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Endoscopic vacuum assisted closure therapy for esophagopericardial fistula in a 16-year-old male:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 533-539页

作者： simón muñoz-González Samir Quejada-Cuesta Daniel González-Arroyave Carlos m Ardila Department of Surgery University of AntioquiaMedellin 050010AntioquiaColombia Department of Surgery Pontificia Universidad BolivarianaMedellín 050031AntioquiaColombia Department of Basic Sciences University of AntioquiaMedellín 050010AntioquiaColombia

BACKGROUND Esophagopericardial fistula(EPF)is a rare,life-threatening condition with limited scientific literature and no established management *** case report highlights a successful multidisciplinary approach and the innovative use of endoscopic vacuum assisted closure(endoVAC)therapy in treating this complex *** SUmmARY A 16-year-old male with a history of esophageal atresia and colon interposition presented with progressive chest pain,fever,and *** revealed an EPF with associated pleural and pericardial *** management with an esophageal stent failed,prompting the use of an endoVAC *** patient underwent multiple endoVAC device changes and received broad-spectrum antibiotics and nutritional *** fistula successfully closed,and the patient recovered,demonstrating no new symptoms at a 6-month *** EndoVAC therapy can effectively manage EPF,providing a minimally invasive treatment option.

关键词： Esophagopericardial fistula Endoscopic vacuum assisted closure Esophageal atresia multidisciplinary approach Pleural effusion Case report

Remote ischemic conditioning prevents ischemic cerebrovascular events in children with moyamoya disease:a randomized controlled trial

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World Journal of Pediatrics 2024年第9期20卷 925-934页

作者： Shuang-Feng Huang Jia-Li Xu Chang-Hong Ren Nathan sim Cong Han Yi-Qin Han Wen-Bo Zhao Yu-Chuan Ding Xun-ming Ji Si-Jie Li Department of Neurology Xuanwu HospitalCapital Medical UniversityNo 45Changchun StreetXicheng DistrictBeijing100053China Department of Rehabilitation medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityNo.10XitoutiaoYou’anmenwaiFengtai DistrictBeijing100053China Beijing Key Laboratory of Hypoxic Conditioning Translational medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Wayne State UniversityDetroitMIUSA Department of Neurosurgery The Fifth Medical CentreChinese PLA General HospitalBeijingChina Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina

Background moyamoya disease(mmD)is a significant cause of childhood stroke and transient ischemic attacks(TIAs).This study aimed to assess the safety and efficacy of remote ischemic conditioning(RIC)in children with *** In a single-center pilot study,46 mmD patients aged 4 to 14 years,with no history of reconstructive surgery,were randomly assigned to receive either RIC or sham RIC treatment twice daily for a *** primary outcome measured was the cumulative incidence of major adverse cerebrovascular events(mACEs).Secondary outcomes included ischemic stroke,recurrent TIA,hemorrhagic stroke,revascularization rates,and clinical improvement assessed using the patient global impression of change(PGIC)scale during ***-related adverse events were also recorded,and cerebral hemodynamics were evaluated using transcranial *** All 46 patients completed the final follow-up(23 each in the RIC and sham RIC groups).No severe adverse events associated with RIC were ***-meier analysis indicated a significant reduction in mACEs frequency after RIC treatment[log-rank test(mantel-Cox),P=0.021].At 3-year follow-up,two(4.35%)patients had an ischemic stroke,four(8.70%)experienced TIAs,and two(4.35%)underwent revascularization as the qualifying *** clinical improvement rate in the RIC group was higher than the sham RIC group on the PGIC scale(65.2%vs.26.1%,Pmodynamics post-treatment was *** RIC is a safe and effective adjunct therapy for asymptomatic children with *** was largely due to the reduced incidence of ischemic cerebrovascular events.

