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Open Journal of Anesthesiology 2021年第2期11卷 49-58页

作者： Sérgio Menezes silvio caldas neto Ruy Lins Filho Jayme Santos neto Rossana Lins Universidade Federal de Pernambuco Recife Brazil

Objectives: Adequate control of hemodynamic parameters in patients undergoing otolaryngology-head and neck (OLHN) surgeries is one of the objectives of peri-operative anesthesia management. In this context, we seek to evaluate the effectiveness of metoprolol compared to clonidine in the post-operative control of systolic (SBP) and diastolic (DBP) blood pressures, and heart rate (HR), when these medications are used in the immediate pre-operative period. Method: this is a randomized double-blind clinical trial. Patients over 18 years old, according to the American Society of Anesthesiologists Physical Status Classification (ASA) I or II, who would undergo OLHN surgery, presenting with greater than 140 mmHg (SBP) or 90 mmHg (DBP), upon arrival at the surgical ward, were included in the study. 46 patients were randomized into two groups (C or M) who received clonidine (75 or 150 mcg) or metoprolol (5 or 10 mg), respectively. The averages of SBP, DBP and HR were compared between groups upon arrival at the post anesthesia care unit (PACU) and four hours post-surgery. Results: In group C, SBP (127.7 ± 18.8 vs 137.3 ± 14.1 mmHg, p = 0.03) and DBP (73.1 ± 15.46 vs 82.6 ± 7.9 mmHg, p 0.01) were lower, when compared with group M. No difference was observed in HR immediately upon PACU arrival. In addition, for four hours post-surgery, no change was noted in the SBP, DBP or HR. Conclusion: metoprolol was less effective than clonidine in reducing systolic and diastolic blood pressures in the immediate post-operative period of OLHN surgeries.

关键词： Clonidine Metoprolol Hypertension Post-Operative

Gastroesophageal reflux disease and non-esophageal cancer

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World Journal of Gastroenterology 2015年第3期21卷 815-819页

作者： Fernando AM Herbella Sebastiao Pannocchia neto Ilka Lopes Santoro Licia caldas Figueiredo Department of Surgery Federal University of Sao PauloSao Paulo 04037-003Brazil Pneumology Division Department of MedicineFederal University of Sao PauloSao Paulo 04037-003Brazil

The association of gastroesophageal reflux disease(GERD) and esophageal cancer is well *** carcinogenic properties of the gastroduodenal contents may also lead to cancer in target organs for GERD especially considering that they do not have intrinsic protective mechanisms as found in the *** review focuses on the putative relation between GERD and non-esophageal *** of the papers reviewed are far from ideal to prove the relationship of extraesophageal cancer and GERD since a small number ofpatients is presented,most do not control cases based on tobacco usage and obesity,and the diagnosis of GERD is variable,not always from an objective measurement such as p H monitoring but relying on symptoms in most ***,head and neck and lung cancer have a growing incidence parallel to GERD and a shift towards non-smoking,female gender and adenocarcinoma(compared to squamous cell carcinoma) is arising,similar to the example of esophageal cancer with the exception of the female gender.

关键词： Gastroesophageal reflux Cancer Pharynx Larynx Trachea Lung

Analyzing the economic viability of a large-scale integrated model of municipal solid waste:a study case for the most important Brazilian economic region

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Waste Disposal and Sustainable Energy 2020年第3期2卷 231-247页

作者： Octavio Pimenta Reis neto Mechanical Engineering Faculty at State University of Campinas(PDSE/FEM/UNICAMP) Av.Mofarrej275-Apto 212 B1São PauloSP CEP 05311-000Brazil

Despite the National Policy for Solid Waste(PNRS)in 2010,nothing has changed to waste disposal in *** to reach 100%of all Municipal Solid Waste(MSW)collected and treated in landfills by Aug.2nd,2014,until nowadays,42%of this total remains in *** the most important national economic region treating its urban waste in landfills,what it has is no more than 4%of recycling and its landfills reaching the *** other ones is getting harder year by year,due to water reservoirs around the region,high freight costs,waste disposal and the severe control of emissions associated with its *** article comes to break the paradigm of investment and profitability proposing an alternative to the land-use,achieving higher rates of *** economic viability,carried out through well-known financial variables and Monte Carlo analysis,has taken into account proven local waste characteristics and market prices for recyclables and energy without *** considered a proposal highly intensive in capital and people,the revenues from the sales would be enough to guarantee the viability of 100%equity with IRR of 33.7%and ROI of 24.5%per year within the confidence of 99%.

