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Oral health status and performance of oral functions in children and adolescents in the treatment for overweight or obesity

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Open Journal of Stomatology 2013年第9期3卷 59-64页

作者： Maria ívina Gomes Janoca Manoel de Oliveira Dantas Filho Fernando Henrique Pereira de Vasconcelos Armiliana Soares nascimento Rosa Maria Mariz de Melo Marmhoud Coury Criseuda Maria Benício Barros silvio romero do nascimento Luciana de Barros Correia Fontes Rua Ester Foigel 110 ap. 1102 Ed. Victor Rodrigues Iputinga Recife Pernambuco Brasil

The objective of this study was to evaluate the performance of oral functions and oral conditions in children and adolescents with overweight or obesity, investigating possible associations with treatment for weight reduction. Developing a cross-sectional research and quantitative approach with inductive and descriptive and critical analysis of data, such as from a range of 95%, the universe was represented by children and adolescents who were overweight or obese, in both sexes, treated at reference centers for the treatment of obesity by the National Health System, in Campina Grande, Paraíba, 2010-2012. As the control group considered subjects of the same age, in the process of screening for attention in the places listed, but without the condition of overweight or obese, the research was started after the approval by the Ethics Resarch Committee of the UEPB under the protocol number 0513.***.133.000-09. As instruments for data collection were used in the questionnaire and clinical examination, of the 70 surveyed, most were female, ranging in age from 3 to 17 years, overweight, without comorbidities and carriers of deleterious oral habits;especially the nail biting, significantly associated with female sex p < 0.05. Consistency was the preferred food paste and chewing quickly, unilaterally, without discomfort or gagging constant. There was a significant difference between the values of the DMFT index, the presence of visible biofilm and the frequency of halitosis, for groups with overweight or obesity, with association between time of treatment and medications.

关键词： Stomatognathic System Oral Health Overweight Obesity Comprehensive Health Care of Children and Adolescents Pediatric Dentistry

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叶绿素生物合成途径终端酶的研究

叶绿素生物合成途径终端酶的研究

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作者： silvio Moreno Delgado nascimento 中国农业科学院

学位级别：硕士

本研究利用生物信息学方法,总结了叶绿素/细菌叶绿素生物合成途径中的四个末端酶,有利用更好地理解叶绿素生物合成途径的反应机制。叶绿素(Chl)/细菌叶绿素(Bchl)的生物合成对于光合作用的发生是必要的,其中四种不同的酶催化最后的化学... 详细信息

本研究利用生物信息学方法,总结了叶绿素/细菌叶绿素生物合成途径中的四个末端酶,有利用更好地理解叶绿素生物合成途径的反应机制。叶绿素(Chl)/细菌叶绿素(Bchl)的生物合成对于光合作用的发生是必要的,其中四种不同的酶催化最后的化学反应步骤,以合成叶绿素/细菌叶绿素,它们是:依赖光的原叶绿素酸酯(Pchlide)氧化还原酶(LPOR:EC 1.***.1.33),不依赖光的原叶绿素酸酯氧化还原酶(DPOR:EC 1.***.7.7),负责减少C17=C18双D形环的四吡咯原叶绿素酸酯形成叶绿素酸酯。叶绿素酸酯氧化还原酶(COR:EC 1.***.99.15)负责B环中C7=C8双键的还原。二乙烯基还原酶(DVR:EC 1.***.1.75)负责8乙烯基集团的还原。本研究通过这些酶的序列比对、系统发育和分子进化分析,以及与其结构交互作用的分析,找到他们的相似之处。研究利用MEGA 6软件完成,明确了DVR,DPOR和COR以及固氮酶具有非常高的相似度,具有共同的特征,LPOR与它们具有较小的相似度,并且,序列比对结果显示了新的保守区域。

关键词：叶绿素和细菌叶绿素生物合成 DVR DPOR LPOR COR

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Review of Studies on the Last Enzymes in Bacteriochlorophyll (Bchl) and Chlorophyll (Chl) Biosynthesis

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American Journal of Plant Sciences 2016年第12期7卷 1639-1651页

作者： silvio M. D. nascimento Yuanyuan Zou Qi Cheng Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing China

This paper summarizes the information available online related to mechanisms of Chlorophyll and Bacteriochlorophyll biosynthesis, emphasizing four enzymes in its last steps. The biosynthesis of Chlorophyll (Chl)/Bacteriochlorophyll (Bchl) is essential for the occurrence of photosynthesis. Four enzymes catalyze parts of the last chemical reactions steps to biosynthesize Bchl/Chl;they are: The Light-Dependent Protochlorophyllide (Pchlide) Oxidoreductase (LPOR: EC 1.***.1.33), the Light-Independent Pchlide oxidoreductase (DPOR: EC 1.***.7.7), Chlide Reductase (COR: EC 1.***.99.35) and the Divinyl Reductase (DVR: EC 1.***.1.75). These enzymes catalyze the reductions reactions of tetrapyrrole’s rings in the Chlorophyll and Bacteriochlorophyll biosynthesis process. This review has the aim to organize, analyze and compare the most important discoveries related to these four enzymes discovered so far. The comparisons are made with the information from the bibliography used, and the sequence of these enzymes got from online database. Sequence alignment, phylogenetic and molecular evolutionary analysis of all the four enzymes was conducted to find their levels of similarities.

关键词： Photosynthesis Chlorophyll Bacteriochlorophyll Biosynthesis Enzymes DVR DPOR LPOR and COR

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Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： José Carlos Rodrigues nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá Department of Anesthesia and Surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of Surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical School Royal Free CampusLondon NW32PFUnited Kingdom Department of Specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver *** To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E Polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

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