关键词： Asymptomatic moyamoya disease Children Remote ischemic conditioning Stroke

Vine pruning waste-based activated carbon for cerium and lanthanum adsorption from water and real leachate

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Journal of Rare Earths 2024年第10期42卷 1960-1968页

作者： Raphael Forgearini Pinheiro Alejandro Grimm Kátia da Boit martinello mohammad Rizwan Khan Naushad Ahmad Luis Felipe Oliveira Silva Irineu Antônio Schadach De Brum Guilherme Luiz Dotto Glaydson simões dos Reis Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima1000-797105900Santa MariaRSBrazi Department of Forest Biomaterials and Technology Biomass Technology CentreSwedish University of Agricultural SciencesUmed SE-90183Sweden Universidad De La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Department of Chemistry College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Institute of Chemistry Federal University of Rio Grande do Sul90040-060Porto AlegreBrazil

In this study,vine pruning wastes(VPW)were used as raw material to develop an alternative activated carbon(VPW-AC)for adsorbing and concentrating rare earth elements cerium(Ce(Ⅲ))and lanthanum(La(Ⅲ))from synthetic and real leachate *** Ce and La adsorption studies evaluated the effects of VPW-AC dosage,pH,contact time,rare earth initial concentration,and *** VPW-AC adsorbent was subjected to many physicochemical characterization methods to correlate and understand its adsorptive *** characterization data indicate a carbonaceous adsorbent with a specific surface area of 467 m^(2)/*** potential indicates a material with a negatively charged surface at a pH higher than 3.1,which is extremely beneficial to cations *** both rare earths elements(REEs),the adsorption capacity increases with the increase of the pH,reaching its maximum at pH *** kinetic data are well fitted by Avrami-fractional o rder,while the Liu model agreeably fits equilibrium *** maximum adsorption capacities for Ce(Ⅲ)and La(Ⅲ)are 48.45 and 53.65 mg/g at 298 K,*** thermodynamic studies suggest that the adsorption process is favorable,spontaneous,and exothermic for both *** filling,surface complexation,and ion exchange are the dominant ***,the VPW-AC was subjected to the recovery of REEs from real phosphogypsum leachate,and it is proved that it can be successfully used to recover REEs in a real process.

关键词： Vine pruning wastes Sustainable carbon adsorbent Rare earth elements Phosphogypsum leachate Ion-exchange mechanism

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Phenazines:Natural products for microbial growth control

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hLife 2024年第3期2卷 100-112页

作者： Cátia A Sousa marta Ribeiro Francisca Vale manuel simões ISEP/P.PORTO School of EngineeringPolytechnic of PortoPortoPortugal LEPABE-Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoPortoPortugal ALiCE-Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoPortoPortugal

The unprecedented problem of antibiotic resistance has become a major challenge for public health,which has contributed to an increase in infections caused by such *** microbial infections,typically biofilm-related,are alsocoupled to an increase in human mortality and ***,the demand for new antimicrobial agents hasincreased along with the evolution of microbial resistance *** products produced by bacteria,such as phenazines,have been recognized as an important source for the development of new antimicrobial agents,through the exploitation of their capacity to increase oxidative stress in other *** are a large groupof nitrogen-containing heterocyclic compounds and are essential for several cellular processes including iron acquisition,signaling events,enzymatic processes,and biofilm ***-inspired antibiotics(i.e.,2-bromo-1-hydroxyphenazine,2,4-dibromo-1-hydroxyphenazine,bromophenazine-21,phenazine-13,and phenazine-14)are veryactive against a wide range of gram-positive and gram-negative bacteria,including those associated with severe *** this study,mechanisms of phenazine-inspired antibiotics in the cellular processes of planktonic and sessilebacteria are ***,the application of phenazine-inspired antibiotics for the eradication of multidrugresistant planktonic and biofilm bacterial infections is also reviewed.

关键词： antimicrobial agents biofilms multidrug-resistant natural products phenazines

Heavy metal Remediation in AgoèNyivéLandfill Soils: Enhancing Stability through Organic Amendments

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Open Journal of Applied Sciences 2024年第4期14卷 961-975页

作者： Bassaï magnoudéwa Bodjona Diyakadola Dihéénane Bafai Gado Tchangbedji waste management Treatment and Valorization Laboratory (GTVD) Faculty of Sciences University of Lom&#233 Lom&#233 Togo