关键词： Solid waste Sorting Recycling Waste-to-energy Metropolitan Region of São Paulo Energy recovering

A beta regression analysis of COVID-19 mortality in Brazil

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Infectious Disease Modelling 2023年第2期8卷 309-317页

作者： Francisco Cribari-neto Department of Statistics Federal University of PernambucoRecifePE50670-901Brazil

Brazil was one of the countries most impacted by the COVID-19 pandemic,with a cumulative total of nearly 700,000 deaths by early *** country's federative units were unevenly affected by the pandemic and adopted mitigation measures of different scopes and *** was intense conflict between the federal government and state governments over the relevance and extent of such *** build a simple regression model with good predictive power on state COVID-19 mortality rates in *** results reveal that the federative units'urbanization rate and per capita income are important for determining their mean mortality rate and that the number of physicians per 100,000 inhabitants is important for modeling the mortality rate *** on the fitted model,we obtain approximations for the levels of administrative efficiency of local governments in dealing with the pandemic.

关键词： Beta regression Coronavirus COVID-19 Pandemic Regression analysis

Integrated Design Fabrication and Control of a Bioinspired Multimaterial Soft Robotic Hand

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Cyborg and Bionic Systems 2023年第1期4卷 156-165页

作者： Samuel Alves Mihail Babcinschi Afonso Silva Diogo neto Diogo Fonseca Pedro neto University of Coimbra CEMMPREARISEDepartment of Mechanical Engineering3030-788 CoimbraPortugal

Machines that mimic humans have inspired scientists for *** soft robotic hands are a good example of such an endeavor,featuring intrinsic material compliance and continuous motion to deal with uncertainty and adapt to unstructured *** research led to impactful achievements in functional designs,modeling,fabrication,and control of soft ***,the full realization of life-like movements is still challenging to achieve,often based on trial-and-error considerations from design to fabrication,consuming time and *** this study,a soft robotic hand is proposed,composed of soft actuator cores and an exoskeleton,featuring a multimaterial design aided by finite element analysis(FEA)to define the hand geometry and promote finger’s *** actuators are fabricated using molding,and the exoskeleton is 3D-printed in a single *** ON-OFF controller keeps the set fingers’inner pressures related to specific bending angles,even in the presence of *** FEA numerical results were validated by experimental tests,as well as the ability of the hand to grasp objects with different shapes,weights,and *** integrated solution will make soft robotic hands more available to people,at a reduced cost,avoiding the time-consuming design-fabrication trial-and-error processes.

关键词： consuming skeleton realization

Calculations of Optical Rotation from Density Functional Theory

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Chinese Physics Letters 2007年第5期24卷 1207-1209页

作者： Antǒnio Canal neto Francisco Elias Jorge Departamento de Fisica Universidade Federal do Espírito Santo 29060-900 Vitória ES Brazil

Density function theory calculations of frequency-dependent optical rotations [α]ω for three rigid chiral molecules are reported. Calculations have been carried out at the sodium D line frequency, using the ADZP basis set and a wide variety of functionals. Gauge-invariant atomic orbitals are used to guarantee origin-independent values of [ω]D. In addition, study of geometry dependence of [ω]D is reported. Using the geometries optimized at the B3LYP/ADZP level, the mean absolute deviation of B3LYP/ADZP and experimental laiD values yields 60.1°/（dm g/cm^3）. According to our knowledge, this value has not been achieved until now with any other model.

关键词： MOLECULAR WAVE-FUNCTIONS BASIS-SETS MP2 HF

Zircon U-Pb and Lu-Hf isotope constraints on Archean crustal evolution in Southeastern Guyana Shield

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Geoscience Frontiers 2019年第4期10卷 1477-1506页

作者： Joao Marinho Milhomem neto Jean-Michel Lafon Programa de Pos-graduacao em Geologia e Geoquimica-PPGG Instituto de Geociencias-IGUniversidade Federal do Para-UFPA66075-110BelemParaBrazil Laboratório de Geologia Isotópica-Pará-Iso IG-UFPA66075-110BelémParáBrazil

