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De.ign multifunctiona. Mg–Zr coa.ings re.ula.ing Mg a.loy bioa.sorption

Journa. of Ma.ne.ium a.d a.loys 2024年第4期12卷 1461-1478页

作者： Zohra Be.za.ti Sa.de.h Ita.i joséDa.id castro Sa.dra carva.ho a.a.Sofia.ramos Unive.sity of coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal La.oratory of Multifunctiona. Ma.e.ia.s a.d a.plications(La.Ma. Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Ma.ne.ium(Mg)a.loys a.e.wide.y use. for te.porary bone.impla.ts due.to the.r fa.orable.biode.rada.ility,cytocompa.ibility,he.ocompa.ibility,a.d close.me.ha.ical prope.tie. to ***,rapid de.rada.ion a.d ina.e.ua.e.stre.gth limit the.r *** ove.come.this,the.dire.t curre.t ma.ne.ron sputte.ing te.hnique.is e.ploye. for surfa.e.coa.ing in Mg-ba.e. a.loys using va.ious zirconium(Zr)*** a.proa.h pre.e.ts a.promising strate.y for simulta.e.usly improving corrosion re.ista.ce.ma.nta.ning biocompa.ibility,a.d e.ha.cing stre.gth without compromising *** le.e.a.ing Mg’s inhe.e.t biode.rada.ility,it ha. the.pote.tia. to minimize.the.ne.d for se.onda.y surge.ie.,the.e.y re.ucing costs a.d *** pa.e. is a.syste.a.ic study a.me. a. unde.sta.ding the.corrosion me.ha.isms of Mg–Zr coa.ings,de.ote. Mg-xZr(x=0–5 a..%).Zr-dope. coa.ings e.hibite. columna. growth le.ding to de.se. a.d re.ine. structure. with incre.sing Zr *** a.a.ysis confirme. the.pre.e.ce.of the.Mg(00.2)ba.a. pla.e.shifting towa.ds highe. a.gle.(1.15°)with 5 a..%Zr doping due.to la.tice.pa.5}me.e. cha.ge.(i.e.,de.re.se.a.d incre.se.of“c”a.d“a.la.tice.pa.5}me.e.s,re.pe.tive.y).Mg–Zr coa.ings e.hibite.“liquidphilic”be.a.ior,while.Young’s modulus re.a.ne. a.ste.dy va.ue.a.ound 80 GPa.a.ross a.l ***,the.ha.dne.s ha. significantly improve. a.ross a.l sa.ple.’coa.ing,re.ching the.highe.t va.ue.of(2.2±0.3)GPa.for 5 a..%*** te.ting in simula.e. body fluid(SBF)a. 37℃ re.e.le. a.significant e.ha.ce.e.t in corrosion re.ista.ce.for Mg–Zr coa.ings conta.ning 1.0–3.4 a..%*** with the.5 a..%Zr coa.ing which e.hibite. a.corrosion rate.of 32 mm/ye.r,the.e.coa.ings displa.e. lowe. corrosion rate.,ranging from 1 to 12 mm/*** syne.gistic e.ha.ce.e.t in me.ha.ical prope.tie. a.d corrosion re.ista.ce.a.hie.e. with 2.0–3.4 a..%Zr,sugge.ts pote.tia. a.ility for re.ucing stre.s shie.ding a.d controlle. de.rada.ion pe.forma.ce.a.d conse.ue.tl

关键词： Mg-Zr coa.ings Ma.ne.ron sputte.ing na.oinde.ta.ion corrosion re.ista.ce Bone.impla.ts

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simplifie. se.smic sce.a.io a.a.ysis of e.isting ma.onry buildings a.counting for local site.e.fe.ts

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Frontie.s of Structural a.d Civil e.gine.ring 2024年第2期18卷 309-318页

作者： a.şe.e.ÖZSOYÖZBa. Işıl Sa.RI Ka.2}PIna. Ze.ra n.KUTLU İsma.l e.KILIÇ De.a.tme.t of Civil e.gine.ring Maltepe UniversityIstanbul 34857Turkey School of e.gine.ring a.d construction Oryx Universal CollegeDoha 12253Qatar

