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Real-world comparison of non-vitamin K antagonist oral anticoagulants and warfarin in Asian octogenarian patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第7期13卷 566-572页

作者： Chang Hee Kwon Minsu Kim gi-Byoung Nam Kee-Joon Choi You-Ho Kim Division of Cardiology Konkuk University Medical Center Konkuk University School of Medicine Seoul South Korea Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul South Korea

Background The efficacy and safety of non-vitamin K antagonist oral anticoagulants （NOACs） and warfarin in Asian octogenarian atrial fibrillation （AF） patients have not been established in a real-world setting. We aimed to evaluate the efficacy and safety of NOACs and warfarin in Korean octogenarian patients. Methods A total of 293 consecutive patients aged 〉 80 years with non-valvular AF who had taken either NOACs 048 cases, 50.5%） or warfarin （145 cases, 49.5%） were retrospectively reviewed. The efficacy outcome was the com- posite of stroke or systemic embolism. The safety outcome was major bleeding. Results The follow-up duration was 375 patient-years （ 172 patient-years with NOACs and 203 patient-years with warfarin）. patients on NOACs were slightly older （P = 0.006） and had slightly higher HAS-BLED scores （P = 0.034）. The efficacy of both anticoagulants was high （1.16% for NOACs vs. 2.98% for warfarin per 100 pa- tient-years, P = 0.46）. The safety outcome was relatively high in both NOACs and warfarin groups （8.96% vs. 12.46%, P = 0.29）. The effi- cacy and safety outcomes tended to decrease non-significantly in low dose NOACs than in common dose NOACs or warfarin （0.85% vs. 1.84% vs. 2.98% in efficacy outcome, P = 0.69; and 6.97% vs. 13.29% vs. 12.46% in safety outcome, P = 0.34）. Conclusions NOACs were highly effective for prevention of stroke or systemic embolism in Asian octogenarian AF patients. However, major bleeding occurred excessively high in both anticoagulant groups. Further study is required on the optimal anticoagulant regimen in octogenarian population.

关键词： Anticoagulants Atrial fibrillation Efficacy Octogenarian Safety

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Correlates of resistance to gastrointestinal nematode infection in Nigerian West African dwarf sheep

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Asian pacific Journal of Tropical Medicine 2012年第7期5卷 529-532页

作者： IK Idika SN Chiejina LI Mhomga pa Nnadi LA Ngongeh Department of Veterinary parasitology and Entomology University of NigeriaNsukkaNigeria Department of Veterinary parasitology and Microbiology Michael Okpara University of AgricultureUmudikeNigeria Department of Animal Health and Production University of AgricultureMakurdiNigeria Department of Animal Health and Production University of NigeriaNsukkaNigeria

Objective:To investigate correlates of resistance to G1 nematode infection in Nigerian West African dwarf(WAD) ***:Thirty three sheep were randomly assigned to two groups, A(n=27) which were used for experimental infections,and B(n=6) which served as uninfected *** infected animal received weekly escalating infections with infective larvae(60% Haemonchus contortus(***) and 40%Trichostrongylus colubriformis(***) for 4 *** responses of all the infected and control sheep were assessed by faecal egg count(FEC),worm burden(Wb),packed cell volume(PCV),body weight(Bwt).and body condition score(BCS).On the basis of their individual faecal egg output,Lambs in group A with epg≤1 000 on any sampling day were classified as low faecal egg count(LFEC) phenotype(n = 16),those with epg between 1 000 and 10 000 as intermediate(n=5) and lambs with epg > 10 000 as high feacal egg count(HFEC) phenotype(n=6).Results:The difference between the FEC classes was highly significant(P=0.001).The BCS and weight gained at the end of the experiment by the control and LFEC sheep was significandy higher(P≤0.05) than those of the intermediate and HFEC *** was a significant and negative correlation between the parasitological measures and the trio of BCS,PCV and Bwt of ***:The result of the study indicated that the FEC,weight gain,PCV,and BCS are correlates and potential selection crileria of G1 nematode resistant WAD sheep.

关键词： WAD sheep Phenotypic markers Resistance Resilience gi nematode

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Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma

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Hepatobiliary & pancreatic Diseases International 2020年第3期19卷 244-251页

作者： gil Chun park Sung Gyu Lee Young In Yoon Kyu Bo Sung gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE *** present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall ***:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November *** were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control *** baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were ***:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well *** TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both Ppatients with HCC scheduled for major hepatic *** active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression.

