swelling and rheological ***,the presence of La3＋ within the polymeric network was characterized by thermogravimetric analysis,environmental scanning electron microscopy and Fourier transformed infrared *** results showed that the rare earth presented uniform distribution in the hydrogel network due to the formation of chemical bonds after polymerization without being modified its luminescence emission spectrum that allowed hydrogel *** results made the obtained host-guest system a useful tool for analytical research studies concerning regenerative medical applications that could also be potentially taken up with in vivo experiments.

关键词： hydrogel acrylic acid agarose lanthanum luminescence drug delivery rare earths

Normal and varicocele testis in adolescents

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Asian Journal of Andrology 2001年第4期3卷 259-262页

作者： G.santoro C.Romeo Department of Biomorphology and Biotechnologies Department of Medical and Surgical Paediatric Sciences University of Messina 98125 Messina Italy

The authors reviewed the results of their research on the structure and composition of normal and varicocele semi-niferous tubules in adolescents. They give new evidences of normal structure of adolescent testis and demonstrate, forthe first time, the ultrastructural and immunohistochemical modifications of the lamina propria and basal lamina in theadolescent varicocele patients, which are similar to those observed in adults, but less severe, and of the adherence junc-tions in seminiferous tubules. They also report the presence of oxidative stress in adolescents limited to testis and notgeneralised as in the adults. These data are well correlated to different clinical studies that support the hypothesis of aprogressive course of varicocele and the need for surgical treatment in adolescent varicocele patients. (Asian J Androl2001 Dec; 3: 259-262)

关键词： varicocele testis seminiferous tubules adolescence

Treatment for isolated loco-regional recurrence of gastric adenocarcinoma: Does surgery play a role?

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World Journal of Gastroenterology 2005年第44期11卷 7014-7017页

作者： Fabio Carboni Pasquale Lepiane Roberto santoro Riccardo Lorusso Pietro Mancini Massimo Carlini Eugenio santoro Department of Digestive Surgery and Liver Transplantation Division of General A.T.Surgery

AIM： To evaluate the role of surgical treatment for isolated Ioco-regional recurrences of operated gastric adenocarcinoma. METHODS： Among the 837 patients operated for gastric adenocarcinoma between December 1979 and April 2004, 713 （85%） underwent resection with curative intent. A retrospective review of a prospectively collected gastric cancer database was carried out. Overall recurrence rate was 44% （315 cases）, with 75% occurring within the first 2 years from the operation. Isolated L-R recurrences were observed in 38 （12%） patients. Symptomatic lesions were observed in 27 （71%）. RESULTS： Six （16%） patients were macroscopically resected with curative intent. The recurrence was located in the gastric stump after a STG in three patients, in the esophagojejunal anastomosis after a TG in two patients and in the gastric bed after a TG in one patient. Surgical procedures consisted of three secondary TG, two esophagojejunal resection and one excision of an extraluminal recurrence. Postoperative complications occurred in two patients （33%）, including one anastomotic leakage and one hemorrhage. The latter patient died of sepsis 35 d after the surgery （mortality rate 17%）. All patients died of recurrent gastric cancer： 2 within 1 year from surgery （8 and 11 mo, respectively）, 2 after 16 and 17 mo respectively and 1 after 28 mo from the second operation. CONCLUSION： Surgery plays a very limited role in the treatment for isolated Ioco-regional recurrence of gastric adenocarcinoma.

关键词： Gastric adenocarcinoma Recurrence Diagnosis Surgery

Towards a knowledge base to support global change policy goals

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International Journal of Digital Earth 2020年第2期13卷 188-216页

作者： Stefano Nativi Mattia santoro Gregory Giuliani Paolo Mazzetti European Commission–DG Joint Research Centre Ispra(VA)Italy National research Council of Italy–Institute on Atmospheric research pollution Sesto Fiorentino(FI)Italy University of Geneva Institute for Environmental SciencesGenevaSwitzerland UN Environment Science DivisionGRID-GenevaGenevaSwitzerland

In 2015,it was adopted the 2030 Agenda for Sustainable Development to end poverty,protect the planet and ensure that all people enjoy peace and *** year after,17 Sustainable Development Goals(SDGs)officially came into *** 2015,GEO(Group on Earth Observation)declared to support the implementation of *** GEO Global Earth Observation System of Systems(GEOSS)required a change of paradigm,moving from a data-centric approach to a more knowledge-driven *** this end,the GEO System-of-Systems(SoS)framework may refer to the well-known Data-Information-Knowledge-Wisdom(DIKW)*** the context of an Earth Observation(EO)SoS,a set of main elements are recognized as connecting links for generating knowledge from EO and non-EO data–*** and economic *** elements are:Essential Variables(EVs),Indicators and Indexes,Goals and *** generation and use requires the development of a SoS KB whose management process has evolved the GEOSS Software Ecosystem into a GEOSS Social *** includes:collect,formalize,publish,access,use,and update *** project analysed the knowledge necessary to recognize,formalize,access,and use *** analysis recognized GEOSS gaps providing recommendations on supporting global decision-making within and across different domains.

关键词： Knowledge base from data to knowledge essential variables SDGs GEOSS interoperability science big earth data