This study discusse. the.e.fe.ts of local site. a.d ha.a.d a.plification on the.se.smic vulne.a.ility a.se.sme.t of e.isting ma.onry *** this conte.t,a.rapid se.smic e.a.ua.ion proce.ure.wa. imple.e.te. on a. old ma.onry building stock in the.historical ce.te. Ga.a.a.locate. inİsta.bul,to de.e.mine.the.se.smic risk priority of the.built *** sce.a.ios we.e.ge.e.a.e. for a.l soil cla.se.,diffe.e.t mome.t ma.nitude.,a.d source.to-site.dista.ce. to obta.n more.a.curate.re.ults for the.se.smic vulne.a.ility a.se.sme.t of the.studie. building ***,da.a.e.distributions e.tima.e. unde. nine.diffe.e.t sce.a.ios with/without site.e.fe.ts we.e.compa.e. a.d illustrate. in ma.s to discuss cha.ge. in vulne.a.ility owing to a.plification *** this study,by re.e.a.ining the.rapid se.smic e.a.ua.ion proce.ure.by including ge.-ha.a.d-ba.e. a.se.sme.t,the.importa.ce.of site.e.fe.ts on the.vulne.a.ility a.d risk a.se.sme.t of built he.ita.e.wa. *** propose. frame.ork inte.rating fie.d da.a.a.d local site.e.fe.ts is be.ie.e. to a.va.ce.the.curre.t a.plications for vulne.a.ility a.se.sme.t of ma.onry buildings a.d provide.a. improve.e.t in the.a.plication of rapid se.smic a.se.sme.t proce.ure. with more.re.ia.le.re.ults.

关键词： ma.onry buildings se.smic vulne.a.ility a.se.sme.t cultural he.ita.e local site.e.fe.t

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a.re.ie. on the.scale.up of high-she.r we. granula.ion proce.se. a.d the.impa.t of proce.s pa.7}me.e.s

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Pa.ticuology 2024年第9期92卷 180-195页

作者： a.a.Rita.a.ve. Ma.ta.Filipe.simõe. Sérgio simõe. João Gome. Unive.sity of coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Blue.ha.ma.Indústria.Fa.ma.êutica São Martinho do BispoCoimbra3045-016Portugal Fa.ulty of Pha.ma.y University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

We. granula.ion is one.of the.most importa.t a.glome.a.ion proce.se.,a.d high-she.r granula.ion(HSG)one.of the.most e.ploye. te.hnologie. in the.pha.ma.e.tical *** most critical proce.s pa.1}me.e.s of HSG a.e.discusse. in this *** ma.n conce.n in scaling up the.we. granula.ion proce.s is the.diffe.e.ce. be.we.n scale.,which pre.e.t the.pa.ticle. from ha.ing the.sa.e.e.pe.ie.ce.a.ross a.l *** scale.up of we. granula.ion proce.se. is commonly divide. into two cate.orie.:e.gine.ring a.d a.tribute.ba.e. *** e.gine.ring-ba.e. scale.up a.proa.h is a.strate.y ba.e. on dime.siona. a.a.ysis a.d a. a.tribute.ba.e. supporte. on the.principle. of“e.uifina.ity”,whe.e.proce.s va.ia.le. a.e.a.juste. to obta.n e.uiva.e.t granule.*** work pre.e.ts the.e.fe.t of diffe.e.t HSG proce.s pa.1}me.e.s on the.scale.up,a. we.l a. the.use.of proce.s a.a.ytical tools(Pa.)a.d mode.ling *** a.m is to re.ie. a.plie. scale.up a.proa.he. in HSG a.d discuss be.e.its a.d *** is prove. why the.scale.up for oral solid pha.ma.e.tical products is still conside.e. a.hot topic a.d a.ve.y cha.le.ging ta.k for de.e.opme.t a.d e.gine.ring te.ms.

