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Microspheres give improved resolution in nondestructive examination of semiconductor devices

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Light(Science & Applications) 2022年第3期11卷 13-14页

作者： r.c.Woods college of Engineering University of South AlabamaMobileALUSA

The minimum spatial resolution of typical optical inspection systems used in the microelectronics industry is generally governed by the classical relations of Ernst *** et *** in a new Light:Science and Applications a... 详细信息

关键词： optical resolution governed

Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural regeneration research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard Liwen Zhou cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale r.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

Transient Thermal Management comparison of a Microprocessor Using PcMs in Various configurations

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Journal of Thermal Science 2011年第6期20卷 516-520页

作者： Thenmozhi r Sharmeela c Natarajan P Velraj r Ganthipathy Tulsis' Engineering college AUIndia Anna University ChennaiIndia Bharathidasan Engineering college AUIndia

There has been a strong interest in the use of Phase change Materials (PcMs) for the transient thermal abatement of high powered *** paper presents a set of transient computational analysis for selected Ic packages with the purpose of calibrating the merits of PcM in different *** transient analysis of high powered microprocessors with heat sinks was performed as a benchmark for comparison with the same microprocessors fitted with PcM in the following configurations:a) PcM imbedded into the finned region of the heat sink,b) PcM mounted between the microprocessor and heat sink,c) sealed PcM underfill to the microprocessor and d) PcM fitted to the underside of the printed circuit board directly beneath the *** analysis was performed using a commercial cFD tool together with an approximation to the phase change mechanism using the slope *** indicate the merit of each configuration.

关键词： Phase change Materials cFD Thermal Management Transient Latent heat

Optimizing the dataset size of a topo-bathymetric survey for Hammam Debagh Dam, Algeria

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International Journal of Sediment research 2018年第4期33卷 518-524页

作者： Djamel Bengora Lotfi Khiari Jacques Gallichand Noureddine Dechemi silvio José Gumiere Department of Hydraulics Polytechnic National School Department of Soil and Agrifood Engineering Laval University

The capacity of water reservoirs may be considerably reduced by sediment transport and *** phenomenon may occur quickly in regions prone to erosion, such as Hammam Debagh Dam region in Algeria. For better management of water resources, it is important to estimate the volume of a reservoir by regular and frequent topo-bathymetric surveys. Topo-bathymetric surveys with a high point measurement density are expensive and time-consuming. To reduce this expense and to increase the frequency of topo-bathymetric surveys, it is required to optimize their size and density. The complete survey of the reservoir created by the Hammam Debagh Dam in Algeria was examined in comparison with 19 reduction subsets using geostatistics. The study showed that the complete dataset of 32,164 points, corresponding to a density of 42 points ha-1could be reduced to 10,000 points, i.e. 13 points ha-1,without affecting the estimation of the water volume in the reservoir. This reduction could considerably simplify the work load, reduce the expenses to do these surveys, and, therefore, allow for an increased frequency of topo-bathymetric surveys.

关键词： Dam reservoir Silting Volume estimation Point measurement density Volume/elevation curve

Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming

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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： Duc-Vinh Pham Thi-Kem Nguyen Bao-Loc Nguyen Jong-Oh Kim Jee-Heon Jeong inho choi Pil-Hoon Park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam college of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea research Institute of cell culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSc).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSc(ADSc).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSc in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSc,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSc against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity

Green indoor optical wireless communication systems:Pathway towards pervasive deployment

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Digital communications and Networks 2021年第3期7卷 410-444页

作者： c.Jenila r.K.Jeyachitra Department of Electronics and communication Engineering National Institute of TechnologyTiruchirappalli620015India

The Optical Wireless communication(OWc)offers the high capacity of optical fiber communication with the flexibility of wireless *** it works in the optical region of the ElectroMagnetic(EM)spectrum,it guarantees safety and security which are critical in radio and microwave frequency *** principal objective of this paper is to analyze the indoor OWc systems on these guaranteed features,and safety and security are jointly denoted by the term *** high obstacle impermeability of optical signals and their directivity strengthen the security of indoor OWc data *** confidentiality and authenticity of optical wireless data can also be preserved with the Quantum Key Distribution(QKD).This paper provides a technological overview and a review of literature about the OWc system that helps to identify the challenges in the path of a ubiquitous deployment of green wireless communication *** advancements in the sources and detectors are discussed together with the coding,modulation and multiplexing techniques for making highly robust OWc *** ubiquitous deployment of green OWc necessitates the development of optical transmitters and receivers,performance enhancement techniques,incorporation of uplink and energy harvesting abilities,and safety and security enhancement ***,a special emphasis is placed on these aspects and their challenges towards the green ***,the paper explores some significant indoor applications based on the OWc that have great impacts on the Next Generation Networks(NGN)and the Internet of Things(IoT).

关键词： Data rate Energy efficiency Green communication Infrared communication Optical wireless communication Visible light communication

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural regeneration research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

The Brio System with Initial conditions Involving Dirac Masses: A result Afforded by a Distributional Product

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chinese Annals of Mathematics,Series B 2014年第6期35卷 941-954页

作者： c.O.r.SArrIcO cMAF University of LisbonAv. Prof. Gama Pinto 2 1649-003LisboaPortugal

The Brio system is a 2 × 2 fully nonlinear system of conservation laws which arises as a simplified model in the study of plasmas. The present paper offers explicit solutions to this system subjected to initial conditions containing Dirac masses. The concept of a solution emerges within the framework of a distributional product and represents a consistent extension of the concept of a classical solution. Among other features, the result shows that the space of measures is not sufficient to contain all solutions of this problem.

关键词： Products of distributions Brio's system δ-Shock waves δ-Shock waves riemann problem

compounds from Stevia rebaudiana Bertoni leaves: An overview of non-conventional extraction methods and challenges

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Food Bioscience 2022年第2期46卷 108-121页

作者： Dj´essica Tatiane raspe camila da Silva silvio cl´audio da costa ograma de P´os-Graduaç˜ao em ciˆencia de Alimentos Universidade Estadual de Maring´aAv.Colombo579087020-900Maring´aPRBrazil Departamento de Tecnologia Universidade Estadual de Maring´aAv.ˆAngelo Moreira da Fonseca180087506-370UmuaramaPRBrazil Departamento de Bioquímica Universidade Estadual de Maring´aAv.Colombo579087020-900Maring´aPRBrazil

To overcome the inconveniences related to its conventional obtainment of natural sweeteners and active compounds from Stevia rebaudiana Bertoni,methods involving application of technology,such as ultrasound assisted extraction,microwave assisted extraction,extraction under pressurized conditions by means of pressurized liquid extraction,subcritical water extraction and supercritical fluid extraction have been *** this review,these emerging techniques were analyzed and discussed,the process variables and operational strategies,their impacts on the extraction and their comparison against the conventional techniques were *** and the possibility of operational automation,the use of less energy and solvents,in addition to the reduced complexity of the subsequent purification steps,make up viable alternatives suitable for a possible industrial *** processes leverage the concept of green chemistry,but still suffer limitations related to acquisition and maintenance costs,in addition to the effects of the action of some of these technologies remaining unexplored.

关键词： Active compounds Natural sweeteners Steviol glycosides Technology application