The southeastern Guyana Shield,northeast Amazonian Craton,in the north of Brazil,is part of a widespread orogenic belt developed during the Transamazonian orogenic cycle(2.26-1.95 Ga)that includes a large Archean continental landmass strongly reworked during the Transamazonian orogeny,named Amapa *** consists mainly of a high-grade metamorphic granulitic-migmatitic-gneiss complex,of Meso-to Neoarchean age and Rhyacian granitoids and supracrustal *** the first time,coupled U-Pb and Lu-Hf isotope data were obtained on zircon by LA-ICP-MS from five tectono-stratigraphic units of the Archean basement and one Paleoproterozoic intrusive rock,in order to investigate the main episodes of crustal growth and ***-rock Sm-Nd isotope data were compared to the zircon Lu-Hf *** main magmatic episodes were defined by U-Pb zircon dating,two in the Mesoarchean(~3.19 Ga and 2.85 Ga)and one in the Neoarchean(~2.69-2.65 Ga).SubchondriticεHf(t)values obtained for almost all investigated units indicate that crustal reworking processes were predominant during the formation of rocks that today make up the Amapa ***-TDMC model ages,ranging from2.99 Ga to 3.97 Ga,indicate that at least two important periods of mantle extraction and continental crust formation occurred during the Archean in southeastern Guyana Shield,an older one in the Eoarchean(~4.0 Ga)and a younger one in the Mesoarchean(~3.0-3.1 Ga).The latter is recognized as an important period of crustal accretion *** recognition of an Eoarchean episode to the southeastern most part of the Guyana Shield is unprecedented and was not recorded by whole-rock Sm-Nd data,which were restricted to the Meso-Paleoarchean(2.83 Ga to 3.51 Ga).This finding reveals t hat continental crust generation in the Amazonian Craton began at least 500 Ma earlier than previously suggested by the SmNd systematics.

关键词： U-Pb-Lu-Hf isotopes Zircon Archean crustal evolution Southeastern Guyana Shield Amazonian Craton

Plant growth and nutrient use efficiency of two native Fabaceae species for mineland revegetation in the eastern Amazon

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Journal of Forestry Research 2020年第6期31卷 2287-2293页

作者： silvio J.Ramos Markus Gastauer Simone K.Mitre Cecı´lio F.Caldeira Joyce R.Silva Antonio E.Furtini neto Guilherme Oliveira Pedro W.M.Souza Filho Jose´O.Siqueira Instituto Tecnolo´gico Vale Rua Boaventura da Silva955Belem 66055-090Brazil Departamento de Ciencia do Solo Universidade Federal de LavrasLavras 37200-000Brazil

The primary challenge of mineland revegetation is the establishment of species able to cope with low availability of nutrients,especially in steep slopes such as of mine *** evaluated plant growth response and nutrient use efficiency(NUE)of two promising native Fabaceae species(Dioclea apurensis—liana from metalliferous savannas;Bauhinia longipedicellata—tree from Amazon rainforest)from the Caraja´s Mineral Province,eastern *** were grown separately in 2-kg pots filled with mining *** were fertilized with nitrogen,phosphorus,potassium(NPK),lime,and *** results showed increments on growth of both species when nutrients were applied to the mining *** showed increases in leaf area,plant height,stem diameter,and shoot dry mass production when NPK or NPK?micronutrients were applied,while *** was responsive to application of NPK?lime or NPK?lime?***,*** showed higher NUE than ***,especially at the lowest doses of N,P and *** findings may indicate a substantial advantage of *** for mineland revegetation,as this species may require lower nutrient inputs,being,therefore,a more sustainable way to revegetate degraded areas.

关键词： Fertilizer application Mining soil Tropical forest Nutrient use efficiency

All-electron basis sets for H to Xe specific for ZORA calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.Gomes F.E.Jorge A.Canal neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-CCSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–Hess Hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe CCSD(T)method atomic and molecular properties

HER2 testing in gastric cancer: An update

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World Journal of Gastroenterology 2016年第19期22卷 4619-4625页

作者： Lucas Faria Abrahao-Machado Cristovam Scapulatempo-neto Department of Pathology Barretos Cancer Hospital

Human epidermal growth factor receptor 2(HER2) overexpression is increasingly recognized as a frequent molecular abnormality in gastric and gastroesophageal cancer. With the recent introduction of HER2 molecular targeted therapy for patients with advanced gastric cancer, determination of HER2 status is crucial in order to select patients who may benefit from this treatment. This paper provides an update on our knowledge of HER2 in gastric and gastroesophageal cancer, including the prognostic relevance of HER2, the key differences between HER2 protein expression interpretation in breast and gastric cancer, the detection methods and the immunohistochemistry scoring system.

关键词： Human epidermal growth factor receptor 2 testing Gastric cancer Immunohistochemistry Scoring system Trastuzumab