关键词： High-she.r we.granula.ion Pa.0}me.ric-ba.e. a.tribute.ba.e. Physics-ba.e. mode.ling Impe.le. de.ign Scale.up

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capsule.e.doscopy a.d pa.e.doscopy:a.journe. to the.future.of ga.trointe.tina. e.doscopy

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World Journa. of Ga.troe.te.ology 2024年第10期30卷 1270-1279页

作者： Bruno Rosa.josécotte. De.a.tme.t of Ga.troe.te.ology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life.a.d He.lth Scie.ce. Re.e.rch Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the.sma.l bowe. capsule.re.olutionize. the.ma.a.e.e.t of pa.ie.ts with sma.l bowe. ***,the.te.hnological de.e.opme.t a.hie.e. by the.ne. mode.s of double.he.de. e.doscopic capsule.,a. minia.urize. de.ice. to e.a.ua.e.the.sma.l bowe. a.d colon[pa.-inte.tina. capsule.e.doscopy(PCe.],ma.e. this non-inva.ive.proce.ure.a.disruptive.conce.t for the.ma.a.e.e.t of pa.ie.ts with dige.tive.*** te.hnology is e.pe.te. to ide.tify which pa.ie.ts will re.uire.conve.tiona. inva.ive.e.doscopic proce.ure.(colonoscopy or ba.loon-a.siste. e.te.oscopy),ba.e. on the.le.ions de.e.te. by the.capsule.i.e.,those.with a. indication for biopsie. or e.doscopic *** use.of PCe.in pa.ie.ts with infla.ma.ory bowe. dise.se.,na.e.y Crohn’s dise.se.a. we.l a. in pa.ie.ts with iron de.icie.cy a.a.0}ia.a.d/or ove.t ga.trointe.tina.(GI)ble.ding,a.te. a.non-dia.nostic uppe. e.doscopy(e.opha.oga.troduode.oscopy),e.a.le. a. e.fe.tive.sa.e.a.d comforta.le.wa. to ide.tify pa.ie.ts with re.e.a.t le.ions,who should unde.go subse.ue.t inva.ive.e.doscopic *** re.e.t de.e.opme.t of ma.ne.ically controlle. capsule.e.doscopy to e.a.ua.e.the.uppe. GI tract,is a.furthe. ste. towa.ds the.possibility of a. e.tire.y non-inva.ive.a.se.sme.t of a.l the.se.me.ts of the.dige.tive.tract,from mouth-to-a.us,me.ting the.e.pe.ta.ions of the.e.rly de.e.ope.s of capsule.e.doscopy.

关键词： non-inva.ive.e.doscopy Pa.e.doscopy Ma.ne.ically controlle. capsule.e.doscopy Crohn’s dise.se Dige.tive.ble.ding

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In vivo a.trocyte.re.rogramming following spina. cord injury

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ne.ral Re.e.e.a.ion Re.e.rch 2024年第3期19卷 487-488页

作者： Ya.nick n.Ge.be. Flore.ce.e.Pe.rin MMDn University of MontpellierEPHEINSERMMontpellierFrance Institut Unive.sita.re.de.France.IUF) ParisFrance

Ha.mful a.d he.pful role. of a.trocyte. in spina. cord injury(SCI):SCI induce.grada.le.se.sory,motor a.d a.tonomic impa.rme.ts tha. corre.a.e.with the.le.ion se.e.ity a.d the.rostro-cauda. location of the.injury *** a.se.ce.of sponta.e.us a.ona. re.e.e.a.ion a.te. injury re.ults from ne.ron-intrinsic a.d ne.ron-e.trinsic ***,not only a.ult ne.rons displa. limite. capa.ility to re.row a.ons but a.so the.injury e.vironme.t conta.ns inhibitors to a.ona. re.e.e.a.ion a.d a.la.k of growth-promoting *** othe. ce.l popula.ions tha. re.pond to the.le.ion,re.ctive.a.trocyte. we.e.first conside.e. a. only de.rime.ta. to sponta.e.us a.ona. ***,a.trocyte..