The burial of waste in developing countries, which is often carried out without respect for environmental standards, constitutes a risk of contamination of soils and even groundwater given the toxic elements they contain. The objective of this work is to carry out a study of the retention of heavy metals through the contribution of cattle manure to soil samples from the final Agoè Nyivé landfill in Lomé, Togo. Soil samples from the final landfill were taken from the surface and depth at several locations to form a composite sample. The amendment of the composite sample was carried out with bovine manure on the mock-up in the Laboratory for six months. The determination of the total contents of heavy metals by the atomic absorption spectrophotometer (SAA) on the composite sample showed high contents exceeding the thresholds recommended by the AFNOR NF U 44-041 standard. Sequential extraction on these composite samples showed that the mobile portions of lead, cadmium, copper and zinc are respectively estimated at 78.06%, 50%, 28.89% and 91.59%. The bovine manure used to amend the landfill samples presents physicochemical parameters that can contribute to rendering heavy metals immobile in the soil matrix under natural conditions. The addition of manure initially made it possible to increase the values of pH, electrical conductivity, cation exchange capacity and organic matter, which promote the retention of heavy metals. Secondly, the addition of manure made it possible to reduce the mobile portion of the heavy metals studied;from 78.06% to 14.39% for lead, from 50% to 11.52% for cadmium, from 28.89% to almost 0% for copper and from 91.15% to 80.58% for zinc. The use of cattle manure as an amendment on the composite sample was decisive in reducing the mobility of heavy metals in the polluted soils of the final landfill.

关键词： Pollution Heavy metals Soil Sequential Extraction Discharge

Accuracy of tree mapping based on hand-held laser scanning comparing leaf-on and leaf-off conditions in mixed forests

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Journal of Forestry Research 2024年第5期 18-29页

作者： Frederico Tupinambá-sim?es Adrián Pascual Juan Guerra-Hernández Cristóbal Ordó?ez Tiago de Conto Felipe Bravo iuFOR Sustainable Forest Management Research Institute University of Valladolid & INIA Department of Geographical Sciences University of Maryland Forest Research Centre School of Agriculture University of Lisbon

The use of mobile laser scanning to survey forest ecosystems is a promising, scalable technology to describe forest 3D structures at high resolution. To confirm the consistency in the retrieval of forest structural parameters using hand-held laser scanning(HLS), before operationalizing the method, confirming the data is crucial. We analyzed the performance of tree-level mapping based on HLS under different phenology conditions on a mixed forest in western Spain comprising Pinus pinaster and two deciduous species, Alnus glutinosa and Quercus pyrenaica. The area was surveyed twice during the growing season(July 2022) and once in the deciduous season(February 2022) using several scanning paths. Ground reference data(418 trees, 15 snags) was used to calibrate the HLS data and to assess the influence of phenology when converting 3D data into tree-level attributes(DBH, height and volume). The HLS-based workflow was robust at isolating tree positions and recognizing stems despite changes in phenology. Ninety-six percent of all pairs matched below 65 cm. For DBH, phenology barely altered estimates. We observed a strong agreement when comparing HLS-based tree height distributions. The values exceeded 2 m when comparing height measurements, confirming height data should be carefully used as reference in remote sensing-based inventories, especially for deciduous species. Tree volume was more precise for pines(r = 0.95, and relative RmSE = 21.3 –23.8%) compared to deciduous species(r = 0.91 –0.96, and relative RmSE = 27.3–30.5%). HLS data and the forest structural complexity tool performed remarkably, especially in tree positioning considering mixed forests and mixed phenology conditions.

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina Silvera-simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi mohanka Ramesh Kumar Ashwani Kumar mishra Shivanand Gamanagatti Shashi bala Paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIm To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

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无法持续吸引消费者桃园眷村走向没落

中国食品 2024年第3期 120-121页

作者： bala 新消费Daily 新消费Daily

曾红极一时,主打早餐场景的连锁餐饮品牌“桃园眷村”目前在全国仅剩4家门店。天眼查显示,桃园眷村的所属公司上海眷飨餐饮管理有限公司,已经被红字标注了包括“限制高消费、股权冻结、被执行人”等标签。开在LV旁边、一根油条8元等标签... 详细信息

曾红极一时,主打早餐场景的连锁餐饮品牌“桃园眷村”目前在全国仅剩4家门店。天眼查显示,桃园眷村的所属公司上海眷飨餐饮管理有限公司,已经被红字标注了包括“限制高消费、股权冻结、被执行人”等标签。开在LV旁边、一根油条8元等标签,让桃园眷村被称为“早餐届的爱马仕”,但随着消费市场与消费观念的变化,不求变的品牌与故事性风口已经不被接纳,被淘汰是早晚的事。

关键词：餐饮管理连锁餐饮消费观念爱马仕门店眷村被执行人消费市场

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