关键词： Sequential selective transcatheter Arterial chemoembolization Portal vein embolization Hepatocellular carcinoma Future liver remnant

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Flt3L对COPD大鼠铜绿假单胞菌肺炎的防治研究

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重庆医学 2009年第12期38卷 1466-1467,1470页

作者：曹国强姬军生吴奎第三军医大学大坪医院野战外科研究所呼吸科重庆400042 第三军医大学西南医院重庆400038

目的建立铜绿假单胞菌（pa）肺部感染大鼠慢性阻塞性肺疾病（COPD）模型，研究Flt3L（Fms—like tyrosine kinase-3 ligand）对其炎症反应的防治作用。方法将50只健康雄性清洁级Wistar大鼠随机分为对照组（NS组）、pa感染对照组（Npa组... 详细信息

目的建立铜绿假单胞菌（pa）肺部感染大鼠慢性阻塞性肺疾病（COPD）模型，研究Flt3L（Fms—like tyrosine kinase-3 ligand）对其炎症反应的防治作用。方法将50只健康雄性清洁级Wistar大鼠随机分为对照组（NS组）、pa感染对照组（Npa组）、COPD大鼠组（COPD组）、COPD大鼠pa感染组（Cpa组）和COPD大鼠pa感染Flt3L处理组（Flt3L组），每组动物各10只。用烟雾暴露法复制大鼠COPD模型，气管内滴入pa溶液复制肺部pa感染模型。COPD组、Cpa组、Flt3L组大鼠分别在第1～60天以烟雾暴露法复制COPD模型，Flt3L组于第61～65天连续给予Flt3L（20g／kg）腹腔注射，每天1次，连续5d，第66天同时建立Npa组、Cpa组和Flt3L组模型。24h后计算大鼠死亡率，对支气管肺泡灌洗液（BALF）、肺组织进行细菌学、细胞学、病理学等研究。无菌操作下取出大鼠脏器进行细菌培养、菌落计数及细菌鉴定。结果Flt3L组大鼠存活率（87．5%）显著高于Cpa组（50．0％）（P〈0．01），Flt3L组大鼠支气管肺泡灌洗液中淋巴细胞数[（0．41～0．05）×10^9／L]与Cpa组（（0．24～0．04）×10^9／L]比较显著增加（P〈0．01），光镜下观察比较发现Flt3L组大鼠肺组织炎症反应较Cpa组明显减轻，脏器细菌培养阳性率Cpa组（37．5％）显著高于Flt3L组（12．5％）（P〈0．01）。结论Flt3L能够增强COPD大鼠对pa肺部感染的抗痛力。

关键词：慢性阻塞性肺疾病动物模型铜绿假单胞菌肺部感染

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《王统世系明鉴》若干疑点再探

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青海师范大学学报（藏文版） 2022年第2期 72-80页

作者：索巴尖措西藏大学文学院

《王统世系明鉴》(RGyal rabs gsal bavi me long)系元末明初由萨迦派高僧索南坚赞(1312—1375)所撰写的一部藏史名著。关于这部藏史名著是否由萨迦索南坚赞完成,学术界观点不一。有学者根据《大昭寺志》和《萨迦世系宝库》等的相关记... 详细信息

《王统世系明鉴》(RGyal rabs gsal bavi me long)系元末明初由萨迦派高僧索南坚赞(1312—1375)所撰写的一部藏史名著。关于这部藏史名著是否由萨迦索南坚赞完成,学术界观点不一。有学者根据《大昭寺志》和《萨迦世系宝库》等的相关记载否定《萨迦王统世系明鉴》由萨迦索南坚赞所著,而国外学者(***)则认为该书不仅由萨迦•索南坚赞所著,而且是在公元1328—1388年间撰写完成的一部藏史名著。全书以吐蕃王朝历代赞普世系为主线,叙述了整个吐蕃王朝的政治、军事和宗教、文化之历史。该书在书写风格上借鉴当时流行涉藏地区的历史叙述风格并征引大量藏族历史文献,采用诗文结合的文体,集宗教、文学、历史于一体,创造性地突破了旧式编年叙事体例,对研究吐蕃历史文化具有重要的史料价值。在版本上,1981年由民族出版社出版的《王统世系明鉴》存在把“不知者莫改”写成“不知者可改”的严重对勘错误问题,对此问题,论文以表格形式细列该版本与德格版本不同的所在。在书写特点上,如,关于“年保桑哇”的记载,《松巴佛教史》与《格扎佛教史》《徳迥佛教史》都写成“■”,而《王统世系明鉴》里写成“■”,属较为特殊的写法。在语法上,呈现的否定词“■”为语法化和出现“■”等亦是该书讨论的内容。

关键词：《王统世系明鉴》版本语法

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