关键词： injury impa.rme.t programming

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na.omotion of ba.te.ia.to de.e.mine.me.a.olic profile

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na.ote.hnology a.d Pre.ision e.gine.ring 2024年第1期7卷 1-9页

作者： S.n.Ple.kova.e.V.La.a.e.ko n.a.Be.rukov R.n.Kriukov a.V.Borya.ov M.e.Dokukin S.I.Surodin Re.e.rch La.oratory of Scanning Probe.Microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia De.a.tme.t of na.ote.hnology a.d Biote.hnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sa.ov Physics a.d Te.hnology Institute National Research Nuclear University MEPhISarov 607186Russia

In a.dition to the.r visible.motion such a. swimming(e.g.,with the.he.p ofﬂa.e.la.,ba.te.ia.can a.so e.hibit na.omotion tha. is de.e.ta.le.only with highly se.sitive.instrume.ts,a.d this study shows tha. it is possible.to de.e.t ba.te.ia. na.omotion using a. a.M de.e.tion *** re.ults show tha. the.na.omotion cha.23}cte.istics de.e.d on the.ba.te.ia. strain,a.d tha. na.omotion can be.use. to se.se.the.me.a.olic a.tivity of ba.te.ia.be.a.se.the.oscilla.ions a.e.se.sitive.to the.food pre.e.e.ce. of the.ba.te.ia.a.d the.type.of surrounding me.ium.

关键词： na.omotion Ba.te.ia cantile.e. Oscilla.ion a.omic force.microscopy Me.a.olism

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Diffe.e.tia. re.ponse.of injure. a.d he.lthy re.ina. to synge.e.c a.d a.loge.e.c transpla.ta.ion of a.clona. ce.l line.of immorta.ize. olfa.tory e.she.thing glia.a.double.e.ge. sword

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ne.ral Re.e.e.a.ion Re.e.rch 2025年第8期20卷 2395-2407页

作者： Ma.ía.norte.Muñoz Ma.ía.Porte.a.Lomba.Pa.oma.Sobrado-calvo Dia.a.simón Johnny Di Pie.dome.ico a.e.a.dro Ga.le.o-Orte.a.Ma. Pére. joséMcabre.a.Ma.ue.a.Ja.ie. Sie.ra Ma.ue. Vida.-Sa.z Ma.ía.Te.e.a.More.o-Flore. Ma.ta.a.udo-Ba.riuso Grupo de.Inve.tiga.ión Ofta.mología.e.pe.ime.ta. Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain e.pe.ime.ta. Scie.ce. Fa.ulty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain a.a.omy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Ce.te. of ne.roimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Me.icine.Fa.ulty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfa.tory e.she.thing glia.promote.a.ona. re.e.e.a.ion in the.ma.ma.ia. ce.tral ne.vous syste.,including re.ina. ga.glion ce.l a.ona. growth through the.injure. optic ***,it is unknown whe.he. olfa.tory e.she.thing glia.a.so ha.e.ne.roprote.tive.*** e.she.thing glia.e.pre.s brain-de.ive. ne.rotrophic fa.tor,one.of the.be.t ne.roprote.ta.ts for a.otomize. re.ina. ga.glion ***,we.a.me. to inve.tiga.e.the.ne.roprote.tive.capa.ity of olfa.tory e.she.ting glia.a.te. optic ne.ve.*** e.she.thing glia.ce.ls from a. e.ta.lishe. rat immorta.ize. clona. ce.l line.Te.3,we.e.intravitre.lly inje.te. in inta.t a.d a.otomize. re.ina. in synge.e.c a.d a.loge.e.c mode.with or without microglia. inhibition or immunosuppre.sive.*** a.d ge.e.e.pre.sion a.a.yse. we.e.*** bulb-de.ive. prima.y olfa.tory e.she.thing glia.a.d Te.3 e.pre.s ma.or histocompa.ibility comple. cla.sⅡ*** a.d synge.ically transpla.te. Te.3 ce.ls survive. in the.vitre.us for up to 21 da.s,forming a. *** a.otomize. re.ina.,only the.a.loge.e.c Te.3 transpla.t re.cue. re.ina. ga.glion ce.ls a. 7 da.s but not a. 21 *** the.e.re.ina.,microglia. a.a.omical a.tiva.ion wa. highe. tha. a.te. optic ne.ve.crush *** inta.t re.ina.,both transpla.ts a.tiva.e. microglia. ce.ls a.d cause. re.ina. ga.glion ce.l de.th a. 21 da.s,a.loss tha. wa. highe. a.te. a.lotranspla.ta.ion,trigge.e. by pyroptosis a.d pa.tia.ly re.cue. by microglia. inhibition or ***,ne.roprote.tion of a.otomize. re.ina. ga.glion ce.ls did not improve.with the.e.*** diffe.e.t ne.roprote.tive.prope.tie.,diffe.e.t toxic e.fe.ts,a.d diffe.e.t re.ponse. to microglia. inhibitory tre.tme.ts of olfa.tory e.she.thing glia.in the.re.ina.de.e.ding on the.type.of transpla.t highlight the.importa.ce.of thorough pre.linical studie. to e.plore.the.e.va.ia.le..

关键词： ce.l the.a.y immune.re.ognition ma.or histocompa.ibility comple. cla.s II(MHCII) ne.roprote.tion olfa.tory e.she.thing glia re.ina. ga.glion ce.ls

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La.da. qua.tiza.ion e.fe.ts on da.ping Ka.a.a.2} solitons in e.e.tron–positron–ion pla.ma.in rota.ing ionize. me.ium

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communications in The.re.ical Physics 2024年第10期76卷 143-152页

作者： e.I e.-a.a.y S Hussa.n n a.hta. De.a.tme.t of Physics Faculty of Science Port Said University The.re.ical Physics Division (TPD) PINSTECH

For the.dyna.ics of thre.-dime.siona. e.e.tron–positron–ion pla.ma., a.fluid qua.tum hydrodyna.ic mode. is propose. by conside.ing La.da. qua.tiza.ion e.fe.ts in de.se.***–ne.tral collisions in the.pre.e.ce.of the.coriolis force.a.e.a.so conside.e.. The.a.plication of the.re.uctive.pe.turba.ion te.hnique.produce. a.wa.e.e.olution e.ua.ion re.re.e.te. by a.da.pe. Korte.e.–de.Vrie. e.ua.ion. This e.ua.ion, howe.e., is insufficie.t for de.cribing wa.e. in our syste. a. ve.y low dispe.sion coe.ficie.ts. a. a.re.ult, we.conside.e. the.highe.t-orde. pe.turba.ion, which re.ulte. in the.da.pe. Ka.a.a.14} e.ua.ion. The.e.fe.ts of the.ma.ne.ic fie.d, La.da. qua.tiza.ion, the.ratio of positron de.sity to e.e.tron de.sity, the.ratio of positron de.sity to ion de.sity, a.d the.dire.tion cosine.on line.r dispe.sion la.s a. we.l a. soliton a.d conoida. solutions of the.da.pe. Ka.a.a.14} e.ua.ion a.e.e.plore.. The.unde.sta.ding from this re.e.rch can contribute.to the.broa.e. fie.d of a.trophysics a.d a.d in the.inte.pre.a.ion of obse.va.iona. da.a.from white.dwa.fs.

关键词： coriolis force Ka.a.a.0} e.ua.ion La.da. qua.tiza.ion ma.ne.opla.ma. qua.tum pla.ma solita.y a.d cnoida. wa.e.

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e.a.ua.ion of Ma.dibula. De.rogramming Using Te.S (Transcuta.e.us e.e.trical ne.ve.Stimula.ion) in Pa.ie.ts a. the.Spe.ia.ty Clinic of the.Jua.e. a.tonomous Unive.sity of Ta.a.co from 2022 to 2024

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Journa. of Bioscie.ce. a.d Me.icine. 2024年第7期12卷 245-251页

作者： Christia. C. a.uila.-caa.a. La.dy V. Limonchi-Pa.a.io Cryste.l G. Guzmán-Prie.o Je.nne.te.ramíre.-Me.doza.josé M. Le.ma.n-Me.doza.Migue. a. Lópe.-a.va.6}do Xa.ie. e. More.o-e.rique. Jorda.a. a.ba.rán-Me.ze. a.0}de.ic Division of He.lth Scie.ce. Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico cardiome.a.olism La.oratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico

Te.poroma.dibula. disorde.s (TMD) ne.a.ive.y a.fe.t qua.ity of life. causing pa.n a.d re.tricte. ja. move.e.ts. This study e.a.ua.e. the.e.fe.tive.e.s of Transcuta.e.us e.e.trical ne.ve.Stimula.ion (Te.S) on TMD pa.ie.ts be.ore.orthodontic tre.tme.t a. the.Jua.e. a.tonomous Unive.sity of Ta.a.co. a.qua.tita.ive. qua.i-e.pe.ime.ta. study wa. conducte. with 30 pa.ie.ts who me. the.inclusion crite.ia. a.e. 18 to 65 ye.rs, with TMJ pa.n symptoms, dia.nose. with te.poroma.dibula. disorde.s using the.He.kimo inde., a.d who ha. provide. informe. conse.t for the.study. The.range.of ma.dibula. move.e.t a.d the.Visua. a.a.og Scale.(Va.) we.e.me.sure. to re.ord va.ue. be.ore.the.a.y. The.e.e.trode. of the.Te.S the.a.y we.e.positione. on both side. of the.ja. in the.pre.uricula. a.e. a.d the.ma.se.e. muscle. the.the.a.y wa. a.ministe.e. for 40 minute., utilizing a.fre.ue.cy of 2 - 4 Hz a.d a.pulse.duration of 300 microse.onds. Following this, the.range.of ma.dibula. move.e.t a.d the.Va. we.e.re.sse.se. to e.a.ua.e.the.outcome.., significantly improve. ma.imum mouth ope.ing (37.7 ± 6.4 mm to 44.6 ± 5.88 mm), right la.e.a.ity (3.86 ± 1.57 mm to 5.43 ± 1.21 mm), le.t la.e.a.ity (3.13 ± 1.63 mm to 4.53 ± 1.61 mm), protrusion (4.01 ± 1.7 mm to 5.36 ± 1.32 mm), a.d pa.n pe.ce.tion (4.56 ± 2.045 to 2.03 ± 1.5) (P e.S the.a.y e.ha.ce. ma.dibula. move.e.t a.d re.uce. pa.n, ma.ing it a.we.l-tole.a.e., non-inva.ive.comple.e.ta.y tre.tme.t for TMD.

关键词： Te.S Ope.ing De.rogramming e.e.trostimula.ion TMJ (Te.poroma.dibula. Joint)

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Fle.ible.ne.ral probe.:a.re.ie. of the.curre.t a.va.ta.e.,drawba.ks,a.d future.de.a.ds

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Journa. of Zhe.ia.g Unive.sity-Scie.ce.B(Biome.icine.& Biote.hnology) 2024年第2期25卷 153-167页

作者： Sa.0} PIMe.Ta.Joa. R.FRe.Ta. joséH.coRRe.A CMe.S-UMinho University of MinhoGuimarães4800-058Portugal La.Be.S-a.socia.e.La.oratory Braga/GuimarãesPortugal

Brain dise.se. a.fe.t millions of pe.ple.a.d ha.e.a.huge.socia. a.d e.onomic *** use.of ne.ral probe. for studie. in a.ima.s ha. be.n the.ma.n a.proa.h to incre.sing knowle.ge.a.out ne.ral ne.work ***,ne.roscie.tists a.e.trying to de.e.op ne. a.d more.e.fe.tive.the.a.e.tic a.proa.he. to tre.ting ne.rological *** imple.e.ta.ion of ne.ral probe. with multifunctiona.itie.(e.e.trical,optical,a.d fluidic inte.a.tions)ha. be.n incre.sing in the.la.t fe. ye.rs,le.ding to the.cre.tion of de.ice. with high te.poral a.d spa.ia. *** the.a.plicability of,a.d e.e.e.ts inte.rate. into,ne.ral probe. ha. a.so le. to the.ne.e.sity to cre.te.fle.ible.inte.fa.e.,re.ucing ne.ral tissue.da.a.e.during probe.impla.ta.ion a.d incre.sing the.qua.ity of ne.ral a.quisition *** this pa.e.,we.re.ie. the.fa.rication,cha.0}cte.iza.ion,a.d va.ida.ion of se.e.a. type. of fle.ible.ne.ral probe.,e.ploring the.ma.n a.va.ta.e. a.d drawba.ks of the.e.***,future.de.e.opme.ts a.d a.plications a.e.***,this re.ie. a.ms to pre.e.t the.curre.tly a.a.la.le.fle.ible.de.ice. a.d future.a.propria.e.a.e.ue. for de.e.opme.t a. possible.guida.ce.for future.e.gine.re. de.ice..

关键词： Brain knowle.ge Fle.ible.inte.fa.e Multifunctiona. probe

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